iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011229

Ensembl Protein ID

ENSAMXP00000006545.1

UniProt Accession

W5KG33; W5KG33_ASTMX

Genbank Protein ID

ENSAMXP00000006545

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

APWO01024072

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000006369.1	ENSAMXT00000006545.1	ENSAMXP00000006545.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.80e-35	118.1	50	80
UBD/Beta-Prp	5.30e-75	252.6	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++++  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWILASLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tir+w++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRIWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgavet 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                       +++ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   ++t++gh +nv++  f+p++e+++s s
   Q: 180  evrgitgvdlfgASDAVVKHVLEGHDRGVNWAAFHPSMPLIVSGADDRQVKIWRMNESKAweLDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888877777********************************8888789************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++   + +++ n +++g  ds   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLGA-HPNLNLFAAG-HDSGMLVFKLERERP 324
           ***************************9999.4444444333.589999999988765 PP

Organism

Astyanax mexicanus

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILASLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGACATGTG CTGGATTTGG GACTCGCCCA CACTGAGTGT GACGTGGAGG TTCCGCTGCA 60
GCGCTGGAGC TGAGTGTGAG TGAGCGGGTT TGTGTAGACG TGTCAGCTCC GGAAGCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0061053--P:somite development
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	61.32	0.00e+00	1087.00
IUUC-Aml-001758	Ailuropoda melanoleuca	85.97	0.00e+00	2233.00
IUUC-Atr-002493	Amborella trichopoda	54.17	0.00e+00	1307.00
IUUC-Apl-003385	Anas platyrhynchos	83.99	0.00e+00	1868.00
IUUC-Aca-005154	Anolis carolinensis	94.20	4.00e-119	420.00
IUUC-Aly-006020	Arabidopsis lyrata	52.35	0.00e+00	1286.00
IUUC-Ath-007058	Arabidopsis thaliana	61.06	0.00e+00	1070.00
IUUC-Ago-007992	Ashbya gossypii	44.63	0.00e+00	1030.00
IUUC-Acl-008027	Aspergillus clavatus	56.80	0.00e+00	1006.00
IUUC-Afl-008644	Aspergillus flavus	56.95	0.00e+00	999.00
IUUC-Afu-008964	Aspergillus fumigatus	56.97	0.00e+00	1010.00
IUUC-Ani-009379	Aspergillus nidulans	56.60	0.00e+00	1017.00
IUUC-Ang-009756	Aspergillus niger	57.40	0.00e+00	1015.00
IUUC-Aor-010174	Aspergillus oryzae	56.95	0.00e+00	998.00
IUUC-Ate-010302	Aspergillus terreus	48.54	0.00e+00	1196.00
IUUC-Bgr-012300	Blumeria graminis	47.26	0.00e+00	1126.00
IUUC-Bta-012524	Bos taurus	86.68	0.00e+00	2224.00
IUUC-Bci-013781	Botrytis cinerea	48.87	0.00e+00	1187.00
IUUC-Bdi-014549	Brachypodium distachyon	53.28	0.00e+00	1318.00
IUUC-Bol-015925	Brassica oleracea	60.58	0.00e+00	1061.00
IUUC-Bra-016978	Brassica rapa	60.00	0.00e+00	1057.00
IUUC-Cel-018115	Caenorhabditis elegans	63.64	0.00e+00	1114.00
IUUC-Cja-019107	Callithrix jacchus	84.02	0.00e+00	2165.00
IUUC-Cfa-020675	Canis familiaris	85.82	0.00e+00	2199.00
IUUC-Cpo-021813	Cavia porcellus	86.76	0.00e+00	2242.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	63.65	0.00e+00	1098.00
IUUC-Csa-023523	Chlorocebus sabaeus	86.68	0.00e+00	2244.00
IUUC-Cho-024704	Choloepus hoffmanni	73.47	0.00e+00	1703.00
IUUC-Cin-025572	Ciona intestinalis	71.88	0.00e+00	1837.00
IUUC-Csv-025864	Ciona savignyi	75.24	0.00e+00	1296.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.86	0.00e+00	1027.00
IUUC-Cne-027053	Cryptococcus neoformans	59.50	0.00e+00	1051.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.39	0.00e+00	646.00
IUUC-Dre-027421	Danio rerio	95.67	0.00e+00	2378.00
IUUC-Dno-029303	Dasypus novemcinctus	86.32	0.00e+00	2236.00
IUUC-Dor-030290	Dipodomys ordii	78.58	0.00e+00	919.00
IUUC-Dse-031543	Dothistroma septosporum	46.93	0.00e+00	1121.00
IUUC-Dme-031945	Drosophila melanogaster	67.93	0.00e+00	1677.00
IUUC-Ete-032873	Echinops telfairi	81.81	0.00e+00	1943.00
IUUC-Eca-033773	Equus caballus	84.91	0.00e+00	2175.00
IUUC-Eeu-034874	Erinaceus europaeus	73.57	0.00e+00	1310.00
IUUC-Fca-035739	Felis catus	85.93	0.00e+00	2184.00
IUUC-Fal-037263	Ficedula albicollis	80.39	0.00e+00	1989.00
IUUC-Fox-037738	Fusarium oxysporum	48.54	0.00e+00	1194.00
IUUC-Fso-038153	Fusarium solani	49.19	0.00e+00	1186.00
IUUC-Gmo-039602	Gadus morhua	89.89	0.00e+00	2193.00
IUUC-Ggr-039931	Gaeumannomyces graminis	57.21	0.00e+00	1019.00
IUUC-Gga-040590	Gallus gallus	86.11	0.00e+00	2224.00
IUUC-Gac-041318	Gasterosteus aculeatus	92.74	0.00e+00	2355.00
IUUC-Gma-043894	Glycine max	54.01	0.00e+00	1332.00
IUUC-Ggo-045029	Gorilla gorilla	86.13	0.00e+00	2238.00
IUUC-Hsa-046078	Homo sapiens	86.05	0.00e+00	2236.00
IUUC-Hvu-047556	Hordeum vulgare	54.16	0.00e+00	1338.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	82.03	0.00e+00	1505.00
IUUC-Kpa-049256	Komagataella pastoris	45.34	0.00e+00	1086.00
IUUC-Lch-049706	Latimeria chalumnae	86.68	0.00e+00	2204.00
IUUC-Lpe-051316	Leersia perrieri	61.44	0.00e+00	1087.00
IUUC-Loc-051867	Lepisosteus oculatus	70.35	0.00e+00	1225.00
IUUC-Lma-053138	Leptosphaeria maculans	47.70	0.00e+00	1153.00
IUUC-Laf-053510	Loxodonta africana	87.75	0.00e+00	2249.00
IUUC-Mcc-055836	Macaca mulatta	85.97	0.00e+00	2228.00
IUUC-Meu-056238	Macropus eugenii	82.04	0.00e+00	1129.00
IUUC-Mor-057172	Magnaporthe oryzae	49.19	0.00e+00	1175.00
IUUC-Mpo-057300	Magnaporthe poae	48.84	0.00e+00	1169.00
IUUC-Mtr-058248	Medicago truncatula	54.26	0.00e+00	1341.00
IUUC-Mla-059019	Melampsora laricipopulina	51.57	0.00e+00	1268.00
IUUC-Mga-059499	Meleagris gallopavo	85.97	0.00e+00	2219.00
IUUC-Mvi-060336	Microbotryum violaceum	59.23	0.00e+00	1072.00
IUUC-Mmr-061102	Microcebus murinus	86.05	0.00e+00	2205.00
IUUC-Mdo-062594	Monodelphis domestica	87.43	0.00e+00	2258.00
IUUC-Mmu-063736	Mus musculus	85.97	0.00e+00	2229.00
IUUC-Mac-065398	Musa acuminata	50.81	0.00e+00	1207.00
IUUC-Mpu-066701	Mustela putorius furo	86.40	0.00e+00	2221.00
IUUC-Mlu-067392	Myotis lucifugus	86.30	0.00e+00	2233.00
IUUC-Nfi-068270	Neosartorya fischeri	57.18	0.00e+00	1009.00
IUUC-Ncr-068892	Neurospora crassa	56.53	0.00e+00	1018.00
IUUC-Nle-069634	Nomascus leucogenys	93.33	0.00e+00	1321.00
IUUC-Opr-070952	Ochotona princeps	73.57	0.00e+00	1576.00
IUUC-Ont-072488	Oreochromis niloticus	93.30	0.00e+00	2325.00
IUUC-Oan-073184	Ornithorhynchus anatinus	44.22	3.00e-68	251.00
IUUC-Ocu-074211	Oryctolagus cuniculus	86.76	0.00e+00	2244.00
IUUC-Oba-075761	Oryza barthii	61.20	0.00e+00	1084.00
IUUC-Obr-076429	Oryza brachyantha	61.44	0.00e+00	1083.00
IUUC-Ogl-077364	Oryza glaberrima	61.20	0.00e+00	1085.00
IUUC-Ogu-078257	Oryza glumaepatula	61.20	0.00e+00	1083.00
IUUC-Oin-079274	Oryza indica	61.08	0.00e+00	1083.00
IUUC-Olo-080466	Oryza longistaminata	61.58	0.00e+00	1073.00
IUUC-Ome-081993	Oryza meridionalis	63.72	0.00e+00	1016.00
IUUC-Oni-082874	Oryza nivara	61.20	0.00e+00	1083.00
IUUC-Opu-083370	Oryza punctata	52.92	0.00e+00	1296.00
IUUC-Oru-084274	Oryza rufipogon	61.20	0.00e+00	1084.00
IUUC-Osa-085565	Oryza sativa	61.20	0.00e+00	1084.00
IUUC-Ola-086921	Oryzias latipes	91.82	0.00e+00	2281.00
IUUC-Olu-087639	Ostreococcus lucimarinus	54.72	0.00e+00	1327.00
IUUC-Oga-087991	Otolemur garnettii	81.68	0.00e+00	2102.00
IUUC-Oar-089590	Ovis aries	86.60	0.00e+00	2244.00
IUUC-Ptr-090808	Pan troglodytes	86.13	0.00e+00	2238.00
IUUC-Pan-092475	Papio anubis	86.29	0.00e+00	2231.00
IUUC-Psi-093044	Pelodiscus sinensis	78.07	0.00e+00	1320.00
IUUC-Pno-094839	Phaeosphaeria nodorum	47.08	0.00e+00	1095.00
IUUC-Ppa-095254	Physcomitrella patens	56.08	0.00e+00	1384.00
IUUC-Pfo-097493	Poecilia formosa	93.55	0.00e+00	2288.00
IUUC-Pab-098497	Pongo abelii	86.76	0.00e+00	2245.00
IUUC-Pop-099992	Populus trichocarpa	64.17	0.00e+00	1096.00
IUUC-Pca-100413	Procavia capensis	83.85	0.00e+00	966.00
IUUC-Ppe-101899	Prunus persica	53.74	0.00e+00	1311.00
IUUC-Pva-102126	Pteropus vampyrus	82.81	0.00e+00	2135.00
IUUC-Pgr-103376	Puccinia graminis	58.14	0.00e+00	1045.00
IUUC-Ptt-103978	Puccinia triticina	50.12	0.00e+00	825.00
IUUC-Pte-104126	Pyrenophora teres	55.24	0.00e+00	973.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	45.64	3.00e-178	619.00
IUUC-Rno-105428	Rattus norvegicus	86.52	0.00e+00	2235.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.08	0.00e+00	999.00
IUUC-Sha-107301	Sarcophilus harrisii	86.62	0.00e+00	2222.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.57	0.00e+00	1076.00
IUUC-Spo-108217	Schizosaccharomyces pombe	47.03	0.00e+00	1115.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	49.11	0.00e+00	1192.00
IUUC-Smo-109582	Selaginella moellendorffii	63.98	0.00e+00	1144.00
IUUC-Sit-109697	Setaria italica	61.44	0.00e+00	1084.00
IUUC-Sly-111447	Solanum lycopersicum	54.16	0.00e+00	1350.00
IUUC-Stu-112564	Solanum tuberosum	54.38	0.00e+00	1347.00
IUUC-Sar-113313	Sorex araneus	75.00	0.00e+00	1303.00
IUUC-Sbi-114388	Sorghum bicolor	61.68	0.00e+00	1087.00
IUUC-Sre-115209	Sporisorium reilianum	57.53	0.00e+00	1041.00
IUUC-Ssc-115933	Sus scrofa	86.60	0.00e+00	2240.00
IUUC-Tgu-117109	Taeniopygia guttata	71.26	0.00e+00	680.00
IUUC-Tru-117772	Takifugu rubripes	91.36	0.00e+00	2276.00
IUUC-Tsy-119105	Tarsius syrichta	74.88	0.00e+00	1894.00
IUUC-Tni-120556	Tetraodon nigroviridis	75.17	0.00e+00	1630.00
IUUC-Tca-121046	Theobroma cacao	53.80	0.00e+00	1334.00
IUUC-Tre-121951	Trichoderma reesei	56.51	0.00e+00	1018.00
IUUC-Tvi-122359	Trichoderma virens	57.67	0.00e+00	1022.00
IUUC-Tae-123688	Triticum aestivum	54.13	0.00e+00	1338.00
IUUC-Tur-126016	Triticum urartu	52.52	0.00e+00	1202.00
IUUC-Tme-127170	Tuber melanosporum	49.76	0.00e+00	1209.00
IUUC-Tbe-127882	Tupaia belangeri	68.50	0.00e+00	772.00
IUUC-Ttr-128217	Tursiops truncatus	83.86	0.00e+00	2163.00
IUUC-Uma-129337	Ustilago maydis	57.76	0.00e+00	1042.00
IUUC-Vda-129828	Verticillium dahliae	48.23	0.00e+00	1170.00
IUUC-Vpa-130537	Vicugna pacos	85.56	0.00e+00	2211.00
IUUC-Vvi-130958	Vitis vinifera	62.91	0.00e+00	1102.00
IUUC-Xtr-132857	Xenopus tropicalis	83.02	0.00e+00	2087.00
IUUC-Xma-133138	Xiphophorus maculatus	93.38	0.00e+00	2285.00
IUUC-Yli-134399	Yarrowia lipolytica	50.64	0.00e+00	867.00
IUUC-Zma-135612	Zea mays	52.95	0.00e+00	1312.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence