iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107514

Ensembl Protein ID

ENSSHAP00000010980.1

UniProt Accession

G3W6C5; G3W6C5_SARHA

Genbank Protein ID

ENSSHAP00000010980

Protein Name

Protein HIRA

Genbank Nucleotide ID

AEFK01103720

Gene Name

HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000009464.1	ENSSHAT00000011074.1	ENSSHAP00000010980.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.60e-14	51.7	123	152

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           H+++v ++a+  +d  l+s+s D+t+ +W+
   Q: 123  HSGDVMDVAWspHDAWLASCSVDNTVVIWN 152
           9*********9655779************9 PP

Organism

Sarcophilus harrisii

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

LDMEKSVWKK ALGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMAPVLK EEDEKNENIP 60
KMLCQMDNHP LVCILCPWCS LRTGGDLWDS LSPRYIGPST VFGSSSKLAN VEQWRCVSIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGACATGG AGAAAAGCGT TTGGAAAAAA GTTTGTTTAG TGGGGTACAA AGAGCTTGCT 60
CTTGGAATCC AAAGGCCTCC ATTGAAATCC TGGTTCCCAT GCTTGGGAAA GACACTTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	36.82	7.00e-73	268.00
IUUC-Aml-001723	Ailuropoda melanoleuca	81.34	0.00e+00	1448.00
IUUC-Atr-003132	Amborella trichopoda	33.53	7.00e-72	265.00
IUUC-Apl-003197	Anas platyrhynchos	83.35	0.00e+00	1536.00
IUUC-Aca-004733	Anolis carolinensis	79.79	0.00e+00	1479.00
IUUC-Aly-005446	Arabidopsis lyrata	33.33	1.00e-67	251.00
IUUC-Ath-007627	Arabidopsis thaliana	36.66	4.00e-71	263.00
IUUC-Ago-007766	Ashbya gossypii	29.51	3.00e-47	183.00
IUUC-Acl-008104	Aspergillus clavatus	28.24	2.00e-50	194.00
IUUC-Afl-008591	Aspergillus flavus	28.94	3.00e-49	190.00
IUUC-Afu-008781	Aspergillus fumigatus	31.12	4.00e-48	186.00
IUUC-Ani-009272	Aspergillus nidulans	31.27	1.00e-45	178.00
IUUC-Ang-009655	Aspergillus niger	31.05	8.00e-51	195.00
IUUC-Aor-010119	Aspergillus oryzae	28.02	1.00e-49	191.00
IUUC-Ate-010530	Aspergillus terreus	30.22	5.00e-45	176.00
IUUC-Ame-011147	Astyanax mexicanus	68.13	2.00e-30	123.00
IUUC-Bgr-012237	Blumeria graminis	31.85	1.00e-49	191.00
IUUC-Bta-013320	Bos taurus	78.96	0.00e+00	1494.00
IUUC-Bci-013795	Botrytis cinerea	32.11	3.00e-53	203.00
IUUC-Bdi-014075	Brachypodium distachyon	34.78	3.00e-76	280.00
IUUC-Bol-016440	Brassica oleracea	32.96	5.00e-74	272.00
IUUC-Bra-016651	Brassica rapa	34.12	6.00e-73	269.00
IUUC-Cel-018692	Caenorhabditis elegans	36.49	5.00e-66	246.00
IUUC-Cja-018987	Callithrix jacchus	80.26	0.00e+00	1421.00
IUUC-Cfa-020132	Canis familiaris	81.54	0.00e+00	1449.00
IUUC-Cpo-021484	Cavia porcellus	80.29	0.00e+00	1468.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	34.55	2.00e-51	197.00
IUUC-Csa-023081	Chlorocebus sabaeus	80.39	0.00e+00	1496.00
IUUC-Cin-025182	Ciona intestinalis	51.12	3.00e-135	476.00
IUUC-Csv-026154	Ciona savignyi	51.70	3.00e-129	456.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	29.64	1.00e-51	198.00
IUUC-Cne-026891	Cryptococcus neoformans	39.29	3.00e-72	266.00
IUUC-Cme-027349	Cyanidioschyzon merolae	31.95	6.00e-44	172.00
IUUC-Dre-027655	Danio rerio	65.63	0.00e+00	1228.00
IUUC-Dno-029557	Dasypus novemcinctus	71.51	0.00e+00	850.00
IUUC-Dor-030687	Dipodomys ordii	76.92	0.00e+00	631.00
IUUC-Dse-031334	Dothistroma septosporum	29.72	9.00e-50	192.00
IUUC-Dme-031746	Drosophila melanogaster	50.64	2.00e-136	480.00
IUUC-Ete-032384	Echinops telfairi	77.90	0.00e+00	1431.00
IUUC-Eca-033430	Equus caballus	81.24	0.00e+00	1452.00
IUUC-Fca-036121	Felis catus	80.94	0.00e+00	1450.00
IUUC-Fal-036817	Ficedula albicollis	82.64	0.00e+00	1538.00
IUUC-Fox-037906	Fusarium oxysporum	33.00	1.00e-53	204.00
IUUC-Fso-038409	Fusarium solani	29.82	6.00e-53	202.00
IUUC-Gmo-039151	Gadus morhua	78.88	4.00e-177	615.00
IUUC-Ggr-040016	Gaeumannomyces graminis	33.75	6.00e-55	209.00
IUUC-Gga-040936	Gallus gallus	82.20	0.00e+00	1578.00
IUUC-Gac-041405	Gasterosteus aculeatus	59.37	0.00e+00	1068.00
IUUC-Gma-044252	Glycine max	33.73	8.00e-73	268.00
IUUC-Ggo-045430	Gorilla gorilla	80.60	0.00e+00	1498.00
IUUC-Hsa-046442	Homo sapiens	80.39	0.00e+00	1498.00
IUUC-Hvu-047587	Hordeum vulgare	32.97	6.00e-66	245.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	89.11	2.00e-150	524.00
IUUC-Kpa-049145	Komagataella pastoris	29.56	2.00e-47	184.00
IUUC-Lch-050474	Latimeria chalumnae	83.89	0.00e+00	753.00
IUUC-Lpe-051209	Leersia perrieri	33.27	2.00e-68	253.00
IUUC-Loc-052119	Lepisosteus oculatus	68.77	0.00e+00	1245.00
IUUC-Lma-053237	Leptosphaeria maculans	31.71	5.00e-53	202.00
IUUC-Laf-053718	Loxodonta africana	80.76	0.00e+00	1482.00
IUUC-Mcc-055621	Macaca mulatta	80.65	0.00e+00	1427.00
IUUC-Meu-055914	Macropus eugenii	83.81	0.00e+00	1466.00
IUUC-Mor-057090	Magnaporthe oryzae	32.43	7.00e-52	199.00
IUUC-Mpo-057364	Magnaporthe poae	34.01	5.00e-56	213.00
IUUC-Mtr-057744	Medicago truncatula	33.93	1.00e-74	275.00
IUUC-Mla-058914	Melampsora laricipopulina	39.55	4.00e-69	256.00
IUUC-Mga-060181	Meleagris gallopavo	81.71	0.00e+00	1556.00
IUUC-Mvi-060432	Microbotryum violaceum	35.64	1.00e-60	228.00
IUUC-Mmr-060871	Microcebus murinus	80.29	0.00e+00	1519.00
IUUC-Mdo-062301	Monodelphis domestica	88.27	0.00e+00	1586.00
IUUC-Mmu-063888	Mus musculus	79.98	0.00e+00	1448.00
IUUC-Mac-065137	Musa acuminata	35.62	7.00e-74	271.00
IUUC-Mpu-066732	Mustela putorius furo	81.15	0.00e+00	1475.00
IUUC-Mlu-067542	Myotis lucifugus	81.23	0.00e+00	1432.00
IUUC-Nfi-068396	Neosartorya fischeri	31.65	4.00e-48	186.00
IUUC-Ncr-068842	Neurospora crassa	31.99	6.00e-54	206.00
IUUC-Nle-070156	Nomascus leucogenys	80.59	0.00e+00	1507.00
IUUC-Opr-070808	Ochotona princeps	81.41	0.00e+00	1226.00
IUUC-Ont-072105	Oreochromis niloticus	63.47	0.00e+00	1209.00
IUUC-Ocu-074962	Oryctolagus cuniculus	81.66	0.00e+00	1472.00
IUUC-Oba-075178	Oryza barthii	38.36	2.00e-74	273.00
IUUC-Obr-076399	Oryza brachyantha	34.04	8.00e-75	275.00
IUUC-Ogu-078797	Oryza glumaepatula	38.36	2.00e-74	273.00
IUUC-Oin-080085	Oryza indica	40.13	8.00e-64	238.00
IUUC-Olo-081048	Oryza longistaminata	40.13	7.00e-64	239.00
IUUC-Ome-081324	Oryza meridionalis	38.36	2.00e-74	274.00
IUUC-Oni-082548	Oryza nivara	38.36	2.00e-74	273.00
IUUC-Opu-084008	Oryza punctata	38.42	2.00e-74	273.00
IUUC-Oru-084339	Oryza rufipogon	38.11	6.00e-74	272.00
IUUC-Osa-085782	Oryza sativa	38.11	6.00e-74	272.00
IUUC-Ola-087302	Oryzias latipes	66.39	0.00e+00	721.00
IUUC-Olu-087611	Ostreococcus lucimarinus	34.22	2.00e-77	283.00
IUUC-Oga-087935	Otolemur garnettii	81.12	0.00e+00	1459.00
IUUC-Oar-089229	Ovis aries	63.38	0.00e+00	926.00
IUUC-Ptr-090715	Pan troglodytes	80.39	0.00e+00	1496.00
IUUC-Pan-092318	Papio anubis	80.59	0.00e+00	1497.00
IUUC-Psi-094053	Pelodiscus sinensis	82.99	0.00e+00	1546.00
IUUC-Pno-094985	Phaeosphaeria nodorum	32.26	3.00e-49	190.00
IUUC-Ppa-095819	Physcomitrella patens	34.16	2.00e-77	283.00
IUUC-Pfo-096857	Poecilia formosa	62.29	0.00e+00	1157.00
IUUC-Pab-098047	Pongo abelii	80.49	0.00e+00	1498.00
IUUC-Pop-099587	Populus trichocarpa	34.53	2.00e-73	270.00
IUUC-Pca-100558	Procavia capensis	78.59	2.00e-174	606.00
IUUC-Ppe-101261	Prunus persica	34.02	7.00e-75	275.00
IUUC-Pva-102683	Pteropus vampyrus	81.34	0.00e+00	1479.00
IUUC-Pgr-103660	Puccinia graminis	38.62	2.00e-63	237.00
IUUC-Ptt-103900	Puccinia triticina	39.60	7.00e-65	241.00
IUUC-Pte-104209	Pyrenophora teres	30.53	2.00e-51	197.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	32.89	1.00e-50	194.00
IUUC-Rno-105566	Rattus norvegicus	79.88	0.00e+00	1468.00
IUUC-Sce-106291	Saccharomyces cerevisiae	28.48	3.00e-49	190.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	38.44	8.00e-65	241.00
IUUC-Spo-108162	Schizosaccharomyces pombe	35.88	1.00e-64	241.00
IUUC-Ssl-108629	Sclerotinia sclerotiorum	33.33	1.00e-16	82.00
IUUC-Smo-109186	Selaginella moellendorffii	37.72	6.00e-74	272.00
IUUC-Sit-109980	Setaria italica	35.83	1.00e-77	284.00
IUUC-Sly-111547	Solanum lycopersicum	34.60	8.00e-76	278.00
IUUC-Stu-112705	Solanum tuberosum	34.60	2.00e-75	277.00
IUUC-Sar-113222	Sorex araneus	75.85	0.00e+00	1282.00
IUUC-Sbi-114272	Sorghum bicolor	35.77	2.00e-78	286.00
IUUC-Sre-115061	Sporisorium reilianum	32.98	2.00e-66	247.00
IUUC-Ssc-116364	Sus scrofa	79.96	0.00e+00	1523.00
IUUC-Tgu-116645	Taeniopygia guttata	83.04	0.00e+00	1578.00
IUUC-Tru-117590	Takifugu rubripes	62.26	0.00e+00	1189.00
IUUC-Tsy-119212	Tarsius syrichta	77.30	0.00e+00	832.00
IUUC-Tni-119915	Tetraodon nigroviridis	62.59	0.00e+00	1151.00
IUUC-Tca-121765	Theobroma cacao	33.67	3.00e-74	273.00
IUUC-Tre-121887	Trichoderma reesei	31.81	4.00e-44	173.00
IUUC-Tvi-122262	Trichoderma virens	31.81	5.00e-44	172.00
IUUC-Tur-126483	Triticum urartu	39.90	8.00e-77	281.00
IUUC-Tme-127202	Tuber melanosporum	29.24	9.00e-47	182.00
IUUC-Tbe-127350	Tupaia belangeri	78.54	3.00e-174	605.00
IUUC-Ttr-129077	Tursiops truncatus	76.38	0.00e+00	1452.00
IUUC-Uma-129465	Ustilago maydis	34.34	3.00e-70	259.00
IUUC-Vda-129844	Verticillium dahliae	32.05	6.00e-51	196.00
IUUC-Vvi-131397	Vitis vinifera	34.21	4.00e-76	279.00
IUUC-Xtr-132057	Xenopus tropicalis	71.18	0.00e+00	1280.00
IUUC-Xma-134139	Xiphophorus maculatus	64.83	0.00e+00	731.00
IUUC-Yli-134424	Yarrowia lipolytica	29.88	2.00e-51	197.00
IUUC-Zma-135839	Zea mays	34.86	6.00e-76	279.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence