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Tag Content
iUUCD ID IUUC-Gga-040988
Ensembl Protein ID ENSGALP00000021137.2
UniProt Accession P06212; ESR1_CHICK
Genbank Protein ID CAA27433.1
Protein Name Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Genbank Nucleotide ID X03805
Gene Name ESR1; ESR; NR3A1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000012973.5 ENSGALT00000021168.4 ENSGALP00000021137.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UMI 78.78 0.00e+00 870.00 IUUC-Hsa-046944
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).
 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).
Protein Sequence
(Fasta)
MTMTLHTKAS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVESNKTG VFNYPEGATY 60
DFGTTAPVYG STTLSYAPTS ESFGSSSLAG FHSLNNVPPS PVVFLQTAPQ LSPFIHHHSQ 120
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Protein Fasta Sequence


>IUUC-Gga-040988|UBD,UMI|Gallus gallus
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Nucleotide Sequence
(Fasta)
TGTGCCTTTC CAGTGCTCAC CCTGCATTTG TTAGTATACT CCTGCTTGCC GAGATCAGAG 60
GAATACCTAT GTATTGCTGC TTTAACATGA TTTCTGCTGA GCCTCAGAAT AGGTTCTGGT 120
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Nucleotide Fasta Sequence


>IUUC-Gga-040988|UBD,UMI|Gallus gallus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA
PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2
Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4
PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER
SMART

SM00430--HOLI
SM00399--ZnF_C4
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0051879--F:Hsp90 protein binding
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0010628--P:positive regulation of gene expression
GO:0006351--P:transcription, DNA-templated
KEGG gga:396099
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001925 Ailuropoda melanoleuca 84.89 0.00e+00 729.00
IUUC-Apl-003688 Anas platyrhynchos 98.87 0.00e+00 1003.00
IUUC-Aca-005222 Anolis carolinensis 83.53 0.00e+00 961.00
IUUC-Ame-010731 Astyanax mexicanus 51.65 3.00e-139 488.00
IUUC-Bta-013112 Bos taurus 74.20 0.00e+00 833.00
IUUC-Cja-019408 Callithrix jacchus 79.70 0.00e+00 878.00
IUUC-Cfa-020694 Canis familiaris 77.78 0.00e+00 855.00
IUUC-Cpo-021426 Cavia porcellus 74.71 0.00e+00 819.00
IUUC-Csa-023736 Chlorocebus sabaeus 83.78 0.00e+00 784.00
IUUC-Dre-027698 Danio rerio 51.62 2.00e-139 488.00
IUUC-Dno-029477 Dasypus novemcinctus 80.68 0.00e+00 721.00
IUUC-Dor-030572 Dipodomys ordii 84.27 0.00e+00 699.00
IUUC-Ete-032849 Echinops telfairi 62.35 7.00e-170 590.00
IUUC-Eca-033605 Equus caballus 75.34 0.00e+00 833.00
IUUC-Eeu-034683 Erinaceus europaeus 83.64 5.00e-99 354.00
IUUC-Fca-035928 Felis catus 87.61 0.00e+00 729.00
IUUC-Fal-036754 Ficedula albicollis 97.28 0.00e+00 1125.00
IUUC-Gmo-038872 Gadus morhua 54.25 2.00e-113 402.00
IUUC-Gac-042015 Gasterosteus aculeatus 64.08 2.00e-129 456.00
IUUC-Ggo-044749 Gorilla gorilla 79.63 0.00e+00 872.00
IUUC-Hsa-046944 Homo sapiens 78.78 0.00e+00 860.00
IUUC-Itr-048863 Ictidomys tridecemlineatus 78.52 0.00e+00 869.00
IUUC-Loc-052414 Lepisosteus oculatus 60.95 0.00e+00 689.00
IUUC-Mcc-054781 Macaca mulatta 79.80 0.00e+00 874.00
IUUC-Meu-056232 Macropus eugenii 82.54 0.00e+00 923.00
IUUC-Mga-059319 Meleagris gallopavo 99.32 0.00e+00 1125.00
IUUC-Mmr-061636 Microcebus murinus 73.91 4.00e-142 497.00
IUUC-Mdo-062661 Monodelphis domestica 84.41 0.00e+00 946.00
IUUC-Mmu-063330 Mus musculus 76.79 0.00e+00 842.00
IUUC-Mpu-065757 Mustela putorius furo 76.76 0.00e+00 868.00
IUUC-Mlu-067712 Myotis lucifugus 79.13 0.00e+00 781.00
IUUC-Nle-069283 Nomascus leucogenys 78.78 0.00e+00 845.00
IUUC-Opr-070391 Ochotona princeps 77.61 0.00e+00 882.00
IUUC-Ont-071369 Oreochromis niloticus 51.91 2.00e-124 439.00
IUUC-Oan-073734 Ornithorhynchus anatinus 72.59 7.00e-130 456.00
IUUC-Ocu-074292 Oryctolagus cuniculus 79.60 0.00e+00 877.00
IUUC-Oba-075103 Oryza barthii 26.92 1.20e-02 34.30
IUUC-Ogu-079042 Oryza glumaepatula 26.92 3.00e-03 36.60
IUUC-Olo-080944 Oryza longistaminata 26.92 4.00e-03 34.30
IUUC-Oni-082560 Oryza nivara 26.92 9.00e-03 34.70
IUUC-Ola-087052 Oryzias latipes 53.31 5.00e-134 471.00
IUUC-Oga-088586 Otolemur garnettii 78.30 0.00e+00 850.00
IUUC-Oar-090156 Ovis aries 78.26 0.00e+00 745.00
IUUC-Ptr-091321 Pan troglodytes 79.63 0.00e+00 872.00
IUUC-Pan-092851 Papio anubis 79.63 0.00e+00 871.00
IUUC-Psi-093434 Pelodiscus sinensis 87.78 0.00e+00 1026.00
IUUC-Pfo-097379 Poecilia formosa 57.53 2.00e-139 489.00
IUUC-Pab-097735 Pongo abelii 79.46 0.00e+00 869.00
IUUC-Pva-102125 Pteropus vampyrus 77.65 0.00e+00 862.00
IUUC-Rno-106121 Rattus norvegicus 76.67 0.00e+00 842.00
IUUC-Sha-107547 Sarcophilus harrisii 84.58 0.00e+00 946.00
IUUC-Sar-113650 Sorex araneus 68.75 2.00e-159 555.00
IUUC-Tgu-117175 Taeniopygia guttata 97.28 0.00e+00 1125.00
IUUC-Tru-117545 Takifugu rubripes 53.21 6.00e-143 501.00
IUUC-Tsy-119586 Tarsius syrichta 69.32 0.00e+00 738.00
IUUC-Tni-120121 Tetraodon nigroviridis 52.06 1.00e-144 506.00
IUUC-Tbe-127548 Tupaia belangeri 73.42 3.00e-168 584.00
IUUC-Ttr-128374 Tursiops truncatus 71.14 0.00e+00 754.00
IUUC-Vpa-130464 Vicugna pacos 74.86 2.00e-140 491.00
IUUC-Xtr-132171 Xenopus tropicalis 76.99 0.00e+00 818.00
Created Date 25-Jun-2017

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