iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.00e-43	147.9	319	787
UBD/Alpha-Helix/UBA	9.80e-07	29.0	658	693

Active Site

Position(s)	Description	Evidence
328	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
750	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw........kskkkavsprellkalkkeaeefsgyeqqDaqE 94
           tGl N g +CYmNSvLQ+L+ + +++  + e+  e+l +   ++ ++++  ++ k++++++        + ++++++p +++++ +  ++ fs+++qqD++E
   Q: 319  TGLVNTGSSCYMNSVLQALVTVDSFQTRYGEQGLETLVNCPLDKLHNDFNAQFSKVVRAMLsgdyssemDPTNNHIKPLQFKRVAAGNHRDFSTSKQQDVEE 420
           7******************************888888888889999**************75554444466666**************************** PP
   S: 95   flaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           +++fl++++ e+          ++e             +++ + k    + F+ + + +++  + ++   r     dl  p+p+ e++   +++ ++++++ 
   Q: 421  YIRFLFEKIAENS---------RTEVI-----------DPTDSFKFKAINRFEDRGTRRVRYTDQEEMLIRLPISGDLLRPIPDTENRYSVDMKAAIHAYFD 502
           ************9.........23223...........466777777888899999999999999999999999999*9*****9999999*********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................... 267
            +++++   y ++   + + a+ ++++k++P++L ++ ++f ++ + + ++k++ ++e+ +eLdls +  +                               
   Q: 503  VQKIDD---YISPITGEPKGATNTISMKTFPDYLFFQVSKFAYNVD-GTQKKLDMELEIEEELDLSGYRGHgkleheialpdeeptaprttpdipasvrfva 600
           ****97...99999999999***********************997.7788***************999997788888888888888777777777777777 PP
   S: 268  ...................................................................................................... 267
                                                                                                                 
   Q: 601  gelmlmgfcenacyraayysngnveiasnwlmehmddsdindlfvipsgtpsargevdpnlvasivemgfsnhqakyalkqvptvaeavewlfanmdsipve 702
           777777777777777777777777777777777777777777777777776666666666666666666666666666666666666665555555555555 PP
   S: 268  ..........peekqke...............kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                     p     e                +kY+Li++++H+G  ++sGHYva++ + +gkW+lf+D+kV  +  ++  +   + aYv++Ykr
   Q: 703  saavglssdaP-----EpsvtesatqktfkdgGEKYKLIGMISHMGsRPDSGHYVAHMLK-EGKWVLFNDEKVALS--QDPPK---KLAYVYLYKR 787
           55555555550.....0555555666667777****************************.9***********998..68888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLra..annnleaAveyLl 39
           d  +++ +veMGF++++a+ aL +  +   + +Ave+L+
   Q: 658  DPNLVASIVEMGFSNHQAKYALKQvpT---VAEAVEWLF 693
           566899****************98432...556666665 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MDVETAVRSA VDAGAFIRPT FDQKIFKDQC AYCFKDPHGK DGLYISLKNY HAFCREHAEI 60
YGTTSGNTLF VQFESTKKII EERTDGEPTS KMTKLTIDSD PKFEFEDKYC VVVHPEYSQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGTATGGA CGTCGAAACC GCCGTTCGTT CTGCTGTTGA TGCCGGCGCG TTCATTCGTC 60
CAACTTTCGA CCAGAAAATC TTCAAGGATC AGTGCGCGTA CTGTTTCAAA GACCCACACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_T27A3.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.10	2.00e-100	358.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.27	9.00e-132	462.00
IUUC-Atr-002580	Amborella trichopoda	35.73	3.00e-63	235.00
IUUC-Apl-003774	Anas platyrhynchos	35.54	4.00e-130	457.00
IUUC-Aca-005368	Anolis carolinensis	35.10	1.00e-134	472.00
IUUC-Aly-005727	Arabidopsis lyrata	34.73	6.00e-120	423.00
IUUC-Ath-006974	Arabidopsis thaliana	34.26	5.00e-121	427.00
IUUC-Ago-007890	Ashbya gossypii	25.61	5.00e-57	214.00
IUUC-Acl-008057	Aspergillus clavatus	30.68	3.00e-85	308.00
IUUC-Afl-008547	Aspergillus flavus	32.53	7.00e-78	283.00
IUUC-Afu-008805	Aspergillus fumigatus	32.44	1.00e-71	263.00
IUUC-Ani-009441	Aspergillus nidulans	33.43	2.00e-45	176.00
IUUC-Ang-009720	Aspergillus niger	30.36	4.00e-80	291.00
IUUC-Aor-010111	Aspergillus oryzae	30.10	3.00e-85	308.00
IUUC-Ate-010531	Aspergillus terreus	29.34	3.00e-56	212.00
IUUC-Ame-011470	Astyanax mexicanus	29.80	1.00e-105	376.00
IUUC-Bgr-012183	Blumeria graminis	28.06	6.00e-75	274.00
IUUC-Bta-013179	Bos taurus	34.35	5.00e-132	464.00
IUUC-Bci-013858	Botrytis cinerea	30.89	7.00e-81	293.00
IUUC-Bdi-014904	Brachypodium distachyon	33.13	2.00e-108	385.00
IUUC-Bol-015536	Brassica oleracea	33.83	4.00e-118	417.00
IUUC-Bra-017939	Brassica rapa	34.06	2.00e-119	422.00
IUUC-Cja-019063	Callithrix jacchus	33.99	7.00e-129	453.00
IUUC-Cfa-020976	Canis familiaris	35.17	7.00e-136	476.00
IUUC-Cpo-022265	Cavia porcellus	35.13	5.00e-136	477.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	31.43	9.00e-66	243.00
IUUC-Csa-024177	Chlorocebus sabaeus	33.33	2.00e-113	402.00
IUUC-Cho-024702	Choloepus hoffmanni	35.06	5.00e-65	241.00
IUUC-Cin-025411	Ciona intestinalis	35.00	3.00e-116	411.00
IUUC-Csv-026347	Ciona savignyi	34.09	9.00e-113	399.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	29.45	7.00e-76	277.00
IUUC-Cne-026831	Cryptococcus neoformans	31.35	5.00e-82	297.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.30	1.00e-23	104.00
IUUC-Dre-027982	Danio rerio	32.06	2.00e-107	382.00
IUUC-Dno-029034	Dasypus novemcinctus	34.70	9.00e-134	469.00
IUUC-Dor-030479	Dipodomys ordii	36.27	9.00e-57	214.00
IUUC-Dse-031467	Dothistroma septosporum	30.67	5.00e-81	294.00
IUUC-Dme-032075	Drosophila melanogaster	37.39	2.00e-128	451.00
IUUC-Ete-032865	Echinops telfairi	31.77	5.00e-111	394.00
IUUC-Eca-034059	Equus caballus	34.35	1.00e-130	459.00
IUUC-Eeu-035304	Erinaceus europaeus	34.99	1.00e-120	426.00
IUUC-Fca-035515	Felis catus	34.35	1.00e-132	466.00
IUUC-Fal-037271	Ficedula albicollis	36.16	9.00e-128	449.00
IUUC-Fox-037745	Fusarium oxysporum	29.28	1.00e-79	290.00
IUUC-Fso-038158	Fusarium solani	31.30	1.00e-85	309.00
IUUC-Gmo-039071	Gadus morhua	33.22	8.00e-111	393.00
IUUC-Ggr-040098	Gaeumannomyces graminis	29.40	1.00e-79	290.00
IUUC-Gga-040635	Gallus gallus	35.17	1.00e-134	473.00
IUUC-Gac-042528	Gasterosteus aculeatus	32.18	2.00e-109	389.00
IUUC-Gma-043614	Glycine max	33.54	1.00e-115	409.00
IUUC-Ggo-044602	Gorilla gorilla	34.23	4.00e-131	461.00
IUUC-Hsa-045959	Homo sapiens	34.23	4.00e-131	461.00
IUUC-Hvu-047563	Hordeum vulgare	35.22	3.00e-101	361.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	34.23	3.00e-132	464.00
IUUC-Kpa-049156	Komagataella pastoris	29.88	1.00e-78	286.00
IUUC-Lch-049648	Latimeria chalumnae	34.50	2.00e-119	422.00
IUUC-Lpe-051523	Leersia perrieri	31.59	3.00e-106	378.00
IUUC-Loc-052072	Lepisosteus oculatus	31.05	9.00e-110	390.00
IUUC-Lma-053216	Leptosphaeria maculans	30.74	9.00e-75	275.00
IUUC-Laf-054327	Loxodonta africana	34.23	5.00e-132	464.00
IUUC-Mcc-055443	Macaca mulatta	34.35	1.00e-132	466.00
IUUC-Meu-056298	Macropus eugenii	32.01	2.00e-88	318.00
IUUC-Mor-057106	Magnaporthe oryzae	29.57	3.00e-80	291.00
IUUC-Mpo-057589	Magnaporthe poae	29.73	7.00e-82	297.00
IUUC-Mtr-058680	Medicago truncatula	33.70	1.00e-114	405.00
IUUC-Mla-058903	Melampsora laricipopulina	28.67	3.00e-79	288.00
IUUC-Mga-059669	Meleagris gallopavo	35.13	2.00e-127	448.00
IUUC-Mvi-060476	Microbotryum violaceum	30.54	4.00e-82	298.00
IUUC-Mmr-060575	Microcebus murinus	34.23	3.00e-131	461.00
IUUC-Mdo-062183	Monodelphis domestica	34.40	4.00e-130	457.00
IUUC-Mmu-063592	Mus musculus	34.35	6.00e-133	467.00
IUUC-Mac-065446	Musa acuminata	30.44	4.00e-96	344.00
IUUC-Mpu-066082	Mustela putorius furo	35.41	5.00e-136	477.00
IUUC-Mlu-067345	Myotis lucifugus	34.23	3.00e-133	468.00
IUUC-Nfi-068558	Neosartorya fischeri	30.82	2.00e-79	288.00
IUUC-Ncr-068960	Neurospora crassa	30.21	3.00e-76	278.00
IUUC-Nle-070173	Nomascus leucogenys	34.93	2.00e-133	468.00
IUUC-Opr-070556	Ochotona princeps	34.39	1.00e-131	462.00
IUUC-Ont-071502	Oreochromis niloticus	33.41	4.00e-112	397.00
IUUC-Oan-072959	Ornithorhynchus anatinus	40.26	5.00e-45	172.00
IUUC-Ocu-074861	Oryctolagus cuniculus	35.05	6.00e-135	473.00
IUUC-Oba-075109	Oryza barthii	32.59	2.00e-110	392.00
IUUC-Obr-076292	Oryza brachyantha	32.67	4.00e-107	380.00
IUUC-Ogl-077065	Oryza glaberrima	33.29	3.00e-117	414.00
IUUC-Ogu-078776	Oryza glumaepatula	32.31	5.00e-107	380.00
IUUC-Oin-080048	Oryza indica	33.62	3.00e-116	411.00
IUUC-Olo-080711	Oryza longistaminata	31.50	1.00e-97	349.00
IUUC-Ome-081506	Oryza meridionalis	32.18	3.00e-102	364.00
IUUC-Oni-082320	Oryza nivara	31.33	2.00e-108	385.00
IUUC-Opu-083801	Oryza punctata	31.97	1.00e-103	369.00
IUUC-Oru-085139	Oryza rufipogon	31.57	2.00e-109	389.00
IUUC-Osa-085713	Oryza sativa	33.42	4.00e-118	417.00
IUUC-Ola-086951	Oryzias latipes	32.74	6.00e-107	380.00
IUUC-Olu-087822	Ostreococcus lucimarinus	31.00	7.00e-102	363.00
IUUC-Oga-088625	Otolemur garnettii	34.00	4.00e-132	464.00
IUUC-Oar-089995	Ovis aries	34.03	3.00e-129	454.00
IUUC-Ptr-090640	Pan troglodytes	35.05	2.00e-134	471.00
IUUC-Pan-091974	Papio anubis	34.23	1.00e-131	462.00
IUUC-Psi-093957	Pelodiscus sinensis	34.85	2.00e-133	468.00
IUUC-Pma-094242	Petromyzon marinus	35.16	4.00e-56	210.00
IUUC-Pno-094835	Phaeosphaeria nodorum	29.82	7.00e-69	254.00
IUUC-Ppa-095901	Physcomitrella patens	32.15	1.00e-106	379.00
IUUC-Pfo-097148	Poecilia formosa	33.09	6.00e-110	390.00
IUUC-Pab-098068	Pongo abelii	32.08	4.00e-110	391.00
IUUC-Pop-098943	Populus trichocarpa	33.87	7.00e-113	400.00
IUUC-Pca-100738	Procavia capensis	35.70	4.00e-95	341.00
IUUC-Ppe-101315	Prunus persica	33.17	2.00e-109	388.00
IUUC-Pva-102154	Pteropus vampyrus	34.00	8.00e-129	453.00
IUUC-Pgr-103343	Puccinia graminis	29.51	3.00e-65	241.00
IUUC-Ptt-103928	Puccinia triticina	27.15	1.00e-61	229.00
IUUC-Pte-104306	Pyrenophora teres	28.71	3.00e-66	245.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	28.32	6.00e-69	254.00
IUUC-Rno-105801	Rattus norvegicus	34.23	9.00e-132	463.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.03	7.00e-57	214.00
IUUC-Sha-107635	Sarcophilus harrisii	34.98	7.00e-133	466.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	27.56	3.00e-65	242.00
IUUC-Spo-108144	Schizosaccharomyces pombe	30.01	5.00e-78	284.00
IUUC-Smo-108703	Selaginella moellendorffii	34.33	9.00e-117	413.00
IUUC-Sit-110728	Setaria italica	33.58	1.00e-115	409.00
IUUC-Sly-111523	Solanum lycopersicum	34.03	3.00e-115	408.00
IUUC-Sar-113733	Sorex araneus	32.52	3.00e-53	202.00
IUUC-Sbi-114419	Sorghum bicolor	33.00	6.00e-112	397.00
IUUC-Sre-115225	Sporisorium reilianum	29.37	3.00e-75	275.00
IUUC-Ssc-115686	Sus scrofa	34.42	1.00e-133	469.00
IUUC-Tgu-117346	Taeniopygia guttata	35.36	1.00e-132	466.00
IUUC-Tru-118350	Takifugu rubripes	32.36	1.00e-111	395.00
IUUC-Tsy-119278	Tarsius syrichta	28.29	2.00e-81	295.00
IUUC-Tni-120658	Tetraodon nigroviridis	32.82	2.00e-109	389.00
IUUC-Tca-121585	Theobroma cacao	33.00	3.00e-107	381.00
IUUC-Tre-122043	Trichoderma reesei	31.43	2.00e-80	292.00
IUUC-Tvi-122303	Trichoderma virens	30.73	5.00e-85	307.00
IUUC-Tae-123798	Triticum aestivum	33.87	2.00e-116	412.00
IUUC-Tur-126732	Triticum urartu	31.93	4.00e-105	374.00
IUUC-Tme-126909	Tuber melanosporum	31.97	1.00e-77	283.00
IUUC-Tbe-127261	Tupaia belangeri	33.55	2.00e-82	299.00
IUUC-Ttr-128295	Tursiops truncatus	28.15	4.00e-82	298.00
IUUC-Uma-129599	Ustilago maydis	29.14	1.00e-80	293.00
IUUC-Vda-129688	Verticillium dahliae	30.05	4.00e-79	288.00
IUUC-Vpa-130170	Vicugna pacos	26.58	3.00e-71	261.00
IUUC-Vvi-131116	Vitis vinifera	32.46	5.00e-109	387.00
IUUC-Xtr-131953	Xenopus tropicalis	33.91	2.00e-122	432.00
IUUC-Xma-133837	Xiphophorus maculatus	33.21	2.00e-110	392.00
IUUC-Yli-134510	Yarrowia lipolytica	30.12	4.00e-77	281.00
IUUC-Zma-135786	Zea mays	32.88	2.00e-106	379.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence