iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004031

Ensembl Protein ID

ENSAPLP00000000573.1

UniProt Accession

U3I003; U3I003_ANAPL

Genbank Protein ID

ENSAPLP00000000573

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01003137

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000000901.1	ENSAPLT00000001141.1	ENSAPLP00000000573.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-63	213.4	105	478
ULD/UDP/UBQ/UBQ_Other	6.50e-09	35.3	6	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pe++e+l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPEVKEALKR-YGGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekgd 191
           7******************************.****************************.99999******************99*** PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+           e d+   +d+    +++k+ksli++ F +++++ +kc e +++ +++ + ++l
   Q: 192  qgQYLQQDANECWVQMMRVLQQKLEG---------IEGDTVMETDSGAAATTSKKKSLIDQFFSIEFETAMKCTEAEEEEVTKGKENQL 271
           999*********************55.........444444555677899****************************99999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +      +++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 272  QLSCFINQEV--KYLFTGLKLRLQEEITK-----LSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 353
           8888877754..58999999999998887.....7899999999********************************************* PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 354  YELCTPdlqekmvsyrskfkdledkkvnqqP-----KnssksdgaqkevkyepfsfpddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 437
           ******7777777777777777666665551.....0445556666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 438  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 478
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           v vk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd +++++++k+g+t++++ +
   Q: 6    VNVKWGKEKFDGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNLKIKNGMTLLMMGS 74
           6799999998899***********************************999.9**************965 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

ILLFAVNVKW GKEKFDGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
LKIKNGMTLL MMGSADALPE EPIARPVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACTTTTGT TTGCAGTTAA CGTGAAATGG GGAAAAGAGA AATTCGATGG TGTGGAGCTT 60
AACACTGATG AACCTCCAAT GGTCTTCAAA GCCCAGTTGT TTGCACTGAC TGGAGTTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	43.96	2.00e-38	153.00
IUUC-Aml-002053	Ailuropoda melanoleuca	90.49	0.00e+00	886.00
IUUC-Atr-002725	Amborella trichopoda	42.08	3.00e-101	362.00
IUUC-Aca-004361	Anolis carolinensis	93.10	0.00e+00	951.00
IUUC-Aly-006176	Arabidopsis lyrata	42.22	9.00e-112	396.00
IUUC-Ath-007658	Arabidopsis thaliana	41.43	3.00e-111	395.00
IUUC-Ago-007796	Ashbya gossypii	32.56	4.00e-58	218.00
IUUC-Acl-008258	Aspergillus clavatus	38.50	3.00e-65	242.00
IUUC-Afl-008732	Aspergillus flavus	34.76	1.00e-80	293.00
IUUC-Afu-008755	Aspergillus fumigatus	35.06	7.00e-83	301.00
IUUC-Ani-009148	Aspergillus nidulans	39.36	4.00e-70	258.00
IUUC-Ang-009878	Aspergillus niger	35.10	5.00e-78	284.00
IUUC-Aor-010239	Aspergillus oryzae	34.76	1.00e-80	293.00
IUUC-Ate-010243	Aspergillus terreus	35.14	4.00e-79	288.00
IUUC-Ame-011327	Astyanax mexicanus	51.91	7.00e-128	450.00
IUUC-Bgr-012231	Blumeria graminis	34.15	2.00e-76	279.00
IUUC-Bta-012553	Bos taurus	90.65	0.00e+00	893.00
IUUC-Bci-013606	Botrytis cinerea	39.31	2.00e-69	256.00
IUUC-Bdi-014567	Brachypodium distachyon	42.83	3.00e-113	401.00
IUUC-Bol-015565	Brassica oleracea	41.88	5.00e-113	400.00
IUUC-Bra-017297	Brassica rapa	41.92	4.00e-113	401.00
IUUC-Cel-018140	Caenorhabditis elegans	41.43	1.00e-101	362.00
IUUC-Cja-019516	Callithrix jacchus	90.28	0.00e+00	895.00
IUUC-Cfa-020808	Canis familiaris	91.67	0.00e+00	904.00
IUUC-Cpo-021688	Cavia porcellus	90.51	0.00e+00	894.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	39.31	1.00e-85	309.00
IUUC-Csa-023429	Chlorocebus sabaeus	91.04	0.00e+00	877.00
IUUC-Cho-024347	Choloepus hoffmanni	91.04	0.00e+00	895.00
IUUC-Cin-025198	Ciona intestinalis	54.40	1.00e-152	532.00
IUUC-Csv-026007	Ciona savignyi	53.85	8.00e-154	536.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	39.30	7.00e-63	234.00
IUUC-Cne-026963	Cryptococcus neoformans	35.50	8.00e-76	277.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.41	2.00e-58	219.00
IUUC-Dre-027647	Danio rerio	83.98	0.00e+00	847.00
IUUC-Dno-029967	Dasypus novemcinctus	89.63	0.00e+00	878.00
IUUC-Dor-030886	Dipodomys ordii	85.00	0.00e+00	721.00
IUUC-Dse-031466	Dothistroma septosporum	36.02	2.00e-57	216.00
IUUC-Dme-032079	Drosophila melanogaster	54.89	1.00e-155	542.00
IUUC-Ete-032351	Echinops telfairi	81.84	0.00e+00	818.00
IUUC-Eca-033461	Equus caballus	90.08	0.00e+00	936.00
IUUC-Eeu-035220	Erinaceus europaeus	69.34	0.00e+00	646.00
IUUC-Fca-036210	Felis catus	91.46	0.00e+00	903.00
IUUC-Fal-037528	Ficedula albicollis	98.36	0.00e+00	940.00
IUUC-Fox-037805	Fusarium oxysporum	40.47	3.00e-70	259.00
IUUC-Fso-038177	Fusarium solani	38.24	4.00e-66	245.00
IUUC-Gmo-038953	Gadus morhua	78.69	0.00e+00	766.00
IUUC-Ggr-039972	Gaeumannomyces graminis	35.04	6.00e-75	274.00
IUUC-Gga-040462	Gallus gallus	97.14	0.00e+00	949.00
IUUC-Gac-041312	Gasterosteus aculeatus	80.33	0.00e+00	807.00
IUUC-Gma-043255	Glycine max	42.05	1.00e-106	379.00
IUUC-Ggo-045458	Gorilla gorilla	75.86	0.00e+00	741.00
IUUC-Hsa-045706	Homo sapiens	90.04	0.00e+00	880.00
IUUC-Hvu-047821	Hordeum vulgare	47.66	1.00e-57	216.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	88.62	0.00e+00	900.00
IUUC-Lch-050464	Latimeria chalumnae	84.29	0.00e+00	847.00
IUUC-Lpe-051419	Leersia perrieri	41.88	6.00e-108	384.00
IUUC-Loc-052732	Lepisosteus oculatus	82.82	0.00e+00	857.00
IUUC-Lma-053177	Leptosphaeria maculans	42.05	4.00e-70	258.00
IUUC-Laf-053822	Loxodonta africana	91.28	0.00e+00	900.00
IUUC-Mcc-055893	Macaca mulatta	91.24	0.00e+00	878.00
IUUC-Meu-056307	Macropus eugenii	81.43	0.00e+00	793.00
IUUC-Mor-057171	Magnaporthe oryzae	39.58	1.00e-66	246.00
IUUC-Mpo-057415	Magnaporthe poae	41.38	2.00e-70	259.00
IUUC-Mtr-057901	Medicago truncatula	42.89	1.00e-110	393.00
IUUC-Mla-058897	Melampsora laricipopulina	40.37	4.00e-76	278.00
IUUC-Mga-060016	Meleagris gallopavo	98.58	0.00e+00	965.00
IUUC-Mvi-060562	Microbotryum violaceum	40.00	7.00e-67	247.00
IUUC-Mmr-060624	Microcebus murinus	90.65	0.00e+00	934.00
IUUC-Mdo-061809	Monodelphis domestica	93.12	0.00e+00	905.00
IUUC-Mmu-063869	Mus musculus	89.43	0.00e+00	883.00
IUUC-Mac-064876	Musa acuminata	39.15	5.00e-96	344.00
IUUC-Mpu-066480	Mustela putorius furo	91.26	0.00e+00	899.00
IUUC-Mlu-067866	Myotis lucifugus	89.68	0.00e+00	904.00
IUUC-Nfi-068393	Neosartorya fischeri	34.66	1.00e-76	280.00
IUUC-Ncr-068815	Neurospora crassa	36.76	5.00e-79	288.00
IUUC-Nle-070121	Nomascus leucogenys	90.44	3.00e-129	453.00
IUUC-Opr-070712	Ochotona princeps	72.66	8.00e-165	573.00
IUUC-Ont-071544	Oreochromis niloticus	81.76	0.00e+00	772.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.80	0.00e+00	760.00
IUUC-Ocu-074926	Oryctolagus cuniculus	90.43	0.00e+00	874.00
IUUC-Oba-075633	Oryza barthii	41.58	1.00e-107	383.00
IUUC-Obr-076423	Oryza brachyantha	42.33	4.00e-110	391.00
IUUC-Ogl-077913	Oryza glaberrima	41.46	2.00e-110	392.00
IUUC-Ogu-078435	Oryza glumaepatula	41.58	1.00e-107	383.00
IUUC-Oin-080072	Oryza indica	41.61	7.00e-108	384.00
IUUC-Olo-080535	Oryza longistaminata	39.23	6.00e-93	334.00
IUUC-Ome-081309	Oryza meridionalis	41.58	1.00e-107	383.00
IUUC-Oni-083113	Oryza nivara	41.58	1.00e-107	383.00
IUUC-Opu-083168	Oryza punctata	40.42	6.00e-102	363.00
IUUC-Oru-084253	Oryza rufipogon	41.58	1.00e-107	383.00
IUUC-Osa-085554	Oryza sativa	41.46	1.00e-110	392.00
IUUC-Ola-086998	Oryzias latipes	80.61	0.00e+00	797.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.57	2.00e-70	259.00
IUUC-Oga-088571	Otolemur garnettii	91.04	0.00e+00	899.00
IUUC-Oar-089526	Ovis aries	91.26	0.00e+00	897.00
IUUC-Ptr-091433	Pan troglodytes	91.24	0.00e+00	878.00
IUUC-Pan-091966	Papio anubis	91.04	0.00e+00	877.00
IUUC-Psi-093458	Pelodiscus sinensis	92.86	0.00e+00	890.00
IUUC-Pma-094343	Petromyzon marinus	68.38	3.00e-120	424.00
IUUC-Pno-095109	Phaeosphaeria nodorum	40.05	2.00e-65	243.00
IUUC-Ppa-095756	Physcomitrella patens	42.38	6.00e-111	394.00
IUUC-Pfo-096514	Poecilia formosa	82.99	0.00e+00	793.00
IUUC-Pab-098477	Pongo abelii	80.00	0.00e+00	699.00
IUUC-Pop-099221	Populus trichocarpa	41.80	1.00e-104	373.00
IUUC-Pca-100791	Procavia capensis	74.59	2.00e-166	578.00
IUUC-Ppe-101812	Prunus persica	41.58	2.00e-108	385.00
IUUC-Pva-102462	Pteropus vampyrus	85.78	0.00e+00	723.00
IUUC-Pgr-103623	Puccinia graminis	42.07	2.00e-77	283.00
IUUC-Ptt-103767	Puccinia triticina	40.24	1.00e-68	253.00
IUUC-Pte-104109	Pyrenophora teres	40.37	2.00e-70	259.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	41.02	7.00e-71	261.00
IUUC-Rno-105351	Rattus norvegicus	88.41	0.00e+00	852.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.23	2.00e-61	229.00
IUUC-Sha-107491	Sarcophilus harrisii	93.31	0.00e+00	919.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	35.38	3.00e-80	291.00
IUUC-Spo-108174	Schizosaccharomyces pombe	36.79	2.00e-79	289.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	34.87	5.00e-83	301.00
IUUC-Smo-109276	Selaginella moellendorffii	43.54	3.00e-109	388.00
IUUC-Sit-110361	Setaria italica	43.12	6.00e-114	404.00
IUUC-Sly-110965	Solanum lycopersicum	41.28	1.00e-108	386.00
IUUC-Sar-113355	Sorex araneus	79.86	0.00e+00	638.00
IUUC-Sbi-114778	Sorghum bicolor	43.76	2.00e-112	399.00
IUUC-Sre-115011	Sporisorium reilianum	36.64	5.00e-63	234.00
IUUC-Ssc-116273	Sus scrofa	91.04	0.00e+00	887.00
IUUC-Tgu-117063	Taeniopygia guttata	97.96	0.00e+00	941.00
IUUC-Tru-118381	Takifugu rubripes	80.86	0.00e+00	803.00
IUUC-Tsy-119076	Tarsius syrichta	75.89	2.00e-111	395.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.31	0.00e+00	793.00
IUUC-Tca-121246	Theobroma cacao	42.00	7.00e-109	387.00
IUUC-Tre-121969	Trichoderma reesei	37.66	3.00e-64	238.00
IUUC-Tvi-122543	Trichoderma virens	32.74	3.00e-66	245.00
IUUC-Tae-125484	Triticum aestivum	43.15	6.00e-110	390.00
IUUC-Tur-126128	Triticum urartu	42.36	6.00e-39	154.00
IUUC-Tbe-128030	Tupaia belangeri	84.22	0.00e+00	801.00
IUUC-Ttr-128701	Tursiops truncatus	90.09	0.00e+00	735.00
IUUC-Uma-129657	Ustilago maydis	37.01	2.00e-65	243.00
IUUC-Vda-129723	Verticillium dahliae	36.92	4.00e-58	218.00
IUUC-Vpa-130284	Vicugna pacos	64.75	2.00e-169	588.00
IUUC-Vvi-131037	Vitis vinifera	43.72	4.00e-111	394.00
IUUC-Xtr-132235	Xenopus tropicalis	87.63	0.00e+00	899.00
IUUC-Xma-133840	Xiphophorus maculatus	82.99	0.00e+00	818.00
IUUC-Yli-134453	Yarrowia lipolytica	36.53	8.00e-82	297.00
IUUC-Zma-135669	Zea mays	36.73	2.00e-94	339.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence