iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048654

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01055408

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000006456.2	ENSSTOT00000006459.2	ENSSTOP00000005775.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-65	220.9	105	480
ULD/UDP/UBQ/UBQ_Other	1.30e-09	37.8	5	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  ++ +++e+        s++a+  +++k+ksli++ F++++++++kc e d++ +++ + ++l
   Q: 192  qgQYLQQDANECWIQMMRVLQQKLEAIDDDSVKESD-------SSSASAVTPSKKKSLIDQFFGVEFETTMKCTESDEEEVTKGKENQL 273
           999*********************554444444433.......3346778999***************************999999999 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 274  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 355
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 356  YELCTPelqekmisfrskfkdledkkvnqqP-----NtgdkkssphkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 439
           *****97777777777777666666555551.....0555556666666677777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKIKNGITLLMMGS 74
           69********99*************************************999.9**************965 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKIKNGITLL MMGSADALPE EPSSKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCTGCGT ACCCCCGCCA TGCCACTGTA CTCCGGTGAG CTCCCTCCTC GCCTCTTATC 60
TCACTCTCGG GGCCGACGCT TAGGCCTCCA CATAGGCCTA GCCTGCAGAG GCGGGCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	43.96	3.00e-38	152.00
IUUC-Aml-002053	Ailuropoda melanoleuca	97.35	0.00e+00	929.00
IUUC-Atr-002725	Amborella trichopoda	42.43	1.00e-102	366.00
IUUC-Apl-004031	Anas platyrhynchos	89.63	0.00e+00	890.00
IUUC-Aca-004361	Anolis carolinensis	87.68	0.00e+00	905.00
IUUC-Aly-006078	Arabidopsis lyrata	42.00	2.00e-111	395.00
IUUC-Ath-007623	Arabidopsis thaliana	42.38	6.00e-112	397.00
IUUC-Ago-007796	Ashbya gossypii	32.64	2.00e-59	223.00
IUUC-Acl-008258	Aspergillus clavatus	36.95	6.00e-67	248.00
IUUC-Afl-008732	Aspergillus flavus	33.51	2.00e-73	269.00
IUUC-Afu-008755	Aspergillus fumigatus	38.63	3.00e-69	255.00
IUUC-Ani-009148	Aspergillus nidulans	39.12	2.00e-72	266.00
IUUC-Ang-009878	Aspergillus niger	38.24	2.00e-67	249.00
IUUC-Aor-010239	Aspergillus oryzae	33.51	2.00e-73	269.00
IUUC-Ate-010243	Aspergillus terreus	33.22	2.00e-67	249.00
IUUC-Ame-011327	Astyanax mexicanus	50.00	6.00e-127	447.00
IUUC-Bgr-012231	Blumeria graminis	34.50	1.00e-79	290.00
IUUC-Bta-012553	Bos taurus	96.76	0.00e+00	957.00
IUUC-Bci-013606	Botrytis cinerea	40.26	9.00e-71	261.00
IUUC-Bdi-014567	Brachypodium distachyon	43.52	6.00e-113	400.00
IUUC-Bol-016127	Brassica oleracea	42.40	3.00e-113	401.00
IUUC-Bra-017501	Brassica rapa	42.20	2.00e-112	399.00
IUUC-Cel-018140	Caenorhabditis elegans	40.91	3.00e-101	362.00
IUUC-Cja-019516	Callithrix jacchus	96.98	0.00e+00	955.00
IUUC-Cfa-020808	Canis familiaris	97.98	0.00e+00	967.00
IUUC-Cpo-021688	Cavia porcellus	96.56	0.00e+00	947.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.63	9.00e-84	303.00
IUUC-Csa-023429	Chlorocebus sabaeus	97.97	0.00e+00	937.00
IUUC-Cho-024347	Choloepus hoffmanni	96.96	0.00e+00	957.00
IUUC-Cin-025198	Ciona intestinalis	55.21	5.00e-153	533.00
IUUC-Csv-026007	Ciona savignyi	53.01	1.00e-154	539.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	39.43	9.00e-65	241.00
IUUC-Cne-026963	Cryptococcus neoformans	34.68	1.00e-76	280.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.62	7.00e-60	224.00
IUUC-Dre-027647	Danio rerio	81.43	0.00e+00	828.00
IUUC-Dno-029967	Dasypus novemcinctus	97.37	0.00e+00	934.00
IUUC-Dor-030886	Dipodomys ordii	91.59	0.00e+00	761.00
IUUC-Dse-031466	Dothistroma septosporum	35.83	1.00e-58	221.00
IUUC-Dme-032079	Drosophila melanogaster	55.35	9.00e-160	556.00
IUUC-Ete-032351	Echinops telfairi	85.63	0.00e+00	858.00
IUUC-Eca-033461	Equus caballus	97.17	0.00e+00	999.00
IUUC-Eeu-035220	Erinaceus europaeus	74.39	0.00e+00	700.00
IUUC-Fca-036210	Felis catus	98.18	0.00e+00	967.00
IUUC-Fal-037528	Ficedula albicollis	89.25	0.00e+00	871.00
IUUC-Fox-037805	Fusarium oxysporum	39.85	3.00e-70	259.00
IUUC-Fso-038177	Fusarium solani	38.60	4.00e-69	255.00
IUUC-Gmo-038953	Gadus morhua	77.19	0.00e+00	768.00
IUUC-Ggr-039972	Gaeumannomyces graminis	38.46	2.00e-64	239.00
IUUC-Gga-040462	Gallus gallus	88.87	0.00e+00	883.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.11	0.00e+00	803.00
IUUC-Gma-043255	Glycine max	43.23	2.00e-109	389.00
IUUC-Ggo-045458	Gorilla gorilla	81.01	0.00e+00	789.00
IUUC-Hsa-045706	Homo sapiens	97.98	0.00e+00	939.00
IUUC-Hvu-047821	Hordeum vulgare	46.76	1.00e-57	216.00
IUUC-Lch-050464	Latimeria chalumnae	81.43	0.00e+00	820.00
IUUC-Lpe-051419	Leersia perrieri	42.71	2.00e-108	385.00
IUUC-Loc-052732	Lepisosteus oculatus	80.24	0.00e+00	841.00
IUUC-Lma-053177	Leptosphaeria maculans	41.28	2.00e-71	263.00
IUUC-Laf-053822	Loxodonta africana	96.75	0.00e+00	953.00
IUUC-Mcc-055893	Macaca mulatta	97.97	0.00e+00	937.00
IUUC-Meu-056307	Macropus eugenii	81.63	0.00e+00	793.00
IUUC-Mor-057171	Magnaporthe oryzae	38.37	4.00e-68	252.00
IUUC-Mpo-057415	Magnaporthe poae	39.34	4.00e-70	258.00
IUUC-Mtr-057901	Medicago truncatula	43.00	1.00e-111	396.00
IUUC-Mla-058897	Melampsora laricipopulina	39.89	9.00e-76	277.00
IUUC-Mga-060016	Meleagris gallopavo	89.43	0.00e+00	888.00
IUUC-Mvi-060562	Microbotryum violaceum	40.11	5.00e-68	251.00
IUUC-Mmr-060624	Microcebus murinus	96.76	0.00e+00	1002.00
IUUC-Mdo-061809	Monodelphis domestica	91.53	0.00e+00	895.00
IUUC-Mmu-063869	Mus musculus	95.95	0.00e+00	947.00
IUUC-Mac-064876	Musa acuminata	39.68	1.00e-96	346.00
IUUC-Mpu-066480	Mustela putorius furo	97.57	0.00e+00	963.00
IUUC-Mlu-067866	Myotis lucifugus	96.96	0.00e+00	966.00
IUUC-Nfi-068393	Neosartorya fischeri	37.90	7.00e-67	248.00
IUUC-Ncr-068815	Neurospora crassa	36.02	2.00e-83	302.00
IUUC-Nle-070121	Nomascus leucogenys	98.02	3.00e-140	490.00
IUUC-Opr-070712	Ochotona princeps	76.69	9.00e-175	606.00
IUUC-Ont-071544	Oreochromis niloticus	81.26	0.00e+00	770.00
IUUC-Oan-073635	Ornithorhynchus anatinus	90.19	0.00e+00	746.00
IUUC-Ocu-074926	Oryctolagus cuniculus	95.55	0.00e+00	925.00
IUUC-Oba-075633	Oryza barthii	41.98	5.00e-109	387.00
IUUC-Obr-076423	Oryza brachyantha	42.63	2.00e-111	395.00
IUUC-Ogl-077913	Oryza glaberrima	41.82	3.00e-111	395.00
IUUC-Ogu-078435	Oryza glumaepatula	41.98	5.00e-109	387.00
IUUC-Oin-080072	Oryza indica	41.94	4.00e-109	387.00
IUUC-Olo-080535	Oryza longistaminata	39.00	1.00e-92	333.00
IUUC-Ome-081309	Oryza meridionalis	41.98	5.00e-109	387.00
IUUC-Oni-083113	Oryza nivara	41.98	5.00e-109	387.00
IUUC-Opu-083168	Oryza punctata	41.03	2.00e-103	368.00
IUUC-Oru-084253	Oryza rufipogon	41.98	5.00e-109	387.00
IUUC-Osa-085554	Oryza sativa	41.82	2.00e-111	395.00
IUUC-Ola-086998	Oryzias latipes	80.32	0.00e+00	793.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.69	2.00e-71	262.00
IUUC-Oga-088571	Otolemur garnettii	96.76	0.00e+00	953.00
IUUC-Oar-089526	Ovis aries	96.54	0.00e+00	951.00
IUUC-Ptr-091433	Pan troglodytes	97.97	0.00e+00	937.00
IUUC-Pan-091966	Papio anubis	97.97	0.00e+00	937.00
IUUC-Psi-093458	Pelodiscus sinensis	87.50	0.00e+00	843.00
IUUC-Pma-094343	Petromyzon marinus	68.86	2.00e-121	428.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.36	1.00e-66	247.00
IUUC-Ppa-095756	Physcomitrella patens	43.30	5.00e-112	397.00
IUUC-Pfo-096514	Poecilia formosa	81.67	0.00e+00	783.00
IUUC-Pab-098477	Pongo abelii	85.96	0.00e+00	743.00
IUUC-Pop-099221	Populus trichocarpa	41.12	1.00e-102	366.00
IUUC-Pca-100791	Procavia capensis	79.95	0.00e+00	625.00
IUUC-Ppe-101812	Prunus persica	42.77	3.00e-107	381.00
IUUC-Pva-102462	Pteropus vampyrus	92.07	0.00e+00	775.00
IUUC-Pgr-103623	Puccinia graminis	40.40	1.00e-74	273.00
IUUC-Ptt-103767	Puccinia triticina	39.40	6.00e-68	251.00
IUUC-Pte-104109	Pyrenophora teres	39.45	1.00e-70	260.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	39.80	6.00e-71	261.00
IUUC-Rno-105351	Rattus norvegicus	96.15	0.00e+00	905.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.80	6.00e-63	234.00
IUUC-Sha-107491	Sarcophilus harrisii	91.72	0.00e+00	915.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.20	1.00e-78	286.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.42	3.00e-80	291.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.45	7.00e-85	307.00
IUUC-Smo-108805	Selaginella moellendorffii	43.21	4.00e-110	391.00
IUUC-Sit-110361	Setaria italica	43.15	8.00e-115	407.00
IUUC-Sly-110965	Solanum lycopersicum	41.24	5.00e-108	384.00
IUUC-Sar-113355	Sorex araneus	83.22	0.00e+00	660.00
IUUC-Sbi-114778	Sorghum bicolor	43.84	2.00e-114	405.00
IUUC-Sre-115011	Sporisorium reilianum	36.34	7.00e-62	231.00
IUUC-Ssc-116273	Sus scrofa	96.54	0.00e+00	941.00
IUUC-Tgu-117063	Taeniopygia guttata	88.62	0.00e+00	867.00
IUUC-Tru-118381	Takifugu rubripes	78.79	0.00e+00	794.00
IUUC-Tsy-119076	Tarsius syrichta	81.03	2.00e-118	418.00
IUUC-Tni-119941	Tetraodon nigroviridis	80.49	0.00e+00	784.00
IUUC-Tca-121246	Theobroma cacao	42.77	2.00e-109	389.00
IUUC-Tre-121969	Trichoderma reesei	39.44	5.00e-69	254.00
IUUC-Tvi-122543	Trichoderma virens	34.33	3.00e-77	282.00
IUUC-Tae-125484	Triticum aestivum	42.37	1.00e-109	390.00
IUUC-Tur-126128	Triticum urartu	41.87	3.00e-39	155.00
IUUC-Tbe-128030	Tupaia belangeri	89.96	0.00e+00	859.00
IUUC-Ttr-128701	Tursiops truncatus	96.23	0.00e+00	776.00
IUUC-Uma-129657	Ustilago maydis	37.08	5.00e-65	241.00
IUUC-Vda-129723	Verticillium dahliae	35.95	1.00e-59	224.00
IUUC-Vpa-130284	Vicugna pacos	69.67	0.00e+00	637.00
IUUC-Vvi-131037	Vitis vinifera	43.00	1.00e-108	386.00
IUUC-Xtr-132235	Xenopus tropicalis	84.68	0.00e+00	876.00
IUUC-Xma-133840	Xiphophorus maculatus	81.67	0.00e+00	809.00
IUUC-Yli-134453	Yarrowia lipolytica	37.18	2.00e-83	302.00
IUUC-Zma-135669	Zea mays	36.80	4.00e-96	344.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence