iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	23479607

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-31	106.9	181	218
UBD/Beta-Prp	7.10e-57	192.9	284	542

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++++G+dD  ik+W+  +g+ll
   Q: 181  GHLSSVYCVLFdRTgRYIITGADDLLIKIWSAADGRLL 218
           8**********9555****************9999887 PP

UBD/Beta-Prp

   S: 23   sllatgsrdgtikvwdvttgkl............lrslsgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfspsg 106
           ++l+t+s+dg+i  w+++t+               ++l   +a+  +++fsp g +l+ gs D++++v+    + +k +   ++ +d v s+++s  g
   Q: 284  KYLVTTSTDGSIAFWQYSTPRGqkitfapkptqyHEKLRPGQAQMMCTTFSPGGIFLAAGSADHHVRVYmmGEDGPKRILETEAYTDAVDSVQWSHRG 381
           79*****************8888899*******99999*******************************65556888888888*************** PP
   S: 107  dklvsGshdrtirvwdletgqclee.............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsn 191
            +++sGs+d t+++w  e++q+ ++             +++g++  v++v+++ ++++++++ +D t+++Wd+k++kl r l+g h+d  y l+ ++ 
   Q: 382  LRFISGSKDGTAHIWTFESQQWKSSklcmterlascpePEEGKRLKVTMVAWDASDRYVITAVNDFTIKIWDSKSAKLHRVLRG-HKDELYVLESNPR 478
           ***********************99**********************************************************9.*********9887 PP
   S: 192  g.kelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
               l+s+++dg+v lwd+++g cv  + +         v + + sp+++ ++ + s+g i i+
   Q: 479  DeHVLLSAGHDGQVFLWDIEQGVCVANFLNDIdgqghGSVFDAKWSPDGTMIAATDSHGHILIF 542
           736689******************8776543323334556666777999999999999998886 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

METRQPSSGD DLKPELYFLI SKFLAAGPLE ETAKVLIREL EEKKVLPRRL DWQGNEHEQT 60
FEELERKYKH IGANHLLEIC SRLGPLVDRE LPPSVPGINS LLGTGRQNLL RTKETVYCHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCATTCGGTG GGAATGGCAA TCGAGTGTCA CACGGGAAGA AGAAGCTGCG AAAAGAATTT 60
TAGAAGAAAG CAACTGCAAT TTTGTCATAA TCGGAGCTGC AATTCGCAAT GAATAATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0035072--P:ecdysone-mediated induction of salivary gland cell autophagic cell death
GO:0035096--P:larval midgut cell programmed cell death
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0035562--P:negative regulation of chromatin binding
GO:0006909--P:phagocytosis
GO:0046427--P:positive regulation of JAK-STAT cascade
GO:0008360--P:regulation of cell shape
GO:0010468--P:regulation of gene expression
GO:0046532--P:regulation of photoreceptor cell differentiation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

dme:Dmel_CG31132

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	29.35	8.00e-57	216.00
IUUC-Aml-001881	Ailuropoda melanoleuca	48.89	0.00e+00	670.00
IUUC-Atr-002600	Amborella trichopoda	28.28	7.00e-61	229.00
IUUC-Apl-003700	Anas platyrhynchos	51.38	3.00e-168	585.00
IUUC-Aca-004474	Anolis carolinensis	51.27	0.00e+00	671.00
IUUC-Aly-006517	Arabidopsis lyrata	27.55	9.00e-66	245.00
IUUC-Ath-006577	Arabidopsis thaliana	27.20	6.00e-65	242.00
IUUC-Ame-010718	Astyanax mexicanus	48.73	0.00e+00	642.00
IUUC-Bta-013217	Bos taurus	49.44	0.00e+00	656.00
IUUC-Bdi-014797	Brachypodium distachyon	29.96	8.00e-51	195.00
IUUC-Bol-015737	Brassica oleracea	27.30	9.00e-62	232.00
IUUC-Bra-017961	Brassica rapa	27.50	3.00e-62	233.00
IUUC-Cja-018868	Callithrix jacchus	51.03	0.00e+00	668.00
IUUC-Cfa-020963	Canis familiaris	48.97	0.00e+00	672.00
IUUC-Cpo-021934	Cavia porcellus	49.60	0.00e+00	653.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	33.92	1.00e-33	137.00
IUUC-Csa-023166	Chlorocebus sabaeus	48.89	0.00e+00	669.00
IUUC-Cho-024690	Choloepus hoffmanni	50.43	3.00e-115	410.00
IUUC-Cin-025553	Ciona intestinalis	35.89	2.00e-95	342.00
IUUC-Csv-025813	Ciona savignyi	41.85	1.00e-147	515.00
IUUC-Dre-028029	Danio rerio	51.43	0.00e+00	678.00
IUUC-Dno-030048	Dasypus novemcinctus	49.07	0.00e+00	634.00
IUUC-Dor-030195	Dipodomys ordii	41.35	8.00e-111	395.00
IUUC-Ete-032650	Echinops telfairi	47.25	2.00e-143	503.00
IUUC-Eca-034349	Equus caballus	49.30	3.00e-174	606.00
IUUC-Eeu-034688	Erinaceus europaeus	47.33	1.00e-157	550.00
IUUC-Fca-036099	Felis catus	48.73	0.00e+00	670.00
IUUC-Fal-037307	Ficedula albicollis	51.28	0.00e+00	672.00
IUUC-Gmo-039451	Gadus morhua	41.45	6.00e-114	404.00
IUUC-Gga-040865	Gallus gallus	50.96	0.00e+00	671.00
IUUC-Gac-042435	Gasterosteus aculeatus	46.58	9.00e-169	587.00
IUUC-Gma-043340	Glycine max	27.46	5.00e-60	226.00
IUUC-Ggo-045500	Gorilla gorilla	49.60	0.00e+00	653.00
IUUC-Hsa-046350	Homo sapiens	49.60	0.00e+00	656.00
IUUC-Hvu-047706	Hordeum vulgare	28.25	2.00e-34	139.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	44.94	1.00e-136	479.00
IUUC-Lch-049662	Latimeria chalumnae	50.95	0.00e+00	702.00
IUUC-Lpe-051619	Leersia perrieri	28.04	1.00e-64	242.00
IUUC-Loc-052672	Lepisosteus oculatus	52.37	0.00e+00	682.00
IUUC-Laf-053942	Loxodonta africana	49.44	0.00e+00	674.00
IUUC-Mcc-054638	Macaca mulatta	49.60	0.00e+00	656.00
IUUC-Meu-056321	Macropus eugenii	42.52	7.00e-139	488.00
IUUC-Mtr-058094	Medicago truncatula	29.23	1.00e-64	241.00
IUUC-Mga-060165	Meleagris gallopavo	50.72	0.00e+00	667.00
IUUC-Mmr-061227	Microcebus murinus	49.60	0.00e+00	657.00
IUUC-Mdo-062074	Monodelphis domestica	49.76	0.00e+00	659.00
IUUC-Mmu-064075	Mus musculus	49.36	0.00e+00	661.00
IUUC-Mac-065343	Musa acuminata	28.99	2.00e-66	248.00
IUUC-Mpu-066628	Mustela putorius furo	49.44	0.00e+00	674.00
IUUC-Mlu-068082	Myotis lucifugus	48.42	0.00e+00	667.00
IUUC-Nle-069609	Nomascus leucogenys	48.73	0.00e+00	671.00
IUUC-Opr-070971	Ochotona princeps	44.11	5.00e-107	382.00
IUUC-Ont-072221	Oreochromis niloticus	51.90	0.00e+00	656.00
IUUC-Oan-072954	Ornithorhynchus anatinus	49.20	0.00e+00	667.00
IUUC-Ocu-074456	Oryctolagus cuniculus	48.37	9.00e-174	604.00
IUUC-Oba-075709	Oryza barthii	27.25	8.00e-58	219.00
IUUC-Obr-076619	Oryza brachyantha	27.98	6.00e-64	239.00
IUUC-Ogl-077493	Oryza glaberrima	26.65	6.00e-33	136.00
IUUC-Ogu-078641	Oryza glumaepatula	26.64	2.00e-30	127.00
IUUC-Oin-079669	Oryza indica	28.97	2.00e-45	176.00
IUUC-Olo-080755	Oryza longistaminata	28.51	7.00e-47	182.00
IUUC-Oni-082991	Oryza nivara	26.64	8.00e-31	129.00
IUUC-Opu-083233	Oryza punctata	27.35	4.00e-61	229.00
IUUC-Oru-085195	Oryza rufipogon	27.25	9.00e-58	218.00
IUUC-Ola-086648	Oryzias latipes	51.59	0.00e+00	671.00
IUUC-Olu-087745	Ostreococcus lucimarinus	25.50	2.00e-55	210.00
IUUC-Oga-089053	Otolemur garnettii	48.66	0.00e+00	667.00
IUUC-Oar-090042	Ovis aries	48.73	0.00e+00	668.00
IUUC-Ptr-091213	Pan troglodytes	49.60	0.00e+00	656.00
IUUC-Pan-092444	Papio anubis	49.68	0.00e+00	659.00
IUUC-Psi-093408	Pelodiscus sinensis	48.87	3.00e-172	599.00
IUUC-Pma-094427	Petromyzon marinus	46.25	2.00e-83	301.00
IUUC-Ppa-095793	Physcomitrella patens	26.42	4.00e-59	223.00
IUUC-Pfo-096191	Poecilia formosa	51.75	0.00e+00	673.00
IUUC-Pab-098402	Pongo abelii	50.87	0.00e+00	668.00
IUUC-Pop-099185	Populus trichocarpa	28.77	1.00e-63	238.00
IUUC-Pca-101128	Procavia capensis	50.95	7.00e-171	594.00
IUUC-Ppe-101849	Prunus persica	27.88	3.00e-61	230.00
IUUC-Pva-102512	Pteropus vampyrus	48.58	0.00e+00	668.00
IUUC-Rno-105687	Rattus norvegicus	49.20	0.00e+00	655.00
IUUC-Sha-106680	Sarcophilus harrisii	49.68	0.00e+00	652.00
IUUC-Sit-110017	Setaria italica	29.23	3.00e-50	193.00
IUUC-Sly-111348	Solanum lycopersicum	27.58	3.00e-61	230.00
IUUC-Sar-113004	Sorex araneus	46.13	4.00e-154	538.00
IUUC-Sbi-114195	Sorghum bicolor	31.27	6.00e-42	165.00
IUUC-Ssc-115461	Sus scrofa	48.04	6.00e-156	545.00
IUUC-Tgu-116513	Taeniopygia guttata	50.96	0.00e+00	670.00
IUUC-Tru-117625	Takifugu rubripes	51.75	0.00e+00	676.00
IUUC-Tsy-119003	Tarsius syrichta	45.57	6.00e-172	598.00
IUUC-Tni-120716	Tetraodon nigroviridis	52.07	0.00e+00	676.00
IUUC-Tca-121615	Theobroma cacao	28.35	2.00e-58	221.00
IUUC-Tae-125478	Triticum aestivum	29.17	3.00e-68	253.00
IUUC-Tur-126809	Triticum urartu	29.07	7.00e-65	242.00
IUUC-Tbe-127479	Tupaia belangeri	45.39	3.00e-138	486.00
IUUC-Ttr-128561	Tursiops truncatus	49.44	0.00e+00	646.00
IUUC-Vpa-130160	Vicugna pacos	50.09	3.00e-173	602.00
IUUC-Vvi-131332	Vitis vinifera	29.27	9.00e-70	258.00
IUUC-Xtr-132717	Xenopus tropicalis	50.79	0.00e+00	682.00
IUUC-Xma-134120	Xiphophorus maculatus	51.75	0.00e+00	671.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence