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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046807
UUCD1 version UUC-HoS-01035
Ensembl Protein ID ENSP00000380460.3
UniProt Accession Q9Y263; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y5L1; PLAP_HUMAN
Genbank Protein ID BAA91803.1; BAA92105.1; CAB63739.1; CAH72641.1; AAH32551.1; AAD42075.1; BAD97264.1; CAB42881.1; AAD03030.1
Protein Name Phospholipase A-2-activating protein
Genbank Nucleotide ID AK001642; AK002143; AL133608; AL356133; BC032551; AF145020; AK223544; AJ238243; AF083395
Gene Name PLAA; PLAP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137055.14 ENST00000397292.7 ENSP00000380460.3
ENSG00000137055.14 ENST00000517642.5 ENSP00000430447.1
ENSG00000137055.14 ENST00000487173.5 ENSP00000430734.1
ENSG00000137055.14 ENST00000520884.5 ENSP00000429372.1
ENSG00000137055.14 ENST00000523212.1 ENSP00000428111.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/PFU PFU 19423704; 21070969
UBD/Beta-Prp Beta-Prp 19423704; 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-26 93.0 149 179
UBD/Beta-Prp 2.10e-66 225.8 12 302
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt+ v++++  ++ +l+++Gs D+t+k+W 
   Q: 149  GHTAAVWAVKIlPEqGLMLTGSADKTVKLWK 179
           8*********99999***************7 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl....lrslsgheaevtavkfspdgk.....ilvtgseDrtikvwdlstgk 85
           ++l+gh+ +v   v+++     +++ srd+t+++w  ++++     ++++sgh+++v++v+++p+++     +++tg++D++i++++l+++ 
   Q: 12   CSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRsfteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFSLDSPM 103
           8999************55555699999************99999***********************999999******************* PP
   S: 86   cvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++++lkgh+++v+sls+ +   +l+sGs+d t++vw   +++c+  tl+gh+++v+ v++ p++ l+ +Gs+D+tv+lW  k g++ rt++g
   Q: 104  PLYILKGHKNTVCSLSSGK-FGTLLSGSWDTTAKVW--LNDKCMM-TLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSG 189
           ******************9.9***************..9******.*********************************..88********9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
            h+d v+ l++ s+ +e++s+++d +++ w++ tgec++ + ght+ ++s+ ++pn   +v++++D+s+riW  ++g++ +t+ l+++s+++
   Q: 190  -HEDCVRGLAILSE-TEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWC 276
           .*********9996.8****************.***************************************..9***************** PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkkn 297
           ++v  +++  +v g++d++++++  +++
   Q: 277  CCV--LDNGDIVVGASDGIIRVFTESED 302
           ***..9999*************997766 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in the maintenance of ubiquitin levels.
 Involved in the maintenance of ubiquitin levels.
Protein Sequence
(Fasta)
MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS PNRSFTEMHC 60
MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKNTVCSLSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046807|UBD,PFU;UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACAAACTGT TGGGCCCGGA GTCGGAAGAG ACCCGGGTTT GGGAAGGACC CCAGGGTCAG 60
GCGTCCTGGT GGAAGGGCGG GCCTCTTTCT CTCTTGCTCA GCAGGGAGTC CAGAGCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046807|UBD,PFU;UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR033510--PLAA/Doa1/Lub1
IPR015155--PLAA_fam_Ub-bd_PFU
IPR013535--PUL_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS51394--PFU
PS51396--PUL
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF09070--PFU
PF08324--PUL
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0016005--F:phospholipase A2 activator activity
GO:0043130--F:ubiquitin binding
GO:0006954--P:inflammatory response
GO:0006644--P:phospholipid metabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0007165--P:signal transduction
GO:0010992--P:ubiquitin homeostasis
KEGG hsa:9373
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000146 Aegilops tauschii 31.30 7.00e-92 331.00
IUUC-Aml-002125 Ailuropoda melanoleuca 95.74 0.00e+00 1583.00
IUUC-Atr-002554 Amborella trichopoda 31.01 3.00e-96 346.00
IUUC-Apl-004094 Anas platyrhynchos 81.42 0.00e+00 1264.00
IUUC-Aca-004726 Anolis carolinensis 80.00 0.00e+00 1325.00
IUUC-Aly-005961 Arabidopsis lyrata 32.58 5.00e-108 385.00
IUUC-Ath-006639 Arabidopsis thaliana 32.52 5.00e-104 372.00
IUUC-Ago-007772 Ashbya gossypii 28.89 2.00e-79 290.00
IUUC-Acl-008316 Aspergillus clavatus 31.39 2.00e-88 320.00
IUUC-Afl-008532 Aspergillus flavus 32.58 2.00e-89 323.00
IUUC-Afu-008950 Aspergillus fumigatus 31.98 2.00e-90 327.00
IUUC-Ani-009186 Aspergillus nidulans 33.37 5.00e-93 335.00
IUUC-Ang-009575 Aspergillus niger 31.11 3.00e-85 310.00
IUUC-Aor-010086 Aspergillus oryzae 32.58 2.00e-89 323.00
IUUC-Ate-010541 Aspergillus terreus 29.97 2.00e-84 307.00
IUUC-Ame-011633 Astyanax mexicanus 67.29 0.00e+00 1115.00
IUUC-Bgr-012292 Blumeria graminis 30.01 7.00e-92 332.00
IUUC-Bta-013218 Bos taurus 93.84 0.00e+00 1572.00
IUUC-Bci-013876 Botrytis cinerea 39.48 1.00e-90 327.00
IUUC-Bdi-014810 Brachypodium distachyon 33.20 7.00e-106 378.00
IUUC-Bol-016006 Brassica oleracea 33.07 4.00e-108 385.00
IUUC-Bra-017593 Brassica rapa 33.46 6.00e-109 388.00
IUUC-Cel-018703 Caenorhabditis elegans 27.41 2.00e-71 264.00
IUUC-Cja-019270 Callithrix jacchus 97.36 0.00e+00 1617.00
IUUC-Cfa-021262 Canis familiaris 95.50 0.00e+00 1574.00
IUUC-Cpo-021449 Cavia porcellus 89.47 0.00e+00 1444.00
IUUC-Csa-024140 Chlorocebus sabaeus 98.87 0.00e+00 1639.00
IUUC-Cho-024923 Choloepus hoffmanni 94.21 0.00e+00 767.00
IUUC-Cin-025373 Ciona intestinalis 40.29 2.00e-175 609.00
IUUC-Csv-026324 Ciona savignyi 42.35 0.00e+00 657.00
IUUC-Cgl-026711 Colletotrichum gloeosporioides 31.37 4.00e-84 306.00
IUUC-Cne-026998 Cryptococcus neoformans 32.26 2.00e-87 317.00
IUUC-Cme-027154 Cyanidioschyzon merolae 29.94 3.00e-58 219.00
IUUC-Dre-028674 Danio rerio 65.33 0.00e+00 1100.00
IUUC-Dno-028966 Dasypus novemcinctus 94.21 0.00e+00 1572.00
IUUC-Dor-030343 Dipodomys ordii 88.71 0.00e+00 914.00
IUUC-Dse-031385 Dothistroma septosporum 31.20 3.00e-83 303.00
IUUC-Dme-032044 Drosophila melanogaster 36.28 2.00e-126 446.00
IUUC-Ete-032506 Echinops telfairi 84.78 0.00e+00 831.00
IUUC-Eca-033547 Equus caballus 95.23 0.00e+00 1580.00
IUUC-Eeu-034462 Erinaceus europaeus 80.09 0.00e+00 671.00
IUUC-Fca-035893 Felis catus 95.10 0.00e+00 1576.00
IUUC-Fal-037235 Ficedula albicollis 81.78 0.00e+00 1371.00
IUUC-Fox-037836 Fusarium oxysporum 31.76 5.00e-96 345.00
IUUC-Fso-038251 Fusarium solani 31.04 2.00e-93 337.00
IUUC-Gmo-038648 Gadus morhua 65.93 0.00e+00 959.00
IUUC-Ggr-039867 Gaeumannomyces graminis 29.73 2.00e-82 300.00
IUUC-Gga-040989 Gallus gallus 79.40 0.00e+00 1316.00
IUUC-Gac-041344 Gasterosteus aculeatus 67.08 0.00e+00 1068.00
IUUC-Gma-043067 Glycine max 31.84 5.00e-105 375.00
IUUC-Ggo-045009 Gorilla gorilla 99.01 0.00e+00 1261.00
IUUC-Itr-048636 Ictidomys tridecemlineatus 95.85 0.00e+00 1594.00
IUUC-Kpa-049134 Komagataella pastoris 43.35 1.00e-89 324.00
IUUC-Lch-049597 Latimeria chalumnae 72.57 0.00e+00 738.00
IUUC-Lpe-050821 Leersia perrieri 31.27 1.00e-98 354.00
IUUC-Loc-051849 Lepisosteus oculatus 72.19 0.00e+00 1195.00
IUUC-Lma-053297 Leptosphaeria maculans 33.58 2.00e-103 370.00
IUUC-Laf-053495 Loxodonta africana 93.74 0.00e+00 1554.00
IUUC-Meu-055983 Macropus eugenii 81.31 0.00e+00 651.00
IUUC-Mor-057006 Magnaporthe oryzae 35.97 4.00e-73 269.00
IUUC-Mpo-057465 Magnaporthe poae 35.48 1.00e-72 268.00
IUUC-Mtr-058374 Medicago truncatula 32.58 7.00e-114 405.00
IUUC-Mla-058895 Melampsora laricipopulina 36.03 1.00e-77 283.00
IUUC-Mvi-060297 Microbotryum violaceum 35.38 8.00e-109 388.00
IUUC-Mmr-060810 Microcebus murinus 90.49 0.00e+00 1474.00
IUUC-Mdo-062671 Monodelphis domestica 87.69 0.00e+00 1442.00
IUUC-Mmu-063536 Mus musculus 94.09 0.00e+00 1538.00
IUUC-Mac-064902 Musa acuminata 32.00 4.00e-100 359.00
IUUC-Mpu-066085 Mustela putorius furo 95.98 0.00e+00 1593.00
IUUC-Mlu-067907 Myotis lucifugus 91.76 0.00e+00 995.00
IUUC-Nfi-068457 Neosartorya fischeri 31.09 1.00e-72 267.00
IUUC-Ncr-068622 Neurospora crassa 30.56 5.00e-97 349.00
IUUC-Nle-069049 Nomascus leucogenys 98.36 0.00e+00 1618.00
IUUC-Opr-071013 Ochotona princeps 74.78 0.00e+00 658.00
IUUC-Ont-071339 Oreochromis niloticus 69.86 0.00e+00 1155.00
IUUC-Oan-073353 Ornithorhynchus anatinus 83.40 1.00e-112 399.00
IUUC-Ocu-074625 Oryctolagus cuniculus 95.85 0.00e+00 1596.00
IUUC-Oba-075226 Oryza barthii 29.15 1.00e-85 310.00
IUUC-Obr-076875 Oryza brachyantha 33.17 1.00e-110 394.00
IUUC-Ogl-077057 Oryza glaberrima 32.29 5.00e-110 392.00
IUUC-Ogu-078156 Oryza glumaepatula 32.16 1.00e-109 390.00
IUUC-Oin-079373 Oryza indica 31.91 2.00e-108 386.00
IUUC-Olo-080849 Oryza longistaminata 29.64 4.00e-75 276.00
IUUC-Ome-081654 Oryza meridionalis 28.64 4.00e-85 309.00
IUUC-Oni-082221 Oryza nivara 29.15 3.00e-87 316.00
IUUC-Opu-084103 Oryza punctata 29.18 3.00e-87 316.00
IUUC-Oru-084751 Oryza rufipogon 28.41 6.00e-84 305.00
IUUC-Osa-085584 Oryza sativa 32.04 3.00e-108 386.00
IUUC-Ola-086974 Oryzias latipes 68.68 0.00e+00 1151.00
IUUC-Oga-088052 Otolemur garnettii 90.95 0.00e+00 1491.00
IUUC-Oar-089509 Ovis aries 93.52 0.00e+00 1560.00
IUUC-Ptr-090911 Pan troglodytes 99.87 0.00e+00 1652.00
IUUC-Pan-092141 Papio anubis 98.37 0.00e+00 1628.00
IUUC-Psi-093543 Pelodiscus sinensis 82.41 0.00e+00 1286.00
IUUC-Pno-094952 Phaeosphaeria nodorum 32.81 1.00e-96 347.00
IUUC-Ppa-095881 Physcomitrella patens 32.76 2.00e-109 390.00
IUUC-Pfo-096739 Poecilia formosa 67.84 0.00e+00 1132.00
IUUC-Pab-098641 Pongo abelii 99.62 0.00e+00 1649.00
IUUC-Pop-099621 Populus trichocarpa 31.14 8.00e-103 368.00
IUUC-Pca-100599 Procavia capensis 85.12 0.00e+00 1306.00
IUUC-Ppe-101874 Prunus persica 32.46 3.00e-110 392.00
IUUC-Pva-103009 Pteropus vampyrus 91.63 0.00e+00 1281.00
IUUC-Pgr-103260 Puccinia graminis 32.31 3.00e-91 329.00
IUUC-Ptt-103711 Puccinia triticina 32.32 5.00e-91 328.00
IUUC-Pte-104337 Pyrenophora teres 32.86 7.00e-94 338.00
IUUC-Pyt-104475 Pyrenophora triticirepentis 33.03 9.00e-95 341.00
IUUC-Rno-105273 Rattus norvegicus 94.59 0.00e+00 1578.00
IUUC-Sce-106351 Saccharomyces cerevisiae 39.22 2.00e-80 293.00
IUUC-Sha-106758 Sarcophilus harrisii 87.23 0.00e+00 1442.00
IUUC-Sja-107687 Schizosaccharomyces japonicus 39.87 3.00e-96 346.00
IUUC-Spo-108093 Schizosaccharomyces pombe 34.08 5.00e-100 358.00
IUUC-Ssl-108623 Sclerotinia sclerotiorum 40.04 1.00e-91 331.00
IUUC-Smo-109368 Selaginella moellendorffii 30.36 1.00e-95 344.00
IUUC-Sit-109699 Setaria italica 33.63 9.00e-111 394.00
IUUC-Sly-111063 Solanum lycopersicum 32.60 1.00e-104 374.00
IUUC-Sar-113199 Sorex araneus 95.99 0.00e+00 821.00
IUUC-Sbi-114745 Sorghum bicolor 33.02 1.00e-102 367.00
IUUC-Sre-115080 Sporisorium reilianum 33.13 1.00e-105 377.00
IUUC-Ssc-115666 Sus scrofa 93.50 0.00e+00 1558.00
IUUC-Tgu-116877 Taeniopygia guttata 80.78 0.00e+00 1356.00
IUUC-Tru-117580 Takifugu rubripes 67.05 0.00e+00 1131.00
IUUC-Tsy-118946 Tarsius syrichta 96.64 0.00e+00 1478.00
IUUC-Tni-119755 Tetraodon nigroviridis 64.51 0.00e+00 1057.00
IUUC-Tca-120977 Theobroma cacao 31.64 1.00e-101 364.00
IUUC-Tre-122217 Trichoderma reesei 31.67 3.00e-96 346.00
IUUC-Tvi-122671 Trichoderma virens 30.83 2.00e-92 333.00
IUUC-Tae-125581 Triticum aestivum 33.20 2.00e-107 383.00
IUUC-Tur-126404 Triticum urartu 24.17 4.00e-22 100.00
IUUC-Tme-126971 Tuber melanosporum 34.44 6.00e-115 408.00
IUUC-Tbe-127858 Tupaia belangeri 77.98 0.00e+00 662.00
IUUC-Ttr-128173 Tursiops truncatus 92.21 0.00e+00 1518.00
IUUC-Uma-129322 Ustilago maydis 33.42 3.00e-106 379.00
IUUC-Vda-129682 Verticillium dahliae 31.08 4.00e-90 325.00
IUUC-Vpa-130607 Vicugna pacos 91.69 0.00e+00 1405.00
IUUC-Vvi-131153 Vitis vinifera 32.73 1.00e-111 397.00
IUUC-Xtr-132208 Xenopus tropicalis 74.81 0.00e+00 1240.00
IUUC-Xma-133098 Xiphophorus maculatus 68.58 0.00e+00 1129.00
IUUC-Yli-134646 Yarrowia lipolytica 39.38 8.00e-97 348.00
IUUC-Zma-135920 Zea mays 31.00 6.00e-93 335.00
Created Date 25-Jun-2017

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