iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069661

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01071508

Gene Name

USP10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000011245.2	ENSNLET00000014401.2	ENSNLEP00000013723.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.80e-70	235.9	439	817

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+
   Q: 439  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPT 525
           9***************************99.333333.334799***************7666654333337777888888888***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsdeaeekkkkknk... 139
            +++ l   ++++s + +q+Da+E+l f+l++l+ee+ +                  kn++++eee+e++ e s++++e+   +nk   
   Q: 526  YIYRLLTVNKSSLSeKGRQEDAEEYLGFILNGLHEEMLNlkkllspnnekltisngPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKtsv 614
           ******99999866599********************4456688889999999999888888888888888888887777777777777 PP
   S: 140  ........slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekk 220
                   ++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y++k k+++e +++
   Q: 615  trqadfvqTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDKIR---TVQDALESLVARESVQG----YTTKTKQEVEISRR 695
           77777888***********9.688999999*******************99...****************8....99999********* PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssGHYvayvknekgk 305
           ++l+klP+vL+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G s+ +GHY+++v +   +
   Q: 696  VTLEKLPPVLVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKNKNfkcHRTYRLFAVVYHHGnSATGGHYTTDVFQIGLN 783
           *******************9998886.****************999988777777879***************************8777 PP
   S: 306  .WllfdDskVtevkeeevleetg.staYvlfYkr 337
            Wl++dD++V+++++ +v++ t+ +taY+l+Y+r
   Q: 784  gWLRIDDQTVKVISQYQVVKPTAeRTAYLLYYRR 817
           7*******************9889********98 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MAGGGGSSVS KPEERRVPLK RAAMALHSPQ YIFGDFSPDE FNQFFVTPRS SVELPPYSGT 60
VLCGTQAVDK LPDGQEYQRI EFGVDEVIEP SDTLPRTPSY SISSTLNPQA PEFILGCTTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGCGGCC GATGCGAGTG TGTATGTGCG GGCGAGAAGA TGGCGGGCGG CGGGGGAAGC 60
AGCGTGAGCA AGCCGGAGGA GCGCCGAGTC CCATTGAAAC GGGCAGCCAT GGCTCTCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF07145--PAM2
PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nle:100594856

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	30.41	2.00e-44	173.00
IUUC-Aml-001584	Ailuropoda melanoleuca	88.51	0.00e+00	1334.00
IUUC-Atr-002927	Amborella trichopoda	34.96	6.00e-58	218.00
IUUC-Apl-003988	Anas platyrhynchos	78.74	0.00e+00	1152.00
IUUC-Aca-004461	Anolis carolinensis	89.22	1.00e-164	572.00
IUUC-Aly-006038	Arabidopsis lyrata	36.15	8.00e-55	207.00
IUUC-Ath-007328	Arabidopsis thaliana	35.90	2.00e-53	203.00
IUUC-Ago-007717	Ashbya gossypii	30.11	2.00e-43	170.00
IUUC-Acl-008188	Aspergillus clavatus	33.12	3.00e-62	233.00
IUUC-Afl-008456	Aspergillus flavus	37.42	4.00e-47	182.00
IUUC-Afu-009067	Aspergillus fumigatus	36.02	4.00e-65	243.00
IUUC-Ani-009483	Aspergillus nidulans	33.12	2.00e-62	234.00
IUUC-Ang-009639	Aspergillus niger	35.20	7.00e-60	225.00
IUUC-Aor-010040	Aspergillus oryzae	35.37	9.00e-60	225.00
IUUC-Ate-010310	Aspergillus terreus	31.98	7.00e-62	232.00
IUUC-Ame-011012	Astyanax mexicanus	71.19	1.00e-162	567.00
IUUC-Bgr-012311	Blumeria graminis	34.59	6.00e-43	169.00
IUUC-Bta-013299	Bos taurus	87.25	0.00e+00	1274.00
IUUC-Bci-013783	Botrytis cinerea	36.76	2.00e-58	220.00
IUUC-Bdi-015039	Brachypodium distachyon	31.58	3.00e-49	189.00
IUUC-Bol-015806	Brassica oleracea	37.50	1.00e-62	234.00
IUUC-Bra-017076	Brassica rapa	37.50	6.00e-63	235.00
IUUC-Cja-018715	Callithrix jacchus	95.83	0.00e+00	1479.00
IUUC-Cfa-020194	Canis familiaris	89.39	0.00e+00	1351.00
IUUC-Cpo-022272	Cavia porcellus	75.28	0.00e+00	1065.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	34.11	2.00e-34	140.00
IUUC-Csa-023310	Chlorocebus sabaeus	98.36	0.00e+00	1509.00
IUUC-Cho-024966	Choloepus hoffmanni	78.89	0.00e+00	965.00
IUUC-Cin-025616	Ciona intestinalis	43.51	8.00e-105	374.00
IUUC-Csv-026043	Ciona savignyi	46.34	9.00e-98	350.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	34.05	2.00e-46	180.00
IUUC-Cne-026962	Cryptococcus neoformans	34.70	4.00e-50	193.00
IUUC-Cme-027113	Cyanidioschyzon merolae	30.45	1.00e-37	150.00
IUUC-Dre-028072	Danio rerio	78.28	0.00e+00	716.00
IUUC-Dno-029489	Dasypus novemcinctus	89.16	0.00e+00	1379.00
IUUC-Dor-031068	Dipodomys ordii	74.19	9.00e-139	487.00
IUUC-Dse-031553	Dothistroma septosporum	36.18	4.00e-56	213.00
IUUC-Dme-031759	Drosophila melanogaster	40.95	2.00e-83	304.00
IUUC-Ete-032549	Echinops telfairi	77.31	0.00e+00	880.00
IUUC-Eca-033380	Equus caballus	87.14	0.00e+00	1349.00
IUUC-Eeu-034818	Erinaceus europaeus	84.08	0.00e+00	1270.00
IUUC-Fca-035535	Felis catus	86.89	0.00e+00	1207.00
IUUC-Fal-036627	Ficedula albicollis	76.07	0.00e+00	1098.00
IUUC-Fox-037904	Fusarium oxysporum	36.49	6.00e-53	202.00
IUUC-Fso-038170	Fusarium solani	34.10	2.00e-52	201.00
IUUC-Gmo-039499	Gadus morhua	70.40	0.00e+00	665.00
IUUC-Ggr-040042	Gaeumannomyces graminis	35.37	5.00e-61	229.00
IUUC-Gga-040571	Gallus gallus	78.25	0.00e+00	1143.00
IUUC-Gac-041345	Gasterosteus aculeatus	76.51	0.00e+00	663.00
IUUC-Gma-044407	Glycine max	35.04	2.00e-58	219.00
IUUC-Ggo-044652	Gorilla gorilla	98.87	0.00e+00	1558.00
IUUC-Hsa-045864	Homo sapiens	99.12	0.00e+00	1563.00
IUUC-Hvu-047071	Hordeum vulgare	33.00	2.00e-52	199.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	90.57	0.00e+00	1021.00
IUUC-Kpa-049132	Komagataella pastoris	30.04	1.00e-45	177.00
IUUC-Lch-050040	Latimeria chalumnae	69.07	0.00e+00	922.00
IUUC-Loc-052449	Lepisosteus oculatus	76.53	0.00e+00	714.00
IUUC-Lma-053248	Leptosphaeria maculans	35.81	5.00e-57	216.00
IUUC-Laf-054121	Loxodonta africana	88.27	0.00e+00	1331.00
IUUC-Mcc-055514	Macaca mulatta	98.61	0.00e+00	1514.00
IUUC-Meu-056873	Macropus eugenii	72.84	0.00e+00	826.00
IUUC-Mor-057243	Magnaporthe oryzae	33.93	2.00e-58	221.00
IUUC-Mpo-057439	Magnaporthe poae	35.64	1.00e-60	228.00
IUUC-Mtr-058457	Medicago truncatula	33.33	5.00e-57	215.00
IUUC-Mla-058929	Melampsora laricipopulina	31.38	2.00e-56	214.00
IUUC-Mga-060157	Meleagris gallopavo	76.67	0.00e+00	1140.00
IUUC-Mvi-060442	Microbotryum violaceum	33.65	3.00e-56	213.00
IUUC-Mmr-061062	Microcebus murinus	92.63	0.00e+00	1464.00
IUUC-Mdo-062798	Monodelphis domestica	80.73	0.00e+00	1214.00
IUUC-Mmu-064050	Mus musculus	83.23	0.00e+00	1281.00
IUUC-Mac-065619	Musa acuminata	34.09	2.00e-53	202.00
IUUC-Mpu-066554	Mustela putorius furo	88.27	0.00e+00	1310.00
IUUC-Mlu-068003	Myotis lucifugus	86.97	0.00e+00	1329.00
IUUC-Nfi-068612	Neosartorya fischeri	34.46	2.00e-63	236.00
IUUC-Ncr-068878	Neurospora crassa	34.88	3.00e-52	200.00
IUUC-Opr-070944	Ochotona princeps	76.27	6.00e-170	590.00
IUUC-Ont-071266	Oreochromis niloticus	58.29	0.00e+00	803.00
IUUC-Oan-073442	Ornithorhynchus anatinus	79.20	0.00e+00	1135.00
IUUC-Ocu-073788	Oryctolagus cuniculus	80.83	0.00e+00	1132.00
IUUC-Oba-075085	Oryza barthii	33.45	9.00e-38	150.00
IUUC-Obr-076663	Oryza brachyantha	32.65	1.00e-45	177.00
IUUC-Ogl-076937	Oryza glaberrima	29.85	6.00e-48	185.00
IUUC-Ogu-078909	Oryza glumaepatula	30.63	3.00e-46	180.00
IUUC-Oin-079617	Oryza indica	30.67	2.00e-47	184.00
IUUC-Olo-081043	Oryza longistaminata	25.75	7.00e-25	108.00
IUUC-Ome-081646	Oryza meridionalis	24.74	9.00e-24	105.00
IUUC-Oni-082914	Oryza nivara	29.57	3.00e-46	179.00
IUUC-Oru-084878	Oryza rufipogon	29.57	3.00e-46	179.00
IUUC-Osa-085822	Oryza sativa	30.93	4.00e-50	192.00
IUUC-Ola-086931	Oryzias latipes	70.16	0.00e+00	666.00
IUUC-Oga-088443	Otolemur garnettii	92.30	0.00e+00	1441.00
IUUC-Oar-089325	Ovis aries	83.98	0.00e+00	1187.00
IUUC-Ptr-091584	Pan troglodytes	95.74	0.00e+00	1462.00
IUUC-Pan-092551	Papio anubis	96.49	0.00e+00	1486.00
IUUC-Psi-093366	Pelodiscus sinensis	74.34	0.00e+00	696.00
IUUC-Pno-095136	Phaeosphaeria nodorum	34.96	1.00e-51	198.00
IUUC-Ppa-095574	Physcomitrella patens	36.22	2.00e-59	223.00
IUUC-Pfo-097462	Poecilia formosa	77.04	0.00e+00	693.00
IUUC-Pab-098547	Pongo abelii	99.37	0.00e+00	1535.00
IUUC-Pop-099529	Populus trichocarpa	37.34	4.00e-61	229.00
IUUC-Pca-101066	Procavia capensis	78.82	0.00e+00	1203.00
IUUC-Ppe-102110	Prunus persica	35.37	1.00e-58	220.00
IUUC-Pva-103015	Pteropus vampyrus	83.33	0.00e+00	1268.00
IUUC-Ptt-103998	Puccinia triticina	32.12	5.00e-53	202.00
IUUC-Pte-104417	Pyrenophora teres	33.67	2.00e-54	207.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	34.95	1.00e-54	208.00
IUUC-Rno-105533	Rattus norvegicus	84.25	0.00e+00	1282.00
IUUC-Sce-106160	Saccharomyces cerevisiae	28.05	3.00e-37	150.00
IUUC-Sha-106590	Sarcophilus harrisii	81.23	0.00e+00	1214.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	35.85	1.00e-57	217.00
IUUC-Spo-108353	Schizosaccharomyces pombe	37.23	6.00e-65	241.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	36.22	5.00e-58	219.00
IUUC-Smo-108842	Selaginella moellendorffii	36.20	1.00e-37	149.00
IUUC-Sit-110781	Setaria italica	31.75	2.00e-55	210.00
IUUC-Sly-111797	Solanum lycopersicum	33.76	6.00e-55	208.00
IUUC-Stu-112188	Solanum tuberosum	34.77	1.00e-55	210.00
IUUC-Sbi-114862	Sorghum bicolor	32.78	4.00e-45	176.00
IUUC-Sre-115162	Sporisorium reilianum	34.57	2.00e-66	247.00
IUUC-Ssc-115505	Sus scrofa	95.47	1.00e-165	575.00
IUUC-Tgu-116535	Taeniopygia guttata	76.04	0.00e+00	1103.00
IUUC-Tru-117542	Takifugu rubripes	57.36	0.00e+00	809.00
IUUC-Tni-120200	Tetraodon nigroviridis	57.88	0.00e+00	803.00
IUUC-Tca-121548	Theobroma cacao	34.60	2.00e-43	170.00
IUUC-Tre-122124	Trichoderma reesei	31.95	2.00e-62	234.00
IUUC-Tvi-122457	Trichoderma virens	34.85	4.00e-54	206.00
IUUC-Tae-125646	Triticum aestivum	33.67	2.00e-54	207.00
IUUC-Tme-127180	Tuber melanosporum	39.08	9.00e-69	254.00
IUUC-Tbe-127530	Tupaia belangeri	75.35	0.00e+00	1051.00
IUUC-Ttr-128549	Tursiops truncatus	79.82	0.00e+00	1189.00
IUUC-Uma-129381	Ustilago maydis	33.41	3.00e-65	243.00
IUUC-Vda-129889	Verticillium dahliae	32.63	1.00e-52	201.00
IUUC-Vpa-130100	Vicugna pacos	81.86	0.00e+00	1216.00
IUUC-Vvi-131366	Vitis vinifera	35.37	6.00e-63	234.00
IUUC-Xtr-132048	Xenopus tropicalis	63.24	0.00e+00	903.00
IUUC-Xma-133593	Xiphophorus maculatus	77.52	0.00e+00	690.00
IUUC-Yli-134338	Yarrowia lipolytica	30.42	1.00e-32	134.00
IUUC-Zma-135586	Zea mays	31.44	3.00e-48	186.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence