iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062032

UUCD1 version

UUC-MoD-01058

Ensembl Protein ID

ENSMODP00000013378.2

UniProt Accession

F7C1J2; F7C1J2_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000010677.3	ENSMODT00000043462.1	ENSMODP00000040356.1
ENSMODG00000010677.3	ENSMODT00000013623.2	ENSMODP00000013378.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.40e-207	689.9	460	940

Active Site

Position(s)	Description	Evidence
641	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl++++++lvGag++GcEllKn++++G+     g++ v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 460  YDGQVAVFGSHLQEKLGKQRYFLVGAGAIGCELLKNFAMIGLgcgdsGEVIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQM 548
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v++h++++ +++e+i+   Ff+ +d+V +aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 549  NPQIHVTSHQNRVGPDTERIYdddFFQALDGVTNALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 637
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a+ +++ 
   Q: 638  IPICTLKNFPNAIEHTLQWArdefeglfkqpaESVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPRSWADCVAWACLHWHA 725
           ***************************************.999999******************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv......................................................sfcsnaea 282
           ++ n+i+qll++f+++++t+s++pfw+                                                      +f +    
   Q: 726  QYANNIRQLLHNFPPEQLTSSGAPFWSgpkrcphpltfdvhnplhldyimaaanlfaqtyglvgsrdraavatllqtvhipEFTPK--- 811
           ****************************************************************9999977666666544422222... PP
   S: 283  lqvpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagn 364
            +  + +++d+e ++a+ +     l+ l+++l + ek +g k++ ++fekddd   ++d++ aa+nlrae+++i+p +d+++ k iag+
   Q: 812  -SGVKIHVSDQELQSANTSvddsrLEELKATLPSPEKLSGFKMYPIDFEKDDDNnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGK 898
           .22244444444444444455557****************************************************.************ PP
   S: 365  iipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iipaiatt+a+v Gl+++E++Kvv+g  + e++kn fl++a+
   Q: 899  IIPAIATTTAAVVGLVCLELYKVVQGhqRLEAYKNGFLNLAL 940
           **************************988999******9875 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGPDPKPG SNCSPAHPVP SDAPTAPANG MAKNGNEADI DEGLYSRQLP 60
VQGLMPGPLL TLTPTPSNPY WSISGQLGPG GDSGQNIILG GVKAVTLHDQ GAAQWADLSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCT CGCCGCTGTC CAAGAAGCGT CGCGTGTCCG GGCCTGATCC AAAACCAGGT 60
TCTAACTGCT CTCCTGCCCA CCCTGTTCCC TCTGACGCAC CCACTGCACC TGCCAACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	45.28	0.00e+00	837.00
IUUC-Aml-001311	Ailuropoda melanoleuca	85.15	0.00e+00	1868.00
IUUC-Atr-002684	Amborella trichopoda	44.32	0.00e+00	870.00
IUUC-Aca-004620	Anolis carolinensis	77.49	0.00e+00	1707.00
IUUC-Aly-005515	Arabidopsis lyrata	44.94	0.00e+00	882.00
IUUC-Ath-006891	Arabidopsis thaliana	45.32	0.00e+00	893.00
IUUC-Ago-007873	Ashbya gossypii	51.86	0.00e+00	1026.00
IUUC-Acl-008181	Aspergillus clavatus	52.38	0.00e+00	1038.00
IUUC-Afl-008455	Aspergillus flavus	51.54	0.00e+00	990.00
IUUC-Afu-009065	Aspergillus fumigatus	52.52	0.00e+00	1035.00
IUUC-Ani-009371	Aspergillus nidulans	51.67	0.00e+00	1018.00
IUUC-Ang-009737	Aspergillus niger	51.83	0.00e+00	1031.00
IUUC-Aor-010007	Aspergillus oryzae	51.54	0.00e+00	990.00
IUUC-Ate-010466	Aspergillus terreus	52.18	0.00e+00	1043.00
IUUC-Ame-010933	Astyanax mexicanus	76.40	0.00e+00	1606.00
IUUC-Bgr-012281	Blumeria graminis	51.80	0.00e+00	1032.00
IUUC-Bta-012767	Bos taurus	86.50	0.00e+00	1899.00
IUUC-Bci-013721	Botrytis cinerea	53.26	0.00e+00	991.00
IUUC-Bdi-014843	Brachypodium distachyon	44.79	0.00e+00	845.00
IUUC-Bol-015665	Brassica oleracea	44.04	0.00e+00	866.00
IUUC-Bra-017522	Brassica rapa	45.28	0.00e+00	865.00
IUUC-Cel-018260	Caenorhabditis elegans	48.09	0.00e+00	913.00
IUUC-Cja-019152	Callithrix jacchus	86.13	0.00e+00	1883.00
IUUC-Cfa-020622	Canis familiaris	83.69	0.00e+00	1805.00
IUUC-Cpo-022526	Cavia porcellus	85.94	0.00e+00	1865.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.44	0.00e+00	802.00
IUUC-Csa-023780	Chlorocebus sabaeus	86.32	0.00e+00	1890.00
IUUC-Cho-024896	Choloepus hoffmanni	73.64	7.00e-100	358.00
IUUC-Cin-025790	Ciona intestinalis	61.52	0.00e+00	1315.00
IUUC-Csv-026084	Ciona savignyi	59.21	0.00e+00	1291.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	52.08	0.00e+00	1056.00
IUUC-Cne-026960	Cryptococcus neoformans	54.81	0.00e+00	1079.00
IUUC-Cme-027290	Cyanidioschyzon merolae	42.65	0.00e+00	777.00
IUUC-Dre-028149	Danio rerio	76.50	0.00e+00	1644.00
IUUC-Dno-028884	Dasypus novemcinctus	85.47	0.00e+00	1878.00
IUUC-Dor-030229	Dipodomys ordii	82.10	0.00e+00	1782.00
IUUC-Dse-031524	Dothistroma septosporum	50.19	0.00e+00	1032.00
IUUC-Dme-032045	Drosophila melanogaster	58.34	0.00e+00	1231.00
IUUC-Ete-032544	Echinops telfairi	91.02	0.00e+00	771.00
IUUC-Eca-033330	Equus caballus	86.41	0.00e+00	1899.00
IUUC-Fca-036255	Felis catus	86.41	0.00e+00	1883.00
IUUC-Fal-037445	Ficedula albicollis	48.58	0.00e+00	870.00
IUUC-Fox-038007	Fusarium oxysporum	54.53	5.00e-168	584.00
IUUC-Fso-038339	Fusarium solani	52.32	0.00e+00	1005.00
IUUC-Gmo-039338	Gadus morhua	73.08	0.00e+00	1544.00
IUUC-Ggr-039823	Gaeumannomyces graminis	52.90	0.00e+00	1071.00
IUUC-Gga-040365	Gallus gallus	46.62	0.00e+00	800.00
IUUC-Gac-041773	Gasterosteus aculeatus	73.93	0.00e+00	1561.00
IUUC-Gma-043198	Glycine max	43.37	0.00e+00	840.00
IUUC-Ggo-045336	Gorilla gorilla	86.69	0.00e+00	1875.00
IUUC-Hsa-045982	Homo sapiens	86.41	0.00e+00	1866.00
IUUC-Hvu-047418	Hordeum vulgare	45.00	0.00e+00	854.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	86.60	0.00e+00	1898.00
IUUC-Kpa-049112	Komagataella pastoris	49.71	0.00e+00	959.00
IUUC-Lch-050371	Latimeria chalumnae	77.43	0.00e+00	1710.00
IUUC-Lpe-051299	Leersia perrieri	43.21	0.00e+00	861.00
IUUC-Loc-052936	Lepisosteus oculatus	77.90	0.00e+00	1684.00
IUUC-Lma-053315	Leptosphaeria maculans	50.48	0.00e+00	1032.00
IUUC-Laf-053948	Loxodonta africana	83.69	0.00e+00	1829.00
IUUC-Mcc-055843	Macaca mulatta	86.22	0.00e+00	1891.00
IUUC-Meu-056258	Macropus eugenii	92.13	0.00e+00	1993.00
IUUC-Mor-057269	Magnaporthe oryzae	52.37	0.00e+00	1046.00
IUUC-Mpo-057435	Magnaporthe poae	52.66	0.00e+00	1035.00
IUUC-Mtr-058572	Medicago truncatula	44.15	0.00e+00	842.00
IUUC-Mla-059176	Melampsora laricipopulina	54.78	0.00e+00	1055.00
IUUC-Mga-060052	Meleagris gallopavo	49.64	0.00e+00	728.00
IUUC-Mvi-060437	Microbotryum violaceum	52.29	0.00e+00	1021.00
IUUC-Mmr-061405	Microcebus murinus	83.69	0.00e+00	1822.00
IUUC-Mmu-063280	Mus musculus	85.00	0.00e+00	1855.00
IUUC-Mac-065505	Musa acuminata	44.49	0.00e+00	864.00
IUUC-Mpu-066409	Mustela putorius furo	86.13	0.00e+00	1895.00
IUUC-Mlu-067217	Myotis lucifugus	85.10	0.00e+00	1862.00
IUUC-Nfi-068407	Neosartorya fischeri	52.33	0.00e+00	1032.00
IUUC-Ncr-068698	Neurospora crassa	52.84	0.00e+00	1055.00
IUUC-Nle-070072	Nomascus leucogenys	84.22	0.00e+00	1799.00
IUUC-Ont-071671	Oreochromis niloticus	75.55	0.00e+00	1617.00
IUUC-Ocu-074544	Oryctolagus cuniculus	86.50	0.00e+00	1899.00
IUUC-Oba-075120	Oryza barthii	44.83	0.00e+00	854.00
IUUC-Obr-076557	Oryza brachyantha	45.05	0.00e+00	843.00
IUUC-Ogl-077887	Oryza glaberrima	44.83	0.00e+00	856.00
IUUC-Ogu-078305	Oryza glumaepatula	43.18	0.00e+00	854.00
IUUC-Oin-079370	Oryza indica	44.27	0.00e+00	853.00
IUUC-Olo-081089	Oryza longistaminata	43.28	0.00e+00	854.00
IUUC-Ome-081942	Oryza meridionalis	44.83	0.00e+00	855.00
IUUC-Oni-082365	Oryza nivara	44.73	0.00e+00	857.00
IUUC-Opu-083977	Oryza punctata	45.35	0.00e+00	858.00
IUUC-Oru-084469	Oryza rufipogon	43.28	0.00e+00	858.00
IUUC-Osa-085949	Oryza sativa	45.02	0.00e+00	864.00
IUUC-Ola-087002	Oryzias latipes	75.07	0.00e+00	1606.00
IUUC-Olu-087687	Ostreococcus lucimarinus	43.20	0.00e+00	785.00
IUUC-Oga-088594	Otolemur garnettii	85.77	0.00e+00	1855.00
IUUC-Oar-090068	Ovis aries	86.05	0.00e+00	1889.00
IUUC-Pan-092114	Papio anubis	86.32	0.00e+00	1892.00
IUUC-Pno-095154	Phaeosphaeria nodorum	50.28	0.00e+00	1034.00
IUUC-Ppa-095416	Physcomitrella patens	44.81	0.00e+00	867.00
IUUC-Pfo-097184	Poecilia formosa	74.98	0.00e+00	1603.00
IUUC-Pab-097861	Pongo abelii	86.41	0.00e+00	1858.00
IUUC-Pop-098934	Populus trichocarpa	43.94	0.00e+00	885.00
IUUC-Pca-100347	Procavia capensis	84.68	0.00e+00	1535.00
IUUC-Ppe-102012	Prunus persica	43.68	0.00e+00	873.00
IUUC-Pva-102584	Pteropus vampyrus	86.22	0.00e+00	1907.00
IUUC-Pgr-103336	Puccinia graminis	53.43	0.00e+00	1021.00
IUUC-Ptt-103939	Puccinia triticina	52.93	0.00e+00	1023.00
IUUC-Pte-104200	Pyrenophora teres	50.05	0.00e+00	1033.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	49.81	0.00e+00	1021.00
IUUC-Rno-105462	Rattus norvegicus	85.47	0.00e+00	1854.00
IUUC-Sce-106245	Saccharomyces cerevisiae	49.56	0.00e+00	1014.00
IUUC-Sha-107142	Sarcophilus harrisii	91.19	0.00e+00	1995.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	52.76	0.00e+00	1071.00
IUUC-Spo-108034	Schizosaccharomyces pombe	52.45	0.00e+00	1044.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	53.44	0.00e+00	1013.00
IUUC-Smo-109211	Selaginella moellendorffii	44.02	0.00e+00	844.00
IUUC-Sit-110281	Setaria italica	44.90	0.00e+00	876.00
IUUC-Sly-110914	Solanum lycopersicum	43.88	0.00e+00	874.00
IUUC-Stu-112109	Solanum tuberosum	43.59	0.00e+00	879.00
IUUC-Sar-113737	Sorex araneus	85.29	0.00e+00	1865.00
IUUC-Sbi-114089	Sorghum bicolor	44.13	0.00e+00	869.00
IUUC-Sre-115148	Sporisorium reilianum	53.19	0.00e+00	1048.00
IUUC-Ssc-115777	Sus scrofa	86.42	0.00e+00	1891.00
IUUC-Tru-118742	Takifugu rubripes	75.73	0.00e+00	1568.00
IUUC-Tni-120401	Tetraodon nigroviridis	75.83	0.00e+00	1569.00
IUUC-Tca-121672	Theobroma cacao	44.10	0.00e+00	885.00
IUUC-Tre-122009	Trichoderma reesei	51.60	0.00e+00	991.00
IUUC-Tvi-122259	Trichoderma virens	51.90	0.00e+00	998.00
IUUC-Tae-125113	Triticum aestivum	45.33	0.00e+00	837.00
IUUC-Tur-126189	Triticum urartu	44.93	0.00e+00	831.00
IUUC-Tme-127055	Tuber melanosporum	50.67	0.00e+00	959.00
IUUC-Tbe-127487	Tupaia belangeri	79.45	0.00e+00	875.00
IUUC-Ttr-128331	Tursiops truncatus	85.75	0.00e+00	1870.00
IUUC-Uma-129387	Ustilago maydis	53.06	0.00e+00	1045.00
IUUC-Vda-129977	Verticillium dahliae	52.12	0.00e+00	966.00
IUUC-Vvi-130857	Vitis vinifera	44.62	0.00e+00	876.00
IUUC-Xtr-132026	Xenopus tropicalis	62.39	0.00e+00	1228.00
IUUC-Xma-133805	Xiphophorus maculatus	74.60	0.00e+00	1580.00
IUUC-Yli-134547	Yarrowia lipolytica	52.49	0.00e+00	1053.00
IUUC-Zma-135052	Zea mays	44.13	0.00e+00	873.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence