iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000182325.10	ENST00000455319.6	ENSP00000403873.2
ENSG00000182325.10	ENST00000331890.5	ENSP00000330098.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19159283

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	1.40e-84	283.2	10	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 1    rrraraaprprsaedwwwdrlaprgsgyhllqsdsmllvlsepgparpraqrrasrrtprqpprgpsaaakpkaglrseaaaapapapaptp 92
           rrraraaprprsaedwwwdrlaprgsgyhllqsdsmllvlsepgparpraqrrasrrtprqpprgpsaaakpkaglrseaaaapapapaptp
   Q: 10   RRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDSMLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAAKPKAGLRSEAAAAPAPAPAPTP 101
           8******************************************************************************************* PP
   S: 93   tpeegpdaglldrlpeeilveilkll...dkee..llraarvcrrwqelasqkalwktvt 147
           tpeegpdag++dr+p+eilv+i++ll   d+++  l+raarvcrrwqe+asq+alw+tvt
   Q: 102  TPEEGPDAGWGDRIPLEILVQIFGLLvaaDGPMpfLGRAARVCRRWQEAASQPALWHTVT 161
           **************************999888788***********************98 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Protein Sequence
(Fasta)

MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS EPGPARPRAQ 60
RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT PTPEEGPDAG WGDRIPLEIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGACCGCAG CCCAGGAGCC CATGCCGAAG AGAGCCACCA GCAGGTGGGT CAGCACCGGA 60
CGGGCGGGCG TGGGTGCTGC CATTCAGCCC AAGGCTGGGC CCTTCCAGGT CAGGGCAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00367--LRR_CC

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0006508--P:proteolysis

KEGG

hsa:26233

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002047	Ailuropoda melanoleuca	82.25	0.00e+00	768.00
IUUC-Aca-004785	Anolis carolinensis	52.06	3.00e-54	205.00
IUUC-Ame-011690	Astyanax mexicanus	40.74	2.00e-40	159.00
IUUC-Bta-012781	Bos taurus	84.59	0.00e+00	808.00
IUUC-Cja-018799	Callithrix jacchus	77.76	0.00e+00	648.00
IUUC-Cfa-020518	Canis familiaris	90.33	0.00e+00	699.00
IUUC-Cpo-022012	Cavia porcellus	81.68	0.00e+00	795.00
IUUC-Csa-023717	Chlorocebus sabaeus	97.71	0.00e+00	729.00
IUUC-Dre-028685	Danio rerio	43.97	8.00e-99	354.00
IUUC-Dno-029881	Dasypus novemcinctus	88.67	9.00e-121	426.00
IUUC-Dme-032069	Drosophila melanogaster	33.49	6.00e-49	189.00
IUUC-Eca-034384	Equus caballus	90.61	0.00e+00	738.00
IUUC-Eeu-034885	Erinaceus europaeus	73.04	0.00e+00	674.00
IUUC-Fca-036109	Felis catus	84.63	0.00e+00	780.00
IUUC-Gmo-039122	Gadus morhua	35.98	3.00e-71	263.00
IUUC-Gac-042048	Gasterosteus aculeatus	39.01	4.00e-97	348.00
IUUC-Ggo-045521	Gorilla gorilla	98.27	0.00e+00	876.00
IUUC-Itr-048984	Ictidomys tridecemlineatus	89.04	0.00e+00	740.00
IUUC-Loc-052284	Lepisosteus oculatus	45.63	7.00e-97	348.00
IUUC-Laf-053367	Loxodonta africana	86.15	0.00e+00	636.00
IUUC-Mcc-055865	Macaca mulatta	92.84	0.00e+00	852.00
IUUC-Meu-056048	Macropus eugenii	60.10	1.00e-115	409.00
IUUC-Mmr-061506	Microcebus murinus	82.68	0.00e+00	780.00
IUUC-Mdo-062323	Monodelphis domestica	55.98	2.00e-142	499.00
IUUC-Mmu-063382	Mus musculus	80.35	0.00e+00	764.00
IUUC-Mpu-066188	Mustela putorius furo	88.54	0.00e+00	682.00
IUUC-Nle-069437	Nomascus leucogenys	93.83	0.00e+00	803.00
IUUC-Ont-072058	Oreochromis niloticus	42.92	6.00e-82	298.00
IUUC-Oan-072773	Ornithorhynchus anatinus	51.93	7.00e-116	410.00
IUUC-Ogl-077479	Oryza glaberrima	25.00	4.00e-08	52.40
IUUC-Ogu-078215	Oryza glumaepatula	24.22	3.00e-08	52.40
IUUC-Oin-079411	Oryza indica	27.34	1.00e-09	57.80
IUUC-Ome-081759	Oryza meridionalis	26.56	2.00e-08	55.50
IUUC-Oni-082766	Oryza nivara	25.09	8.00e-08	52.80
IUUC-Oru-084766	Oryza rufipogon	26.91	1.00e-08	55.80
IUUC-Osa-085658	Oryza sativa	27.34	1.00e-09	57.80
IUUC-Ola-086656	Oryzias latipes	39.81	7.00e-63	234.00
IUUC-Oga-088299	Otolemur garnettii	83.69	0.00e+00	761.00
IUUC-Oar-089657	Ovis aries	82.66	0.00e+00	783.00
IUUC-Ptr-090950	Pan troglodytes	98.65	0.00e+00	872.00
IUUC-Pan-092741	Papio anubis	93.62	0.00e+00	854.00
IUUC-Psi-093324	Pelodiscus sinensis	52.53	2.00e-78	285.00
IUUC-Pma-094256	Petromyzon marinus	35.60	8.00e-45	174.00
IUUC-Pfo-096992	Poecilia formosa	40.80	3.00e-83	302.00
IUUC-Pca-100265	Procavia capensis	74.35	3.00e-105	374.00
IUUC-Pva-103253	Pteropus vampyrus	86.67	0.00e+00	649.00
IUUC-Rno-106011	Rattus norvegicus	79.88	0.00e+00	741.00
IUUC-Sha-106485	Sarcophilus harrisii	57.93	1.00e-142	499.00
IUUC-Ssc-115464	Sus scrofa	82.05	0.00e+00	734.00
IUUC-Tsy-119633	Tarsius syrichta	71.81	1.00e-153	536.00
IUUC-Tni-120580	Tetraodon nigroviridis	46.22	7.00e-22	96.70
IUUC-Ttr-128827	Tursiops truncatus	88.73	0.00e+00	750.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence