iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047316

Ensembl Protein ID

MLOC_36655.2

UniProt Accession

M0VRJ9; M0VRJ9_HORVV

Protein Name

Coatomer subunit alpha

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_36655	MLOC_36655.2	MLOC_36655.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-36	123.3	16	52
UBD/Beta-Prp	2.40e-70	238.2	2	289

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           H ++v++++f  + +l+vsG+dD +ikvW+++t+++l
   Q: 16   HDGPVRGVHFhaTQPLFVSGGDDYKIKVWNYKTHRCL 52
           99*********6449********************98 PP

UBD/Beta-Prp

   S: 37   wdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetl 133
           wd+++g+ll ++ +h+++v+ v f+ +++++v+g++D+ ikvw+++t  c+ tl+gh d++++++f+ +  ++vs+s+d+tir+w++++++c+  +l
   Q: 2    WDYRMGTLLDRFDEHDGPVRGVHFHATQPLFVSGGDDYKIKVWNYKTHRCLFTLTGHLDYIRTVQFHHEYPWIVSASDDQTIRIWNWQSRTCVA-VL 97
           **********************************************************************************************.** PP
   S: 134  sghdgvvncvvvhpdgnllvsGslDrtvrlWdl...........................ktgkllrtltgghtdsvyslsfdsngkelvsgsldgt 203
           +gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                             + + + l+g h++ v++ sf+++ + +vsg++d++
   Q: 98   TGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIgalrkktvspaddimrltqmntdlfggVDAVVKYVLEG-HDRGVNWASFHPTLPLIVSGADDRQ 193
           ******************************************99999977777777666444444444466.************************* PP
   S: 204  vklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           vklw +  ++   v+tl+gh +nv++v f+ +++++vs s+D+siriWd ++++ ++t+ +++++++  a+ +++ n l++g  ds   ++kl++++
   Q: 194  VKLWRMNDTKAweVDTLRGHMNNVSCVMFHAKQDIIVSNSEDKSIRIWDATKRTGIQTFRREHDRFWILAA-HPEMNLLAAG-HDSGMIVFKLERER 288
           *******777668**********************************************************.6666655555.68999999998876 PP
   S: 299  p 299
           p
   Q: 289  P 289
           5 PP

Organism

Hordeum vulgare

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MWDYRMGTLL DRFDEHDGPV RGVHFHATQP LFVSGGDDYK IKVWNYKTHR CLFTLTGHLD 60
YIRTVQFHHE YPWIVSASDD QTIRIWNWQS RTCVAVLTGH NHYVMCASFH PKEDLVVSAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTCGCCA GCCTCCACAG CGGGGTGATC CAGATGTGGG ACTACCGCAT GGGCACCCTC 60
CTCGACCGCT TCGACGAGCA CGACGGCCCC GTCCGCGGCG TGCACTTCCA CGCCACCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	98.65	0.00e+00	2303.00
IUUC-Ang-009756	Aspergillus niger	47.13	0.00e+00	1083.00
IUUC-Bgr-012300	Blumeria graminis	46.72	0.00e+00	1073.00
IUUC-Lpe-051316	Leersia perrieri	93.75	0.00e+00	2215.00
IUUC-Lma-053138	Leptosphaeria maculans	46.35	0.00e+00	1065.00
IUUC-Meu-056238	Macropus eugenii	58.97	0.00e+00	767.00
IUUC-Opr-070952	Ochotona princeps	41.45	0.00e+00	649.00
IUUC-Oba-075761	Oryza barthii	92.48	0.00e+00	2227.00
IUUC-Obr-076429	Oryza brachyantha	91.65	0.00e+00	2218.00
IUUC-Ogl-077364	Oryza glaberrima	92.48	0.00e+00	2230.00
IUUC-Ogu-078257	Oryza glumaepatula	92.44	0.00e+00	2164.00
IUUC-Oin-079274	Oryza indica	92.31	0.00e+00	2227.00
IUUC-Oni-082874	Oryza nivara	92.31	0.00e+00	2226.00
IUUC-Opu-083885	Oryza punctata	92.65	0.00e+00	2236.00
IUUC-Oru-084274	Oryza rufipogon	92.40	0.00e+00	2227.00
IUUC-Osa-085565	Oryza sativa	92.40	0.00e+00	2227.00
IUUC-Pno-094839	Phaeosphaeria nodorum	45.76	0.00e+00	1051.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	39.45	0.00e+00	731.00
IUUC-Sar-113313	Sorex araneus	41.56	0.00e+00	629.00
IUUC-Tvi-122359	Trichoderma virens	46.21	0.00e+00	1059.00
IUUC-Tae-125527	Triticum aestivum	98.82	0.00e+00	2308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence