iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132756

Ensembl Protein ID

ENSXETP00000018712.3

UniProt Accession

F7C949; F7C949_XENTR

Genbank Protein ID

ENSXETP00000018712

Protein Name

Presenilin

Genbank Nucleotide ID

AAMC01001126

Gene Name

psen2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000008548.3	ENSXETT00000018712.3	ENSXETP00000018712.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	5.70e-08	32.8	283	315

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgslea 34
           +eta+e++++iFP+l+ys+ +v+ + +++s +a
   Q: 283  VETAQERNEPIFPALIYSSAMVWTVGMADSATA 315
           89****************************987 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFANSSDS EDDECNERTS LITSQSPPLP SYQDGLQASG GSESSDPMKT QTDTQVIEDV 60
PNGRTSGADA YNSDAAMENE EEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTTTATCC TAAAAGTCGT GCCACGTAGT TACTTGTTAA AAATAGTAAG TTTGATAAAT 60
TAACTTCTGT GTCCCTAGGT ATAGCTACTA TTCCGGATAT GATAACATTC GCAAACAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0007420--P:brain development
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0022008--P:neurogenesis
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	66.00	2.00e-128	451.00
IUUC-Apl-003959	Anas platyrhynchos	75.59	1.00e-170	592.00
IUUC-Aca-005160	Anolis carolinensis	75.99	1.00e-170	592.00
IUUC-Ath-006730	Arabidopsis thaliana	34.26	2.00e-19	90.10
IUUC-Ame-010686	Astyanax mexicanus	77.27	3.00e-154	537.00
IUUC-Bta-013097	Bos taurus	73.35	3.00e-156	544.00
IUUC-Bra-017580	Brassica rapa	53.68	2.00e-18	86.70
IUUC-Cel-018553	Caenorhabditis elegans	48.00	3.00e-98	352.00
IUUC-Cja-018824	Callithrix jacchus	70.93	1.00e-152	532.00
IUUC-Cfa-020253	Canis familiaris	72.19	2.00e-156	545.00
IUUC-Cpo-021401	Cavia porcellus	73.57	9.00e-157	546.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.25	5.00e-29	122.00
IUUC-Csa-023369	Chlorocebus sabaeus	71.80	3.00e-156	544.00
IUUC-Csv-025967	Ciona savignyi	62.23	1.00e-123	436.00
IUUC-Dre-028526	Danio rerio	72.35	8.00e-157	546.00
IUUC-Dor-031127	Dipodomys ordii	71.08	1.00e-156	545.00
IUUC-Dme-031929	Drosophila melanogaster	53.46	5.00e-114	404.00
IUUC-Ete-033081	Echinops telfairi	65.96	3.00e-69	255.00
IUUC-Eca-034387	Equus caballus	71.86	2.00e-151	528.00
IUUC-Eeu-034846	Erinaceus europaeus	61.13	4.00e-102	364.00
IUUC-Fca-035396	Felis catus	71.65	1.00e-162	565.00
IUUC-Fal-037457	Ficedula albicollis	77.12	9.00e-168	582.00
IUUC-Gmo-038550	Gadus morhua	71.25	8.00e-137	479.00
IUUC-Gga-040706	Gallus gallus	76.75	1.00e-166	579.00
IUUC-Gac-042511	Gasterosteus aculeatus	67.31	4.00e-140	491.00
IUUC-Gma-043822	Glycine max	35.12	4.00e-26	112.00
IUUC-Ggo-045338	Gorilla gorilla	71.80	4.00e-156	544.00
IUUC-Hsa-046455	Homo sapiens	71.80	4.00e-156	544.00
IUUC-Hvu-047141	Hordeum vulgare	30.96	1.00e-28	120.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	72.59	3.00e-157	547.00
IUUC-Lch-049638	Latimeria chalumnae	67.45	6.00e-151	526.00
IUUC-Lpe-051132	Leersia perrieri	46.09	1.00e-17	84.00
IUUC-Loc-052427	Lepisosteus oculatus	73.68	2.00e-169	588.00
IUUC-Laf-053758	Loxodonta africana	71.77	1.00e-167	582.00
IUUC-Mcc-054755	Macaca mulatta	71.80	1.00e-155	543.00
IUUC-Mtr-058392	Medicago truncatula	33.16	1.00e-32	133.00
IUUC-Mmr-060890	Microcebus murinus	71.74	3.00e-154	537.00
IUUC-Mdo-062197	Monodelphis domestica	75.22	3.00e-165	574.00
IUUC-Mmu-063823	Mus musculus	72.71	4.00e-158	550.00
IUUC-Mac-064858	Musa acuminata	42.26	2.00e-23	103.00
IUUC-Mpu-066181	Mustela putorius furo	72.91	4.00e-157	547.00
IUUC-Nle-069596	Nomascus leucogenys	68.63	5.00e-142	497.00
IUUC-Opr-070344	Ochotona princeps	72.54	5.00e-159	553.00
IUUC-Ont-071867	Oreochromis niloticus	71.81	5.00e-143	500.00
IUUC-Oan-073378	Ornithorhynchus anatinus	71.60	7.00e-150	523.00
IUUC-Ocu-074652	Oryctolagus cuniculus	72.35	9.00e-156	543.00
IUUC-Oba-075256	Oryza barthii	49.56	3.00e-17	82.80
IUUC-Obr-076302	Oryza brachyantha	48.70	5.00e-18	85.50
IUUC-Ogl-077097	Oryza glaberrima	50.96	4.00e-17	82.80
IUUC-Ogu-078570	Oryza glumaepatula	50.96	4.00e-17	82.40
IUUC-Oin-079244	Oryza indica	49.56	4.00e-17	82.40
IUUC-Olo-080484	Oryza longistaminata	49.56	2.00e-17	82.40
IUUC-Ome-081814	Oryza meridionalis	49.56	3.00e-17	82.80
IUUC-Oni-082057	Oryza nivara	50.96	4.00e-17	82.00
IUUC-Opu-084176	Oryza punctata	49.56	8.00e-17	81.30
IUUC-Oru-084618	Oryza rufipogon	50.96	4.00e-17	82.40
IUUC-Osa-085602	Oryza sativa	50.96	6.00e-17	81.60
IUUC-Ola-086707	Oryzias latipes	72.85	4.00e-111	393.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.05	6.00e-46	177.00
IUUC-Oga-088560	Otolemur garnettii	70.81	9.00e-153	533.00
IUUC-Oar-089200	Ovis aries	73.20	1.00e-154	539.00
IUUC-Ptr-090569	Pan troglodytes	71.80	2.00e-156	545.00
IUUC-Pan-091742	Papio anubis	71.80	7.00e-156	543.00
IUUC-Pma-094612	Petromyzon marinus	73.35	3.00e-129	454.00
IUUC-Ppa-095431	Physcomitrella patens	32.74	2.00e-26	113.00
IUUC-Pab-098531	Pongo abelii	71.80	3.00e-156	544.00
IUUC-Pop-099661	Populus trichocarpa	33.58	1.00e-35	143.00
IUUC-Pca-101120	Procavia capensis	69.63	1.00e-150	526.00
IUUC-Ppe-101495	Prunus persica	31.57	3.00e-39	156.00
IUUC-Pva-102934	Pteropus vampyrus	67.53	5.00e-152	530.00
IUUC-Rno-106052	Rattus norvegicus	71.37	3.00e-161	561.00
IUUC-Sha-106876	Sarcophilus harrisii	74.03	2.00e-162	565.00
IUUC-Sit-110624	Setaria italica	31.98	3.00e-29	122.00
IUUC-Stu-112433	Solanum tuberosum	34.22	9.00e-33	134.00
IUUC-Sbi-114305	Sorghum bicolor	31.51	9.00e-29	121.00
IUUC-Ssc-115380	Sus scrofa	72.02	1.00e-162	565.00
IUUC-Tgu-117280	Taeniopygia guttata	76.91	3.00e-169	587.00
IUUC-Tca-121865	Theobroma cacao	31.17	2.00e-33	136.00
IUUC-Tbe-127632	Tupaia belangeri	74.06	7.00e-128	450.00
IUUC-Ttr-129008	Tursiops truncatus	71.65	9.00e-154	536.00
IUUC-Vvi-131312	Vitis vinifera	38.12	1.00e-20	94.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence