iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063518

UUCD1 version

UUC-MuM-01082

Ensembl Protein ID

ENSMUSP00000131206.1

UniProt Accession

P62838; P51669; UB2D2_MOUSE

Genbank Protein ID

AAB05772.1; AAH03923.1

Protein Name

Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2

Genbank Nucleotide ID

U62483; BC003923

Gene Name

Ube2d2a; Ube2d2; Ubc4; Ubch4; Ubch5b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000091896.7	ENSMUST00000167406.1	ENSMUSP00000131206.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.30e-56	191.3	5	139
UBD/UBC-like/UBD_UBC	2.30e-85	284.8	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++l++dpp+++sa+pv + d+++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+t+i+hPn+++nG++Cl+il+  
   Q: 5    RIHKELNDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR-- 90
           99**********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wspal++++vllsi+sll++pnp++pl  e+a+++k++re+y++++r
   Q: 91   SQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAR 139
           *********************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqw 89
           ri+kel+dl+rd++aq+sa++v+dd+f+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+t+iyhpninsngsicldilrsqw
   Q: 5    RIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQW 93
           8**************************************************************************************** PP
   S: 90   saaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           s+alt+skvlls+csll+d++pddplv+eiariyktd+eky+riarewt
   Q: 94   SPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWT 142
           ************************************************8 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Protein Sequence
(Fasta)

MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGCCG CCCGCCCGCG CGTCCCTTAG TCCACCTGCA CCAGGCAGGA GAGCAGGCTC 60
CCCCCGGCTC CGCCACCGTA AGGCGCTGGG CGAGCCCGGA GCTTGGGGGC TCTTCCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination

KEGG

mmu:56550

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000292	Aegilops tauschii	79.59	2.00e-69	254.00
IUUC-Aml-001778	Ailuropoda melanoleuca	100.00	1.00e-81	294.00
IUUC-Atr-002861	Amborella trichopoda	80.95	3.00e-70	257.00
IUUC-Apl-003199	Anas platyrhynchos	100.00	3.00e-81	293.00
IUUC-Aca-005236	Anolis carolinensis	100.00	4.00e-86	309.00
IUUC-Ago-007967	Ashbya gossypii	80.95	2.00e-71	260.00
IUUC-Ang-009725	Aspergillus niger	84.80	4.00e-62	229.00
IUUC-Ame-011831	Astyanax mexicanus	96.60	3.00e-83	300.00
IUUC-Bgr-012238	Blumeria graminis	80.27	1.00e-69	254.00
IUUC-Bta-013158	Bos taurus	100.00	4.00e-86	309.00
IUUC-Bdi-014561	Brachypodium distachyon	80.27	1.00e-70	258.00
IUUC-Cel-018362	Caenorhabditis elegans	93.88	2.00e-81	294.00
IUUC-Cja-019886	Callithrix jacchus	100.00	4.00e-86	309.00
IUUC-Cfa-020436	Canis familiaris	100.00	4.00e-86	309.00
IUUC-Cpo-021714	Cavia porcellus	97.96	3.00e-84	303.00
IUUC-Cre-022765	Chlamydomonas reinhardtii	78.91	3.00e-69	253.00
IUUC-Csa-023148	Chlorocebus sabaeus	95.27	5.00e-81	292.00
IUUC-Csv-026311	Ciona savignyi	85.62	9.00e-73	265.00
IUUC-Dre-027758	Danio rerio	98.64	6.00e-85	305.00
IUUC-Dno-028952	Dasypus novemcinctus	100.00	7.00e-82	295.00
IUUC-Dor-030323	Dipodomys ordii	92.52	5.00e-81	292.00
IUUC-Ete-032295	Echinops telfairi	100.00	3.00e-81	293.00
IUUC-Eca-033293	Equus caballus	100.00	2.00e-81	294.00
IUUC-Gga-040758	Gallus gallus	100.00	4.00e-86	309.00
IUUC-Gac-042231	Gasterosteus aculeatus	97.28	6.00e-84	302.00
IUUC-Ggo-045375	Gorilla gorilla	95.95	3.00e-82	296.00
IUUC-Hsa-045885	Homo sapiens	100.00	4.00e-86	309.00
IUUC-Hvu-047546	Hordeum vulgare	78.23	6.00e-69	252.00
IUUC-Itr-048882	Ictidomys tridecemlineatus	96.62	4.00e-82	296.00
IUUC-Lch-050109	Latimeria chalumnae	86.39	3.00e-77	280.00
IUUC-Lpe-051289	Leersia perrieri	80.27	2.00e-70	257.00
IUUC-Loc-052838	Lepisosteus oculatus	93.20	2.00e-81	293.00
IUUC-Laf-053580	Loxodonta africana	100.00	9.00e-82	295.00
IUUC-Mcc-054673	Macaca mulatta	100.00	2.00e-81	294.00
IUUC-Mtr-058257	Medicago truncatula	80.27	9.00e-70	255.00
IUUC-Mdo-062962	Monodelphis domestica	100.00	4.00e-86	309.00
IUUC-Mac-065211	Musa acuminata	80.95	5.00e-70	256.00
IUUC-Mpu-066604	Mustela putorius furo	95.89	3.00e-82	296.00
IUUC-Nle-069715	Nomascus leucogenys	93.20	2.00e-81	293.00
IUUC-Ont-071766	Oreochromis niloticus	98.64	4.00e-85	306.00
IUUC-Oan-073026	Ornithorhynchus anatinus	92.86	2.00e-77	281.00
IUUC-Ocu-074315	Oryctolagus cuniculus	100.00	4.00e-86	309.00
IUUC-Oba-075411	Oryza barthii	80.27	3.00e-70	256.00
IUUC-Obr-076658	Oryza brachyantha	80.27	2.00e-70	257.00
IUUC-Ogl-076968	Oryza glaberrima	80.95	8.00e-71	258.00
IUUC-Ogu-078091	Oryza glumaepatula	80.00	1.00e-69	256.00
IUUC-Oin-079659	Oryza indica	80.95	8.00e-71	258.00
IUUC-Olo-080786	Oryza longistaminata	80.27	3.00e-70	256.00
IUUC-Ome-081920	Oryza meridionalis	80.95	2.00e-69	254.00
IUUC-Oni-082391	Oryza nivara	80.95	5.00e-71	261.00
IUUC-Opu-083833	Oryza punctata	80.27	2.00e-70	257.00
IUUC-Oru-085167	Oryza rufipogon	80.95	7.00e-71	260.00
IUUC-Osa-086003	Oryza sativa	80.95	8.00e-71	258.00
IUUC-Ola-086331	Oryzias latipes	98.64	4.00e-85	306.00
IUUC-Ptr-090707	Pan troglodytes	100.00	4.00e-86	309.00
IUUC-Pan-092143	Papio anubis	100.00	4.00e-86	309.00
IUUC-Pma-094405	Petromyzon marinus	94.81	1.00e-75	274.00
IUUC-Ppa-095177	Physcomitrella patens	80.95	3.00e-70	256.00
IUUC-Pfo-096753	Poecilia formosa	98.64	4.00e-85	306.00
IUUC-Pab-097764	Pongo abelii	100.00	4.00e-86	309.00
IUUC-Pop-098799	Populus trichocarpa	80.95	3.00e-70	256.00
IUUC-Ptt-103723	Puccinia triticina	77.86	2.00e-61	227.00
IUUC-Smo-109317	Selaginella moellendorffii	80.95	8.00e-70	255.00
IUUC-Sit-109936	Setaria italica	79.59	2.00e-70	258.00
IUUC-Sly-111055	Solanum lycopersicum	81.63	1.00e-70	258.00
IUUC-Stu-112436	Solanum tuberosum	79.59	5.00e-71	259.00
IUUC-Sar-113302	Sorex araneus	100.00	3.00e-81	293.00
IUUC-Sbi-114840	Sorghum bicolor	80.95	7.00e-71	258.00
IUUC-Tru-118272	Takifugu rubripes	98.64	1.00e-84	305.00
IUUC-Tsy-118832	Tarsius syrichta	90.48	2.00e-78	283.00
IUUC-Tni-120056	Tetraodon nigroviridis	98.64	1.00e-84	305.00
IUUC-Tca-121542	Theobroma cacao	79.59	1.00e-70	259.00
IUUC-Tae-123340	Triticum aestivum	81.63	7.00e-72	262.00
IUUC-Tur-126518	Triticum urartu	79.59	9.00e-70	256.00
IUUC-Tbe-127609	Tupaia belangeri	100.00	1.00e-67	247.00
IUUC-Vpa-130446	Vicugna pacos	99.29	2.00e-80	291.00
IUUC-Xtr-132329	Xenopus tropicalis	100.00	4.00e-86	309.00
IUUC-Xma-133829	Xiphophorus maculatus	98.64	4.00e-85	306.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence