iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088365

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03099430

Gene Name

TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000011398.2	ENSOGAT00000011401.2	ENSOGAP00000010208.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-46	152.9	502	540
UBD/Beta-Prp	2.90e-65	220.4	295	573

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 502  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 540
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++llatgs+dg  ++w  ++g+l ++l +h++++ a+k++++g+++++++ D+t  +wd  tg+  + +  h++ +l+++++  + 
   Q: 295  QSDGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQN-NT 381
           5699***************5.777************************************************************99.89 PP
   S: 108  klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.... 192
           +++s s d  i+v  l  +  ++ t++gh+  vn ++++p+g ll+s+s+D t+++W++k+++++++l+  h + +y ++++++g    
   Q: 382  TFASCSTDMCIHVCRLGCDRPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQA-HSKEIYTIKWSPTGpats 468
           9**********************.*********************************************8.************99**** PP
   S: 193  .....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfg 276
                  l+s+s d+tv+lwd+++g c +tl+ h+++v+sv+fsp++++l+sgs D+ + iW+++sg l++++ ++    i   +++  
   Q: 469  npnssIMLASASFDSTVRLWDVERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTG--GIFEVCWNAR 555
           **99999*****************************************************************99965..2222333444 PP
   S: 277  dnvlvlgsedskvniwkl 294
           + ++ + ++d++v +++l
   Q: 556  GDKVGASASDGSVCVLDL 573
           444444444566666665 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

PRGGVPVQGV AETFNRLHFA EGGSHFVKTS SLRGEAKMSI TSDEVNFLVY RYLQESGFSH 60
SAFTFGIESH ISQSNINGTL VPPAALISIL QKGLQYVEAE ISINEDGTVF DGRPIESLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGAGGTG GGGTGCCTGT GCAGGGTGTC GCTGAAACAT TTAACCGTTT ACACTTTGGC 60
AAGTGAAAGG TGTTGCAGTC AGTCATTTCT CTTGAAACTT GTGGTTACTC TTCGCAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0005667--C:transcription factor complex
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0045444--P:fat cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0007605--P:sensory perception of sound

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Kpa-049338	Komagataella pastoris	29.67	7.00e-30	125.00
IUUC-Meu-056563	Macropus eugenii	90.34	2.00e-128	451.00
IUUC-Oba-075618	Oryza barthii	43.73	1.00e-126	446.00
IUUC-Ogl-077302	Oryza glaberrima	45.88	1.00e-138	486.00
IUUC-Ogu-078718	Oryza glumaepatula	45.88	1.00e-138	486.00
IUUC-Ome-081696	Oryza meridionalis	44.80	3.00e-133	468.00
IUUC-Oni-082137	Oryza nivara	45.88	1.00e-138	486.00
IUUC-Oru-085276	Oryza rufipogon	45.88	8.00e-139	487.00
IUUC-Osa-085791	Oryza sativa	45.88	1.00e-138	486.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence