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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064198
UUCD1 version UUC-MuM-00558
Ensembl Protein ID ENSMUSP00000025739.7
UniProt Accession Q7TMI3; Q8BG56; Q8BJP6; Q8BY30; Q8K1I5; UHRF2_MOUSE
Genbank Protein ID BAC81739.1; AAM33798.1; BAC27224.1; BAC30987.1; BAC31223.1; BAC34750.1; BAC38081.1; AAH60241.1
Protein Name E3 ubiquitin-protein ligase UHRF2; NIRF; Np95-like ring finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2
Genbank Nucleotide ID AB116653; AF274047; AK031036; AK041564; AK042321; AK051743; AK080925; BC060241
Gene Name Uhrf2; Nirf
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024817.13 ENSMUST00000025739.13 ENSMUSP00000025739.7
ENSMUSG00000024817.13 ENSMUST00000112552.1 ENSMUSP00000108171.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_PIM 2.10e-17 64.0 1 77
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgke..fel.evseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           m+++v+t +g++    + +vs++ t+eel+e++++ ++v pe+q+L y Gk+L++  tL ++++  ++++ l+v++++
   Q: 1    MWIQVRTIDGSQtrT-IeDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDS 77
           89********99744.45********************************************************9876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.
 E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.
Protein Sequence
(Fasta)
MWIQVRTIDG SQTRTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK QLENGYTLFD 60
YDVGLNDIIQ LLVRPDSSLP STSKQNDAQV KPSSHNPPKV KKTARGGSSS QPSTSARTCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064198|ULD,UBQ_PIM|Mus musculus
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Nucleotide Sequence
(Fasta)
CCGAGCCATG GCTCCTTCCT ATTTGTGAGG CGCGGGCTGC GCTCGCACCT CGGGCGGGTT 60
CCGGTTTCCT TCCACCGAGG AGGGGCGGGC GGGCGGTCGC GCGGTCTAAG AGCGTCAGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064198|ULD,UBQ_PIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015947--PUA-like_domain
IPR014722--Rib_L2_dom2
IPR003105--SRA_YDG
IPR021991--TTD_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50053--UBIQUITIN_2
PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF02182--SAD_SRA
PF12148--TTD
PF00240--ubiquitin
SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
SM00213--UBQ
Gene Ontology

GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030154--P:cell differentiation
GO:0008283--P:cell proliferation
GO:0010216--P:maintenance of DNA methylation
GO:0071158--P:positive regulation of cell cycle arrest
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0090308--P:regulation of methylation-dependent chromatin silencing
KEGG mmu:109113
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001401 Ailuropoda melanoleuca 90.41 0.00e+00 1457.00
IUUC-Aca-005287 Anolis carolinensis 69.60 0.00e+00 1172.00
IUUC-Bta-012710 Bos taurus 88.45 0.00e+00 1359.00
IUUC-Cja-019807 Callithrix jacchus 91.67 0.00e+00 1478.00
IUUC-Cfa-021096 Canis familiaris 90.66 0.00e+00 1442.00
IUUC-Cpo-022368 Cavia porcellus 94.02 0.00e+00 1535.00
IUUC-Csa-023951 Chlorocebus sabaeus 91.29 0.00e+00 1471.00
IUUC-Cho-024857 Choloepus hoffmanni 90.09 0.00e+00 981.00
IUUC-Dno-029950 Dasypus novemcinctus 91.04 0.00e+00 1452.00
IUUC-Ete-032375 Echinops telfairi 86.51 2.00e-147 516.00
IUUC-Eca-033272 Equus caballus 90.82 0.00e+00 1432.00
IUUC-Fca-035570 Felis catus 90.33 0.00e+00 1365.00
IUUC-Fal-037082 Ficedula albicollis 70.12 0.00e+00 1150.00
IUUC-Gmo-038826 Gadus morhua 60.90 0.00e+00 954.00
IUUC-Gga-041062 Gallus gallus 70.21 0.00e+00 1160.00
IUUC-Gac-041859 Gasterosteus aculeatus 62.89 0.00e+00 1026.00
IUUC-Ggo-045639 Gorilla gorilla 90.80 0.00e+00 1472.00
IUUC-Hsa-046422 Homo sapiens 90.67 0.00e+00 1471.00
IUUC-Itr-048532 Ictidomys tridecemlineatus 95.13 0.00e+00 1056.00
IUUC-Lpe-050756 Leersia perrieri 32.60 2.00e-44 174.00
IUUC-Loc-052318 Lepisosteus oculatus 63.88 0.00e+00 1069.00
IUUC-Laf-053529 Loxodonta africana 91.78 0.00e+00 1483.00
IUUC-Mcc-055815 Macaca mulatta 91.54 0.00e+00 1476.00
IUUC-Meu-056189 Macropus eugenii 63.92 9.00e-145 507.00
IUUC-Mmr-060646 Microcebus murinus 90.92 0.00e+00 1469.00
IUUC-Mdo-062659 Monodelphis domestica 71.39 0.00e+00 1189.00
IUUC-Mlu-067256 Myotis lucifugus 79.22 0.00e+00 1255.00
IUUC-Nle-069901 Nomascus leucogenys 90.70 0.00e+00 1367.00
IUUC-Opr-070219 Ochotona princeps 88.64 2.00e-136 479.00
IUUC-Ont-072019 Oreochromis niloticus 57.42 0.00e+00 996.00
IUUC-Oan-073109 Ornithorhynchus anatinus 77.17 0.00e+00 720.00
IUUC-Ocu-074748 Oryctolagus cuniculus 90.57 0.00e+00 1339.00
IUUC-Oba-075108 Oryza barthii 32.82 3.00e-44 173.00
IUUC-Obr-076572 Oryza brachyantha 33.07 2.00e-44 174.00
IUUC-Ogl-077177 Oryza glaberrima 32.82 3.00e-44 173.00
IUUC-Ogu-078298 Oryza glumaepatula 32.82 3.00e-44 173.00
IUUC-Oin-079911 Oryza indica 33.07 2.00e-44 174.00
IUUC-Olo-080374 Oryza longistaminata 30.83 1.00e-36 147.00
IUUC-Ome-081137 Oryza meridionalis 30.57 3.00e-36 147.00
IUUC-Oni-082510 Oryza nivara 31.39 1.00e-43 171.00
IUUC-Opu-083974 Oryza punctata 33.07 3.00e-44 173.00
IUUC-Oru-084985 Oryza rufipogon 31.39 1.00e-43 171.00
IUUC-Osa-085339 Oryza sativa 32.82 2.00e-44 174.00
IUUC-Ola-086706 Oryzias latipes 62.59 0.00e+00 989.00
IUUC-Oga-088218 Otolemur garnettii 91.29 0.00e+00 1493.00
IUUC-Oar-090189 Ovis aries 89.17 0.00e+00 1462.00
IUUC-Ptr-091290 Pan troglodytes 90.67 0.00e+00 1471.00
IUUC-Pan-092391 Papio anubis 87.97 0.00e+00 1404.00
IUUC-Psi-093033 Pelodiscus sinensis 69.64 0.00e+00 1120.00
IUUC-Pab-098211 Pongo abelii 91.04 0.00e+00 1470.00
IUUC-Pca-100531 Procavia capensis 85.81 0.00e+00 1286.00
IUUC-Pva-102266 Pteropus vampyrus 90.80 0.00e+00 1476.00
IUUC-Pyt-104740 Pyrenophora triticirepentis 28.85 7.00e-11 62.80
IUUC-Rno-105552 Rattus norvegicus 97.26 0.00e+00 1574.00
IUUC-Sha-106687 Sarcophilus harrisii 71.11 0.00e+00 1082.00
IUUC-Sar-113546 Sorex araneus 82.84 1.00e-138 486.00
IUUC-Sbi-114726 Sorghum bicolor 33.94 5.00e-45 176.00
IUUC-Tgu-116945 Taeniopygia guttata 69.46 0.00e+00 1019.00
IUUC-Tru-118292 Takifugu rubripes 62.79 0.00e+00 1026.00
IUUC-Tsy-119249 Tarsius syrichta 90.17 0.00e+00 1370.00
IUUC-Tni-120750 Tetraodon nigroviridis 60.97 0.00e+00 970.00
IUUC-Tbe-127823 Tupaia belangeri 83.82 0.00e+00 983.00
IUUC-Ttr-128215 Tursiops truncatus 81.65 0.00e+00 1302.00
IUUC-Vpa-130073 Vicugna pacos 88.29 0.00e+00 1436.00
IUUC-Xtr-132771 Xenopus tropicalis 64.08 0.00e+00 1076.00
Created Date 25-Jun-2017

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