iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087420

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

BAAF04005585

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000003110.1	ENSORLT00000003876.1	ENSORLP00000003875.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-39	131.1	341	376
UBD/Beta-Prp	4.30e-47	161.0	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++ ++  + lvsGs D+ +k+WD+r+++
   Q: 341  HTGWVTAVKWaPTheHQLVSGSLDNLVKLWDIRSCK 376
           ***********544688**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ v s+ +s   + + s+s+d tirvwd+e g     tl+g + v nc++++p ++ l+sGs+Dr +rlWd +t++ 
   Q: 246  TRTPLMTLSGHNEAVSSVLWSD-AEEVCSASWDHTIRVWDVEAGAMKT-TLTGSK-VFNCISYSPLCRRLASGSTDRHIRLWDPRTKDG 331
           67899****************9.999********************98.999987.99**************************99886 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+ +++ ++   +lvsgsld+ vklwd++  +  ++ l +h+d v +v+ + ++ +++sg++D+ ++ +
   Q: 332  ALVLlslTS-HTGWVTAVKWAPTHeHQLVSGSLDNLVKLWDIRsCKAPLYDLAAHEDKVFCVDWT-ESGLMLSGGADNKLYSY 412
           666666487.***********999788****************54566****************9.99**********99876 PP

Organism

Oryzias latipes

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQIQARFFT ENKRYAVDDV PFSIPAASEV GDLSNIINKL LEAKHASHSK VEFDFLVRGQ 60
FLRMPLSAHM DTEGISTEDV VEIEYVEKIT APEPEECMMH DDWISSIDAD SEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGTACGC ATGCGTAGTG ACAGACGGCA ACACATGGCT GCGGTGTGTT TTGAATGAAT 60
CTTGGCAATT TTGTGCTTCT GTCTGCACTT TTGTGTAACT CTAAAACGGA CATAAAGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

ola:101160390

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.30	4.00e-64	238.00
IUUC-Aml-001997	Ailuropoda melanoleuca	78.05	0.00e+00	639.00
IUUC-Atr-002544	Amborella trichopoda	34.05	1.00e-62	233.00
IUUC-Apl-003981	Anas platyrhynchos	76.98	1.00e-172	598.00
IUUC-Aca-004370	Anolis carolinensis	75.06	0.00e+00	672.00
IUUC-Aly-006455	Arabidopsis lyrata	34.07	6.00e-61	228.00
IUUC-Ath-006669	Arabidopsis thaliana	34.07	7.00e-57	214.00
IUUC-Ago-007864	Ashbya gossypii	30.91	4.00e-45	175.00
IUUC-Acl-008177	Aspergillus clavatus	28.28	1.00e-39	157.00
IUUC-Afl-008617	Aspergillus flavus	29.74	2.00e-40	160.00
IUUC-Afu-008752	Aspergillus fumigatus	27.80	2.00e-36	146.00
IUUC-Ani-009136	Aspergillus nidulans	29.31	1.00e-39	157.00
IUUC-Ang-009701	Aspergillus niger	26.85	1.00e-37	150.00
IUUC-Aor-009884	Aspergillus oryzae	29.23	2.00e-39	156.00
IUUC-Ame-011432	Astyanax mexicanus	81.56	0.00e+00	709.00
IUUC-Bgr-012218	Blumeria graminis	28.34	4.00e-40	158.00
IUUC-Bta-012829	Bos taurus	77.54	0.00e+00	664.00
IUUC-Bci-013953	Botrytis cinerea	28.28	4.00e-39	155.00
IUUC-Bdi-014351	Brachypodium distachyon	34.60	6.00e-62	231.00
IUUC-Bol-016190	Brassica oleracea	32.73	3.00e-58	218.00
IUUC-Bra-018095	Brassica rapa	33.25	4.00e-59	221.00
IUUC-Cel-018569	Caenorhabditis elegans	31.55	2.00e-50	192.00
IUUC-Cja-019468	Callithrix jacchus	76.83	0.00e+00	644.00
IUUC-Cfa-020471	Canis familiaris	76.83	0.00e+00	639.00
IUUC-Cpo-022260	Cavia porcellus	76.60	0.00e+00	650.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	33.42	4.00e-46	178.00
IUUC-Csa-023989	Chlorocebus sabaeus	77.07	0.00e+00	646.00
IUUC-Cho-024426	Choloepus hoffmanni	75.56	8.00e-138	483.00
IUUC-Cin-025789	Ciona intestinalis	42.45	4.00e-100	358.00
IUUC-Cne-027063	Cryptococcus neoformans	27.37	1.00e-15	77.80
IUUC-Dre-027907	Danio rerio	81.80	0.00e+00	718.00
IUUC-Dno-029225	Dasypus novemcinctus	76.12	0.00e+00	655.00
IUUC-Dor-031082	Dipodomys ordii	63.83	7.00e-143	499.00
IUUC-Dse-031308	Dothistroma septosporum	26.79	4.00e-39	155.00
IUUC-Dme-032189	Drosophila melanogaster	42.34	3.00e-98	352.00
IUUC-Ete-032247	Echinops telfairi	73.05	5.00e-176	610.00
IUUC-Eca-034285	Equus caballus	77.54	0.00e+00	661.00
IUUC-Eeu-035322	Erinaceus europaeus	70.85	2.00e-162	564.00
IUUC-Fca-036114	Felis catus	77.30	0.00e+00	661.00
IUUC-Fal-036891	Ficedula albicollis	78.53	6.00e-162	563.00
IUUC-Fox-037965	Fusarium oxysporum	25.38	6.00e-38	151.00
IUUC-Fso-038244	Fusarium solani	25.52	6.00e-36	144.00
IUUC-Gmo-039040	Gadus morhua	84.40	0.00e+00	742.00
IUUC-Ggr-040093	Gaeumannomyces graminis	25.16	7.00e-21	95.10
IUUC-Gga-040610	Gallus gallus	76.36	0.00e+00	667.00
IUUC-Gac-042117	Gasterosteus aculeatus	88.89	0.00e+00	753.00
IUUC-Gma-043146	Glycine max	36.69	9.00e-70	257.00
IUUC-Ggo-045179	Gorilla gorilla	77.30	0.00e+00	644.00
IUUC-Hsa-046114	Homo sapiens	77.54	0.00e+00	646.00
IUUC-Hvu-047331	Hordeum vulgare	33.08	7.00e-60	224.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	76.83	0.00e+00	657.00
IUUC-Kpa-049304	Komagataella pastoris	30.04	6.00e-45	174.00
IUUC-Lch-050655	Latimeria chalumnae	71.68	8.00e-137	479.00
IUUC-Lpe-051675	Leersia perrieri	34.29	5.00e-66	244.00
IUUC-Loc-052868	Lepisosteus oculatus	80.61	0.00e+00	694.00
IUUC-Lma-053258	Leptosphaeria maculans	25.70	3.00e-39	157.00
IUUC-Laf-053993	Loxodonta africana	77.30	0.00e+00	659.00
IUUC-Mcc-055128	Macaca mulatta	62.88	1.00e-144	505.00
IUUC-Meu-056501	Macropus eugenii	67.83	2.00e-145	508.00
IUUC-Mor-057114	Magnaporthe oryzae	26.44	1.00e-32	134.00
IUUC-Mtr-058367	Medicago truncatula	35.97	5.00e-64	238.00
IUUC-Mla-059107	Melampsora laricipopulina	26.94	2.00e-36	146.00
IUUC-Mga-059745	Meleagris gallopavo	75.36	0.00e+00	640.00
IUUC-Mvi-060362	Microbotryum violaceum	27.88	1.00e-36	147.00
IUUC-Mdo-062257	Monodelphis domestica	75.06	0.00e+00	667.00
IUUC-Mmu-063546	Mus musculus	77.78	0.00e+00	659.00
IUUC-Mac-065540	Musa acuminata	33.09	1.00e-64	240.00
IUUC-Mpu-066284	Mustela putorius furo	78.01	0.00e+00	665.00
IUUC-Mlu-067241	Myotis lucifugus	78.01	0.00e+00	662.00
IUUC-Nfi-068260	Neosartorya fischeri	27.32	1.00e-37	150.00
IUUC-Ncr-068719	Neurospora crassa	26.83	5.00e-33	135.00
IUUC-Nle-068981	Nomascus leucogenys	77.30	0.00e+00	630.00
IUUC-Opr-071218	Ochotona princeps	71.36	1.00e-167	582.00
IUUC-Ont-071646	Oreochromis niloticus	88.36	0.00e+00	740.00
IUUC-Oan-073453	Ornithorhynchus anatinus	78.96	0.00e+00	719.00
IUUC-Ocu-074008	Oryctolagus cuniculus	77.78	0.00e+00	666.00
IUUC-Oba-075712	Oryza barthii	30.60	3.00e-49	189.00
IUUC-Obr-076721	Oryza brachyantha	33.97	8.00e-66	244.00
IUUC-Ogl-077229	Oryza glaberrima	34.05	2.00e-65	243.00
IUUC-Ogu-078977	Oryza glumaepatula	30.60	1.00e-49	190.00
IUUC-Oin-079683	Oryza indica	34.77	3.00e-66	245.00
IUUC-Olo-080291	Oryza longistaminata	31.08	6.00e-34	137.00
IUUC-Ome-081834	Oryza meridionalis	34.29	1.00e-66	247.00
IUUC-Oni-082507	Oryza nivara	32.69	3.00e-61	228.00
IUUC-Opu-083396	Oryza punctata	34.05	9.00e-66	244.00
IUUC-Oru-085220	Oryza rufipogon	33.25	8.00e-61	227.00
IUUC-Osa-085767	Oryza sativa	34.77	3.00e-66	245.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.27	7.00e-42	164.00
IUUC-Oga-088264	Otolemur garnettii	76.36	0.00e+00	641.00
IUUC-Oar-089335	Ovis aries	77.30	0.00e+00	659.00
IUUC-Ptr-091320	Pan troglodytes	77.54	0.00e+00	646.00
IUUC-Pan-092833	Papio anubis	77.30	0.00e+00	644.00
IUUC-Psi-093504	Pelodiscus sinensis	78.72	0.00e+00	682.00
IUUC-Pma-094189	Petromyzon marinus	65.09	9.00e-165	572.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.29	8.00e-39	154.00
IUUC-Ppa-095429	Physcomitrella patens	35.70	6.00e-69	254.00
IUUC-Pfo-096337	Poecilia formosa	89.36	0.00e+00	781.00
IUUC-Pab-097571	Pongo abelii	77.30	0.00e+00	645.00
IUUC-Pop-099977	Populus trichocarpa	35.10	1.00e-68	253.00
IUUC-Pca-100394	Procavia capensis	74.82	2.00e-168	584.00
IUUC-Ppe-101848	Prunus persica	35.10	3.00e-66	245.00
IUUC-Pva-102921	Pteropus vampyrus	74.09	2.00e-93	335.00
IUUC-Pgr-103637	Puccinia graminis	29.03	2.00e-42	166.00
IUUC-Ptt-103781	Puccinia triticina	28.48	9.00e-42	164.00
IUUC-Pte-104135	Pyrenophora teres	27.51	2.00e-38	154.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.94	1.00e-37	150.00
IUUC-Rno-105114	Rattus norvegicus	77.30	0.00e+00	655.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.67	3.00e-44	172.00
IUUC-Sha-107122	Sarcophilus harrisii	76.12	0.00e+00	638.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.71	5.00e-54	204.00
IUUC-Spo-108134	Schizosaccharomyces pombe	31.26	2.00e-46	179.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	30.29	2.00e-40	160.00
IUUC-Smo-108720	Selaginella moellendorffii	34.52	1.00e-62	233.00
IUUC-Sit-110311	Setaria italica	34.19	9.00e-64	237.00
IUUC-Sly-111178	Solanum lycopersicum	34.83	5.00e-65	241.00
IUUC-Stu-112778	Solanum tuberosum	36.04	5.00e-69	254.00
IUUC-Sar-113596	Sorex araneus	64.54	1.00e-148	519.00
IUUC-Sbi-114193	Sorghum bicolor	35.97	5.00e-67	248.00
IUUC-Sre-115002	Sporisorium reilianum	27.16	8.00e-18	85.10
IUUC-Ssc-116066	Sus scrofa	77.30	0.00e+00	659.00
IUUC-Tgu-117048	Taeniopygia guttata	77.78	7.00e-173	599.00
IUUC-Tsy-119573	Tarsius syrichta	49.04	1.00e-106	379.00
IUUC-Tni-119820	Tetraodon nigroviridis	87.94	0.00e+00	743.00
IUUC-Tca-121605	Theobroma cacao	35.58	6.00e-66	244.00
IUUC-Tre-121947	Trichoderma reesei	26.36	3.00e-36	145.00
IUUC-Tvi-122481	Trichoderma virens	26.59	9.00e-38	150.00
IUUC-Tae-125861	Triticum aestivum	32.54	1.00e-64	239.00
IUUC-Tur-126586	Triticum urartu	33.08	7.00e-62	231.00
IUUC-Tme-126900	Tuber melanosporum	31.21	5.00e-51	194.00
IUUC-Tbe-127736	Tupaia belangeri	58.54	6.00e-126	443.00
IUUC-Ttr-129041	Tursiops truncatus	67.61	4.00e-161	560.00
IUUC-Uma-129628	Ustilago maydis	28.89	9.00e-11	61.60
IUUC-Vpa-130260	Vicugna pacos	77.54	0.00e+00	661.00
IUUC-Vvi-131009	Vitis vinifera	35.15	9.00e-66	243.00
IUUC-Xtr-132083	Xenopus tropicalis	74.23	0.00e+00	640.00
IUUC-Xma-133094	Xiphophorus maculatus	87.94	0.00e+00	768.00
IUUC-Yli-134531	Yarrowia lipolytica	24.49	3.00e-24	106.00
IUUC-Zma-135509	Zea mays	34.37	1.00e-66	246.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence