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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046074
Ensembl Protein ID ENSP00000330343.6
UniProt Accession P55854; B2R5X4; B4DUW4; Q53HI9; Q6FGD4; Q9BWR4; SUMO3_HUMAN
Genbank Protein ID CAA67896.1; AAP35654.1; CAG46970.1; CAG46985.1; BAD96311.1; BAG62476.1; BAG35271.1; EAX09392.1; AAH00036.1; AAH08420.1
Protein Name Small ubiquitin-related modifier 3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A
Genbank Nucleotide ID X99584; BT007008; CR542173; CR542188; AK222591; AK300822; AK312350; AL773603; BC000036; BC008420
Gene Name SUMO3; SMT3A; SMT3H1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000184900.15 ENST00000397898.7 ENSP00000380995.3
ENSG00000184900.15 ENST00000332859.10 ENSP00000330343.6
ENSG00000184900.15 ENST00000397893.3 ENSP00000380990.3
ENSG00000184900.15 ENST00000411651.6 ENSP00000409666.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UBL/SUMO SUMO 10692421; 24569813
Classification
Family E-value Score Start End
ULD/UBL/SUMO 2.30e-32 113.2 14 92
ULD/UDP/UBQ/UBQ_Other 6.80e-05 24.3 21 90
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/SUMO
   S: 6    kapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
             +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 92
           689*****************************.**********************************************9 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 5    vksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           v   dgs+ ++k++++++ ++L +   +++g+ ++q+r  ++G+++ + +t a++ + d++ti++ +++ 
   Q: 21   VAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQT 90
           5556899**********************************************************98875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
 Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Protein Sequence
(Fasta)
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR 60
FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVPESSLAG HSF 103
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046074|ULD,SUMO;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCCTGGGTT TGCCCGCGCT CGCCGACGTG GCGGCCTGGC CAAGCTCGGC GCCGCTCACC 60
AGCGCTGACC TGGGGGTGGT TTGACCTCCC AGTGCCTCAG TTTCTTCACA GGTAAAACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046074|ULD,SUMO;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF11976--Rad60-SLD
SMART

SM00213--UBQ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0031386--F:protein tag
GO:0070911--P:global genome nucleotide-excision repair
GO:0016925--P:protein sumoylation
KEGG hsa:6612
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002090 Ailuropoda melanoleuca 95.74 5.00e-50 188.00
IUUC-Atr-002794 Amborella trichopoda 57.14 3.00e-20 89.70
IUUC-Aca-004778 Anolis carolinensis 98.92 2.00e-51 192.00
IUUC-Ani-009300 Aspergillus nidulans 48.72 2.00e-16 76.60
IUUC-Ang-009651 Aspergillus niger 51.28 4.00e-17 79.30
IUUC-Ate-010503 Aspergillus terreus 41.24 7.00e-15 72.40
IUUC-Ame-011304 Astyanax mexicanus 97.83 2.00e-50 189.00
IUUC-Bta-012492 Bos taurus 100.00 2.00e-51 193.00
IUUC-Bci-013625 Botrytis cinerea 47.06 2.00e-18 83.20
IUUC-Bdi-014847 Brachypodium distachyon 53.33 2.00e-21 93.60
IUUC-Bol-015122 Brassica oleracea 56.96 3.00e-21 93.20
IUUC-Bra-017377 Brassica rapa 56.96 3.00e-21 93.20
IUUC-Cja-019875 Callithrix jacchus 96.08 5.00e-55 205.00
IUUC-Cpo-022241 Cavia porcellus 98.92 3.00e-51 192.00
IUUC-Cre-022980 Chlamydomonas reinhardtii 43.96 2.00e-18 84.00
IUUC-Csa-023457 Chlorocebus sabaeus 91.26 5.00e-53 198.00
IUUC-Dre-027877 Danio rerio 98.91 8.00e-51 191.00
IUUC-Dme-031967 Drosophila melanogaster 71.28 1.00e-34 137.00
IUUC-Fca-036348 Felis catus 98.84 4.00e-47 179.00
IUUC-Gmo-039337 Gadus morhua 96.77 1.00e-50 190.00
IUUC-Gac-041576 Gasterosteus aculeatus 91.35 2.00e-51 193.00
IUUC-Gma-043091 Glycine max 49.50 1.00e-20 91.70
IUUC-Hvu-047514 Hordeum vulgare 51.55 4.00e-21 92.40
IUUC-Itr-048366 Ictidomys tridecemlineatus 94.62 2.00e-48 183.00
IUUC-Lch-050519 Latimeria chalumnae 90.22 7.00e-45 171.00
IUUC-Lpe-051129 Leersia perrieri 56.04 3.00e-24 102.00
IUUC-Loc-052130 Lepisosteus oculatus 97.85 7.00e-51 191.00
IUUC-Lma-052968 Leptosphaeria maculans 47.19 3.00e-18 83.20
IUUC-Mcc-054714 Macaca mulatta 69.66 2.00e-50 191.00
IUUC-Mor-057132 Magnaporthe oryzae 54.43 3.00e-20 90.10
IUUC-Mpo-057351 Magnaporthe poae 55.84 2.00e-20 90.10
IUUC-Mla-059051 Melampsora laricipopulina 45.65 3.00e-16 77.00
IUUC-Mvi-060478 Microbotryum violaceum 42.31 6.00e-12 62.00
IUUC-Mmr-061052 Microcebus murinus 95.88 1.00e-51 194.00
IUUC-Mmu-064045 Mus musculus 96.84 1.00e-49 187.00
IUUC-Mac-064821 Musa acuminata 57.14 3.00e-20 89.70
IUUC-Mpu-065686 Mustela putorius furo 97.78 3.00e-49 185.00
IUUC-Mlu-066949 Myotis lucifugus 97.67 9.00e-47 177.00
IUUC-Nfi-068364 Neosartorya fischeri 50.00 2.00e-17 80.10
IUUC-Nle-070043 Nomascus leucogenys 74.81 4.00e-51 193.00
IUUC-Ont-071659 Oreochromis niloticus 98.92 3.00e-51 192.00
IUUC-Oan-073080 Ornithorhynchus anatinus 97.75 5.00e-48 182.00
IUUC-Oba-075425 Oryza barthii 59.74 4.00e-22 95.90
IUUC-Obr-076884 Oryza brachyantha 61.04 1.00e-22 97.40
IUUC-Ogl-077346 Oryza glaberrima 59.74 4.00e-22 95.90
IUUC-Ogu-078983 Oryza glumaepatula 52.75 5.00e-21 93.60
IUUC-Oin-079503 Oryza indica 59.74 4.00e-22 95.90
IUUC-Olo-080573 Oryza longistaminata 59.74 4.00e-22 95.90
IUUC-Ome-081885 Oryza meridionalis 59.74 5.00e-22 95.90
IUUC-Oni-082762 Oryza nivara 59.74 4.00e-22 95.90
IUUC-Opu-083431 Oryza punctata 59.74 9.00e-22 96.70
IUUC-Oru-084392 Oryza rufipogon 59.74 4.00e-22 95.90
IUUC-Osa-086070 Oryza sativa 59.74 4.00e-22 95.90
IUUC-Ola-086379 Oryzias latipes 98.90 4.00e-50 189.00
IUUC-Oga-088989 Otolemur garnettii 96.91 3.00e-52 196.00
IUUC-Oar-089406 Ovis aries 98.84 1.00e-47 180.00
IUUC-Ptr-091447 Pan troglodytes 100.00 4.00e-58 215.00
IUUC-Pan-091728 Papio anubis 93.20 5.00e-54 201.00
IUUC-Pno-094884 Phaeosphaeria nodorum 46.67 2.00e-19 86.70
IUUC-Ppa-095772 Physcomitrella patens 52.22 5.00e-20 89.40
IUUC-Pfo-097413 Poecilia formosa 97.85 8.00e-51 191.00
IUUC-Pab-098618 Pongo abelii 98.96 1.00e-53 200.00
IUUC-Pop-099042 Populus trichocarpa 50.98 2.00e-21 93.60
IUUC-Ppe-101721 Prunus persica 56.41 2.00e-20 91.30
IUUC-Ptt-103986 Puccinia triticina 48.05 2.00e-14 70.90
IUUC-Pte-104358 Pyrenophora teres 47.25 5.00e-20 88.60
IUUC-Pyt-104485 Pyrenophora triticirepentis 47.25 5.00e-20 88.60
IUUC-Rno-105136 Rattus norvegicus 98.92 3.00e-51 192.00
IUUC-Sha-106682 Sarcophilus harrisii 96.59 7.00e-48 181.00
IUUC-Smo-109051 Selaginella moellendorffii 52.38 4.00e-21 92.80
IUUC-Sly-110855 Solanum lycopersicum 55.84 3.00e-20 89.70
IUUC-Stu-111935 Solanum tuberosum 51.72 1.00e-20 91.30
IUUC-Ssc-116092 Sus scrofa 98.91 7.00e-51 191.00
IUUC-Tru-118409 Takifugu rubripes 97.83 3.00e-50 188.00
IUUC-Tni-120059 Tetraodon nigroviridis 96.77 3.00e-50 189.00
IUUC-Tca-120927 Theobroma cacao 55.42 1.00e-21 95.10
IUUC-Vvi-130844 Vitis vinifera 53.49 2.00e-21 94.00
IUUC-Xtr-132678 Xenopus tropicalis 98.92 3.00e-51 192.00
IUUC-Xma-133518 Xiphophorus maculatus 98.92 2.00e-51 192.00
Created Date 25-Jun-2017

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