iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093687

Ensembl Protein ID

ENSPSIP00000012587.1

UniProt Accession

K7FX27; K7FX27_PELSI

Genbank Protein ID

ENSPSIP00000012587

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGCU01072821

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000011346.1	ENSPSIT00000012648.1	ENSPSIP00000012587.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	1.00e-125	446.00	IUUC-Dme-031700
E3 activity/RING/RING	95.24	5.00e-179	624.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.29	3.00e-168	588.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pelodiscus sinensis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTGKSALSFL YSWKGGILFT SCFPGSKTSK RKEMSRQTAT ALPTGTSKCT PSQRVPALTG 60
TTASNNDLAS LFECPVCFDY VLPPILQCQS GHLVCSNCRP KLTCCPTCRG PLGSIRNLAM 120

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Nucleotide Sequence
(Fasta)

ATGACGGGAA AATCTGCCTT GAGCTTTCTG TATTCGTGGA AGGGGGGAAT CCTGTTTACA 60
TCATGTTTTC CAGGAAGTAA AACCAGCAAG AGAAAAGGTA TTTTTTTATA ATCTTCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pss:102454051

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.09	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	95.56	0.00e+00	629.00
IUUC-Atr-002857	Amborella trichopoda	36.06	1.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	100.00	5.00e-171	592.00
IUUC-Aca-005014	Anolis carolinensis	100.00	8.00e-172	595.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	9.00e-42	163.00
IUUC-Ath-007049	Arabidopsis thaliana	33.22	7.00e-43	167.00
IUUC-Ame-011196	Astyanax mexicanus	85.63	7.00e-171	592.00
IUUC-Bta-012887	Bos taurus	95.87	0.00e+00	629.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	3.00e-45	175.00
IUUC-Bol-016263	Brassica oleracea	33.22	4.00e-43	167.00
IUUC-Bra-017336	Brassica rapa	36.29	5.00e-41	160.00
IUUC-Cel-018320	Caenorhabditis elegans	71.21	1.00e-114	405.00
IUUC-Cja-019796	Callithrix jacchus	95.24	7.00e-180	622.00
IUUC-Cfa-020642	Canis familiaris	98.62	4.00e-173	599.00
IUUC-Cpo-022348	Cavia porcellus	99.65	3.00e-170	590.00
IUUC-Csa-023974	Chlorocebus sabaeus	95.24	2.00e-180	624.00
IUUC-Cin-025674	Ciona intestinalis	78.01	3.00e-135	473.00
IUUC-Csv-026233	Ciona savignyi	84.25	2.00e-132	464.00
IUUC-Dre-028041	Danio rerio	85.93	2.00e-171	593.00
IUUC-Dno-029764	Dasypus novemcinctus	97.95	4.00e-172	596.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	4.00e-120	424.00
IUUC-Ete-032423	Echinops telfairi	99.63	7.00e-161	559.00
IUUC-Eca-033536	Equus caballus	100.00	5.00e-171	592.00
IUUC-Eeu-035314	Erinaceus europaeus	96.77	5.00e-162	563.00
IUUC-Fca-035362	Felis catus	95.56	0.00e+00	628.00
IUUC-Fal-037487	Ficedula albicollis	95.56	0.00e+00	626.00
IUUC-Gga-040269	Gallus gallus	100.00	5.00e-171	592.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.16	4.00e-167	579.00
IUUC-Gma-042926	Glycine max	34.04	8.00e-41	160.00
IUUC-Ggo-045444	Gorilla gorilla	95.24	2.00e-180	624.00
IUUC-Hsa-046357	Homo sapiens	95.24	2.00e-180	624.00
IUUC-Hvu-047574	Hordeum vulgare	36.73	2.00e-44	172.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	99.65	3.00e-170	590.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	2.00e-169	587.00
IUUC-Lpe-050879	Leersia perrieri	40.25	8.00e-43	167.00
IUUC-Loc-052191	Lepisosteus oculatus	98.94	2.00e-170	590.00
IUUC-Laf-053668	Loxodonta africana	100.00	5.00e-171	592.00
IUUC-Mcc-054640	Macaca mulatta	95.24	2.00e-180	624.00
IUUC-Mtr-058747	Medicago truncatula	34.81	3.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	97.61	2.00e-172	597.00
IUUC-Mmr-060794	Microcebus murinus	99.65	3.00e-170	590.00
IUUC-Mmu-064129	Mus musculus	99.29	1.00e-169	588.00
IUUC-Mac-065670	Musa acuminata	36.07	2.00e-42	165.00
IUUC-Mpu-066488	Mustela putorius furo	95.87	0.00e+00	630.00
IUUC-Mlu-067207	Myotis lucifugus	100.00	6.00e-172	595.00
IUUC-Nle-069706	Nomascus leucogenys	94.92	8.00e-180	622.00
IUUC-Ont-071849	Oreochromis niloticus	97.17	6.00e-168	582.00
IUUC-Ocu-074876	Oryctolagus cuniculus	95.56	0.00e+00	629.00
IUUC-Oba-075454	Oryza barthii	40.66	9.00e-43	166.00
IUUC-Obr-076037	Oryza brachyantha	35.71	2.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	9.00e-43	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.66	1.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	9.00e-43	166.00
IUUC-Olo-080244	Oryza longistaminata	34.83	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	9.00e-43	166.00
IUUC-Oni-083109	Oryza nivara	40.66	9.00e-43	166.00
IUUC-Opu-084065	Oryza punctata	41.08	4.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	9.00e-43	166.00
IUUC-Osa-085610	Oryza sativa	40.66	9.00e-43	166.00
IUUC-Ola-086814	Oryzias latipes	97.16	4.00e-167	579.00
IUUC-Oga-088399	Otolemur garnettii	99.65	3.00e-170	590.00
IUUC-Oar-089323	Ovis aries	95.56	0.00e+00	625.00
IUUC-Ptr-090692	Pan troglodytes	99.65	7.00e-171	592.00
IUUC-Pan-092012	Papio anubis	95.24	2.00e-180	624.00
IUUC-Pma-094387	Petromyzon marinus	94.01	2.00e-161	561.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	5.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	97.16	4.00e-167	579.00
IUUC-Pab-097555	Pongo abelii	95.24	2.00e-180	624.00
IUUC-Pop-099970	Populus trichocarpa	34.90	2.00e-44	172.00
IUUC-Ppe-101760	Prunus persica	35.37	3.00e-44	171.00
IUUC-Rno-104866	Rattus norvegicus	99.29	1.00e-169	588.00
IUUC-Sha-106547	Sarcophilus harrisii	95.87	0.00e+00	630.00
IUUC-Smo-109412	Selaginella moellendorffii	34.69	4.00e-39	154.00
IUUC-Sit-110595	Setaria italica	37.45	8.00e-42	163.00
IUUC-Sly-111259	Solanum lycopersicum	38.04	2.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	38.04	2.00e-41	162.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	2.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	100.00	5.00e-171	592.00
IUUC-Tru-118250	Takifugu rubripes	92.91	5.00e-159	552.00
IUUC-Tni-120488	Tetraodon nigroviridis	96.81	1.00e-163	568.00
IUUC-Tca-121228	Theobroma cacao	35.50	3.00e-41	161.00
IUUC-Tae-123647	Triticum aestivum	37.09	2.00e-44	172.00
IUUC-Tur-126259	Triticum urartu	34.88	5.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	2.00e-143	501.00
IUUC-Vvi-131233	Vitis vinifera	34.88	5.00e-44	171.00
IUUC-Xtr-132553	Xenopus tropicalis	98.94	9.00e-170	588.00
IUUC-Xma-133670	Xiphophorus maculatus	97.16	4.00e-167	579.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence