iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134216

Ensembl Protein ID

ENSXMAP00000013587.1

UniProt Accession

M4AGJ3; M4AGJ3_XIPMA

Genbank Protein ID

ENSXMAP00000013587

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01026655

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000013495.1	ENSXMAT00000013603.1	ENSXMAP00000013587.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-88	297.5	4490	4824
E3 adaptor/Cullin RING/DCX/DWD	8.00e-17	60.7	3395	3427

Active Site

Position(s)	Description	Evidence
4793	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     eh+  F+flG+l+g+a+++++
   Q: 4490 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLFNPsacldEHMIQFKFLGILMGVAVRTKK 4576
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l+ledleevd  ++++lk+i++ ++s i+e +++ ++  ++ + ++++ ++  ++pgG +ip   +N++
   Q: 4577 PLDLHLAPLVWKQLCCIPLQLEDLEEVDLLYVQTLKSILHIEDSGITEDSFHEMIPLDSFVGQSADGKMvpIIPGGGSIPLSFSNRK 4663
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ veyrl+e i++qv+a+reG+++++p  llsl+t+++le+++cG++ei  e lkk  +y++ + e++  +qwFw++leefs+
   Q: 4664 EYVERAVEYRLHE-IDRQVAAVREGMSWIVPVPLLSLLTAQQLEQMVCGMPEICCEVLKKVVRYRE-VDEQHALVQWFWQTLEEFSN 4748
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4749 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQVVMAERLRYAINNCRSIDM 4824
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+++v  +++ s  +ll++++ Dgt++vW++++
   Q: 3395 HQSRVITCSWcSKkGLLATSGSDGTVRVWNVTK 3427
           999999999*9778****************975 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MALMIPPVKL KWLEHLNSSW ITEDSESIAT RDGVSALYAK LLANKEAVLL PQQVLCLKGP 60
QLPDFERESL SSDEQEHYLD ALLGSQLALA KMVCSDSPFA AALRKRVLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCTGA TGATACCCCC GGTGAAACTC AAATGGCTGG AGCACCTGAA CAGCTCGTGG 60
ATCACGGAGG ACAGCGAGTC CATCGCCACG CGGGACGGCG TGTCGGCGCT CTACGCCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	76.84	0.00e+00	4243.00
IUUC-Apl-003461	Anas platyrhynchos	77.06	0.00e+00	4225.00
IUUC-Aca-004452	Anolis carolinensis	74.71	0.00e+00	3909.00
IUUC-Bta-013213	Bos taurus	77.02	0.00e+00	4237.00
IUUC-Bdi-014791	Brachypodium distachyon	35.86	1.00e-54	207.00
IUUC-Cja-019298	Callithrix jacchus	76.81	0.00e+00	4213.00
IUUC-Cfa-021213	Canis familiaris	76.67	0.00e+00	4281.00
IUUC-Cpo-021674	Cavia porcellus	76.54	0.00e+00	4762.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.44	8.00e-50	191.00
IUUC-Csa-023341	Chlorocebus sabaeus	76.35	0.00e+00	4169.00
IUUC-Cho-024567	Choloepus hoffmanni	72.07	0.00e+00	1297.00
IUUC-Dre-028289	Danio rerio	78.60	0.00e+00	6962.00
IUUC-Dno-029988	Dasypus novemcinctus	76.78	0.00e+00	4217.00
IUUC-Dor-030636	Dipodomys ordii	82.29	0.00e+00	1880.00
IUUC-Ete-032598	Echinops telfairi	81.10	0.00e+00	1311.00
IUUC-Eca-033754	Equus caballus	76.74	0.00e+00	4225.00
IUUC-Eeu-034702	Erinaceus europaeus	66.57	0.00e+00	1113.00
IUUC-Fca-035900	Felis catus	76.79	0.00e+00	4229.00
IUUC-Fal-037034	Ficedula albicollis	76.06	0.00e+00	4132.00
IUUC-Gmo-039260	Gadus morhua	76.32	0.00e+00	1274.00
IUUC-Gga-040321	Gallus gallus	77.99	0.00e+00	7007.00
IUUC-Gma-043808	Glycine max	32.90	3.00e-44	174.00
IUUC-Ggo-045134	Gorilla gorilla	73.78	0.00e+00	3627.00
IUUC-Hsa-046516	Homo sapiens	76.83	0.00e+00	4190.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	85.12	0.00e+00	2253.00
IUUC-Lch-049903	Latimeria chalumnae	78.61	0.00e+00	7016.00
IUUC-Lpe-051165	Leersia perrieri	34.83	2.00e-52	199.00
IUUC-Loc-052149	Lepisosteus oculatus	79.44	0.00e+00	4919.00
IUUC-Laf-053426	Loxodonta africana	76.68	0.00e+00	4250.00
IUUC-Mcc-055826	Macaca mulatta	76.79	0.00e+00	4220.00
IUUC-Meu-056521	Macropus eugenii	65.09	0.00e+00	1628.00
IUUC-Mtr-058277	Medicago truncatula	34.95	2.00e-51	196.00
IUUC-Mga-059567	Meleagris gallopavo	84.08	0.00e+00	1796.00
IUUC-Mmr-061512	Microcebus murinus	76.01	0.00e+00	4135.00
IUUC-Mdo-062177	Monodelphis domestica	75.34	0.00e+00	4879.00
IUUC-Mmu-064373	Mus musculus	76.73	0.00e+00	4211.00
IUUC-Mpu-066148	Mustela putorius furo	76.45	0.00e+00	4202.00
IUUC-Mlu-067680	Myotis lucifugus	76.48	0.00e+00	4193.00
IUUC-Nle-069633	Nomascus leucogenys	76.88	0.00e+00	4195.00
IUUC-Opr-070609	Ochotona princeps	83.13	0.00e+00	1194.00
IUUC-Ont-071249	Oreochromis niloticus	86.13	0.00e+00	7871.00
IUUC-Oan-073157	Ornithorhynchus anatinus	77.14	0.00e+00	6853.00
IUUC-Ocu-074841	Oryctolagus cuniculus	76.41	0.00e+00	4217.00
IUUC-Oba-075262	Oryza barthii	34.50	2.00e-51	196.00
IUUC-Obr-076115	Oryza brachyantha	35.11	1.00e-50	193.00
IUUC-Ogl-077586	Oryza glaberrima	34.50	1.00e-51	197.00
IUUC-Ogu-078796	Oryza glumaepatula	34.25	7.00e-51	194.00
IUUC-Oin-079298	Oryza indica	34.25	4.00e-51	195.00
IUUC-Olo-080768	Oryza longistaminata	36.23	5.00e-56	211.00
IUUC-Ome-081908	Oryza meridionalis	33.92	8.00e-50	191.00
IUUC-Oni-082049	Oryza nivara	34.25	7.00e-51	194.00
IUUC-Opu-083608	Oryza punctata	34.50	9.00e-52	197.00
IUUC-Oru-084712	Oryza rufipogon	34.25	7.00e-51	194.00
IUUC-Osa-086078	Oryza sativa	34.25	7.00e-51	194.00
IUUC-Ola-086889	Oryzias latipes	84.21	0.00e+00	7579.00
IUUC-Oga-088459	Otolemur garnettii	75.61	0.00e+00	4147.00
IUUC-Oar-089888	Ovis aries	77.05	0.00e+00	4219.00
IUUC-Ptr-091114	Pan troglodytes	76.79	0.00e+00	4207.00
IUUC-Pan-092442	Papio anubis	76.57	0.00e+00	4195.00
IUUC-Psi-093833	Pelodiscus sinensis	76.21	0.00e+00	4571.00
IUUC-Pma-094275	Petromyzon marinus	78.82	0.00e+00	1442.00
IUUC-Ppa-095790	Physcomitrella patens	36.62	1.00e-55	210.00
IUUC-Pfo-097262	Poecilia formosa	94.05	0.00e+00	8320.00
IUUC-Pab-097760	Pongo abelii	83.77	0.00e+00	2785.00
IUUC-Pca-100465	Procavia capensis	83.54	0.00e+00	2768.00
IUUC-Pva-102950	Pteropus vampyrus	77.92	0.00e+00	3278.00
IUUC-Rno-104892	Rattus norvegicus	76.50	0.00e+00	4191.00
IUUC-Sha-106633	Sarcophilus harrisii	76.89	0.00e+00	6794.00
IUUC-Sit-110415	Setaria italica	37.61	1.00e-55	210.00
IUUC-Sar-113251	Sorex araneus	69.24	0.00e+00	1949.00
IUUC-Ssc-116391	Sus scrofa	76.81	0.00e+00	4238.00
IUUC-Tgu-116554	Taeniopygia guttata	77.92	0.00e+00	6920.00
IUUC-Tru-118695	Takifugu rubripes	85.30	0.00e+00	7749.00
IUUC-Tsy-119647	Tarsius syrichta	69.95	0.00e+00	2692.00
IUUC-Tni-120707	Tetraodon nigroviridis	85.40	0.00e+00	7694.00
IUUC-Tbe-127346	Tupaia belangeri	76.42	0.00e+00	2224.00
IUUC-Ttr-128542	Tursiops truncatus	72.09	0.00e+00	2691.00
IUUC-Vpa-130611	Vicugna pacos	78.95	0.00e+00	3181.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence