iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19521497

Classification

Family	E-value	Score	Start	End
E2/UBC	1.40e-35	123.0	19	145

Active Site

Position(s)	Description	Evidence
99	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.ifhPnvyenGkvClsilkeeekWspals 97
           Rl+kel+e++ +pp+g++ +++d+  l++w ++++G ++t Y++++++l++efp++YP+++P+v f+ +  +hP++y+nG++Cl+il   + Wspa++
   Q: 19   RLQKELSEWQVNPPTGFKHRVTDN--LQKWVIEVTGAPGTLYANETYNLQVEFPQHYPMEAPQVIFVPPaPLHPHIYSNGHICLDILY--DSWSPAMT 112
           9****************9998887..*****************************************9989****************9..******** PP
   S: 98   vesvllsiqsll.aepnpesplneeaaellkkn 129
           v+sv++si s+l ++p+ + p +++ + + +kn
   Q: 113  VSSVCISILSMLsSSPEKQRPTDNDRYVKNCKN 145
           ************667******999987555444 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MTSSSSPSRK ALSKIACNRL QKELSEWQVN PPTGFKHRVT DNLQKWVIEV TGAPGTLYAN 60
ETYNLQVEFP QHYPMEAPQV IFVPPAPLHP HIYSNGHICL DILYDSWSPA MTVSSVCISI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTAGAAGA AGAAAGATCC AGACAAAAGC TTAAGCAAGA CCTCTCTGTC TTCGTCTCTC 60
TCTCTCTCTC TCTTTGTCTC CGCCATGACA AGCTCTTCAT CTCCTTCACG CAAGGTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

ath:AT5G42990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000363	Aegilops tauschii	75.78	4.00e-72	263.00
IUUC-Atr-002673	Amborella trichopoda	84.62	5.00e-37	145.00
IUUC-Aly-006450	Arabidopsis lyrata	100.00	3.00e-85	306.00
IUUC-Bdi-014373	Brachypodium distachyon	86.34	2.00e-78	283.00
IUUC-Bra-017597	Brassica rapa	87.93	2.00e-79	287.00
IUUC-Fox-038001	Fusarium oxysporum	37.50	3.00e-19	86.70
IUUC-Lpe-051342	Leersia perrieri	88.20	9.00e-77	278.00
IUUC-Lma-053151	Leptosphaeria maculans	41.46	4.00e-26	110.00
IUUC-Oba-075133	Oryza barthii	88.82	4.00e-77	279.00
IUUC-Ogu-078744	Oryza glumaepatula	88.82	4.00e-77	279.00
IUUC-Oin-079726	Oryza indica	88.82	4.00e-77	279.00
IUUC-Ome-081951	Oryza meridionalis	88.82	4.00e-77	279.00
IUUC-Oni-082217	Oryza nivara	88.82	4.00e-77	279.00
IUUC-Oru-084326	Oryza rufipogon	88.82	4.00e-77	279.00
IUUC-Osa-085683	Oryza sativa	88.82	4.00e-77	279.00
IUUC-Pop-099724	Populus trichocarpa	85.71	1.00e-68	251.00
IUUC-Ppe-101300	Prunus persica	89.44	1.00e-69	254.00
IUUC-Sly-111778	Solanum lycopersicum	88.82	1.00e-74	271.00
IUUC-Stu-112037	Solanum tuberosum	88.82	1.00e-74	271.00
IUUC-Sre-114974	Sporisorium reilianum	45.10	6.00e-31	125.00
IUUC-Tae-124081	Triticum aestivum	86.96	5.00e-79	285.00
IUUC-Uma-129371	Ustilago maydis	45.10	1.00e-30	124.00
IUUC-Vvi-131675	Vitis vinifera	88.82	5.00e-77	278.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence