iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090793

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AC146484

Gene Name

TBL1Y

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000022475.5	ENSPTRT00000040138.3	ENSPTRP00000037088.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-48	159.2	448	486
UBD/Beta-Prp	5.90e-59	199.7	325	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 448  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 486
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.... 104
           +++  +a+ s+d +i v +++    +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++  cvh l++h+++++++++sp    
   Q: 325  QNNMTFASCSTDMCIHVCRLSCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPtgpa 413
           56677899999999999999999999999999999999999999999999999999999999999999999999999999999987777 PP
   S: 105  .....sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
                s+  l+s+s d+t+ +wd+e+  c + tl +h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +  + +
   Q: 414  tsnpnSSIMLASASFDSTV-LWDVEQVVCTH-TLMKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYQG--TGGIFEVCW 498
           6655333678999999998.89999999999.9999999999999999999999999999999999999999999998..999999999 PP
   S: 189  dsngkelvsgsldgtvklwdlq 210
           +  g  + + + dg+v + dl+
   Q: 499  NARGDKVGASASDGSVCVLDLR 520
           9999999999999999998886 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDSCPIES LSLIDAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGTGCCCC CAATTCGCGC TCGGGAGCGA GGAGCCGCCA ACACCCCAGC TCCGCTGCTG 60
CCGCCACCGC AGTGCTCTCT AGTCGCCATT GGTTACCGAA ACTTTCCGGT ACCCGCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0016575--P:histone deacetylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	89.29	0.00e+00	941.00
IUUC-Apl-003232	Anas platyrhynchos	91.40	0.00e+00	946.00
IUUC-Aca-005035	Anolis carolinensis	90.89	0.00e+00	946.00
IUUC-Bta-013202	Bos taurus	92.23	0.00e+00	957.00
IUUC-Cja-019281	Callithrix jacchus	89.50	0.00e+00	932.00
IUUC-Cfa-020929	Canis familiaris	91.06	0.00e+00	946.00
IUUC-Csa-023943	Chlorocebus sabaeus	90.27	0.00e+00	930.00
IUUC-Cne-026946	Cryptococcus neoformans	38.01	2.00e-30	127.00
IUUC-Dno-028926	Dasypus novemcinctus	90.51	0.00e+00	938.00
IUUC-Ete-032822	Echinops telfairi	81.49	0.00e+00	798.00
IUUC-Eca-033897	Equus caballus	91.83	0.00e+00	950.00
IUUC-Fca-036462	Felis catus	92.22	0.00e+00	948.00
IUUC-Fal-037388	Ficedula albicollis	91.98	0.00e+00	951.00
IUUC-Gga-040671	Gallus gallus	92.18	0.00e+00	951.00
IUUC-Ggo-045373	Gorilla gorilla	89.75	0.00e+00	939.00
IUUC-Hsa-046373	Homo sapiens	96.93	0.00e+00	977.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	95.15	0.00e+00	734.00
IUUC-Laf-054071	Loxodonta africana	91.49	0.00e+00	952.00
IUUC-Mcc-055124	Macaca mulatta	90.70	0.00e+00	924.00
IUUC-Mga-059895	Meleagris gallopavo	92.18	0.00e+00	955.00
IUUC-Mmr-061286	Microcebus murinus	92.08	0.00e+00	957.00
IUUC-Mmu-063447	Mus musculus	91.46	0.00e+00	950.00
IUUC-Nle-069151	Nomascus leucogenys	90.46	0.00e+00	940.00
IUUC-Oan-073562	Ornithorhynchus anatinus	92.41	0.00e+00	959.00
IUUC-Oba-075618	Oryza barthii	47.93	6.00e-138	484.00
IUUC-Ogl-077302	Oryza glaberrima	50.09	6.00e-150	524.00
IUUC-Ogu-078718	Oryza glumaepatula	50.09	6.00e-150	524.00
IUUC-Oin-079515	Oryza indica	43.89	9.00e-92	331.00
IUUC-Ome-081696	Oryza meridionalis	48.83	2.00e-144	505.00
IUUC-Oni-082137	Oryza nivara	50.09	6.00e-150	524.00
IUUC-Opu-083505	Oryza punctata	47.93	1.00e-139	489.00
IUUC-Oru-085276	Oryza rufipogon	50.09	4.00e-150	524.00
IUUC-Osa-085791	Oryza sativa	50.09	6.00e-150	524.00
IUUC-Oar-089506	Ovis aries	91.03	0.00e+00	951.00
IUUC-Pan-091909	Papio anubis	89.75	0.00e+00	935.00
IUUC-Psi-093358	Pelodiscus sinensis	87.93	0.00e+00	903.00
IUUC-Pab-098317	Pongo abelii	89.53	0.00e+00	918.00
IUUC-Rno-105857	Rattus norvegicus	91.46	0.00e+00	950.00
IUUC-Sha-107326	Sarcophilus harrisii	91.22	0.00e+00	969.00
IUUC-Ssc-115646	Sus scrofa	92.06	0.00e+00	959.00
IUUC-Tgu-116898	Taeniopygia guttata	91.20	0.00e+00	944.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence