iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001925

Ensembl Protein ID

ENSAMEP00000011636.1

UniProt Accession

G1LX33; G1LX33_AILME

Genbank Protein ID

ENSAMEP00000011636

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01131820

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000011072.1	ENSAMET00000012131.1	ENSAMEP00000011636.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	93.10	0.00e+00	798.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

FSRPNSDNRR QGGRERLAST SDKGSMAMES AKETRYCAVC NDYASGYHYG VWSCEGCKAF 60
FKRSIQGHND YMCPATNQCT IDKNRRKSCQ ACRLRKCYEV GMMKGGIRKD RRGGRMLKHK 120

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Nucleotide Sequence
(Fasta)

TTTTCCAGGC CAAATTCAGA CAATCGGCGC CAGGGTGGCA GAGAGAGATT GGCCAGTACC 60
AGTGACAAAG GAAGCATGGC CATGGAATCT GCCAAGGAGA CCCGCTACTG TGCAGTGTGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003688	Anas platyrhynchos	87.21	0.00e+00	639.00
IUUC-Aca-005222	Anolis carolinensis	83.67	0.00e+00	698.00
IUUC-Ame-010731	Astyanax mexicanus	60.29	1.00e-131	463.00
IUUC-Bta-013112	Bos taurus	93.10	0.00e+00	800.00
IUUC-Cja-019408	Callithrix jacchus	93.99	0.00e+00	810.00
IUUC-Cfa-020694	Canis familiaris	96.21	0.00e+00	826.00
IUUC-Cpo-021426	Cavia porcellus	86.19	0.00e+00	742.00
IUUC-Csa-023736	Chlorocebus sabaeus	94.21	0.00e+00	808.00
IUUC-Dre-027698	Danio rerio	61.52	2.00e-128	452.00
IUUC-Dno-029477	Dasypus novemcinctus	91.54	0.00e+00	727.00
IUUC-Dor-030572	Dipodomys ordii	90.58	0.00e+00	749.00
IUUC-Ete-032849	Echinops telfairi	82.18	1.00e-169	589.00
IUUC-Eca-033605	Equus caballus	91.31	0.00e+00	788.00
IUUC-Eeu-034683	Erinaceus europaeus	91.12	1.00e-109	389.00
IUUC-Fca-035928	Felis catus	96.66	0.00e+00	825.00
IUUC-Fal-036754	Ficedula albicollis	84.44	0.00e+00	725.00
IUUC-Gmo-038872	Gadus morhua	56.76	3.00e-111	395.00
IUUC-Gga-040988	Gallus gallus	84.89	0.00e+00	712.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.12	8.00e-125	440.00
IUUC-Ggo-044749	Gorilla gorilla	93.76	0.00e+00	807.00
IUUC-Hsa-046944	Homo sapiens	93.10	0.00e+00	796.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	92.87	0.00e+00	803.00
IUUC-Loc-052414	Lepisosteus oculatus	67.97	1.00e-160	560.00
IUUC-Mcc-054781	Macaca mulatta	93.99	0.00e+00	807.00
IUUC-Meu-056232	Macropus eugenii	91.76	0.00e+00	772.00
IUUC-Mga-059319	Meleagris gallopavo	85.56	0.00e+00	717.00
IUUC-Mmr-061636	Microcebus murinus	95.45	4.00e-117	414.00
IUUC-Mdo-062661	Monodelphis domestica	91.54	0.00e+00	778.00
IUUC-Mmu-063330	Mus musculus	91.31	0.00e+00	749.00
IUUC-Mpu-065757	Mustela putorius furo	96.67	0.00e+00	825.00
IUUC-Mlu-067712	Myotis lucifugus	93.10	0.00e+00	792.00
IUUC-Nle-069283	Nomascus leucogenys	94.21	0.00e+00	808.00
IUUC-Opr-070391	Ochotona princeps	89.53	0.00e+00	811.00
IUUC-Ont-071369	Oreochromis niloticus	60.10	1.00e-114	406.00
IUUC-Oan-073734	Ornithorhynchus anatinus	75.07	1.00e-134	472.00
IUUC-Ocu-074292	Oryctolagus cuniculus	92.43	0.00e+00	793.00
IUUC-Oba-075103	Oryza barthii	28.21	9.00e-03	35.00
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.40
IUUC-Olo-080944	Oryza longistaminata	25.00	3.00e-03	34.70
IUUC-Oni-082560	Oryza nivara	28.21	7.00e-03	35.40
IUUC-Ola-087052	Oryzias latipes	58.31	7.00e-121	427.00
IUUC-Oga-088586	Otolemur garnettii	92.22	0.00e+00	792.00
IUUC-Oar-090156	Ovis aries	93.08	0.00e+00	842.00
IUUC-Ptr-091321	Pan troglodytes	93.99	0.00e+00	807.00
IUUC-Pan-092851	Papio anubis	93.99	0.00e+00	807.00
IUUC-Psi-093434	Pelodiscus sinensis	85.08	0.00e+00	766.00
IUUC-Pfo-097379	Poecilia formosa	65.44	4.00e-126	444.00
IUUC-Pab-097735	Pongo abelii	93.99	0.00e+00	807.00
IUUC-Pva-102125	Pteropus vampyrus	89.76	0.00e+00	763.00
IUUC-Rno-106121	Rattus norvegicus	91.54	0.00e+00	751.00
IUUC-Sha-107547	Sarcophilus harrisii	91.54	0.00e+00	775.00
IUUC-Sar-113650	Sorex araneus	87.07	1.00e-126	446.00
IUUC-Tgu-117175	Taeniopygia guttata	86.76	0.00e+00	729.00
IUUC-Tru-117545	Takifugu rubripes	61.79	1.00e-130	461.00
IUUC-Tsy-119586	Tarsius syrichta	79.96	0.00e+00	697.00
IUUC-Tni-120121	Tetraodon nigroviridis	61.24	1.00e-130	460.00
IUUC-Tbe-127548	Tupaia belangeri	82.51	0.00e+00	639.00
IUUC-Ttr-128374	Tursiops truncatus	85.75	0.00e+00	716.00
IUUC-Vpa-130464	Vicugna pacos	82.34	4.00e-155	540.00
IUUC-Xtr-132171	Xenopus tropicalis	75.72	1.00e-173	603.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence