iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	95.07	0.00e+00	1126.00	IUUC-Hsa-046957

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MKLPLLQPAH RQFLCTSDML QSKEYHISME TKSINTSEFL LPKMEPSKKM GAAGAAQPNP 60
PLKLQPDRGA ASVLVPEQGG YKEKFAKTVE DKYKCEKCRL VLCNPKQTEC GHRFCESCMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGAATGAC TGATTCATAG TCGGAGAGCT GCAGAGAGGC TGGAAGGCAG GCGGTTCTGG 60
GATCCAGCTG GGGCCGAATG CACACCTTCC ACCTTCGATT AACACCAAAG GTCAGAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027128--TRAF3
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0042981--P:regulation of apoptotic process
GO:0050688--P:regulation of defense response to virus
GO:0032648--P:regulation of interferon-beta production
GO:0030162--P:regulation of proteolysis
GO:0008063--P:Toll signaling pathway
GO:0002224--P:toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002362	Ailuropoda melanoleuca	96.30	0.00e+00	1140.00
IUUC-Apl-004189	Anas platyrhynchos	88.32	0.00e+00	1055.00
IUUC-Aca-004540	Anolis carolinensis	87.76	0.00e+00	1016.00
IUUC-Ame-010645	Astyanax mexicanus	57.41	0.00e+00	647.00
IUUC-Bgr-012191	Blumeria graminis	25.66	4.00e-14	72.80
IUUC-Bta-013140	Bos taurus	95.25	0.00e+00	1133.00
IUUC-Cja-019436	Callithrix jacchus	95.25	0.00e+00	1129.00
IUUC-Cfa-021072	Canis familiaris	95.77	0.00e+00	1134.00
IUUC-Cpo-022472	Cavia porcellus	96.12	0.00e+00	1143.00
IUUC-Csa-024217	Chlorocebus sabaeus	95.07	0.00e+00	1128.00
IUUC-Cho-025066	Choloepus hoffmanni	82.24	0.00e+00	825.00
IUUC-Cin-025234	Ciona intestinalis	29.38	2.00e-54	206.00
IUUC-Csv-026078	Ciona savignyi	68.54	8.00e-80	289.00
IUUC-Dre-028208	Danio rerio	56.09	1.00e-176	612.00
IUUC-Dno-028868	Dasypus novemcinctus	93.18	0.00e+00	1120.00
IUUC-Dor-031056	Dipodomys ordii	97.33	0.00e+00	991.00
IUUC-Ete-033005	Echinops telfairi	82.05	0.00e+00	787.00
IUUC-Eca-033717	Equus caballus	95.42	0.00e+00	1133.00
IUUC-Eeu-035172	Erinaceus europaeus	82.49	3.00e-179	621.00
IUUC-Fca-035688	Felis catus	96.13	0.00e+00	1137.00
IUUC-Fal-037176	Ficedula albicollis	89.27	0.00e+00	1056.00
IUUC-Gmo-038931	Gadus morhua	55.87	1.00e-169	589.00
IUUC-Gac-042019	Gasterosteus aculeatus	55.77	1.00e-179	623.00
IUUC-Ggo-044424	Gorilla gorilla	95.42	0.00e+00	1130.00
IUUC-Hsa-046957	Homo sapiens	95.07	0.00e+00	1126.00
IUUC-Itr-048352	Ictidomys tridecemlineatus	95.77	0.00e+00	1134.00
IUUC-Lch-050680	Latimeria chalumnae	69.03	0.00e+00	820.00
IUUC-Loc-052093	Lepisosteus oculatus	58.63	0.00e+00	692.00
IUUC-Laf-054573	Loxodonta africana	86.44	0.00e+00	1009.00
IUUC-Mcc-055049	Macaca mulatta	94.25	0.00e+00	1130.00
IUUC-Mga-059244	Meleagris gallopavo	88.55	0.00e+00	1051.00
IUUC-Mmr-061469	Microcebus murinus	95.65	0.00e+00	1147.00
IUUC-Mdo-063049	Monodelphis domestica	91.96	0.00e+00	1093.00
IUUC-Mmu-063763	Mus musculus	98.06	0.00e+00	1162.00
IUUC-Mpu-065956	Mustela putorius furo	95.08	0.00e+00	1107.00
IUUC-Mlu-067482	Myotis lucifugus	93.31	0.00e+00	1110.00
IUUC-Nle-069941	Nomascus leucogenys	95.42	0.00e+00	1131.00
IUUC-Opr-071027	Ochotona princeps	80.46	0.00e+00	894.00
IUUC-Ont-071914	Oreochromis niloticus	57.27	0.00e+00	659.00
IUUC-Oan-072802	Ornithorhynchus anatinus	91.55	0.00e+00	1082.00
IUUC-Ocu-074075	Oryctolagus cuniculus	95.25	0.00e+00	1129.00
IUUC-Oba-075596	Oryza barthii	21.21	2.00e-05	45.40
IUUC-Ogl-077360	Oryza glaberrima	21.21	2.00e-05	44.70
IUUC-Ogu-078462	Oryza glumaepatula	21.21	2.00e-05	45.40
IUUC-Ome-082014	Oryza meridionalis	21.21	1.00e-05	46.20
IUUC-Oni-083105	Oryza nivara	21.21	2.00e-05	45.40
IUUC-Oru-084831	Oryza rufipogon	21.21	2.00e-05	45.40
IUUC-Oga-088149	Otolemur garnettii	95.07	0.00e+00	1131.00
IUUC-Oar-089922	Ovis aries	91.08	0.00e+00	1073.00
IUUC-Ptr-091412	Pan troglodytes	95.25	0.00e+00	1128.00
IUUC-Pan-092789	Papio anubis	95.07	0.00e+00	1128.00
IUUC-Psi-093603	Pelodiscus sinensis	86.56	0.00e+00	1031.00
IUUC-Pma-094463	Petromyzon marinus	49.58	3.00e-140	491.00
IUUC-Pfo-096518	Poecilia formosa	54.91	0.00e+00	654.00
IUUC-Pab-097664	Pongo abelii	95.42	0.00e+00	1130.00
IUUC-Pca-100821	Procavia capensis	85.39	0.00e+00	857.00
IUUC-Pva-103201	Pteropus vampyrus	82.92	0.00e+00	969.00
IUUC-Sha-107416	Sarcophilus harrisii	91.13	0.00e+00	1086.00
IUUC-Sar-113438	Sorex araneus	93.01	4.00e-100	358.00
IUUC-Ssc-115351	Sus scrofa	95.77	0.00e+00	1139.00
IUUC-Tgu-116608	Taeniopygia guttata	90.16	0.00e+00	1052.00
IUUC-Tru-117964	Takifugu rubripes	57.17	1.00e-180	626.00
IUUC-Tni-120211	Tetraodon nigroviridis	55.90	0.00e+00	636.00
IUUC-Tbe-127700	Tupaia belangeri	75.62	1.00e-135	476.00
IUUC-Ttr-128450	Tursiops truncatus	91.56	3.00e-175	607.00
IUUC-Vda-129938	Verticillium dahliae	25.98	2.00e-20	94.40
IUUC-Vpa-130074	Vicugna pacos	97.73	0.00e+00	898.00
IUUC-Xtr-132563	Xenopus tropicalis	78.87	0.00e+00	952.00
IUUC-Xma-133628	Xiphophorus maculatus	54.91	0.00e+00	654.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence