iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067345

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPE02007010

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000013790.2	ENSMLUT00000013798.2	ENSMLUP00000012555.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-63	213.8	328	858
UBD/Alpha-Helix/UBA	1.00e-22	79.6	728	765

Active Site

Position(s)	Description	Evidence
337	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
821	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                     k+ +  ++
   Q: 328  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeysklppesgngeqvseHKEVQDGIA 415
           7******************************.99999999********************77777766666666655432255666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 416  PRMFKALVGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 475
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyycekckkkqeaek 219
            ++v+ ++   + ++lpvp++   +k                              +++cLe++ ++e++++   ++++  ++k+ a+k
   Q: 476  TEKVKYTQRVDYIMQLPVPMDAALNKAeelleyeekkrqaeeeklplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVK 561
           ********************998887799*****************************************97...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................................... 267
           ++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                         
   Q: 562  TTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPDELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsph 649
           ********************997.*******************9888878888888888888888888888888888888888877777 PP
   S: 268  ..................................................................................peekqke 274
                                                                                             +     +
   Q: 650  fssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----T 733
           77777777777777777777777777777777777666666666666666666666666666666666555555555555550.....0 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                              + kY+L+a ++H+G s+ +GHY
   Q: 734  ivsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgSGKYQLFAFISHMGtSTMCGHY 822
           5555555555555566666666666777777777777777777777777777888888888888888********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 823  VCHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 858
           ******.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 728  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 765
           889999******************************97 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRLK EEDTTTGTGD PPRKKPTRLA IGVEGGFDIS EDKFEYDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTACGGGGAG GGGGACTAGG AAAGGTGGGA GCTGCTCTGT GTGAAGGAGC TACTGCCGGT 60
GTCATGGCGG AGCTGAGTGA GGAGGCGCTG CTGTCAGTAT TACCGACGAT CCGGGTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.08	0.00e+00	647.00
IUUC-Aml-002104	Ailuropoda melanoleuca	96.82	0.00e+00	1634.00
IUUC-Atr-002580	Amborella trichopoda	46.04	0.00e+00	740.00
IUUC-Apl-003774	Anas platyrhynchos	88.90	0.00e+00	1511.00
IUUC-Aca-005368	Anolis carolinensis	84.55	0.00e+00	1500.00
IUUC-Aly-005727	Arabidopsis lyrata	47.04	0.00e+00	726.00
IUUC-Ath-006974	Arabidopsis thaliana	47.04	0.00e+00	727.00
IUUC-Ago-007890	Ashbya gossypii	28.76	3.00e-80	293.00
IUUC-Acl-008057	Aspergillus clavatus	33.61	4.00e-121	429.00
IUUC-Afl-008547	Aspergillus flavus	36.15	6.00e-115	408.00
IUUC-Afu-008805	Aspergillus fumigatus	33.91	3.00e-112	399.00
IUUC-Ani-009441	Aspergillus nidulans	31.42	1.00e-94	341.00
IUUC-Ang-009720	Aspergillus niger	34.19	4.00e-118	419.00
IUUC-Aor-010111	Aspergillus oryzae	33.98	6.00e-125	441.00
IUUC-Ate-010531	Aspergillus terreus	32.27	6.00e-106	378.00
IUUC-Ame-011893	Astyanax mexicanus	64.22	0.00e+00	987.00
IUUC-Bgr-012183	Blumeria graminis	33.49	2.00e-120	426.00
IUUC-Bta-013179	Bos taurus	96.35	0.00e+00	1621.00
IUUC-Bci-013858	Botrytis cinerea	34.80	7.00e-131	461.00
IUUC-Bdi-014904	Brachypodium distachyon	46.63	0.00e+00	709.00
IUUC-Bol-015296	Brassica oleracea	47.67	0.00e+00	741.00
IUUC-Bra-017939	Brassica rapa	47.79	0.00e+00	744.00
IUUC-Cel-018625	Caenorhabditis elegans	34.81	9.00e-137	481.00
IUUC-Cja-019063	Callithrix jacchus	96.47	0.00e+00	1619.00
IUUC-Cfa-020976	Canis familiaris	94.12	0.00e+00	1566.00
IUUC-Cpo-022265	Cavia porcellus	93.65	0.00e+00	1555.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.53	2.00e-111	396.00
IUUC-Csa-024177	Chlorocebus sabaeus	93.17	0.00e+00	1424.00
IUUC-Cho-024702	Choloepus hoffmanni	87.74	0.00e+00	974.00
IUUC-Cin-025411	Ciona intestinalis	50.53	0.00e+00	842.00
IUUC-Csv-026347	Ciona savignyi	47.00	0.00e+00	804.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.29	5.00e-112	398.00
IUUC-Cne-026831	Cryptococcus neoformans	35.59	4.00e-130	459.00
IUUC-Dre-027982	Danio rerio	66.78	0.00e+00	1091.00
IUUC-Dno-029034	Dasypus novemcinctus	96.59	0.00e+00	1634.00
IUUC-Dor-030479	Dipodomys ordii	91.90	0.00e+00	706.00
IUUC-Dse-031467	Dothistroma septosporum	36.54	5.00e-132	465.00
IUUC-Dme-032075	Drosophila melanogaster	49.31	0.00e+00	802.00
IUUC-Ete-032865	Echinops telfairi	85.48	0.00e+00	1442.00
IUUC-Eca-034059	Equus caballus	96.51	0.00e+00	1630.00
IUUC-Eeu-035304	Erinaceus europaeus	90.82	0.00e+00	1476.00
IUUC-Fca-035515	Felis catus	96.71	0.00e+00	1624.00
IUUC-Fal-037271	Ficedula albicollis	85.28	0.00e+00	1408.00
IUUC-Fox-037745	Fusarium oxysporum	35.08	1.00e-129	457.00
IUUC-Fso-038158	Fusarium solani	35.41	2.00e-128	453.00
IUUC-Gmo-039071	Gadus morhua	64.39	0.00e+00	1074.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.56	4.00e-118	418.00
IUUC-Gga-040635	Gallus gallus	88.62	0.00e+00	1578.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.19	0.00e+00	1090.00
IUUC-Gma-043614	Glycine max	46.40	0.00e+00	702.00
IUUC-Ggo-044602	Gorilla gorilla	96.24	0.00e+00	1614.00
IUUC-Hsa-045959	Homo sapiens	96.24	0.00e+00	1614.00
IUUC-Hvu-047563	Hordeum vulgare	46.95	3.00e-168	585.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	97.06	0.00e+00	1623.00
IUUC-Kpa-049156	Komagataella pastoris	33.18	7.00e-115	408.00
IUUC-Lch-049648	Latimeria chalumnae	80.54	0.00e+00	1354.00
IUUC-Lpe-051523	Leersia perrieri	46.55	0.00e+00	712.00
IUUC-Loc-052520	Lepisosteus oculatus	61.94	0.00e+00	1016.00
IUUC-Lma-053216	Leptosphaeria maculans	34.91	1.00e-112	402.00
IUUC-Laf-054327	Loxodonta africana	95.88	0.00e+00	1612.00
IUUC-Mcc-055443	Macaca mulatta	96.35	0.00e+00	1618.00
IUUC-Meu-056298	Macropus eugenii	90.33	0.00e+00	1046.00
IUUC-Mor-057106	Magnaporthe oryzae	35.55	3.00e-132	465.00
IUUC-Mpo-057589	Magnaporthe poae	34.98	1.00e-122	434.00
IUUC-Mtr-058680	Medicago truncatula	47.91	0.00e+00	725.00
IUUC-Mla-058903	Melampsora laricipopulina	32.27	8.00e-119	421.00
IUUC-Mga-059669	Meleagris gallopavo	87.68	0.00e+00	1496.00
IUUC-Mvi-060476	Microbotryum violaceum	34.24	7.00e-121	428.00
IUUC-Mmr-060575	Microcebus murinus	96.35	0.00e+00	1621.00
IUUC-Mdo-062183	Monodelphis domestica	89.65	0.00e+00	1515.00
IUUC-Mmu-063592	Mus musculus	96.24	0.00e+00	1617.00
IUUC-Mac-065446	Musa acuminata	41.89	0.00e+00	654.00
IUUC-Mpu-066082	Mustela putorius furo	93.65	0.00e+00	1558.00
IUUC-Nfi-068558	Neosartorya fischeri	34.81	1.00e-120	427.00
IUUC-Ncr-068960	Neurospora crassa	35.33	9.00e-117	414.00
IUUC-Nle-070173	Nomascus leucogenys	93.53	0.00e+00	1551.00
IUUC-Opr-070556	Ochotona princeps	95.53	0.00e+00	1613.00
IUUC-Ont-071502	Oreochromis niloticus	64.39	0.00e+00	1083.00
IUUC-Ocu-074861	Oryctolagus cuniculus	93.41	0.00e+00	1558.00
IUUC-Oba-075109	Oryza barthii	46.14	0.00e+00	713.00
IUUC-Obr-076292	Oryza brachyantha	47.67	0.00e+00	710.00
IUUC-Ogl-077065	Oryza glaberrima	47.44	0.00e+00	743.00
IUUC-Ogu-078776	Oryza glumaepatula	46.14	0.00e+00	728.00
IUUC-Oin-080048	Oryza indica	46.97	0.00e+00	736.00
IUUC-Olo-080711	Oryza longistaminata	44.31	0.00e+00	655.00
IUUC-Ome-081506	Oryza meridionalis	45.35	0.00e+00	667.00
IUUC-Oni-082320	Oryza nivara	45.60	0.00e+00	712.00
IUUC-Opu-083801	Oryza punctata	46.61	0.00e+00	705.00
IUUC-Oru-085139	Oryza rufipogon	45.60	0.00e+00	713.00
IUUC-Osa-085713	Oryza sativa	47.55	0.00e+00	746.00
IUUC-Ola-086951	Oryzias latipes	64.96	0.00e+00	1071.00
IUUC-Olu-087822	Ostreococcus lucimarinus	42.07	0.00e+00	639.00
IUUC-Oga-088625	Otolemur garnettii	96.82	0.00e+00	1617.00
IUUC-Oar-089995	Ovis aries	96.12	0.00e+00	1624.00
IUUC-Ptr-090640	Pan troglodytes	94.00	0.00e+00	1602.00
IUUC-Pan-091974	Papio anubis	97.18	0.00e+00	1630.00
IUUC-Psi-093957	Pelodiscus sinensis	88.76	0.00e+00	1583.00
IUUC-Pma-094242	Petromyzon marinus	71.20	6.00e-166	576.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.02	8.00e-106	377.00
IUUC-Ppa-095901	Physcomitrella patens	48.97	0.00e+00	784.00
IUUC-Pfo-097148	Poecilia formosa	65.97	0.00e+00	1096.00
IUUC-Pab-098068	Pongo abelii	88.71	0.00e+00	1444.00
IUUC-Pop-098943	Populus trichocarpa	46.86	0.00e+00	716.00
IUUC-Pca-100738	Procavia capensis	97.18	0.00e+00	1129.00
IUUC-Ppe-101315	Prunus persica	46.93	0.00e+00	724.00
IUUC-Pva-102154	Pteropus vampyrus	95.41	0.00e+00	1601.00
IUUC-Pgr-103343	Puccinia graminis	33.52	1.00e-106	380.00
IUUC-Ptt-103928	Puccinia triticina	30.41	4.00e-103	369.00
IUUC-Pte-104306	Pyrenophora teres	31.71	5.00e-103	369.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.45	2.00e-106	380.00
IUUC-Rno-105801	Rattus norvegicus	95.88	0.00e+00	1613.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.14	2.00e-75	277.00
IUUC-Sha-107635	Sarcophilus harrisii	89.53	0.00e+00	1522.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.33	2.00e-106	380.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.22	9.00e-112	397.00
IUUC-Smo-108848	Selaginella moellendorffii	48.54	0.00e+00	743.00
IUUC-Sit-110728	Setaria italica	48.02	0.00e+00	771.00
IUUC-Sly-111523	Solanum lycopersicum	47.05	0.00e+00	755.00
IUUC-Sbi-114419	Sorghum bicolor	46.92	0.00e+00	747.00
IUUC-Sre-115225	Sporisorium reilianum	35.42	2.00e-126	446.00
IUUC-Ssc-115686	Sus scrofa	96.59	0.00e+00	1619.00
IUUC-Tgu-117346	Taeniopygia guttata	88.40	0.00e+00	1553.00
IUUC-Tru-118350	Takifugu rubripes	64.86	0.00e+00	1105.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.17	0.00e+00	1095.00
IUUC-Tca-121585	Theobroma cacao	47.28	0.00e+00	719.00
IUUC-Tre-122043	Trichoderma reesei	33.53	9.00e-119	421.00
IUUC-Tvi-122303	Trichoderma virens	33.87	3.00e-123	436.00
IUUC-Tae-125686	Triticum aestivum	46.96	0.00e+00	727.00
IUUC-Tur-126732	Triticum urartu	44.50	0.00e+00	683.00
IUUC-Tme-126909	Tuber melanosporum	34.49	4.00e-117	415.00
IUUC-Tbe-127261	Tupaia belangeri	89.70	0.00e+00	1025.00
IUUC-Uma-129599	Ustilago maydis	33.95	4.00e-128	452.00
IUUC-Vda-129688	Verticillium dahliae	33.72	3.00e-119	422.00
IUUC-Vvi-131116	Vitis vinifera	47.45	0.00e+00	696.00
IUUC-Xtr-131953	Xenopus tropicalis	78.65	0.00e+00	1354.00
IUUC-Xma-133837	Xiphophorus maculatus	66.20	0.00e+00	1099.00
IUUC-Yli-134510	Yarrowia lipolytica	35.64	3.00e-128	452.00
IUUC-Zma-135786	Zea mays	47.04	0.00e+00	714.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence