iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-89	301.4	48	237

Active Site

Position(s)	Description	Evidence
217	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 18   sakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleeeivFfkkfdvVvl 115
           +++vl++GagglGcEllK L+l+G+g+++v+Dmdt+e+snlnrqFLfr+ d+g sKAe+aa++++ ++p ++v++h ++i++ +e+  F+++f++Vv+
   Q: 48   KCQVLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTPHFKKIQDFDES--FYQQFHLVVC 143
           699***********************************************************************************..********** PP
   S: 116  aldnrearrkvnrlclna.............rvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlketpnaaehtiewavlfnklle 198
           +ld++ arr++n ++l++              vp+i++gt+G++G++rvi++g+t+c++c+    ppq+++P+ct+++tp+ +eh+ie++    k+++
   Q: 144  GLDSIVARRWINGMLLSMlryeedgtidtssIVPMIDGGTEGFKGNARVILPGFTACIECTLdlFPPQVNYPLCTIANTPRLPEHCIEYV----KIIQ 237
           **************************************************************99**************************....4443 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of Ubc12. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling.

Protein Sequence
(Fasta)

MSVHSPNPGL ILQSKRFNGL RNILEREGPF CKDGFAASSE NLEFLQTKCQ VLIIGAGGLG 60
CELLKDLALM GFGNLHVIDM DTIELSNLNR QFLFRRTDIG ASKAECAARF INARVPTCRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGTAGTGT TGCTAAACGA ATCACAGTCT CGATTTTGTT TGAAAAATGT CTGTCCACTC 60
ACCCAATCCT GGCTTAATCC TCCAGAGCAA GCGTTTCAAT GGACTGCGGA ACATCCTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014929--E2_binding
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR030468--Uba3
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF08825--E2_bind
PF00899--ThiF

SMART

SM01181--E2_bind

Gene Ontology

GO:0043234--C:protein complex
GO:0016881--F:acid-amino acid ligase activity
GO:0005524--F:ATP binding
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0045116--P:protein neddylation

KEGG

dme:Dmel_CG13343

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001124	Aegilops tauschii	47.93	1.00e-79	289.00
IUUC-Aml-001578	Ailuropoda melanoleuca	63.57	4.00e-164	570.00
IUUC-Atr-002591	Amborella trichopoda	46.45	2.00e-87	315.00
IUUC-Apl-003671	Anas platyrhynchos	63.17	2.00e-163	567.00
IUUC-Aca-004749	Anolis carolinensis	63.57	1.00e-164	571.00
IUUC-Aly-005747	Arabidopsis lyrata	48.29	9.00e-97	346.00
IUUC-Ath-006623	Arabidopsis thaliana	48.54	3.00e-96	344.00
IUUC-Ago-007934	Ashbya gossypii	44.41	3.00e-68	250.00
IUUC-Acl-008047	Aspergillus clavatus	46.74	1.00e-109	388.00
IUUC-Afl-008615	Aspergillus flavus	43.33	6.00e-74	270.00
IUUC-Afu-008996	Aspergillus fumigatus	48.14	4.00e-108	383.00
IUUC-Ani-009281	Aspergillus nidulans	48.31	2.00e-77	281.00
IUUC-Ang-009539	Aspergillus niger	48.95	3.00e-106	377.00
IUUC-Aor-010151	Aspergillus oryzae	47.43	6.00e-102	363.00
IUUC-Ate-010502	Aspergillus terreus	49.07	4.00e-107	380.00
IUUC-Ame-011837	Astyanax mexicanus	63.11	1.00e-160	558.00
IUUC-Bgr-012068	Blumeria graminis	46.62	3.00e-101	361.00
IUUC-Bta-013003	Bos taurus	64.27	3.00e-165	573.00
IUUC-Bci-013983	Botrytis cinerea	50.81	1.00e-110	392.00
IUUC-Bdi-014429	Brachypodium distachyon	49.29	4.00e-86	310.00
IUUC-Bol-015490	Brassica oleracea	49.58	1.00e-86	312.00
IUUC-Bra-018023	Brassica rapa	49.58	4.00e-86	311.00
IUUC-Cel-018684	Caenorhabditis elegans	52.42	1.00e-122	432.00
IUUC-Cja-019200	Callithrix jacchus	63.51	3.00e-162	563.00
IUUC-Cfa-021038	Canis familiaris	64.27	4.00e-165	573.00
IUUC-Cre-022778	Chlamydomonas reinhardtii	47.82	3.00e-100	357.00
IUUC-Csa-024079	Chlorocebus sabaeus	64.04	8.00e-165	572.00
IUUC-Cho-025052	Choloepus hoffmanni	57.08	2.00e-146	511.00
IUUC-Cin-025113	Ciona intestinalis	61.20	1.00e-153	535.00
IUUC-Csv-026231	Ciona savignyi	61.59	3.00e-152	530.00
IUUC-Cgl-026535	Colletotrichum gloeosporioides	50.23	8.00e-117	412.00
IUUC-Cne-026850	Cryptococcus neoformans	46.37	1.00e-102	365.00
IUUC-Cme-027275	Cyanidioschyzon merolae	36.74	1.00e-70	259.00
IUUC-Dre-028751	Danio rerio	64.04	5.00e-162	563.00
IUUC-Dno-029571	Dasypus novemcinctus	63.57	2.00e-163	568.00
IUUC-Dor-030395	Dipodomys ordii	63.11	1.00e-158	552.00
IUUC-Dse-031329	Dothistroma septosporum	44.54	4.00e-96	343.00
IUUC-Ete-032894	Echinops telfairi	56.73	2.00e-49	188.00
IUUC-Eca-034389	Equus caballus	64.27	4.00e-165	573.00
IUUC-Eeu-035152	Erinaceus europaeus	56.40	2.00e-129	454.00
IUUC-Fca-036032	Felis catus	64.04	5.00e-165	573.00
IUUC-Fal-037506	Ficedula albicollis	62.41	1.00e-161	562.00
IUUC-Fox-037871	Fusarium oxysporum	52.25	1.00e-101	362.00
IUUC-Fso-038350	Fusarium solani	50.11	2.00e-113	401.00
IUUC-Gmo-039647	Gadus morhua	63.81	5.00e-162	563.00
IUUC-Ggr-039859	Gaeumannomyces graminis	50.93	7.00e-112	396.00
IUUC-Gga-040843	Gallus gallus	60.32	3.00e-153	533.00
IUUC-Gac-042610	Gasterosteus aculeatus	64.19	8.00e-163	565.00
IUUC-Gma-042744	Glycine max	48.73	1.00e-86	313.00
IUUC-Ggo-044788	Gorilla gorilla	64.12	5.00e-164	569.00
IUUC-Hsa-045849	Homo sapiens	64.27	4.00e-165	573.00
IUUC-Hvu-047819	Hordeum vulgare	53.49	8.00e-81	292.00
IUUC-Itr-047863	Ictidomys tridecemlineatus	63.57	3.00e-163	566.00
IUUC-Kpa-049393	Komagataella pastoris	50.30	9.00e-92	329.00
IUUC-Lch-049471	Latimeria chalumnae	62.65	4.00e-159	553.00
IUUC-Lpe-051297	Leersia perrieri	49.29	5.00e-93	333.00
IUUC-Loc-052910	Lepisosteus oculatus	62.65	1.00e-159	555.00
IUUC-Lma-053181	Leptosphaeria maculans	48.29	2.00e-106	378.00
IUUC-Laf-054314	Loxodonta africana	63.13	2.00e-162	564.00
IUUC-Mcc-054870	Macaca mulatta	64.27	2.00e-165	573.00
IUUC-Meu-056574	Macropus eugenii	54.05	3.00e-85	308.00
IUUC-Mor-056919	Magnaporthe oryzae	49.43	1.00e-107	382.00
IUUC-Mpo-057614	Magnaporthe poae	51.86	3.00e-107	381.00
IUUC-Mtr-058110	Medicago truncatula	48.73	1.00e-86	312.00
IUUC-Mla-058949	Melampsora laricipopulina	49.76	5.00e-106	377.00
IUUC-Mga-059455	Meleagris gallopavo	63.11	7.00e-163	565.00
IUUC-Mvi-060270	Microbotryum violaceum	46.71	2.00e-107	381.00
IUUC-Mmr-061155	Microcebus murinus	63.62	2.00e-159	554.00
IUUC-Mdo-062037	Monodelphis domestica	63.57	5.00e-166	576.00
IUUC-Mmu-063670	Mus musculus	63.87	3.00e-164	570.00
IUUC-Mac-064711	Musa acuminata	47.00	7.00e-84	303.00
IUUC-Mpu-066734	Mustela putorius furo	63.97	6.00e-165	572.00
IUUC-Mlu-067068	Myotis lucifugus	64.04	4.00e-165	573.00
IUUC-Nfi-068349	Neosartorya fischeri	48.14	1.00e-107	382.00
IUUC-Ncr-068626	Neurospora crassa	51.35	1.00e-97	348.00
IUUC-Nle-069366	Nomascus leucogenys	59.95	2.00e-147	514.00
IUUC-Opr-070993	Ochotona princeps	66.92	2.00e-45	175.00
IUUC-Ont-072196	Oreochromis niloticus	63.49	6.00e-160	556.00
IUUC-Oan-073511	Ornithorhynchus anatinus	63.57	1.00e-165	575.00
IUUC-Ocu-073773	Oryctolagus cuniculus	63.57	2.00e-164	571.00
IUUC-Oba-075726	Oryza barthii	44.50	8.00e-81	293.00
IUUC-Obr-076286	Oryza brachyantha	48.01	1.00e-91	329.00
IUUC-Ogu-078473	Oryza glumaepatula	44.50	7.00e-81	293.00
IUUC-Oin-079393	Oryza indica	49.86	1.00e-94	339.00
IUUC-Olo-080446	Oryza longistaminata	47.03	2.00e-84	305.00
IUUC-Ome-081737	Oryza meridionalis	47.03	3.00e-84	305.00
IUUC-Oni-082853	Oryza nivara	44.50	8.00e-81	293.00
IUUC-Opu-083590	Oryza punctata	47.46	5.00e-94	337.00
IUUC-Oru-084184	Oryza rufipogon	44.50	8.00e-81	293.00
IUUC-Osa-085402	Oryza sativa	49.86	1.00e-94	339.00
IUUC-Ola-086615	Oryzias latipes	60.09	2.00e-147	514.00
IUUC-Olu-087738	Ostreococcus lucimarinus	44.36	1.00e-81	296.00
IUUC-Oga-088101	Otolemur garnettii	63.34	4.00e-164	570.00
IUUC-Oar-090293	Ovis aries	63.53	5.00e-163	566.00
IUUC-Ptr-090503	Pan troglodytes	64.27	4.00e-165	573.00
IUUC-Pan-092477	Papio anubis	62.44	4.00e-160	556.00
IUUC-Psi-093442	Pelodiscus sinensis	63.87	3.00e-163	567.00
IUUC-Pma-094247	Petromyzon marinus	63.05	1.00e-158	551.00
IUUC-Pno-094780	Phaeosphaeria nodorum	50.63	1.00e-107	382.00
IUUC-Ppa-095961	Physcomitrella patens	49.76	2.00e-112	398.00
IUUC-Pfo-096846	Poecilia formosa	63.89	7.00e-161	559.00
IUUC-Pab-098060	Pongo abelii	64.04	5.00e-160	556.00
IUUC-Pop-099914	Populus trichocarpa	48.04	1.00e-92	332.00
IUUC-Pca-100500	Procavia capensis	51.74	9.00e-121	426.00
IUUC-Ppe-102008	Prunus persica	48.44	9.00e-85	306.00
IUUC-Pva-103095	Pteropus vampyrus	69.90	8.00e-83	300.00
IUUC-Pgr-103666	Puccinia graminis	47.58	2.00e-108	385.00
IUUC-Ptt-103901	Puccinia triticina	47.15	5.00e-109	387.00
IUUC-Pte-104198	Pyrenophora teres	48.51	3.00e-107	381.00
IUUC-Pyt-104792	Pyrenophora triticirepentis	47.36	3.00e-105	374.00
IUUC-Rno-105446	Rattus norvegicus	63.87	3.00e-164	570.00
IUUC-Sce-106355	Saccharomyces cerevisiae	39.87	1.00e-61	229.00
IUUC-Sha-106664	Sarcophilus harrisii	63.11	2.00e-164	571.00
IUUC-Sja-107982	Schizosaccharomyces japonicus	43.78	4.00e-92	330.00
IUUC-Spo-108345	Schizosaccharomyces pombe	41.65	2.00e-94	338.00
IUUC-Ssl-108540	Sclerotinia sclerotiorum	47.58	8.00e-98	349.00
IUUC-Smo-109098	Selaginella moellendorffii	47.44	4.00e-113	400.00
IUUC-Sit-109724	Setaria italica	49.58	2.00e-88	319.00
IUUC-Sly-110916	Solanum lycopersicum	49.61	5.00e-94	337.00
IUUC-Stu-112236	Solanum tuberosum	49.61	2.00e-94	338.00
IUUC-Sar-113044	Sorex araneus	65.27	1.00e-157	548.00
IUUC-Sbi-114276	Sorghum bicolor	50.71	4.00e-90	324.00
IUUC-Sre-114963	Sporisorium reilianum	48.14	6.00e-107	380.00
IUUC-Ssc-116301	Sus scrofa	63.53	3.00e-163	567.00
IUUC-Tgu-117265	Taeniopygia guttata	62.41	4.00e-162	563.00
IUUC-Tru-117526	Takifugu rubripes	63.64	1.00e-159	555.00
IUUC-Tsy-119483	Tarsius syrichta	64.83	3.00e-162	563.00
IUUC-Tni-120363	Tetraodon nigroviridis	63.08	1.00e-160	558.00
IUUC-Tca-121731	Theobroma cacao	48.44	7.00e-86	310.00
IUUC-Tre-122221	Trichoderma reesei	51.72	2.00e-104	371.00
IUUC-Tvi-122352	Trichoderma virens	49.56	1.00e-115	409.00
IUUC-Tae-123213	Triticum aestivum	48.15	4.00e-87	314.00
IUUC-Tur-126070	Triticum urartu	46.44	3.00e-71	261.00
IUUC-Tme-127199	Tuber melanosporum	48.20	8.00e-97	346.00
IUUC-Tbe-128076	Tupaia belangeri	63.57	5.00e-164	569.00
IUUC-Ttr-128695	Tursiops truncatus	50.12	1.00e-121	428.00
IUUC-Uma-129638	Ustilago maydis	49.41	9.00e-110	389.00
IUUC-Vda-129963	Verticillium dahliae	50.00	2.00e-106	378.00
IUUC-Vpa-130637	Vicugna pacos	57.08	4.00e-140	490.00
IUUC-Vvi-131613	Vitis vinifera	48.44	6.00e-84	303.00
IUUC-Xtr-132924	Xenopus tropicalis	62.50	5.00e-157	546.00
IUUC-Xma-134209	Xiphophorus maculatus	64.27	3.00e-162	563.00
IUUC-Yli-134365	Yarrowia lipolytica	51.03	2.00e-105	375.00
IUUC-Zma-135941	Zea mays	45.92	7.00e-85	306.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence