iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045472

Ensembl Protein ID

ENSGGOP00000027806.1

UniProt Accession

G3SI66; G3SI66_GORGO

Protein Name

Uncharacterized protein

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000024965.1	ENSGGOT00000030730.1	ENSGGOP00000027806.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.80e-37	128.6	202	383
UBD/ZnF/ZnF_A20	1.30e-16	60.6	814	848

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 202  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 290
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 291  lgtN-GancggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 378
           7650.255579****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 379  ALVSM 383
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 814  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 848
           59********************************9 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

ILIYVLPTSS WLKVLDDHMT LDMDAVLSDF VRSTGAEPGL ARDLLEGKNW DVNAALSDFE 60
QLRQVHAGNL PPSFSEGSGG SRTPEKGFSD REPTRPPRPI LQRQDDIVQE KRLSRGISHA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGAGGCC TGAATTTTGA TCTATGTTCT ACCTACATCC AGCTGGCTGA AAGTACTTGA 60
TGATCACATG ACCCTGGACA TGGATGCTGT TCTGTCAGAT TTTGTCCGTT CCACAGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	93.48	0.00e+00	1423.00
IUUC-Apl-003567	Anas platyrhynchos	67.82	0.00e+00	961.00
IUUC-Bta-013398	Bos taurus	93.95	0.00e+00	1381.00
IUUC-Cel-018468	Caenorhabditis elegans	50.67	2.00e-85	310.00
IUUC-Cja-019965	Callithrix jacchus	96.21	0.00e+00	1424.00
IUUC-Cfa-020191	Canis familiaris	93.59	0.00e+00	1415.00
IUUC-Cpo-022232	Cavia porcellus	90.71	0.00e+00	1324.00
IUUC-Csa-023593	Chlorocebus sabaeus	98.46	0.00e+00	1538.00
IUUC-Cho-024729	Choloepus hoffmanni	84.49	2.00e-169	589.00
IUUC-Csv-026177	Ciona savignyi	30.56	3.00e-03	35.00
IUUC-Dno-029900	Dasypus novemcinctus	92.76	0.00e+00	1370.00
IUUC-Dor-031121	Dipodomys ordii	85.15	0.00e+00	685.00
IUUC-Ete-032473	Echinops telfairi	88.57	0.00e+00	1045.00
IUUC-Eca-033946	Equus caballus	95.49	0.00e+00	1049.00
IUUC-Eeu-034670	Erinaceus europaeus	90.77	0.00e+00	1368.00
IUUC-Fca-035871	Felis catus	94.07	0.00e+00	1350.00
IUUC-Fso-038203	Fusarium solani	29.59	4.30e-02	33.50
IUUC-Gmo-039373	Gadus morhua	77.25	0.00e+00	674.00
IUUC-Gga-041105	Gallus gallus	67.72	0.00e+00	981.00
IUUC-Gac-041806	Gasterosteus aculeatus	77.78	0.00e+00	720.00
IUUC-Hsa-046473	Homo sapiens	99.76	0.00e+00	1522.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	94.90	0.00e+00	1420.00
IUUC-Lch-050432	Latimeria chalumnae	63.59	0.00e+00	949.00
IUUC-Mcc-055261	Macaca mulatta	98.10	0.00e+00	1538.00
IUUC-Meu-056477	Macropus eugenii	79.71	0.00e+00	939.00
IUUC-Mga-059533	Meleagris gallopavo	69.42	0.00e+00	982.00
IUUC-Mdo-062847	Monodelphis domestica	82.94	0.00e+00	1157.00
IUUC-Mmu-064260	Mus musculus	89.10	0.00e+00	1318.00
IUUC-Mpu-066876	Mustela putorius furo	88.33	0.00e+00	1313.00
IUUC-Mlu-068039	Myotis lucifugus	93.84	0.00e+00	1385.00
IUUC-Nle-069260	Nomascus leucogenys	99.05	0.00e+00	1514.00
IUUC-Opr-070564	Ochotona princeps	91.84	0.00e+00	784.00
IUUC-Ocu-073824	Oryctolagus cuniculus	95.53	0.00e+00	952.00
IUUC-Opu-083273	Oryza punctata	24.36	4.60e-02	32.70
IUUC-Oga-088124	Otolemur garnettii	94.19	0.00e+00	1390.00
IUUC-Oar-090086	Ovis aries	94.54	0.00e+00	1386.00
IUUC-Ptr-091622	Pan troglodytes	99.53	0.00e+00	1140.00
IUUC-Pan-092724	Papio anubis	98.22	0.00e+00	1535.00
IUUC-Psi-093333	Pelodiscus sinensis	64.27	0.00e+00	964.00
IUUC-Pab-098667	Pongo abelii	99.17	0.00e+00	1494.00
IUUC-Pca-100701	Procavia capensis	92.56	0.00e+00	736.00
IUUC-Pva-102136	Pteropus vampyrus	92.53	0.00e+00	1365.00
IUUC-Rno-105546	Rattus norvegicus	89.93	0.00e+00	1337.00
IUUC-Sha-106732	Sarcophilus harrisii	82.73	0.00e+00	1075.00
IUUC-Sar-113562	Sorex araneus	81.48	0.00e+00	1112.00
IUUC-Ssc-116191	Sus scrofa	94.42	0.00e+00	1404.00
IUUC-Tgu-116942	Taeniopygia guttata	76.56	0.00e+00	779.00
IUUC-Tsy-119343	Tarsius syrichta	84.30	0.00e+00	1219.00
IUUC-Tur-126860	Triticum urartu	24.39	3.00e-02	33.10
IUUC-Tbe-127283	Tupaia belangeri	96.59	0.00e+00	753.00
IUUC-Ttr-128692	Tursiops truncatus	90.75	0.00e+00	1299.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence