iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002333

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

ACTA01179036

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000017095.1	ENSAMET00000018812.1	ENSAMEP00000018080.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.90e-130	435.3	13	527

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedv..gksKAevaaealkelnpd 87
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++  +k++A++a+e+l+eln d
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIgkKKNRAQAAMEFLQELNND 101
           *********************************************************************666799************** PP
   S: 88   vnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiP 172
           v+++++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++P
   Q: 102  VSGSFVEESPENLLDNDPsFFCRFTIVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKP 190
           ***************************************************************************************** PP
   S: 173  fctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafa 246
           f++l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a++
   Q: 191  FPELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRVPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALN 279
           *******99999999998***********************************************9*********************** PP
   S: 247  kttins.ikqllksfecdivtkskspfwv............................................................ 274
           +t+i+s i++++++++c ++tk++++fw+                                                            
   Q: 280  TTQIPSsIEDIFNDDHCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsskyiklqnvyrekakkdaaavgnhvakllq 368
           ***************************************************************************************** PP
   S: 275  ...............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds. 331
                           +c+n++ l+v            ++++k+e+++++++p     lyl+lra++rf+k++gr+pg++++++++d+ 
   Q: 369  sigqapesisekelkLLCTNSAFLRVVrcrslaeeyglDTINKEEITSSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIg 457
           ***************99999999997777777777888**********9999999********************************98 PP
   S: 332  .avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            + ++++ ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  kLKSCLNGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 527
           8888999888....********************************************************9776 PP

Organism

Ailuropoda melanoleuca

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKKKNRAQA AMEFLQELNN DVSGSFVEES PENLLDNDPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCAAC CGGGGAAGCT GCTCAAGGAG CAGAAGTACG ACCGGCAGCT GAGGTGAGCC 60
AGGGCTCACC GAGTCGGGCG GGCCGGCCGG GGTGCTCCTC TGCGTCCCGG CCGGGCCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.59	3.00e-125	442.00
IUUC-Atr-002644	Amborella trichopoda	41.39	8.00e-114	404.00
IUUC-Apl-003446	Anas platyrhynchos	83.49	0.00e+00	914.00
IUUC-Aca-004450	Anolis carolinensis	80.75	0.00e+00	924.00
IUUC-Aly-006187	Arabidopsis lyrata	40.04	2.00e-124	439.00
IUUC-Ath-007600	Arabidopsis thaliana	40.60	6.00e-126	444.00
IUUC-Ago-007900	Ashbya gossypii	27.06	4.00e-39	155.00
IUUC-Acl-008333	Aspergillus clavatus	34.58	1.00e-80	293.00
IUUC-Afl-008529	Aspergillus flavus	35.66	2.00e-86	313.00
IUUC-Afu-009071	Aspergillus fumigatus	33.93	4.00e-81	295.00
IUUC-Ani-009443	Aspergillus nidulans	33.75	3.00e-78	286.00
IUUC-Ang-009669	Aspergillus niger	33.57	9.00e-82	297.00
IUUC-Aor-009914	Aspergillus oryzae	34.99	4.00e-83	301.00
IUUC-Ate-010450	Aspergillus terreus	34.59	2.00e-83	303.00
IUUC-Ame-011183	Astyanax mexicanus	72.13	0.00e+00	829.00
IUUC-Bgr-012111	Blumeria graminis	33.03	1.00e-65	243.00
IUUC-Bta-012583	Bos taurus	97.20	0.00e+00	1086.00
IUUC-Bci-013892	Botrytis cinerea	33.33	1.00e-65	243.00
IUUC-Bdi-014592	Brachypodium distachyon	43.35	5.00e-128	451.00
IUUC-Bol-016399	Brassica oleracea	40.11	5.00e-123	434.00
IUUC-Bra-017506	Brassica rapa	38.66	2.00e-118	419.00
IUUC-Cel-018456	Caenorhabditis elegans	36.03	2.00e-93	336.00
IUUC-Cja-020007	Callithrix jacchus	96.66	0.00e+00	1083.00
IUUC-Cfa-020324	Canis familiaris	98.32	0.00e+00	1096.00
IUUC-Cpo-022248	Cavia porcellus	66.30	0.00e+00	642.00
IUUC-Csa-023149	Chlorocebus sabaeus	95.90	0.00e+00	930.00
IUUC-Cho-024537	Choloepus hoffmanni	84.88	0.00e+00	803.00
IUUC-Cin-025763	Ciona intestinalis	49.72	3.00e-155	541.00
IUUC-Csv-026113	Ciona savignyi	46.67	1.00e-146	513.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.70	5.00e-66	245.00
IUUC-Cne-026884	Cryptococcus neoformans	30.15	8.00e-71	261.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.87	1.00e-17	85.10
IUUC-Dre-028140	Danio rerio	73.13	0.00e+00	850.00
IUUC-Dno-030033	Dasypus novemcinctus	97.05	0.00e+00	958.00
IUUC-Dor-030513	Dipodomys ordii	67.73	5.00e-115	407.00
IUUC-Dse-031536	Dothistroma septosporum	35.35	2.00e-85	310.00
IUUC-Dme-031683	Drosophila melanogaster	44.49	4.00e-126	444.00
IUUC-Ete-032420	Echinops telfairi	83.20	0.00e+00	886.00
IUUC-Eca-033992	Equus caballus	97.53	0.00e+00	913.00
IUUC-Eeu-034713	Erinaceus europaeus	78.35	2.00e-115	409.00
IUUC-Fca-036548	Felis catus	96.83	0.00e+00	1078.00
IUUC-Fal-037600	Ficedula albicollis	80.15	0.00e+00	880.00
IUUC-Fox-038037	Fusarium oxysporum	33.70	8.00e-76	277.00
IUUC-Fso-038387	Fusarium solani	34.54	6.00e-78	285.00
IUUC-Gmo-038562	Gadus morhua	71.13	0.00e+00	819.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.77	7.00e-73	268.00
IUUC-Gga-041129	Gallus gallus	83.99	0.00e+00	938.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.80	0.00e+00	833.00
IUUC-Gma-043610	Glycine max	41.19	1.00e-120	426.00
IUUC-Ggo-045611	Gorilla gorilla	96.66	0.00e+00	1079.00
IUUC-Hsa-046563	Homo sapiens	97.20	0.00e+00	1083.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	5.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	96.64	0.00e+00	1083.00
IUUC-Kpa-049309	Komagataella pastoris	35.54	8.00e-82	297.00
IUUC-Lch-050038	Latimeria chalumnae	76.13	0.00e+00	854.00
IUUC-Lpe-051535	Leersia perrieri	41.28	1.00e-110	393.00
IUUC-Loc-051917	Lepisosteus oculatus	69.85	0.00e+00	800.00
IUUC-Lma-053112	Leptosphaeria maculans	34.98	1.00e-86	313.00
IUUC-Laf-053690	Loxodonta africana	95.71	0.00e+00	1075.00
IUUC-Mcc-055117	Macaca mulatta	96.10	0.00e+00	1076.00
IUUC-Meu-056761	Macropus eugenii	76.52	0.00e+00	826.00
IUUC-Mor-057230	Magnaporthe oryzae	33.87	2.00e-77	283.00
IUUC-Mpo-057514	Magnaporthe poae	34.05	4.00e-71	262.00
IUUC-Mtr-058551	Medicago truncatula	40.00	5.00e-117	414.00
IUUC-Mla-059183	Melampsora laricipopulina	36.35	3.00e-96	345.00
IUUC-Mga-060144	Meleagris gallopavo	82.26	0.00e+00	909.00
IUUC-Mvi-060221	Microbotryum violaceum	36.23	5.00e-83	301.00
IUUC-Mmr-061325	Microcebus murinus	94.79	0.00e+00	1062.00
IUUC-Mdo-062532	Monodelphis domestica	91.03	0.00e+00	1025.00
IUUC-Mmu-063956	Mus musculus	96.27	0.00e+00	1079.00
IUUC-Mac-064521	Musa acuminata	41.19	9.00e-123	433.00
IUUC-Mpu-066716	Mustela putorius furo	97.82	0.00e+00	1032.00
IUUC-Mlu-067459	Myotis lucifugus	94.98	0.00e+00	1059.00
IUUC-Nfi-068245	Neosartorya fischeri	34.76	3.00e-81	296.00
IUUC-Ncr-068910	Neurospora crassa	34.30	3.00e-77	282.00
IUUC-Nle-070034	Nomascus leucogenys	94.50	0.00e+00	1036.00
IUUC-Opr-070552	Ochotona princeps	85.88	0.00e+00	875.00
IUUC-Ont-071426	Oreochromis niloticus	73.45	0.00e+00	852.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.60	0.00e+00	778.00
IUUC-Ocu-074911	Oryctolagus cuniculus	95.34	0.00e+00	1076.00
IUUC-Oba-075437	Oryza barthii	42.78	9.00e-118	417.00
IUUC-Obr-076684	Oryza brachyantha	42.97	5.00e-113	401.00
IUUC-Ogl-077170	Oryza glaberrima	42.78	9.00e-118	417.00
IUUC-Ogu-078844	Oryza glumaepatula	43.54	3.00e-111	395.00
IUUC-Oin-079105	Oryza indica	42.78	3.00e-117	415.00
IUUC-Olo-080943	Oryza longistaminata	41.28	9.00e-106	377.00
IUUC-Oni-082891	Oryza nivara	40.87	3.00e-111	395.00
IUUC-Opu-083457	Oryza punctata	42.78	2.00e-117	415.00
IUUC-Oru-084960	Oryza rufipogon	41.28	7.00e-106	377.00
IUUC-Osa-085358	Oryza sativa	42.97	5.00e-118	418.00
IUUC-Ola-086420	Oryzias latipes	71.31	9.00e-169	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.19	5.00e-60	225.00
IUUC-Oga-088810	Otolemur garnettii	96.27	0.00e+00	1078.00
IUUC-Oar-089196	Ovis aries	96.66	0.00e+00	1082.00
IUUC-Ptr-090617	Pan troglodytes	97.39	0.00e+00	1085.00
IUUC-Pan-092761	Papio anubis	97.39	0.00e+00	1089.00
IUUC-Psi-093191	Pelodiscus sinensis	85.93	0.00e+00	956.00
IUUC-Pma-094380	Petromyzon marinus	61.62	0.00e+00	662.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.15	2.00e-74	274.00
IUUC-Ppa-095875	Physcomitrella patens	40.23	1.00e-118	420.00
IUUC-Pfo-096467	Poecilia formosa	72.69	0.00e+00	833.00
IUUC-Pab-098255	Pongo abelii	96.86	0.00e+00	904.00
IUUC-Pop-099722	Populus trichocarpa	40.82	3.00e-124	438.00
IUUC-Pca-100807	Procavia capensis	79.03	2.00e-118	419.00
IUUC-Ppe-101280	Prunus persica	40.26	1.00e-122	432.00
IUUC-Pva-102333	Pteropus vampyrus	92.76	0.00e+00	1026.00
IUUC-Pgr-103401	Puccinia graminis	31.85	4.00e-81	295.00
IUUC-Ptt-103889	Puccinia triticina	27.95	4.00e-58	219.00
IUUC-Pte-104355	Pyrenophora teres	36.41	1.00e-89	323.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.23	1.00e-91	330.00
IUUC-Rno-105810	Rattus norvegicus	95.71	0.00e+00	1071.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.19	5.00e-37	148.00
IUUC-Sha-106770	Sarcophilus harrisii	89.47	2.00e-154	537.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.21	6.00e-78	285.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.77	1.00e-82	300.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.84	7.00e-68	251.00
IUUC-Smo-109296	Selaginella moellendorffii	42.45	4.00e-124	437.00
IUUC-Sit-110157	Setaria italica	44.24	5.00e-135	474.00
IUUC-Sly-111105	Solanum lycopersicum	40.33	1.00e-121	429.00
IUUC-Stu-112469	Solanum tuberosum	40.47	1.00e-123	436.00
IUUC-Sar-113083	Sorex araneus	73.55	0.00e+00	752.00
IUUC-Sbi-113813	Sorghum bicolor	44.24	7.00e-134	470.00
IUUC-Sre-115058	Sporisorium reilianum	38.80	6.00e-85	308.00
IUUC-Tgu-116772	Taeniopygia guttata	80.11	0.00e+00	884.00
IUUC-Tru-118686	Takifugu rubripes	71.75	0.00e+00	835.00
IUUC-Tsy-119111	Tarsius syrichta	89.12	9.00e-150	523.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.36	0.00e+00	751.00
IUUC-Tca-121491	Theobroma cacao	40.63	1.00e-116	413.00
IUUC-Tre-122103	Trichoderma reesei	37.18	2.00e-83	302.00
IUUC-Tvi-122672	Trichoderma virens	36.70	6.00e-75	275.00
IUUC-Tae-125316	Triticum aestivum	43.18	2.00e-127	449.00
IUUC-Tur-126487	Triticum urartu	41.86	3.00e-121	428.00
IUUC-Tme-127097	Tuber melanosporum	38.41	5.00e-94	338.00
IUUC-Ttr-128465	Tursiops truncatus	89.80	0.00e+00	993.00
IUUC-Uma-129645	Ustilago maydis	37.75	4.00e-84	305.00
IUUC-Vda-129989	Verticillium dahliae	31.35	6.00e-56	211.00
IUUC-Vpa-130529	Vicugna pacos	92.39	0.00e+00	1026.00
IUUC-Vvi-131059	Vitis vinifera	41.19	5.00e-122	431.00
IUUC-Xtr-132002	Xenopus tropicalis	78.83	0.00e+00	904.00
IUUC-Xma-133930	Xiphophorus maculatus	73.11	0.00e+00	838.00
IUUC-Yli-134505	Yarrowia lipolytica	34.91	2.00e-85	309.00
IUUC-Zma-135895	Zea mays	44.49	8.00e-133	467.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence