iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Obr-076684

Ensembl Protein ID

OB03G46000.1

UniProt Accession

J3LU74; J3LU74_ORYBR

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
OB03G46000	OB03G46000.1	OB03G46000.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.60e-107	361.0	53	559

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesi 97
           YDRQ+r+wG+++q++l++a+++l+ +g++G+E  KnLvl+Gvgs+tvvD+++ve s+l+++FL++    g+s+A++++ +l+eln+ vn++++ees+
   Q: 53   YDRQLRIWGDQGQDALEKASICLLTCGPTGTEAMKNLVLGGVGSVTVVDGSKVEPSDLGNNFLLDVGCLGQSRAKSVCSFLQELNDAVNAKFVEESP 149
           ************************************************************************************************* PP
   S: 98   teleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn......... 181
            +l ++++ Ff++f+vV++++ ++++ +k++++c++a++ l+ ++++Gl G vr+++k++ +++s++d   d++++  P+ +lk++           
   Q: 150  LDLIDTNPsFFSQFTVVIATQLPESSLLKLDSICRKANIVLVAARSYGLTGLVRISVKEHNVIESKPDhflDDLRLHDPWTELKQFAKsidindkdp 246
           **************************************************************************************88899999999 PP
   S: 182  aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv... 274
           +++++++++v++  l+e++a +++++ +++++ek+e+kd++++ + + deen++ea+e + k   +  i++ i++++++ + ++v++s+s+fwv   
   Q: 247  VVHKHTPYIVILVRLAEKWADAHDGRLPSTRQEKREFKDLIREHMLNLDEENYKEAVESSYKVSVTPGISDdIRKIIDD-SSAEVNSSSSDFWVlva 342
           ******************************************************************************9.78899************ PP
   S: 275  ........................................................................sfcsnaealq...........vpek 288
                                                                                    fc na++l+           + + 
   Q: 343  alkefianegngepplegtipdmtslteyyvslqriyqakaesdclalehhvrdilkridrdpdsisrayikAFCRNARKLKvcryrsleeefSSPF 439
           **********************************************************************************666666655555599 PP
   S: 289  vekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGl 379
             + +++++++++     +y+llra++r+ ++++r pg ++ e d+d +++l+taa +  + ++g+++ +l++dli+e+++++ ++i++++a++gG+
   Q: 440  LSEAQKYFTDEDYcfainFYVLLRAVDRLTANYSRFPGLFDSEIDED-VPRLKTAAVSV-MREMGLNGaPLSEDLITEMCRFGGAEIHPVAAFIGGV 534
           99999999999999*********************************.******88875.599********************************** PP
   S: 380  aaqEviKvvsgkfeplknfflfdae 404
           a+qEviK+v+++f+pl  +f+f+++
   Q: 535  ASQEVIKLVTKQFVPLLGTFIFNGI 559
           **********************986 PP

Organism

Oryza brachyantha

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MWITILNFRF IPRPKGGGGA GQVSITSERQ RRARRRKPWP PPPASFAEPK TKYDRQLRIW 60
GDQGQDALEK ASICLLTCGP TGTEAMKNLV LGGVGSVTVV DGSKVEPSDL GNNFLLDVGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGATAA CTATTTTAAA GTACGTAAGT ATAGTAGATT TTTAGCCACT CAATAATTAA 60
AAAAAACATT GAAGAAGCTT ATCAGATCAT AATTTATCAA CAATAGATTA TAACACACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	86.50	0.00e+00	912.00
IUUC-Aml-002333	Ailuropoda melanoleuca	43.35	4.00e-129	454.00
IUUC-Atr-002644	Amborella trichopoda	71.13	0.00e+00	753.00
IUUC-Apl-003446	Anas platyrhynchos	42.12	1.00e-118	419.00
IUUC-Aca-004450	Anolis carolinensis	41.06	6.00e-122	430.00
IUUC-Aly-005466	Arabidopsis lyrata	66.67	0.00e+00	747.00
IUUC-Ath-006692	Arabidopsis thaliana	67.05	0.00e+00	745.00
IUUC-Ago-007900	Ashbya gossypii	27.22	7.00e-40	157.00
IUUC-Acl-008333	Aspergillus clavatus	32.19	5.00e-64	237.00
IUUC-Afl-008529	Aspergillus flavus	32.67	3.00e-69	255.00
IUUC-Afu-009071	Aspergillus fumigatus	31.64	6.00e-63	234.00
IUUC-Ani-009443	Aspergillus nidulans	31.40	1.00e-58	219.00
IUUC-Ang-009669	Aspergillus niger	31.34	3.00e-66	245.00
IUUC-Aor-009914	Aspergillus oryzae	32.37	4.00e-67	248.00
IUUC-Ate-010450	Aspergillus terreus	32.24	4.00e-66	244.00
IUUC-Ame-011183	Astyanax mexicanus	40.65	5.00e-122	430.00
IUUC-Bgr-012111	Blumeria graminis	32.39	4.00e-59	221.00
IUUC-Bta-012583	Bos taurus	43.70	2.00e-130	457.00
IUUC-Bci-013892	Botrytis cinerea	31.37	6.00e-56	211.00
IUUC-Bdi-014592	Brachypodium distachyon	86.76	0.00e+00	919.00
IUUC-Bol-016399	Brassica oleracea	66.54	0.00e+00	748.00
IUUC-Bra-017506	Brassica rapa	66.10	0.00e+00	730.00
IUUC-Cel-018456	Caenorhabditis elegans	29.98	7.00e-68	250.00
IUUC-Cja-020007	Callithrix jacchus	43.67	4.00e-129	453.00
IUUC-Cfa-020324	Canis familiaris	43.51	9.00e-131	459.00
IUUC-Cpo-022248	Cavia porcellus	39.94	2.00e-69	255.00
IUUC-Csa-023149	Chlorocebus sabaeus	41.38	2.00e-103	369.00
IUUC-Cho-024537	Choloepus hoffmanni	36.42	4.00e-88	317.00
IUUC-Cin-025763	Ciona intestinalis	42.34	2.00e-113	401.00
IUUC-Csv-026113	Ciona savignyi	39.70	6.00e-103	367.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.54	2.00e-54	205.00
IUUC-Cne-026884	Cryptococcus neoformans	31.32	2.00e-63	236.00
IUUC-Dre-028140	Danio rerio	41.39	3.00e-126	444.00
IUUC-Dno-030033	Dasypus novemcinctus	43.07	2.00e-112	398.00
IUUC-Dor-030513	Dipodomys ordii	36.21	5.00e-38	150.00
IUUC-Dse-031536	Dothistroma septosporum	30.13	1.00e-62	233.00
IUUC-Dme-031683	Drosophila melanogaster	36.72	2.00e-93	335.00
IUUC-Ete-032420	Echinops telfairi	38.65	1.00e-110	392.00
IUUC-Eca-033992	Equus caballus	41.67	6.00e-101	360.00
IUUC-Eeu-034713	Erinaceus europaeus	33.62	7.00e-36	144.00
IUUC-Fca-036548	Felis catus	43.13	7.00e-130	456.00
IUUC-Fal-037600	Ficedula albicollis	41.87	3.00e-117	414.00
IUUC-Fox-038037	Fusarium oxysporum	31.93	5.00e-66	244.00
IUUC-Fso-038387	Fusarium solani	32.05	1.00e-65	243.00
IUUC-Gmo-038562	Gadus morhua	40.26	5.00e-119	420.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.19	2.00e-61	229.00
IUUC-Gga-041129	Gallus gallus	42.02	1.00e-119	422.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.20	1.00e-123	435.00
IUUC-Gma-043610	Glycine max	69.60	0.00e+00	745.00
IUUC-Ggo-045611	Gorilla gorilla	43.10	4.00e-128	450.00
IUUC-Hsa-046563	Homo sapiens	43.51	3.00e-129	454.00
IUUC-Hvu-047790	Hordeum vulgare	87.15	0.00e+00	674.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	43.73	3.00e-129	454.00
IUUC-Kpa-049309	Komagataella pastoris	35.00	1.00e-75	275.00
IUUC-Lch-050038	Latimeria chalumnae	42.31	2.00e-122	432.00
IUUC-Lpe-051535	Leersia perrieri	89.13	0.00e+00	865.00
IUUC-Loc-051917	Lepisosteus oculatus	38.39	2.00e-107	382.00
IUUC-Lma-053112	Leptosphaeria maculans	32.14	5.00e-68	251.00
IUUC-Laf-053690	Loxodonta africana	44.11	1.00e-131	462.00
IUUC-Mcc-055117	Macaca mulatta	43.37	2.00e-127	448.00
IUUC-Meu-056761	Macropus eugenii	36.12	6.00e-94	337.00
IUUC-Mor-057230	Magnaporthe oryzae	31.69	6.00e-66	244.00
IUUC-Mpo-057514	Magnaporthe poae	31.73	4.00e-58	218.00
IUUC-Mtr-058551	Medicago truncatula	66.79	0.00e+00	724.00
IUUC-Mla-059183	Melampsora laricipopulina	34.44	1.00e-83	303.00
IUUC-Mga-060144	Meleagris gallopavo	41.46	2.00e-116	411.00
IUUC-Mvi-060221	Microbotryum violaceum	31.52	3.00e-67	248.00
IUUC-Mmr-061325	Microcebus murinus	42.72	4.00e-127	447.00
IUUC-Mdo-062532	Monodelphis domestica	43.16	2.00e-128	451.00
IUUC-Mmu-063956	Mus musculus	42.94	1.00e-128	452.00
IUUC-Mac-064521	Musa acuminata	73.60	0.00e+00	808.00
IUUC-Mpu-066716	Mustela putorius furo	43.50	3.00e-121	427.00
IUUC-Mlu-067459	Myotis lucifugus	43.77	2.00e-131	461.00
IUUC-Nfi-068245	Neosartorya fischeri	31.69	1.00e-63	236.00
IUUC-Ncr-068910	Neurospora crassa	30.88	1.00e-60	226.00
IUUC-Nle-070034	Nomascus leucogenys	42.12	2.00e-123	434.00
IUUC-Opr-070552	Ochotona princeps	39.24	1.00e-98	352.00
IUUC-Ont-071426	Oreochromis niloticus	41.21	1.00e-124	439.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.86	1.00e-88	319.00
IUUC-Ocu-074911	Oryctolagus cuniculus	43.74	1.00e-130	459.00
IUUC-Oba-075437	Oryza barthii	94.05	0.00e+00	949.00
IUUC-Ogl-077170	Oryza glaberrima	94.05	0.00e+00	949.00
IUUC-Ogu-078844	Oryza glumaepatula	92.96	0.00e+00	889.00
IUUC-Oin-079105	Oryza indica	93.86	0.00e+00	946.00
IUUC-Olo-080943	Oryza longistaminata	90.89	0.00e+00	865.00
IUUC-Oni-082891	Oryza nivara	91.17	0.00e+00	914.00
IUUC-Opu-083457	Oryza punctata	94.24	0.00e+00	951.00
IUUC-Oru-084960	Oryza rufipogon	90.76	0.00e+00	871.00
IUUC-Osa-085358	Oryza sativa	93.47	0.00e+00	939.00
IUUC-Ola-086420	Oryzias latipes	39.36	3.00e-76	277.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.66	5.00e-58	217.00
IUUC-Oga-088810	Otolemur garnettii	43.51	1.00e-129	456.00
IUUC-Oar-089196	Ovis aries	43.45	1.00e-128	452.00
IUUC-Ptr-090617	Pan troglodytes	43.51	2.00e-129	454.00
IUUC-Pan-092761	Papio anubis	43.54	1.00e-130	459.00
IUUC-Psi-093191	Pelodiscus sinensis	40.77	2.00e-122	431.00
IUUC-Pma-094380	Petromyzon marinus	40.81	2.00e-107	382.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.35	2.00e-57	217.00
IUUC-Ppa-095798	Physcomitrella patens	55.09	2.00e-173	601.00
IUUC-Pfo-096467	Poecilia formosa	41.15	9.00e-121	426.00
IUUC-Pab-098255	Pongo abelii	44.83	7.00e-108	383.00
IUUC-Pop-099722	Populus trichocarpa	69.79	0.00e+00	778.00
IUUC-Pca-100807	Procavia capensis	52.41	1.00e-53	202.00
IUUC-Ppe-101280	Prunus persica	69.60	0.00e+00	768.00
IUUC-Pva-102333	Pteropus vampyrus	42.13	3.00e-123	434.00
IUUC-Pgr-103401	Puccinia graminis	29.40	8.00e-68	250.00
IUUC-Ptt-103889	Puccinia triticina	26.93	2.00e-58	219.00
IUUC-Pte-104355	Pyrenophora teres	32.97	6.00e-66	244.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.85	4.00e-66	244.00
IUUC-Rno-105810	Rattus norvegicus	42.40	8.00e-127	446.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.20	2.00e-31	129.00
IUUC-Sha-106770	Sarcophilus harrisii	49.62	1.00e-72	265.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.20	2.00e-76	278.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.52	1.00e-79	289.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.73	1.00e-56	213.00
IUUC-Smo-109296	Selaginella moellendorffii	54.21	2.00e-162	565.00
IUUC-Sit-110157	Setaria italica	86.59	0.00e+00	933.00
IUUC-Sly-111105	Solanum lycopersicum	67.23	0.00e+00	748.00
IUUC-Stu-112469	Solanum tuberosum	68.16	0.00e+00	764.00
IUUC-Sar-113083	Sorex araneus	33.91	1.00e-86	313.00
IUUC-Sbi-113813	Sorghum bicolor	88.31	0.00e+00	946.00
IUUC-Sre-115058	Sporisorium reilianum	34.09	6.00e-63	234.00
IUUC-Tgu-116772	Taeniopygia guttata	42.50	6.00e-117	413.00
IUUC-Tru-118686	Takifugu rubripes	39.85	1.00e-122	432.00
IUUC-Tsy-119111	Tarsius syrichta	45.28	7.00e-64	237.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.11	2.00e-109	389.00
IUUC-Tca-121491	Theobroma cacao	69.98	0.00e+00	735.00
IUUC-Tre-122103	Trichoderma reesei	32.77	5.00e-71	260.00
IUUC-Tvi-122672	Trichoderma virens	31.66	3.00e-65	241.00
IUUC-Tae-125316	Triticum aestivum	87.33	0.00e+00	918.00
IUUC-Tur-126487	Triticum urartu	85.88	0.00e+00	889.00
IUUC-Tme-127097	Tuber melanosporum	34.37	2.00e-76	278.00
IUUC-Ttr-128465	Tursiops truncatus	40.08	4.00e-113	400.00
IUUC-Uma-129645	Ustilago maydis	29.39	5.00e-65	241.00
IUUC-Vda-129989	Verticillium dahliae	28.94	7.00e-48	184.00
IUUC-Vpa-130529	Vicugna pacos	41.02	3.00e-118	417.00
IUUC-Vvi-131059	Vitis vinifera	70.94	0.00e+00	783.00
IUUC-Xtr-132002	Xenopus tropicalis	43.35	2.00e-126	444.00
IUUC-Xma-133930	Xiphophorus maculatus	41.24	5.00e-124	437.00
IUUC-Yli-134505	Yarrowia lipolytica	34.17	7.00e-78	283.00
IUUC-Zma-135619	Zea mays	87.93	0.00e+00	899.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence