iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020442

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAEX03002526

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000015878.3	ENSCAFT00000025162.3	ENSCAFP00000023358.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	9.80e-62	209.5	2	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftl.lvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           ++ ++e +P+++++ ++ ++gv +++++ ++ +L+ e lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+
   Q: 2    QLKPMEINPEMLNKqVLARLGVAGQWRFADVLGLEDEALGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQT 86
           5789********9725689***********************************************99....99*************** PP
   S: 95   igNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvs 182
           igNsC+t++l+++++n++dkl ++ G+ l++++++t++ spe++a++++++++++++h+++a++++++ +          +k +fhf++
   Q: 87   IGNSCGTIGLIHAVANNQDKLeFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFIL 165
           ********************************************************************99..........5679***** PP
   S: 183  yvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           + n++g+lyeldg++pfP+++g ++e+  l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 166  FNNVDGHLYELDGRMPFPVNHGTSSEDSLLQDAAKVCREFTER----EQGEVRFSAVALCKA 223
           *******************************************....************987 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKQVLAR LGVAGQWRFA DVLGLEDEAL GSVPAPACAL LLLFPLTAQH 60
ENFRKKQIEE LKGQEVSPKV YFMKQTIGNS CGTIGLIHAV ANNQDKLEFE DGSVLKQFLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGGTGAGCG CCGGGGGCCC CGCTGCCCGG 60
GGAGCGCGGG GCTGGGGGTC GGCCCTTCGG GGCCGCTGCG TCGGCGACCG GACCGGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	39.13	3.00e-44	171.00
IUUC-Aml-001376	Ailuropoda melanoleuca	81.71	3.00e-113	400.00
IUUC-Apl-003693	Anas platyrhynchos	69.78	2.00e-90	324.00
IUUC-Aca-004716	Anolis carolinensis	74.67	6.00e-99	353.00
IUUC-Aly-005721	Arabidopsis lyrata	41.89	9.00e-46	176.00
IUUC-Ath-006827	Arabidopsis thaliana	42.47	2.00e-47	182.00
IUUC-Ame-011806	Astyanax mexicanus	66.96	6.00e-84	303.00
IUUC-Bta-013521	Bos taurus	82.61	7.00e-115	406.00
IUUC-Bdi-014330	Brachypodium distachyon	42.53	9.00e-47	180.00
IUUC-Bra-017721	Brassica rapa	42.47	5.00e-48	184.00
IUUC-Cel-018302	Caenorhabditis elegans	36.11	4.00e-32	130.00
IUUC-Cja-018752	Callithrix jacchus	96.00	3.00e-116	410.00
IUUC-Cpo-021723	Cavia porcellus	94.12	2.00e-96	343.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	38.68	1.00e-31	129.00
IUUC-Csa-023626	Chlorocebus sabaeus	95.54	4.00e-116	410.00
IUUC-Cho-024548	Choloepus hoffmanni	88.07	4.00e-41	160.00
IUUC-Cin-025545	Ciona intestinalis	46.90	5.00e-55	207.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	33.05	3.00e-26	111.00
IUUC-Cne-026914	Cryptococcus neoformans	33.62	3.00e-23	102.00
IUUC-Dre-027854	Danio rerio	64.89	6.00e-83	299.00
IUUC-Dno-029325	Dasypus novemcinctus	97.32	1.00e-118	418.00
IUUC-Dor-030114	Dipodomys ordii	94.20	4.00e-125	440.00
IUUC-Dme-032146	Drosophila melanogaster	44.93	2.00e-52	198.00
IUUC-Ete-033092	Echinops telfairi	77.68	4.00e-96	343.00
IUUC-Eca-033854	Equus caballus	99.30	3.00e-81	293.00
IUUC-Eeu-034493	Erinaceus europaeus	94.20	7.00e-114	402.00
IUUC-Fal-036693	Ficedula albicollis	75.24	1.00e-93	335.00
IUUC-Gmo-038848	Gadus morhua	61.03	9.00e-74	269.00
IUUC-Gga-041078	Gallus gallus	74.22	9.00e-100	355.00
IUUC-Gac-042064	Gasterosteus aculeatus	61.54	2.00e-76	278.00
IUUC-Gma-043057	Glycine max	42.53	2.00e-41	162.00
IUUC-Ggo-044827	Gorilla gorilla	95.54	2.00e-116	411.00
IUUC-Hsa-045820	Homo sapiens	95.54	2.00e-116	411.00
IUUC-Hvu-047176	Hordeum vulgare	35.56	2.00e-36	145.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	97.77	1.00e-118	418.00
IUUC-Lch-050121	Latimeria chalumnae	72.65	3.00e-97	347.00
IUUC-Lpe-051377	Leersia perrieri	43.37	2.00e-40	158.00
IUUC-Loc-052342	Lepisosteus oculatus	69.60	3.00e-91	327.00
IUUC-Laf-053916	Loxodonta africana	94.69	2.00e-115	407.00
IUUC-Mcc-054838	Macaca mulatta	95.54	4.00e-116	410.00
IUUC-Meu-056478	Macropus eugenii	87.95	1.00e-118	418.00
IUUC-Mor-057271	Magnaporthe oryzae	36.09	8.00e-32	130.00
IUUC-Mpo-057343	Magnaporthe poae	32.20	4.00e-17	80.90
IUUC-Mtr-057713	Medicago truncatula	42.08	5.00e-43	167.00
IUUC-Mla-058942	Melampsora laricipopulina	34.76	2.00e-34	138.00
IUUC-Mga-059878	Meleagris gallopavo	73.27	1.00e-96	345.00
IUUC-Mdo-062544	Monodelphis domestica	87.05	7.00e-108	382.00
IUUC-Mmu-063300	Mus musculus	96.88	2.00e-127	447.00
IUUC-Mac-065075	Musa acuminata	41.89	1.00e-43	169.00
IUUC-Mpu-066128	Mustela putorius furo	97.01	6.00e-104	369.00
IUUC-Mlu-067778	Myotis lucifugus	95.98	2.00e-126	444.00
IUUC-Nle-069686	Nomascus leucogenys	95.54	2.00e-116	410.00
IUUC-Opr-070535	Ochotona princeps	78.57	2.00e-98	351.00
IUUC-Ont-071510	Oreochromis niloticus	61.88	3.00e-78	283.00
IUUC-Ocu-074590	Oryctolagus cuniculus	95.54	7.00e-117	412.00
IUUC-Oba-075098	Oryza barthii	39.45	5.00e-44	170.00
IUUC-Obr-076041	Oryza brachyantha	41.44	2.00e-45	175.00
IUUC-Ogl-076980	Oryza glaberrima	41.89	6.00e-45	173.00
IUUC-Ogu-078978	Oryza glumaepatula	37.25	4.00e-42	164.00
IUUC-Oin-079285	Oryza indica	38.99	2.00e-43	168.00
IUUC-Olo-080671	Oryza longistaminata	38.99	8.00e-43	166.00
IUUC-Ome-081428	Oryza meridionalis	38.07	2.00e-41	161.00
IUUC-Oni-082406	Oryza nivara	39.45	5.00e-44	170.00
IUUC-Opu-083305	Oryza punctata	38.07	3.00e-42	164.00
IUUC-Oru-084969	Oryza rufipogon	39.45	5.00e-44	170.00
IUUC-Osa-085830	Oryza sativa	41.89	6.00e-45	173.00
IUUC-Olu-087858	Ostreococcus lucimarinus	37.39	1.00e-36	145.00
IUUC-Oga-089013	Otolemur garnettii	81.82	8.00e-113	399.00
IUUC-Oar-089861	Ovis aries	82.61	4.00e-115	406.00
IUUC-Ptr-091536	Pan troglodytes	93.75	2.00e-114	404.00
IUUC-Pan-092909	Papio anubis	95.54	4.00e-116	410.00
IUUC-Psi-093818	Pelodiscus sinensis	78.22	4.00e-102	363.00
IUUC-Pfo-097335	Poecilia formosa	57.96	5.00e-76	276.00
IUUC-Pab-098048	Pongo abelii	95.54	2.00e-116	411.00
IUUC-Pop-099282	Populus trichocarpa	43.44	4.00e-44	171.00
IUUC-Pca-100818	Procavia capensis	73.47	1.00e-66	245.00
IUUC-Ppe-101332	Prunus persica	42.53	6.00e-46	177.00
IUUC-Pva-102954	Pteropus vampyrus	96.88	2.00e-113	400.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.22	1.00e-32	133.00
IUUC-Rno-105966	Rattus norvegicus	96.88	2.00e-127	447.00
IUUC-Sha-107111	Sarcophilus harrisii	87.88	1.00e-87	314.00
IUUC-Smo-109283	Selaginella moellendorffii	41.48	9.00e-42	163.00
IUUC-Sit-110163	Setaria italica	40.99	1.00e-45	176.00
IUUC-Sly-111832	Solanum lycopersicum	44.29	1.00e-47	182.00
IUUC-Stu-112526	Solanum tuberosum	44.29	8.00e-48	183.00
IUUC-Sar-113190	Sorex araneus	76.32	8.00e-39	151.00
IUUC-Sbi-114545	Sorghum bicolor	41.26	9.00e-44	169.00
IUUC-Ssc-115908	Sus scrofa	80.09	2.00e-100	357.00
IUUC-Tgu-117465	Taeniopygia guttata	71.09	2.00e-87	314.00
IUUC-Tru-118565	Takifugu rubripes	60.29	2.00e-69	254.00
IUUC-Tsy-119561	Tarsius syrichta	77.68	7.00e-96	342.00
IUUC-Tca-120976	Theobroma cacao	43.84	7.00e-47	180.00
IUUC-Tre-122149	Trichoderma reesei	38.16	2.00e-34	139.00
IUUC-Tvi-122450	Trichoderma virens	37.28	2.00e-34	139.00
IUUC-Tae-122693	Triticum aestivum	40.54	1.00e-45	176.00
IUUC-Tur-126250	Triticum urartu	39.13	7.00e-44	170.00
IUUC-Tme-126961	Tuber melanosporum	38.89	3.00e-31	128.00
IUUC-Tbe-128048	Tupaia belangeri	96.36	8.00e-94	335.00
IUUC-Ttr-128494	Tursiops truncatus	95.52	3.00e-114	403.00
IUUC-Vda-129850	Verticillium dahliae	34.05	3.00e-27	114.00
IUUC-Vvi-131661	Vitis vinifera	39.73	2.00e-44	171.00
IUUC-Xtr-132286	Xenopus tropicalis	68.75	3.00e-90	324.00
IUUC-Xma-133019	Xiphophorus maculatus	58.48	5.00e-76	276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence