iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012786

Ensembl Protein ID

ENSBTAP00000000017.5

UniProt Accession

F1MBG5; F1MBG5_BOVIN

Genbank Protein ID

ENSBTAP00000000017

Protein Name

Non-specific serine/threonine protein kinase

Genbank Nucleotide ID

DAAA02050552

Gene Name

PRKAA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000000013.5	ENSBTAT00000000017.5	ENSBTAP00000000017.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	52.44	2.00e-114	409.00	IUUC-Ath-007014
UBD/Alpha-Helix/UBA	40.28	4.00e-98	353.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Protein Sequence
(Fasta)

MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 60
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGCAGAC TCAGTTCCTG GAGAAAGATG GCGACAGCCG AGAAGCAGAA ACACGACGGG 60
CGGGTGAAGA TCGGTCACTA CATCCTGGGG GATACGCTGG GGGTCGGGAC CTTCGGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0010628--P:positive regulation of gene expression
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0006468--P:protein phosphorylation
GO:0042752--P:regulation of circadian rhythm
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000713	Aegilops tauschii	46.97	1.00e-119	424.00
IUUC-Aml-001907	Ailuropoda melanoleuca	99.28	0.00e+00	1058.00
IUUC-Atr-002770	Amborella trichopoda	48.47	5.00e-125	441.00
IUUC-Apl-003395	Anas platyrhynchos	74.48	0.00e+00	803.00
IUUC-Aca-004480	Anolis carolinensis	76.40	0.00e+00	824.00
IUUC-Aly-006289	Arabidopsis lyrata	52.44	3.00e-123	435.00
IUUC-Ath-007014	Arabidopsis thaliana	52.90	1.00e-124	440.00
IUUC-Ago-007957	Ashbya gossypii	41.76	9.00e-114	404.00
IUUC-Acl-008103	Aspergillus clavatus	59.35	1.00e-99	357.00
IUUC-Afl-008555	Aspergillus flavus	58.63	7.00e-100	358.00
IUUC-Afu-008949	Aspergillus fumigatus	58.99	2.00e-99	357.00
IUUC-Ani-009408	Aspergillus nidulans	59.64	9.00e-100	357.00
IUUC-Ang-009551	Aspergillus niger	59.35	1.00e-100	360.00
IUUC-Aor-010176	Aspergillus oryzae	58.63	8.00e-100	358.00
IUUC-Ate-010287	Aspergillus terreus	60.82	3.00e-99	356.00
IUUC-Ame-011019	Astyanax mexicanus	74.24	0.00e+00	840.00
IUUC-Bgr-012045	Blumeria graminis	58.27	2.00e-99	356.00
IUUC-Bci-013774	Botrytis cinerea	57.00	9.00e-102	364.00
IUUC-Bdi-014319	Brachypodium distachyon	47.12	2.00e-121	429.00
IUUC-Bol-016242	Brassica oleracea	52.25	4.00e-126	444.00
IUUC-Bra-016750	Brassica rapa	53.18	1.00e-126	446.00
IUUC-Cel-018518	Caenorhabditis elegans	58.33	3.00e-180	625.00
IUUC-Cja-019386	Callithrix jacchus	75.27	0.00e+00	856.00
IUUC-Cfa-020177	Canis familiaris	99.42	0.00e+00	1006.00
IUUC-Cpo-021805	Cavia porcellus	75.09	0.00e+00	853.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	55.76	9.00e-96	343.00
IUUC-Csa-024267	Chlorocebus sabaeus	74.86	0.00e+00	852.00
IUUC-Cho-024859	Choloepus hoffmanni	96.61	0.00e+00	991.00
IUUC-Cin-025550	Ciona intestinalis	59.89	0.00e+00	664.00
IUUC-Csv-026139	Ciona savignyi	58.32	0.00e+00	663.00
IUUC-Cne-027044	Cryptococcus neoformans	46.77	2.00e-104	373.00
IUUC-Cme-027289	Cyanidioschyzon merolae	46.44	2.00e-111	395.00
IUUC-Dre-027749	Danio rerio	83.62	0.00e+00	949.00
IUUC-Dno-030006	Dasypus novemcinctus	98.57	0.00e+00	1050.00
IUUC-Dor-030578	Dipodomys ordii	75.77	0.00e+00	853.00
IUUC-Dse-031507	Dothistroma septosporum	62.31	3.00e-104	373.00
IUUC-Dme-031704	Drosophila melanogaster	57.29	1.00e-177	615.00
IUUC-Ete-033055	Echinops telfairi	95.58	0.00e+00	1058.00
IUUC-Eca-034239	Equus caballus	99.42	0.00e+00	1001.00
IUUC-Fca-035754	Felis catus	96.32	0.00e+00	1035.00
IUUC-Fal-037363	Ficedula albicollis	93.24	0.00e+00	1005.00
IUUC-Fox-038073	Fusarium oxysporum	58.60	1.00e-101	363.00
IUUC-Fso-038236	Fusarium solani	57.89	3.00e-98	352.00
IUUC-Gmo-039633	Gadus morhua	82.26	0.00e+00	974.00
IUUC-Ggr-039987	Gaeumannomyces graminis	50.14	2.00e-101	363.00
IUUC-Gga-040546	Gallus gallus	75.45	0.00e+00	852.00
IUUC-Gac-041822	Gasterosteus aculeatus	72.66	0.00e+00	810.00
IUUC-Gma-042712	Glycine max	47.84	9.00e-125	440.00
IUUC-Ggo-044797	Gorilla gorilla	99.11	0.00e+00	1056.00
IUUC-Hsa-045867	Homo sapiens	99.28	0.00e+00	1057.00
IUUC-Hvu-047406	Hordeum vulgare	47.30	3.00e-122	431.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	75.27	0.00e+00	857.00
IUUC-Kpa-049190	Komagataella pastoris	42.13	2.00e-116	413.00
IUUC-Lch-049623	Latimeria chalumnae	90.20	0.00e+00	954.00
IUUC-Lpe-051392	Leersia perrieri	52.24	2.00e-125	442.00
IUUC-Loc-052362	Lepisosteus oculatus	90.20	0.00e+00	934.00
IUUC-Lma-053054	Leptosphaeria maculans	58.90	4.00e-106	379.00
IUUC-Laf-053799	Loxodonta africana	98.93	0.00e+00	1090.00
IUUC-Mcc-055862	Macaca mulatta	75.27	0.00e+00	858.00
IUUC-Mor-057170	Magnaporthe oryzae	49.87	6.00e-102	365.00
IUUC-Mpo-057302	Magnaporthe poae	49.34	8.00e-102	364.00
IUUC-Mtr-058309	Medicago truncatula	48.64	1.00e-125	442.00
IUUC-Mla-059058	Melampsora laricipopulina	41.12	2.00e-104	373.00
IUUC-Mga-059206	Meleagris gallopavo	74.52	0.00e+00	794.00
IUUC-Mvi-060337	Microbotryum violaceum	50.28	6.00e-100	358.00
IUUC-Mmr-061761	Microcebus murinus	99.28	0.00e+00	1057.00
IUUC-Mdo-062160	Monodelphis domestica	75.04	0.00e+00	852.00
IUUC-Mmu-063406	Mus musculus	74.91	0.00e+00	850.00
IUUC-Mac-064518	Musa acuminata	49.03	1.00e-118	420.00
IUUC-Mpu-066326	Mustela putorius furo	74.24	0.00e+00	795.00
IUUC-Mlu-068227	Myotis lucifugus	98.07	0.00e+00	995.00
IUUC-Nfi-068493	Neosartorya fischeri	58.99	1.00e-99	357.00
IUUC-Ncr-068665	Neurospora crassa	59.51	5.00e-104	372.00
IUUC-Nle-070158	Nomascus leucogenys	75.27	0.00e+00	859.00
IUUC-Opr-070272	Ochotona princeps	95.64	0.00e+00	1035.00
IUUC-Ont-072027	Oreochromis niloticus	83.68	0.00e+00	949.00
IUUC-Oan-073322	Ornithorhynchus anatinus	88.17	0.00e+00	984.00
IUUC-Ocu-074188	Oryctolagus cuniculus	96.45	0.00e+00	1024.00
IUUC-Oba-075436	Oryza barthii	48.24	2.00e-126	446.00
IUUC-Obr-076507	Oryza brachyantha	48.16	1.00e-126	446.00
IUUC-Ogl-077718	Oryza glaberrima	51.96	2.00e-122	432.00
IUUC-Ogu-078349	Oryza glumaepatula	47.59	2.00e-126	446.00
IUUC-Oin-079889	Oryza indica	46.91	1.00e-122	433.00
IUUC-Olo-080521	Oryza longistaminata	48.24	1.00e-126	446.00
IUUC-Ome-081630	Oryza meridionalis	48.03	4.00e-126	444.00
IUUC-Oni-082211	Oryza nivara	48.24	1.00e-126	447.00
IUUC-Opu-083617	Oryza punctata	47.47	1.00e-125	443.00
IUUC-Oru-084252	Oryza rufipogon	48.24	1.00e-126	446.00
IUUC-Osa-085548	Oryza sativa	48.24	1.00e-126	446.00
IUUC-Ola-086366	Oryzias latipes	84.23	0.00e+00	964.00
IUUC-Olu-087861	Ostreococcus lucimarinus	48.75	4.00e-118	418.00
IUUC-Oga-088003	Otolemur garnettii	99.46	0.00e+00	1060.00
IUUC-Oar-089933	Ovis aries	100.00	0.00e+00	1071.00
IUUC-Ptr-090718	Pan troglodytes	99.28	0.00e+00	1057.00
IUUC-Pan-092526	Papio anubis	99.11	0.00e+00	1056.00
IUUC-Psi-094034	Pelodiscus sinensis	93.05	0.00e+00	1005.00
IUUC-Pno-095030	Phaeosphaeria nodorum	58.08	2.00e-104	372.00
IUUC-Ppa-095615	Physcomitrella patens	51.26	1.00e-123	436.00
IUUC-Pfo-097050	Poecilia formosa	83.63	0.00e+00	951.00
IUUC-Pab-098519	Pongo abelii	99.28	0.00e+00	1057.00
IUUC-Pop-099781	Populus trichocarpa	54.01	1.00e-126	446.00
IUUC-Pca-101104	Procavia capensis	95.43	0.00e+00	764.00
IUUC-Ppe-101642	Prunus persica	49.47	6.00e-124	437.00
IUUC-Pva-102470	Pteropus vampyrus	75.09	0.00e+00	848.00
IUUC-Pgr-103406	Puccinia graminis	57.49	2.00e-91	330.00
IUUC-Ptt-103713	Puccinia triticina	50.00	3.00e-72	266.00
IUUC-Pte-104259	Pyrenophora teres	56.49	2.00e-104	373.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	50.13	5.00e-105	375.00
IUUC-Rno-104960	Rattus norvegicus	75.41	0.00e+00	854.00
IUUC-Sce-106290	Saccharomyces cerevisiae	41.26	8.00e-112	397.00
IUUC-Sha-107603	Sarcophilus harrisii	96.96	0.00e+00	1044.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	51.53	2.00e-108	385.00
IUUC-Spo-108202	Schizosaccharomyces pombe	40.67	2.00e-107	382.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	57.34	4.00e-101	362.00
IUUC-Smo-109309	Selaginella moellendorffii	46.26	1.00e-122	433.00
IUUC-Sit-109745	Setaria italica	53.16	1.00e-127	449.00
IUUC-Sly-110890	Solanum lycopersicum	53.16	4.00e-125	441.00
IUUC-Stu-112144	Solanum tuberosum	46.17	6.00e-117	414.00
IUUC-Sar-113521	Sorex araneus	89.34	0.00e+00	867.00
IUUC-Sbi-114764	Sorghum bicolor	48.36	1.00e-128	452.00
IUUC-Sre-115141	Sporisorium reilianum	66.54	4.00e-113	402.00
IUUC-Ssc-115732	Sus scrofa	99.81	0.00e+00	1004.00
IUUC-Tgu-117190	Taeniopygia guttata	92.70	0.00e+00	999.00
IUUC-Tru-118735	Takifugu rubripes	73.17	0.00e+00	829.00
IUUC-Tsy-119503	Tarsius syrichta	71.51	0.00e+00	750.00
IUUC-Tni-119833	Tetraodon nigroviridis	84.06	0.00e+00	944.00
IUUC-Tca-121386	Theobroma cacao	47.84	1.00e-125	443.00
IUUC-Tre-122070	Trichoderma reesei	49.21	1.00e-103	370.00
IUUC-Tvi-122305	Trichoderma virens	54.34	6.00e-102	365.00
IUUC-Tae-123515	Triticum aestivum	47.52	3.00e-125	441.00
IUUC-Tur-126416	Triticum urartu	46.60	3.00e-121	428.00
IUUC-Tme-127174	Tuber melanosporum	39.38	2.00e-68	253.00
IUUC-Tbe-127791	Tupaia belangeri	77.83	1.00e-102	366.00
IUUC-Ttr-129224	Tursiops truncatus	95.82	0.00e+00	1055.00
IUUC-Uma-129372	Ustilago maydis	66.18	4.00e-112	399.00
IUUC-Vda-129819	Verticillium dahliae	53.33	2.00e-85	310.00
IUUC-Vpa-130220	Vicugna pacos	74.52	0.00e+00	788.00
IUUC-Vvi-131649	Vitis vinifera	48.57	9.00e-126	443.00
IUUC-Xtr-132954	Xenopus tropicalis	75.27	0.00e+00	857.00
IUUC-Xma-134082	Xiphophorus maculatus	84.03	0.00e+00	872.00
IUUC-Yli-134422	Yarrowia lipolytica	43.10	2.00e-115	409.00
IUUC-Zma-135621	Zea mays	53.49	1.00e-121	430.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence