iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090296

Ensembl Protein ID

ENSOARP00000010285.1

UniProt Accession

W5PIL6; W5PIL6_SHEEP

Genbank Protein ID

ENSOARP00000010285

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AMGL01020380

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009587.1	ENSOART00000010438.1	ENSOARP00000010285.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.50e-99	332.2	1	321

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ + + +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTGNAGQRCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           6677788899********************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTAAK----EEDAF 163
           **************************************************************************999777....89*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           **************************9.78999*********..******************************976665567777777 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
             +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  tDQGSNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 321
           755568**********************************************************993...33344 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MTGNAGQRCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGGCA ATGCCGGGCA GAGGTGCCTC ATGGAGAGCG ACCCCGGGGT CTTCACCGAA 60
CTCATTAAAG GATTTGGTGA GAGCCAGGGG GGCAGGCCTG GGCCGGTGGC GGGTTACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101121952

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.13	3.00e-83	301.00
IUUC-Aml-001866	Ailuropoda melanoleuca	98.72	0.00e+00	645.00
IUUC-Atr-002966	Amborella trichopoda	46.84	2.00e-80	293.00
IUUC-Apl-003306	Anas platyrhynchos	86.03	3.00e-177	613.00
IUUC-Aca-004763	Anolis carolinensis	95.18	2.00e-178	618.00
IUUC-Aly-005581	Arabidopsis lyrata	48.48	2.00e-78	285.00
IUUC-Ath-007283	Arabidopsis thaliana	48.48	4.00e-81	294.00
IUUC-Ago-007999	Ashbya gossypii	33.66	1.00e-32	133.00
IUUC-Acl-008231	Aspergillus clavatus	42.74	8.00e-51	193.00
IUUC-Afl-008557	Aspergillus flavus	37.91	7.00e-53	200.00
IUUC-Afu-008988	Aspergillus fumigatus	44.58	9.00e-53	200.00
IUUC-Ani-009420	Aspergillus nidulans	37.50	4.00e-51	194.00
IUUC-Ang-009859	Aspergillus niger	40.41	1.00e-47	182.00
IUUC-Aor-010145	Aspergillus oryzae	37.91	7.00e-53	200.00
IUUC-Ate-010347	Aspergillus terreus	41.34	3.00e-51	195.00
IUUC-Ame-010791	Astyanax mexicanus	89.67	1.00e-180	625.00
IUUC-Bgr-012298	Blumeria graminis	37.17	2.00e-47	182.00
IUUC-Bta-013251	Bos taurus	99.04	0.00e+00	642.00
IUUC-Bci-013786	Botrytis cinerea	37.17	1.00e-55	210.00
IUUC-Bdi-014132	Brachypodium distachyon	48.92	2.00e-80	292.00
IUUC-Bol-015611	Brassica oleracea	49.85	1.00e-83	303.00
IUUC-Bra-017769	Brassica rapa	49.85	1.00e-83	302.00
IUUC-Cel-018604	Caenorhabditis elegans	46.82	2.00e-80	291.00
IUUC-Cja-019768	Callithrix jacchus	89.44	2.00e-179	621.00
IUUC-Cfa-020207	Canis familiaris	98.72	0.00e+00	645.00
IUUC-Cpo-021925	Cavia porcellus	94.57	2.00e-177	614.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.15	3.00e-72	265.00
IUUC-Csa-023958	Chlorocebus sabaeus	97.76	0.00e+00	635.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	53.87	5.00e-98	350.00
IUUC-Csv-026149	Ciona savignyi	57.05	6.00e-101	360.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.50	3.00e-51	195.00
IUUC-Cne-026955	Cryptococcus neoformans	37.57	3.00e-53	202.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.78	9.00e-47	180.00
IUUC-Dre-027409	Danio rerio	88.75	3.00e-177	613.00
IUUC-Dno-028921	Dasypus novemcinctus	98.08	0.00e+00	641.00
IUUC-Dse-031170	Dothistroma septosporum	39.24	1.00e-57	216.00
IUUC-Dme-031677	Drosophila melanogaster	59.16	3.00e-113	401.00
IUUC-Ete-032707	Echinops telfairi	68.34	9.00e-118	416.00
IUUC-Eca-033776	Equus caballus	98.96	1.00e-171	595.00
IUUC-Eeu-035305	Erinaceus europaeus	78.72	3.00e-82	298.00
IUUC-Fca-035846	Felis catus	90.88	0.00e+00	628.00
IUUC-Fal-037597	Ficedula albicollis	95.83	6.00e-160	556.00
IUUC-Fox-037670	Fusarium oxysporum	42.53	9.00e-54	203.00
IUUC-Fso-038243	Fusarium solani	42.53	4.00e-53	201.00
IUUC-Gmo-038499	Gadus morhua	83.39	4.00e-160	556.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.39	1.00e-46	179.00
IUUC-Gga-040904	Gallus gallus	94.19	0.00e+00	641.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.18	3.00e-169	587.00
IUUC-Gma-043030	Glycine max	48.51	3.00e-84	305.00
IUUC-Ggo-044699	Gorilla gorilla	92.18	1.00e-168	585.00
IUUC-Hsa-046227	Homo sapiens	98.08	0.00e+00	642.00
IUUC-Hvu-047359	Hordeum vulgare	47.56	7.00e-82	296.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.83	0.00e+00	626.00
IUUC-Lch-049829	Latimeria chalumnae	92.01	4.00e-174	603.00
IUUC-Lpe-050899	Leersia perrieri	48.42	6.00e-77	280.00
IUUC-Loc-052264	Lepisosteus oculatus	90.13	5.00e-172	596.00
IUUC-Lma-053110	Leptosphaeria maculans	38.41	3.00e-47	182.00
IUUC-Laf-053639	Loxodonta africana	98.72	0.00e+00	645.00
IUUC-Mcc-055506	Macaca mulatta	97.76	0.00e+00	635.00
IUUC-Mor-057001	Magnaporthe oryzae	44.96	4.00e-53	201.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	2.00e-31	128.00
IUUC-Mtr-057731	Medicago truncatula	49.40	2.00e-84	305.00
IUUC-Mla-059016	Melampsora laricipopulina	42.71	5.00e-42	163.00
IUUC-Mga-060178	Meleagris gallopavo	95.39	2.00e-174	604.00
IUUC-Mvi-060353	Microbotryum violaceum	37.91	8.00e-53	200.00
IUUC-Mmr-060738	Microcebus murinus	98.08	0.00e+00	642.00
IUUC-Mdo-062266	Monodelphis domestica	97.52	7.00e-119	419.00
IUUC-Mmu-063619	Mus musculus	96.17	0.00e+00	631.00
IUUC-Mac-065301	Musa acuminata	50.63	3.00e-87	315.00
IUUC-Mpu-066058	Mustela putorius furo	99.04	0.00e+00	647.00
IUUC-Mlu-067292	Myotis lucifugus	97.44	0.00e+00	632.00
IUUC-Nfi-068275	Neosartorya fischeri	37.82	9.00e-54	203.00
IUUC-Ncr-068713	Neurospora crassa	38.36	4.00e-56	211.00
IUUC-Nle-069013	Nomascus leucogenys	97.44	0.00e+00	632.00
IUUC-Opr-070628	Ochotona princeps	87.06	2.00e-172	598.00
IUUC-Ont-072688	Oreochromis niloticus	88.89	1.00e-169	588.00
IUUC-Oan-073004	Ornithorhynchus anatinus	97.53	6.00e-143	499.00
IUUC-Ocu-074303	Oryctolagus cuniculus	99.04	0.00e+00	649.00
IUUC-Oba-075002	Oryza barthii	48.34	4.00e-81	294.00
IUUC-Obr-076392	Oryza brachyantha	49.37	6.00e-79	287.00
IUUC-Ogl-077271	Oryza glaberrima	48.34	4.00e-81	294.00
IUUC-Ogu-078493	Oryza glumaepatula	48.34	9.00e-82	296.00
IUUC-Oin-080084	Oryza indica	48.34	9.00e-82	296.00
IUUC-Olo-080803	Oryza longistaminata	48.04	2.00e-81	295.00
IUUC-Ome-081146	Oryza meridionalis	47.43	3.00e-80	291.00
IUUC-Oni-082146	Oryza nivara	48.34	9.00e-82	296.00
IUUC-Opu-083633	Oryza punctata	49.05	9.00e-78	283.00
IUUC-Oru-084789	Oryza rufipogon	48.34	9.00e-82	296.00
IUUC-Osa-086196	Oryza sativa	48.34	9.00e-82	296.00
IUUC-Ola-087126	Oryzias latipes	88.82	4.00e-166	577.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.96	5.00e-68	251.00
IUUC-Oga-089140	Otolemur garnettii	89.71	4.00e-180	623.00
IUUC-Ptr-090566	Pan troglodytes	98.08	0.00e+00	642.00
IUUC-Pan-092052	Papio anubis	97.76	0.00e+00	634.00
IUUC-Psi-093723	Pelodiscus sinensis	95.49	4.00e-166	577.00
IUUC-Pma-094568	Petromyzon marinus	61.46	4.00e-107	380.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.27	7.00e-49	187.00
IUUC-Ppa-095761	Physcomitrella patens	47.80	2.00e-83	301.00
IUUC-Pfo-096210	Poecilia formosa	88.18	7.00e-170	589.00
IUUC-Pab-098463	Pongo abelii	98.08	0.00e+00	641.00
IUUC-Pop-099423	Populus trichocarpa	49.11	9.00e-84	303.00
IUUC-Pca-100108	Procavia capensis	96.34	3.00e-141	494.00
IUUC-Ppe-101176	Prunus persica	51.06	6.00e-85	307.00
IUUC-Pva-102629	Pteropus vampyrus	95.42	3.00e-147	514.00
IUUC-Pgr-103419	Puccinia graminis	39.58	1.00e-55	209.00
IUUC-Pte-104207	Pyrenophora teres	44.38	1.00e-31	129.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.34	6.00e-56	210.00
IUUC-Rno-105579	Rattus norvegicus	86.69	6.00e-163	566.00
IUUC-Sha-106894	Sarcophilus harrisii	94.20	3.00e-156	544.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.26	3.00e-58	218.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.00	2.00e-58	219.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.04	3.00e-47	181.00
IUUC-Smo-109396	Selaginella moellendorffii	51.23	5.00e-87	314.00
IUUC-Sit-110630	Setaria italica	49.39	8.00e-85	306.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	5.00e-81	293.00
IUUC-Stu-112185	Solanum tuberosum	49.55	7.00e-88	317.00
IUUC-Sar-113294	Sorex araneus	82.34	2.00e-163	568.00
IUUC-Sbi-113951	Sorghum bicolor	49.69	3.00e-85	308.00
IUUC-Ssc-115501	Sus scrofa	98.32	1.00e-175	608.00
IUUC-Tgu-117152	Taeniopygia guttata	95.49	6.00e-160	556.00
IUUC-Tru-118388	Takifugu rubripes	87.86	2.00e-169	588.00
IUUC-Tsy-119109	Tarsius syrichta	98.40	0.00e+00	642.00
IUUC-Tni-120048	Tetraodon nigroviridis	87.86	5.00e-170	589.00
IUUC-Tca-121750	Theobroma cacao	48.96	2.00e-87	315.00
IUUC-Tre-122130	Trichoderma reesei	39.00	5.00e-54	204.00
IUUC-Tvi-122284	Trichoderma virens	39.20	2.00e-51	196.00
IUUC-Tae-124082	Triticum aestivum	47.73	2.00e-82	299.00
IUUC-Tur-126366	Triticum urartu	42.72	4.00e-66	245.00
IUUC-Tme-127187	Tuber melanosporum	41.25	9.00e-57	213.00
IUUC-Tbe-127619	Tupaia belangeri	89.90	5.00e-145	506.00
IUUC-Ttr-128867	Tursiops truncatus	87.76	3.00e-124	437.00
IUUC-Vda-129912	Verticillium dahliae	37.04	5.00e-51	194.00
IUUC-Vpa-130552	Vicugna pacos	98.56	1.00e-124	439.00
IUUC-Vvi-130881	Vitis vinifera	50.89	7.00e-84	303.00
IUUC-Xtr-131934	Xenopus tropicalis	85.41	1.00e-172	598.00
IUUC-Xma-133312	Xiphophorus maculatus	88.18	1.00e-169	588.00
IUUC-Yli-134487	Yarrowia lipolytica	40.43	1.00e-47	182.00
IUUC-Zma-135462	Zea mays	43.79	2.00e-70	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence