iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117519

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01042185

Gene Name

USP48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000002183.1	ENSTGUT00000002286.1	ENSTGUP00000002266.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-65	220.8	45	376
ULD/UDP/UBQ/UBQ_Other	8.80e-10	38.2	907	964

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.......kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkea 81
           +Gl+Nlg+tCY+N  LQ+ +   elr++l           +++  +++ ++ +++ ++  q+lf +   +  ++  sp+ ++k l++  
   Q: 45   VGLTNLGATCYVNTFLQMWFLNLELRQALYLcpsacgdGVPKDAGAKEADQGHQRAVERGQNLFVSGRgEPGQERKSPSWVIKGLES-- 131
           6*****************************966666665555555555577777899999999987767888888899988888874.. PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
              s+   +DaqEf + +++ le++l                       +++k+   ++++++ F g++   ++c++c+++s+  ++f+
   Q: 132  ---STGGAEDAQEFSKLFMSLLEDTL-----------------------SKQKNPDVRNIVQKQFCGEYAYVTVCNQCGRESKLVSKFY 194
           ...467799*****************.......................457889999******************************* PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleL 259
           +l+l+++g++     +l+dc+ +f kee+leg+n+y+ce+c++kq+a++k++l +lP +L l+L+Rf f++++++++k+n+++ f + L
   Q: 195  ELELNIQGHK-----QLTDCITEFLKEEKLEGDNRYFCETCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSELL 278
           **********.....9**********************************************************************99* PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg................... 327
           d++pf+++++      + YeL+av++H G s+ sGHY+a+vk+ + + W++f+D+ +++++ ++ +   +                   
   Q: 279  DMEPFMEQKNG----VYVYELSAVLIHRGvSAYSGHYIAHVKDPQTGeWYKFNDEDIEKMEGKKLQLGIEedlaepsksqtrkpkcgkg 363
           ********553....79**************************55555************9999998665999**************** PP
   S: 328  ....staYvlfYk 336
               ++aY+l+Y+
   Q: 364  thcsRNAYMLVYR 376
           ************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 17   vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllekks 74
           v+   t +eLK +i +++++p  +q+L ++GkiL +d  tL+++g+ ++s+i+l  +++
   Q: 907  VSANQTLKELKIQIMHAFSVP-FDQNLSLEGKILsDDTATLGSLGVIPESVILLKADEP 964
           88899****************.99*****************************988775 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

RRNCRGNPNC LVGIGEHAWL GEIDENSFHN IDDPNCERRK KNAFVGLTNL GATCYVNTFL 60
QMWFLNLELR QALYLCPSAC GDGVPKDAGA KEADQGHQRA VERGQNLFVS GRGEPGQERK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGGAACT GCCGGGGGAA CCCCAACTGC CTGGTGGGCA TCGGGGAGCA CGCCTGGCTG 60
GGCGAGATCG ACGAGAACAG CTTCCACAAC ATCGACGACC CCAACTGCGA GCGCCGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	31.64	7.00e-68	252.00
IUUC-Aml-001357	Ailuropoda melanoleuca	84.31	0.00e+00	1672.00
IUUC-Atr-002976	Amborella trichopoda	29.82	2.00e-66	246.00
IUUC-Apl-003773	Anas platyrhynchos	91.98	0.00e+00	1731.00
IUUC-Aca-004466	Anolis carolinensis	78.98	0.00e+00	832.00
IUUC-Aly-006249	Arabidopsis lyrata	29.64	2.00e-62	234.00
IUUC-Ath-006700	Arabidopsis thaliana	30.72	9.00e-71	261.00
IUUC-Ame-011554	Astyanax mexicanus	64.54	0.00e+00	1281.00
IUUC-Bta-012573	Bos taurus	83.94	0.00e+00	1671.00
IUUC-Bdi-014149	Brachypodium distachyon	31.67	4.00e-71	263.00
IUUC-Bol-016289	Brassica oleracea	29.14	3.00e-70	259.00
IUUC-Bra-017494	Brassica rapa	31.97	3.00e-73	270.00
IUUC-Cel-018662	Caenorhabditis elegans	28.53	1.00e-28	122.00
IUUC-Cja-019991	Callithrix jacchus	83.33	0.00e+00	1670.00
IUUC-Cfa-020294	Canis familiaris	84.41	0.00e+00	1700.00
IUUC-Cpo-021706	Cavia porcellus	82.39	0.00e+00	1659.00
IUUC-Cre-022636	Chlamydomonas reinhardtii	31.25	1.00e-38	156.00
IUUC-Csa-023931	Chlorocebus sabaeus	84.31	0.00e+00	1684.00
IUUC-Cho-024566	Choloepus hoffmanni	86.28	2.00e-137	483.00
IUUC-Cin-025307	Ciona intestinalis	46.21	6.00e-60	223.00
IUUC-Csv-026006	Ciona savignyi	35.62	4.00e-136	478.00
IUUC-Cne-027065	Cryptococcus neoformans	26.60	2.00e-58	221.00
IUUC-Dre-027624	Danio rerio	65.31	0.00e+00	1322.00
IUUC-Dno-029633	Dasypus novemcinctus	87.03	0.00e+00	1108.00
IUUC-Dor-030809	Dipodomys ordii	62.82	0.00e+00	924.00
IUUC-Ete-032818	Echinops telfairi	77.36	0.00e+00	788.00
IUUC-Eca-033692	Equus caballus	84.81	0.00e+00	1691.00
IUUC-Eeu-035185	Erinaceus europaeus	66.12	0.00e+00	690.00
IUUC-Fca-035676	Felis catus	84.21	0.00e+00	1697.00
IUUC-Fal-036913	Ficedula albicollis	94.56	0.00e+00	1860.00
IUUC-Gmo-038532	Gadus morhua	61.78	0.00e+00	1244.00
IUUC-Gga-041041	Gallus gallus	92.17	0.00e+00	1810.00
IUUC-Gac-042570	Gasterosteus aculeatus	63.00	0.00e+00	1285.00
IUUC-Gma-044136	Glycine max	29.46	6.00e-82	298.00
IUUC-Ggo-045367	Gorilla gorilla	79.84	0.00e+00	1560.00
IUUC-Hsa-046019	Homo sapiens	84.31	0.00e+00	1684.00
IUUC-Hvu-047303	Hordeum vulgare	32.48	5.00e-53	201.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	81.84	0.00e+00	1660.00
IUUC-Lch-049989	Latimeria chalumnae	73.11	0.00e+00	1470.00
IUUC-Lpe-051612	Leersia perrieri	33.04	1.00e-67	251.00
IUUC-Loc-052756	Lepisosteus oculatus	67.86	0.00e+00	1382.00
IUUC-Laf-054043	Loxodonta africana	83.40	0.00e+00	1676.00
IUUC-Mcc-054986	Macaca mulatta	82.95	0.00e+00	1664.00
IUUC-Meu-056228	Macropus eugenii	71.50	0.00e+00	783.00
IUUC-Mtr-058610	Medicago truncatula	28.91	2.00e-69	257.00
IUUC-Mga-059896	Meleagris gallopavo	91.22	0.00e+00	1785.00
IUUC-Mvi-060269	Microbotryum violaceum	34.29	2.00e-51	197.00
IUUC-Mmr-060887	Microcebus murinus	84.21	0.00e+00	1680.00
IUUC-Mdo-062506	Monodelphis domestica	84.71	0.00e+00	1696.00
IUUC-Mmu-063642	Mus musculus	80.93	0.00e+00	1635.00
IUUC-Mac-064896	Musa acuminata	31.02	2.00e-67	250.00
IUUC-Mpu-066194	Mustela putorius furo	84.61	0.00e+00	1685.00
IUUC-Mlu-067233	Myotis lucifugus	83.70	0.00e+00	1676.00
IUUC-Nle-069052	Nomascus leucogenys	83.20	0.00e+00	1668.00
IUUC-Opr-070890	Ochotona princeps	81.09	0.00e+00	967.00
IUUC-Ont-071450	Oreochromis niloticus	61.52	0.00e+00	1228.00
IUUC-Oan-073252	Ornithorhynchus anatinus	85.67	0.00e+00	992.00
IUUC-Ocu-073796	Oryctolagus cuniculus	83.37	0.00e+00	1503.00
IUUC-Oba-075563	Oryza barthii	32.39	3.00e-70	259.00
IUUC-Obr-076394	Oryza brachyantha	32.50	2.00e-69	257.00
IUUC-Ogl-077339	Oryza glaberrima	41.28	2.00e-30	125.00
IUUC-Ogu-079007	Oryza glumaepatula	35.02	2.00e-64	240.00
IUUC-Oin-079997	Oryza indica	32.39	2.00e-70	260.00
IUUC-Olo-080364	Oryza longistaminata	33.04	4.00e-70	259.00
IUUC-Ome-081165	Oryza meridionalis	34.28	1.00e-64	241.00
IUUC-Oni-083026	Oryza nivara	32.39	2.00e-70	260.00
IUUC-Opu-083284	Oryza punctata	35.80	4.00e-64	239.00
IUUC-Oru-084797	Oryza rufipogon	33.04	2.00e-70	260.00
IUUC-Osa-086221	Oryza sativa	41.28	2.00e-30	125.00
IUUC-Ola-086568	Oryzias latipes	63.76	0.00e+00	1293.00
IUUC-Oga-088687	Otolemur garnettii	83.02	0.00e+00	1665.00
IUUC-Oar-090345	Ovis aries	84.14	0.00e+00	1670.00
IUUC-Ptr-090734	Pan troglodytes	84.41	0.00e+00	1685.00
IUUC-Pan-091704	Papio anubis	81.04	0.00e+00	1600.00
IUUC-Psi-092937	Pelodiscus sinensis	88.54	0.00e+00	1608.00
IUUC-Ppa-095808	Physcomitrella patens	27.39	1.00e-59	224.00
IUUC-Pab-098129	Pongo abelii	84.41	0.00e+00	1686.00
IUUC-Pop-099494	Populus trichocarpa	29.93	2.00e-67	250.00
IUUC-Pca-100647	Procavia capensis	79.79	2.00e-134	473.00
IUUC-Ppe-102091	Prunus persica	27.43	3.00e-68	253.00
IUUC-Pva-102719	Pteropus vampyrus	84.31	0.00e+00	1677.00
IUUC-Rno-105363	Rattus norvegicus	82.39	0.00e+00	1657.00
IUUC-Sha-107620	Sarcophilus harrisii	82.19	0.00e+00	1654.00
IUUC-Smo-109487	Selaginella moellendorffii	27.31	7.00e-71	261.00
IUUC-Sit-110683	Setaria italica	28.37	1.00e-69	258.00
IUUC-Sly-111377	Solanum lycopersicum	30.78	7.00e-67	248.00
IUUC-Stu-111969	Solanum tuberosum	30.92	8.00e-58	217.00
IUUC-Sar-113099	Sorex araneus	85.91	0.00e+00	1505.00
IUUC-Sbi-113833	Sorghum bicolor	39.00	7.00e-47	180.00
IUUC-Ssc-115279	Sus scrofa	79.76	0.00e+00	1187.00
IUUC-Tru-117651	Takifugu rubripes	63.34	0.00e+00	1275.00
IUUC-Tsy-119201	Tarsius syrichta	81.24	0.00e+00	1563.00
IUUC-Tni-120840	Tetraodon nigroviridis	64.49	0.00e+00	1291.00
IUUC-Tca-121674	Theobroma cacao	29.73	1.00e-74	274.00
IUUC-Tae-125247	Triticum aestivum	27.88	6.00e-69	256.00
IUUC-Tur-126599	Triticum urartu	32.01	6.00e-67	249.00
IUUC-Tbe-127782	Tupaia belangeri	73.76	0.00e+00	1394.00
IUUC-Ttr-128312	Tursiops truncatus	83.20	0.00e+00	1650.00
IUUC-Vpa-130348	Vicugna pacos	84.09	0.00e+00	1675.00
IUUC-Vvi-131353	Vitis vinifera	31.32	5.00e-73	269.00
IUUC-Xtr-132172	Xenopus tropicalis	67.23	0.00e+00	1242.00
IUUC-Xma-133263	Xiphophorus maculatus	64.09	0.00e+00	1255.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence