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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045683
UUCD1 version UUC-HoS-00096
Ensembl Protein ID ENSP00000362592.4
UniProt Accession Q09028; B2R6G9; B4DRH0; D3DPQ3; P31149; Q53H02; Q96BV9; RBBP4_HUMAN
Genbank Protein ID CAA52321.1; CAA50685.1; AAP35973.1; BAG61282.1; BAG35466.1; BAD96499.1; EAX07513.1; EAX07514.1; AAH03092.1; AAH15123.1; AAH53904.1; AAH75836.1
Protein Name Histone-binding protein RBBP4; Chromatin assembly factor 1 subunit C; Chromatin assembly factor I p48 subunit; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; Retinoblastoma-binding protein p48
Genbank Nucleotide ID X74262; X71810; BT007309; AK299251; AK312571; AK222779; AC114489; CH471059; BC003092; BC015123; BC053904; BC075836
Gene Name RBBP4; RBAP48
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162521.18 ENST00000414241.7 ENSP00000398242.3
ENSG00000162521.18 ENST00000373493.9 ENSP00000362592.4
ENSG00000162521.18 ENST00000527118.5 ENSP00000432780.1
ENSG00000162521.18 ENST00000526193.5 ENSP00000434925.1
ENSG00000162521.18 ENST00000373485.5 ENSP00000362584.1
ENSG00000162521.18 ENST00000477563.6 ENSP00000432774.1
ENSG00000162521.18 ENST00000475321.5 ENSP00000436986.1
ENSG00000162521.18 ENST00000463378.5 ENSP00000433805.1
ENSG00000162521.18 ENST00000482190.1 ENSP00000436565.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-36 124.9 272 306
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 272  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 306
           **********96554568*************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Protein Sequence
(Fasta)
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPEGKD 60
FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045683|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGAGCGCTC CCATTGGCTG ATGTTGGCGC GAAGGTGCGC GAGTCAGCCC TCGCGCTGGG 60
GGCGCAGGAA ACAATAGAGG CCGCGCGCAC AGAGCGAGCT CTTGCAGCCT CCCCGCCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045683|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0033186--C:CAF-1 complex
GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0016589--C:NURF complex
GO:0043234--C:protein complex
GO:0016580--C:Sin3 complex
GO:0042393--F:histone binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0007049--P:cell cycle
GO:0034080--P:CENP-A containing nucleosome assembly
GO:0031497--P:chromatin assembly
GO:0006338--P:chromatin remodeling
GO:0006260--P:DNA replication
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0008285--P:negative regulation of cell proliferation
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0051726--P:regulation of cell cycle
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006355--P:regulation of transcription, DNA-templated
GO:0060416--P:response to growth hormone
GO:0006351--P:transcription, DNA-templated
KEGG hsa:5928
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 60.29 9.00e-141 493.00
IUUC-Aml-001339 Ailuropoda melanoleuca 99.29 0.00e+00 855.00
IUUC-Atr-003075 Amborella trichopoda 67.87 3.00e-171 594.00
IUUC-Apl-003952 Anas platyrhynchos 100.00 0.00e+00 868.00
IUUC-Aca-004508 Anolis carolinensis 98.82 0.00e+00 870.00
IUUC-Aly-006342 Arabidopsis lyrata 68.00 8.00e-166 576.00
IUUC-Ath-006855 Arabidopsis thaliana 68.25 4.00e-166 577.00
IUUC-Ago-007892 Ashbya gossypii 38.77 1.00e-79 290.00
IUUC-Acl-008163 Aspergillus clavatus 53.03 3.00e-125 441.00
IUUC-Afl-008645 Aspergillus flavus 52.99 4.00e-124 437.00
IUUC-Afu-009091 Aspergillus fumigatus 53.28 3.00e-125 441.00
IUUC-Ani-009478 Aspergillus nidulans 48.74 2.00e-103 369.00
IUUC-Ang-009707 Aspergillus niger 52.53 2.00e-120 425.00
IUUC-Aor-010028 Aspergillus oryzae 52.99 4.00e-124 437.00
IUUC-Ate-010416 Aspergillus terreus 51.34 3.00e-124 438.00
IUUC-Ame-010598 Astyanax mexicanus 96.93 0.00e+00 856.00
IUUC-Bgr-012001 Blumeria graminis 49.51 7.00e-108 384.00
IUUC-Bta-012851 Bos taurus 100.00 0.00e+00 879.00
IUUC-Bci-013815 Botrytis cinerea 50.12 3.00e-125 441.00
IUUC-Bdi-014926 Brachypodium distachyon 68.06 6.00e-164 570.00
IUUC-Bol-015856 Brassica oleracea 68.15 1.00e-165 576.00
IUUC-Bra-016725 Brassica rapa 63.00 1.00e-161 562.00
IUUC-Cel-018587 Caenorhabditis elegans 72.51 0.00e+00 631.00
IUUC-Cja-019884 Callithrix jacchus 100.00 0.00e+00 879.00
IUUC-Cfa-020343 Canis familiaris 100.00 0.00e+00 879.00
IUUC-Cpo-021591 Cavia porcellus 100.00 0.00e+00 879.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 62.08 3.00e-157 548.00
IUUC-Cho-024506 Choloepus hoffmanni 99.53 0.00e+00 870.00
IUUC-Cin-025589 Ciona intestinalis 89.18 0.00e+00 802.00
IUUC-Csv-026216 Ciona savignyi 90.19 0.00e+00 806.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 48.55 2.00e-118 419.00
IUUC-Cne-026792 Cryptococcus neoformans 55.64 2.00e-134 472.00
IUUC-Cme-027307 Cyanidioschyzon merolae 52.20 7.00e-129 454.00
IUUC-Dre-028742 Danio rerio 97.41 0.00e+00 858.00
IUUC-Dno-029114 Dasypus novemcinctus 100.00 0.00e+00 879.00
IUUC-Dse-031282 Dothistroma septosporum 47.15 2.00e-102 366.00
IUUC-Dme-032126 Drosophila melanogaster 91.93 0.00e+00 800.00
IUUC-Ete-032731 Echinops telfairi 100.00 0.00e+00 879.00
IUUC-Eca-033533 Equus caballus 98.57 0.00e+00 850.00
IUUC-Eeu-034644 Erinaceus europaeus 100.00 2.00e-130 459.00
IUUC-Fca-036202 Felis catus 100.00 0.00e+00 879.00
IUUC-Fal-037084 Ficedula albicollis 100.00 0.00e+00 869.00
IUUC-Fox-037974 Fusarium oxysporum 50.12 2.00e-123 435.00
IUUC-Fso-038246 Fusarium solani 48.32 5.00e-111 394.00
IUUC-Gmo-039214 Gadus morhua 97.16 0.00e+00 848.00
IUUC-Ggr-039741 Gaeumannomyces graminis 50.36 6.00e-119 421.00
IUUC-Gga-040396 Gallus gallus 100.00 0.00e+00 879.00
IUUC-Gac-041389 Gasterosteus aculeatus 95.75 0.00e+00 840.00
IUUC-Gma-042791 Glycine max 68.17 9.00e-164 569.00
IUUC-Ggo-045422 Gorilla gorilla 91.59 0.00e+00 782.00
IUUC-Hvu-047457 Hordeum vulgare 67.18 3.00e-76 277.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 100.00 0.00e+00 879.00
IUUC-Kpa-049119 Komagataella pastoris 37.19 3.00e-72 265.00
IUUC-Lch-050545 Latimeria chalumnae 93.38 0.00e+00 824.00
IUUC-Lpe-051337 Leersia perrieri 68.55 8.00e-165 573.00
IUUC-Loc-052473 Lepisosteus oculatus 97.88 0.00e+00 863.00
IUUC-Lma-053275 Leptosphaeria maculans 45.33 4.00e-69 254.00
IUUC-Laf-054114 Loxodonta africana 100.00 0.00e+00 879.00
IUUC-Mcc-055648 Macaca mulatta 99.76 0.00e+00 872.00
IUUC-Meu-056490 Macropus eugenii 100.00 0.00e+00 879.00
IUUC-Mor-056947 Magnaporthe oryzae 50.96 2.00e-117 416.00
IUUC-Mpo-057602 Magnaporthe poae 49.64 3.00e-118 418.00
IUUC-Mtr-057853 Medicago truncatula 67.00 2.00e-161 562.00
IUUC-Mla-058884 Melampsora laricipopulina 52.67 7.00e-128 450.00
IUUC-Mga-059452 Meleagris gallopavo 100.00 0.00e+00 869.00
IUUC-Mvi-060450 Microbotryum violaceum 57.52 5.00e-137 481.00
IUUC-Mmr-060678 Microcebus murinus 99.75 0.00e+00 830.00
IUUC-Mdo-062450 Monodelphis domestica 99.51 0.00e+00 838.00
IUUC-Mmu-063282 Mus musculus 100.00 0.00e+00 879.00
IUUC-Mac-065480 Musa acuminata 67.25 5.00e-162 563.00
IUUC-Mpu-066529 Mustela putorius furo 99.06 0.00e+00 872.00
IUUC-Mlu-068072 Myotis lucifugus 100.00 0.00e+00 879.00
IUUC-Nfi-068374 Neosartorya fischeri 53.28 8.00e-122 430.00
IUUC-Ncr-068794 Neurospora crassa 48.04 4.00e-115 408.00
IUUC-Nle-069577 Nomascus leucogenys 100.00 0.00e+00 879.00
IUUC-Opr-070245 Ochotona princeps 84.47 0.00e+00 697.00
IUUC-Ont-071809 Oreochromis niloticus 96.70 0.00e+00 855.00
IUUC-Oan-072839 Ornithorhynchus anatinus 99.76 0.00e+00 864.00
IUUC-Ocu-074515 Oryctolagus cuniculus 94.12 0.00e+00 764.00
IUUC-Oba-075719 Oryza barthii 57.82 9.00e-137 480.00
IUUC-Obr-076859 Oryza brachyantha 68.14 6.00e-163 566.00
IUUC-Ogl-077920 Oryza glaberrima 68.06 1.00e-164 572.00
IUUC-Ogu-078048 Oryza glumaepatula 57.82 6.00e-136 478.00
IUUC-Oin-079960 Oryza indica 56.27 3.00e-124 439.00
IUUC-Olo-080553 Oryza longistaminata 55.45 2.00e-132 466.00
IUUC-Ome-081835 Oryza meridionalis 68.06 3.00e-165 575.00
IUUC-Oni-082494 Oryza nivara 57.58 6.00e-135 474.00
IUUC-Opu-083913 Oryza punctata 65.36 2.00e-153 535.00
IUUC-Oru-084666 Oryza rufipogon 68.06 1.00e-164 572.00
IUUC-Osa-085884 Oryza sativa 68.06 1.00e-164 572.00
IUUC-Ola-086664 Oryzias latipes 96.47 0.00e+00 849.00
IUUC-Olu-087579 Ostreococcus lucimarinus 63.43 1.00e-145 509.00
IUUC-Oga-088364 Otolemur garnettii 91.10 0.00e+00 791.00
IUUC-Oar-089652 Ovis aries 100.00 0.00e+00 879.00
IUUC-Psi-093300 Pelodiscus sinensis 100.00 0.00e+00 806.00
IUUC-Pma-094307 Petromyzon marinus 93.78 0.00e+00 824.00
IUUC-Pno-095153 Phaeosphaeria nodorum 48.43 2.00e-109 389.00
IUUC-Ppa-095800 Physcomitrella patens 68.17 1.00e-169 589.00
IUUC-Pfo-097376 Poecilia formosa 96.47 0.00e+00 850.00
IUUC-Pab-097697 Pongo abelii 100.00 0.00e+00 879.00
IUUC-Pop-099709 Populus trichocarpa 65.70 2.00e-166 578.00
IUUC-Pca-100642 Procavia capensis 89.85 0.00e+00 737.00
IUUC-Ppe-101212 Prunus persica 66.50 7.00e-165 573.00
IUUC-Pva-102253 Pteropus vampyrus 100.00 0.00e+00 879.00
IUUC-Pgr-103441 Puccinia graminis 54.22 5.00e-123 434.00
IUUC-Pte-104332 Pyrenophora teres 48.90 5.00e-112 397.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 48.90 6.00e-112 397.00
IUUC-Rno-105678 Rattus norvegicus 100.00 0.00e+00 879.00
IUUC-Sce-106364 Saccharomyces cerevisiae 37.84 3.00e-71 262.00
IUUC-Sha-106663 Sarcophilus harrisii 100.00 0.00e+00 869.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 47.79 2.00e-106 379.00
IUUC-Spo-108145 Schizosaccharomyces pombe 52.22 1.00e-119 423.00
IUUC-Smo-109159 Selaginella moellendorffii 65.45 3.00e-164 571.00
IUUC-Sit-110144 Setaria italica 68.00 2.00e-155 542.00
IUUC-Sly-111680 Solanum lycopersicum 66.18 3.00e-166 578.00
IUUC-Stu-111931 Solanum tuberosum 65.94 7.00e-165 573.00
IUUC-Sbi-114637 Sorghum bicolor 68.25 5.00e-163 567.00
IUUC-Sre-114980 Sporisorium reilianum 54.29 2.00e-137 482.00
IUUC-Ssc-115711 Sus scrofa 100.00 0.00e+00 806.00
IUUC-Tgu-116925 Taeniopygia guttata 99.76 0.00e+00 868.00
IUUC-Tru-117549 Takifugu rubripes 96.01 0.00e+00 844.00
IUUC-Tni-120398 Tetraodon nigroviridis 96.01 0.00e+00 848.00
IUUC-Tca-121841 Theobroma cacao 68.25 1.00e-165 575.00
IUUC-Tre-122190 Trichoderma reesei 50.36 2.00e-115 409.00
IUUC-Tvi-122304 Trichoderma virens 49.64 1.00e-123 436.00
IUUC-Tae-124648 Triticum aestivum 67.32 9.00e-156 543.00
IUUC-Tur-126850 Triticum urartu 63.55 4.00e-117 414.00
IUUC-Tme-126949 Tuber melanosporum 54.89 2.00e-129 455.00
IUUC-Uma-129424 Ustilago maydis 53.15 2.00e-137 482.00
IUUC-Vda-129873 Verticillium dahliae 49.88 5.00e-125 441.00
IUUC-Vpa-130079 Vicugna pacos 99.53 0.00e+00 873.00
IUUC-Vvi-131585 Vitis vinifera 67.25 2.00e-163 568.00
IUUC-Xma-133066 Xiphophorus maculatus 96.70 0.00e+00 855.00
IUUC-Yli-134334 Yarrowia lipolytica 39.43 1.00e-80 293.00
IUUC-Zma-135710 Zea mays 67.50 5.00e-156 543.00
Created Date 25-Jun-2017

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