iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045611

UUCD1 version

UUC-GoG-01041

Ensembl Protein ID

ENSGGOP00000005939.2

UniProt Accession

G3QTC6; G3QTC6_GORGO

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000006065.2	ENSGGOT00000006097.2	ENSGGOP00000005939.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.40e-132	441.3	13	528

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaG...vgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnp 86
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G   +gs+t++D+++v+ ++ +++F+++++++gk++Ae+a+e+l+eln+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGnvgIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNS 101
           ***************************************753227******************************************** PP
   S: 87   dvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqkti 171
           dv+++++ees+++l ++++ Ff++f+vVv+++ +++++++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++
   Q: 102  DVSGSFVEESPENLLDNDPsFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDK 190
           ***************************************************************************************** PP
   S: 172  Pfctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkaf 245
           Pf++l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+
   Q: 191  PFPELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTAL 279
           ********99999999998***********************************************9********************** PP
   S: 246  akttins.ikqllksfecdivtkskspfwv........................................................... 274
           ++t+i+s i++++++++c ++t+++++fw+                                                           
   Q: 280  NTTQIPSsIEDIFNDDRCINITQQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakll 368
           ***************************************************************************************** PP
   S: 275  ................sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds 331
                            +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+
   Q: 369  qsigqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDI 457
           ****************99********7777777888888**************9*********************************** PP
   S: 332  ..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
             + +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  gkLKSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 528
           999********....********************************************************9776 PP

Organism

Gorilla gorilla

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGNVGIGSF 60
TIIDGNQVSG EDAGNNFFLQ RSSIGKNRAE AAMEFLQELN SDVSGSFVEE SPENLLDNDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCGCCTG CGCGCTTGTG GAGCTGGTGG CGGCGCTCCG CAGGGGCTCG GCTGTTTTCC 60
GCGCGGCAGG CGCGGCCATG GCGCAGCTGG GGAAGCTGCT CAAGGAGCAG AAGTACGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.29	3.00e-124	438.00
IUUC-Aml-002333	Ailuropoda melanoleuca	96.66	0.00e+00	1079.00
IUUC-Atr-002644	Amborella trichopoda	41.03	2.00e-112	399.00
IUUC-Apl-003446	Anas platyrhynchos	83.52	0.00e+00	914.00
IUUC-Aca-004450	Anolis carolinensis	80.04	0.00e+00	914.00
IUUC-Aly-006187	Arabidopsis lyrata	40.23	3.00e-123	435.00
IUUC-Ath-007600	Arabidopsis thaliana	40.80	1.00e-124	440.00
IUUC-Ago-007900	Ashbya gossypii	26.92	3.00e-38	152.00
IUUC-Acl-008333	Aspergillus clavatus	34.86	5.00e-81	295.00
IUUC-Afl-008529	Aspergillus flavus	36.35	2.00e-85	309.00
IUUC-Afu-009071	Aspergillus fumigatus	33.87	4.00e-81	295.00
IUUC-Ani-009443	Aspergillus nidulans	33.87	2.00e-78	286.00
IUUC-Ang-009669	Aspergillus niger	33.51	2.00e-81	296.00
IUUC-Aor-009914	Aspergillus oryzae	35.68	3.00e-82	299.00
IUUC-Ate-010450	Aspergillus terreus	34.70	3.00e-83	302.00
IUUC-Ame-011183	Astyanax mexicanus	71.80	0.00e+00	827.00
IUUC-Bgr-012111	Blumeria graminis	33.15	2.00e-65	243.00
IUUC-Bta-012583	Bos taurus	97.21	0.00e+00	1086.00
IUUC-Bci-013892	Botrytis cinerea	33.15	3.00e-64	239.00
IUUC-Bdi-014592	Brachypodium distachyon	43.07	8.00e-127	447.00
IUUC-Bol-016399	Brassica oleracea	39.70	6.00e-122	431.00
IUUC-Bra-017506	Brassica rapa	38.83	1.00e-117	416.00
IUUC-Cel-018456	Caenorhabditis elegans	35.96	4.00e-93	335.00
IUUC-Cja-020007	Callithrix jacchus	98.51	0.00e+00	1105.00
IUUC-Cfa-020324	Canis familiaris	97.21	0.00e+00	1084.00
IUUC-Cpo-022248	Cavia porcellus	65.99	0.00e+00	640.00
IUUC-Csa-023149	Chlorocebus sabaeus	99.34	0.00e+00	937.00
IUUC-Cho-024537	Choloepus hoffmanni	85.47	0.00e+00	809.00
IUUC-Cin-025763	Ciona intestinalis	49.26	3.00e-155	541.00
IUUC-Csv-026113	Ciona savignyi	46.41	1.00e-145	509.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.48	6.00e-64	238.00
IUUC-Cne-026884	Cryptococcus neoformans	29.91	8.00e-71	261.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.75	9.00e-18	85.10
IUUC-Dre-028140	Danio rerio	73.12	0.00e+00	847.00
IUUC-Dno-030033	Dasypus novemcinctus	97.27	0.00e+00	961.00
IUUC-Dor-030513	Dipodomys ordii	68.69	1.00e-115	409.00
IUUC-Dse-031536	Dothistroma septosporum	35.28	2.00e-84	306.00
IUUC-Dme-031683	Drosophila melanogaster	44.03	2.00e-125	442.00
IUUC-Ete-032420	Echinops telfairi	82.66	0.00e+00	882.00
IUUC-Eca-033992	Equus caballus	97.98	0.00e+00	919.00
IUUC-Eeu-034713	Erinaceus europaeus	79.92	4.00e-118	418.00
IUUC-Fca-036548	Felis catus	96.09	0.00e+00	1073.00
IUUC-Fal-037600	Ficedula albicollis	80.38	0.00e+00	884.00
IUUC-Fox-038037	Fusarium oxysporum	33.69	9.00e-76	277.00
IUUC-Fso-038387	Fusarium solani	34.58	2.00e-77	283.00
IUUC-Gmo-038562	Gadus morhua	71.00	0.00e+00	820.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.11	5.00e-72	265.00
IUUC-Gga-041129	Gallus gallus	83.83	0.00e+00	935.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.28	0.00e+00	830.00
IUUC-Gma-043610	Glycine max	41.21	8.00e-119	420.00
IUUC-Hsa-046563	Homo sapiens	99.07	0.00e+00	1103.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	3.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	97.39	0.00e+00	1087.00
IUUC-Kpa-049309	Komagataella pastoris	35.47	2.00e-81	296.00
IUUC-Lch-050038	Latimeria chalumnae	76.17	0.00e+00	852.00
IUUC-Lpe-051535	Leersia perrieri	41.20	9.00e-110	390.00
IUUC-Loc-051917	Lepisosteus oculatus	69.56	0.00e+00	801.00
IUUC-Lma-053112	Leptosphaeria maculans	35.68	1.00e-86	313.00
IUUC-Laf-053690	Loxodonta africana	95.90	0.00e+00	1077.00
IUUC-Mcc-055117	Macaca mulatta	96.49	0.00e+00	1075.00
IUUC-Meu-056761	Macropus eugenii	77.18	0.00e+00	834.00
IUUC-Mor-057230	Magnaporthe oryzae	33.45	8.00e-77	281.00
IUUC-Mpo-057514	Magnaporthe poae	33.39	5.00e-70	258.00
IUUC-Mtr-058551	Medicago truncatula	40.52	9.00e-116	410.00
IUUC-Mla-059183	Melampsora laricipopulina	36.79	4.00e-95	342.00
IUUC-Mga-060144	Meleagris gallopavo	82.67	0.00e+00	913.00
IUUC-Mvi-060221	Microbotryum violaceum	35.61	2.00e-80	293.00
IUUC-Mmr-061325	Microcebus murinus	94.44	0.00e+00	1055.00
IUUC-Mdo-062532	Monodelphis domestica	91.04	0.00e+00	1024.00
IUUC-Mmu-063956	Mus musculus	96.46	0.00e+00	1079.00
IUUC-Mac-064521	Musa acuminata	40.52	1.00e-121	429.00
IUUC-Mpu-066716	Mustela putorius furo	96.24	0.00e+00	1016.00
IUUC-Mlu-067459	Myotis lucifugus	94.99	0.00e+00	1059.00
IUUC-Nfi-068245	Neosartorya fischeri	34.22	2.00e-81	296.00
IUUC-Ncr-068910	Neurospora crassa	34.30	9.00e-76	277.00
IUUC-Nle-070034	Nomascus leucogenys	95.83	0.00e+00	1045.00
IUUC-Opr-070552	Ochotona princeps	87.82	0.00e+00	897.00
IUUC-Ont-071426	Oreochromis niloticus	72.93	0.00e+00	848.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.60	0.00e+00	778.00
IUUC-Ocu-074911	Oryctolagus cuniculus	95.72	0.00e+00	1077.00
IUUC-Oba-075437	Oryza barthii	41.75	1.00e-117	417.00
IUUC-Obr-076684	Oryza brachyantha	42.53	2.00e-112	399.00
IUUC-Ogl-077170	Oryza glaberrima	41.75	1.00e-117	417.00
IUUC-Ogu-078844	Oryza glumaepatula	42.46	6.00e-111	394.00
IUUC-Oin-079105	Oryza indica	41.75	3.00e-117	415.00
IUUC-Olo-080943	Oryza longistaminata	40.20	3.00e-106	378.00
IUUC-Oni-082891	Oryza nivara	39.85	1.00e-111	396.00
IUUC-Opu-083457	Oryza punctata	42.50	1.00e-116	413.00
IUUC-Oru-084960	Oryza rufipogon	40.20	3.00e-106	379.00
IUUC-Osa-085358	Oryza sativa	41.94	6.00e-118	417.00
IUUC-Ola-086420	Oryzias latipes	71.31	1.00e-168	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.86	6.00e-60	224.00
IUUC-Oga-088810	Otolemur garnettii	95.53	0.00e+00	1071.00
IUUC-Oar-089196	Ovis aries	97.39	0.00e+00	1095.00
IUUC-Ptr-090617	Pan troglodytes	99.07	0.00e+00	1104.00
IUUC-Pan-092761	Papio anubis	98.51	0.00e+00	1096.00
IUUC-Psi-093191	Pelodiscus sinensis	86.54	0.00e+00	961.00
IUUC-Pma-094380	Petromyzon marinus	61.69	0.00e+00	659.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.44	6.00e-73	269.00
IUUC-Ppa-095875	Physcomitrella patens	39.81	4.00e-118	418.00
IUUC-Pfo-096467	Poecilia formosa	72.18	0.00e+00	829.00
IUUC-Pab-098255	Pongo abelii	97.99	0.00e+00	910.00
IUUC-Pop-099722	Populus trichocarpa	40.80	7.00e-123	434.00
IUUC-Pca-100807	Procavia capensis	80.00	1.00e-121	429.00
IUUC-Ppe-101280	Prunus persica	40.45	1.00e-121	430.00
IUUC-Pva-102333	Pteropus vampyrus	93.48	0.00e+00	1037.00
IUUC-Pgr-103401	Puccinia graminis	32.13	4.00e-80	291.00
IUUC-Ptt-103889	Puccinia triticina	27.53	4.00e-57	216.00
IUUC-Pte-104355	Pyrenophora teres	36.46	2.00e-89	323.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.17	2.00e-90	326.00
IUUC-Rno-105810	Rattus norvegicus	95.90	0.00e+00	1074.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.88	9.00e-36	144.00
IUUC-Sha-106770	Sarcophilus harrisii	89.16	1.00e-152	532.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.96	1.00e-76	280.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.82	3.00e-82	298.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.37	2.00e-66	246.00
IUUC-Smo-109296	Selaginella moellendorffii	42.18	1.00e-121	429.00
IUUC-Sit-110157	Setaria italica	44.16	1.00e-133	469.00
IUUC-Sly-111105	Solanum lycopersicum	39.96	3.00e-120	425.00
IUUC-Stu-112469	Solanum tuberosum	40.48	3.00e-122	431.00
IUUC-Sar-113083	Sorex araneus	72.83	0.00e+00	748.00
IUUC-Sbi-113813	Sorghum bicolor	44.16	1.00e-132	466.00
IUUC-Sre-115058	Sporisorium reilianum	38.85	2.00e-84	306.00
IUUC-Tgu-116772	Taeniopygia guttata	80.00	0.00e+00	882.00
IUUC-Tru-118686	Takifugu rubripes	71.24	0.00e+00	831.00
IUUC-Tsy-119111	Tarsius syrichta	89.75	2.00e-152	532.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.11	0.00e+00	749.00
IUUC-Tca-121491	Theobroma cacao	40.49	6.00e-115	407.00
IUUC-Tre-122103	Trichoderma reesei	36.98	1.00e-82	300.00
IUUC-Tvi-122672	Trichoderma virens	36.68	3.00e-74	272.00
IUUC-Tae-125679	Triticum aestivum	42.88	1.00e-126	446.00
IUUC-Tur-126487	Triticum urartu	41.18	9.00e-120	423.00
IUUC-Tme-127097	Tuber melanosporum	38.88	2.00e-93	336.00
IUUC-Ttr-128465	Tursiops truncatus	90.13	0.00e+00	1001.00
IUUC-Uma-129645	Ustilago maydis	33.67	3.00e-89	322.00
IUUC-Vda-129989	Verticillium dahliae	30.51	4.00e-55	208.00
IUUC-Vpa-130529	Vicugna pacos	92.92	0.00e+00	1038.00
IUUC-Vvi-131059	Vitis vinifera	41.40	2.00e-120	425.00
IUUC-Xtr-132002	Xenopus tropicalis	78.30	0.00e+00	901.00
IUUC-Xma-133930	Xiphophorus maculatus	72.59	0.00e+00	835.00
IUUC-Yli-134505	Yarrowia lipolytica	34.66	2.00e-84	306.00
IUUC-Zma-135895	Zea mays	44.40	9.00e-132	463.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence