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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-006744
Ensembl Protein ID AT3G07270.2
UniProt Accession Q9SFV7; Q8S3C2; GCH1_ARATH
Genbank Protein ID AAM03126.1; AAF20219.1; AEE74520.1; AAM20733.1; AAP31944.1
Protein Name GTP cyclohydrolase 1; GTP cyclohydrolase I
Genbank Nucleotide ID AF489530; AC012395; CP002686; AY099882; BT006600
Gene Name GCH1; GCHI; At3g07270; T1B9.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT3G07270 AT3G07270.1 AT3G07270.1
AT3G07270 AT3G07270.2 AT3G07270.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexHINTMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 40.84 4.00e-28 123.00 IUUC-Hsa-046907
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
 GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Protein Sequence
(Fasta)
MDTKDEGCLN LELDIGMKNG CIELAFEHQP ETLAIQDAVK LLLQGLHEDV NREGIKKTPF 60
RVAKALREGT RGYKQKVKDY VQSALFPEAG LDEGVGQAGG VGGLVVVRDL DHYSYCESCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-006744|UBD,UBD/Other/Other|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCTGCCATG GATACAAAAG GTACTTTCCT TGTCCTATCT TTCTTCAATT ATATTACACA 60
GCCCTTATTT TACATTTGAT ATCTACAAAT TAACATACAT TTGTATATGT AAATCAGTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006744|UBD,UBD/Other/Other|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0783--Tetrahydrobiopterin biosynthesis
KW-0862--Zinc
Interpro

IPR001474--GTP_CycHdrlase_I
IPR020602--GTP_CycHdrlase_I_dom
Pfam

PF01227--GTP_cyclohydroI
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0046872--F:metal ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0006729--P:tetrahydrobiopterin biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process
KEGG ath:AT3G07270
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002530 Amborella trichopoda 52.59 2.00e-117 415.00
IUUC-Apl-004135 Anas platyrhynchos 38.74 2.00e-26 110.00
IUUC-Aca-005252 Anolis carolinensis 39.61 4.00e-27 113.00
IUUC-Aly-006454 Arabidopsis lyrata 94.64 0.00e+00 834.00
IUUC-Ago-007744 Ashbya gossypii 39.77 1.00e-27 115.00
IUUC-Acl-008058 Aspergillus clavatus 40.67 3.00e-26 111.00
IUUC-Afl-008668 Aspergillus flavus 37.67 7.00e-28 117.00
IUUC-Afu-008935 Aspergillus fumigatus 40.67 4.00e-26 111.00
IUUC-Ani-009207 Aspergillus nidulans 40.37 9.00e-28 116.00
IUUC-Ang-009686 Aspergillus niger 41.33 1.00e-26 112.00
IUUC-Aor-010202 Aspergillus oryzae 37.67 5.00e-28 117.00
IUUC-Ate-010518 Aspergillus terreus 36.74 7.00e-27 113.00
IUUC-Ame-010958 Astyanax mexicanus 35.96 1.00e-30 125.00
IUUC-Bgr-012060 Blumeria graminis 40.36 1.00e-29 123.00
IUUC-Bta-012416 Bos taurus 41.88 3.00e-31 127.00
IUUC-Bci-013811 Botrytis cinerea 40.12 6.00e-28 117.00
IUUC-Bdi-014794 Brachypodium distachyon 52.22 3.00e-107 381.00
IUUC-Bol-015182 Brassica oleracea 81.62 0.00e+00 734.00
IUUC-Bra-016764 Brassica rapa 80.47 0.00e+00 719.00
IUUC-Cel-018345 Caenorhabditis elegans 36.96 9.00e-29 119.00
IUUC-Cja-019848 Callithrix jacchus 45.16 2.00e-23 100.00
IUUC-Cfa-020630 Canis familiaris 40.96 4.00e-31 127.00
IUUC-Cpo-021420 Cavia porcellus 40.68 1.00e-27 115.00
IUUC-Cre-022618 Chlamydomonas reinhardtii 43.45 1.00e-26 112.00
IUUC-Csa-023403 Chlorocebus sabaeus 36.78 3.00e-21 94.70
IUUC-Cho-024907 Choloepus hoffmanni 41.49 6.00e-32 130.00
IUUC-Cin-025120 Ciona intestinalis 38.56 3.00e-26 110.00
IUUC-Csv-026259 Ciona savignyi 40.52 3.00e-29 120.00
IUUC-Cgl-026508 Colletotrichum gloeosporioides 40.12 6.00e-28 117.00
IUUC-Cne-026810 Cryptococcus neoformans 39.87 7.00e-26 110.00
IUUC-Cme-027139 Cyanidioschyzon merolae 37.91 2.00e-25 108.00
IUUC-Dre-028815 Danio rerio 39.79 1.00e-30 125.00
IUUC-Dno-029017 Dasypus novemcinctus 42.25 4.00e-31 127.00
IUUC-Dor-030417 Dipodomys ordii 45.97 9.00e-24 101.00
IUUC-Dse-031187 Dothistroma septosporum 41.33 2.00e-27 115.00
IUUC-Dme-031615 Drosophila melanogaster 36.70 1.00e-23 103.00
IUUC-Ete-032727 Echinops telfairi 30.07 1.00e-13 68.60
IUUC-Eca-033487 Equus caballus 45.38 2.00e-23 100.00
IUUC-Eeu-034696 Erinaceus europaeus 40.68 4.00e-27 114.00
IUUC-Fca-035975 Felis catus 45.57 2.00e-12 62.80
IUUC-Fal-037439 Ficedula albicollis 44.35 5.00e-23 99.40
IUUC-Fox-037781 Fusarium oxysporum 41.33 7.00e-27 113.00
IUUC-Fso-038377 Fusarium solani 42.48 3.00e-27 114.00
IUUC-Gmo-038945 Gadus morhua 40.00 4.00e-28 117.00
IUUC-Ggr-039834 Gaeumannomyces graminis 43.14 2.00e-28 119.00
IUUC-Gga-040495 Gallus gallus 39.79 2.00e-30 125.00
IUUC-Gac-042306 Gasterosteus aculeatus 39.79 2.00e-30 125.00
IUUC-Gma-043539 Glycine max 62.02 8.00e-154 536.00
IUUC-Ggo-045597 Gorilla gorilla 37.85 8.00e-21 93.20
IUUC-Hsa-046907 Homo sapiens 39.66 3.00e-26 111.00
IUUC-Hvu-047298 Hordeum vulgare 52.47 2.00e-116 411.00
IUUC-Itr-048997 Ictidomys tridecemlineatus 41.36 3.00e-32 130.00
IUUC-Kpa-049319 Komagataella pastoris 39.88 3.00e-28 117.00
IUUC-Lch-049771 Latimeria chalumnae 40.31 7.00e-30 123.00
IUUC-Lpe-050904 Leersia perrieri 51.91 5.00e-114 404.00
IUUC-Loc-052063 Lepisosteus oculatus 40.74 1.00e-30 125.00
IUUC-Lma-053280 Leptosphaeria maculans 31.09 5.00e-16 78.60
IUUC-Laf-054214 Loxodonta africana 40.96 4.00e-31 127.00
IUUC-Mcc-054778 Macaca mulatta 39.66 3.00e-26 111.00
IUUC-Meu-056598 Macropus eugenii 45.07 8.00e-09 53.10
IUUC-Mor-056989 Magnaporthe oryzae 40.72 8.00e-28 116.00
IUUC-Mpo-057591 Magnaporthe poae 41.32 6.00e-29 120.00
IUUC-Mtr-057924 Medicago truncatula 61.42 7.00e-157 546.00
IUUC-Mla-058931 Melampsora laricipopulina 41.83 1.00e-27 116.00
IUUC-Mga-060001 Meleagris gallopavo 44.35 5.00e-23 99.40
IUUC-Mvi-060513 Microbotryum violaceum 43.12 7.00e-29 120.00
IUUC-Mmr-061725 Microcebus murinus 41.49 1.00e-31 129.00
IUUC-Mdo-062715 Monodelphis domestica 41.27 5.00e-30 124.00
IUUC-Mmu-063203 Mus musculus 40.68 3.00e-27 114.00
IUUC-Mac-065392 Musa acuminata 63.23 5.00e-41 160.00
IUUC-Mpu-066174 Mustela putorius furo 40.96 5.00e-31 127.00
IUUC-Mlu-067883 Myotis lucifugus 45.16 2.00e-23 100.00
IUUC-Nfi-068317 Neosartorya fischeri 40.67 3.00e-26 111.00
IUUC-Ncr-068822 Neurospora crassa 38.95 2.00e-28 119.00
IUUC-Nle-069231 Nomascus leucogenys 39.66 3.00e-26 111.00
IUUC-Opr-070417 Ochotona princeps 45.16 2.00e-23 100.00
IUUC-Ont-072168 Oreochromis niloticus 37.50 4.00e-30 124.00
IUUC-Oan-072690 Ornithorhynchus anatinus 45.57 1.00e-12 63.20
IUUC-Ocu-074537 Oryctolagus cuniculus 41.36 3.00e-31 127.00
IUUC-Oba-075333 Oryza barthii 52.12 6.00e-117 413.00
IUUC-Obr-076255 Oryza brachyantha 52.72 2.00e-50 191.00
IUUC-Ogl-077792 Oryza glaberrima 57.14 7.00e-62 229.00
IUUC-Ogu-078354 Oryza glumaepatula 52.58 2.00e-116 412.00
IUUC-Oin-079934 Oryza indica 52.58 3.00e-115 407.00
IUUC-Olo-080643 Oryza longistaminata 51.94 9.00e-104 369.00
IUUC-Ome-081632 Oryza meridionalis 53.48 3.00e-117 414.00
IUUC-Oni-083004 Oryza nivara 52.58 2.00e-115 408.00
IUUC-Opu-083899 Oryza punctata 52.48 1.00e-115 409.00
IUUC-Oru-084386 Oryza rufipogon 52.58 2.00e-115 409.00
IUUC-Osa-085665 Oryza sativa 49.32 2.00e-88 318.00
IUUC-Ola-086577 Oryzias latipes 38.71 2.00e-27 115.00
IUUC-Olu-087867 Ostreococcus lucimarinus 35.00 4.00e-26 110.00
IUUC-Oga-088652 Otolemur garnettii 40.23 7.00e-27 113.00
IUUC-Oar-089965 Ovis aries 41.49 3.00e-31 128.00
IUUC-Ptr-090833 Pan troglodytes 39.66 3.00e-26 111.00
IUUC-Psi-093542 Pelodiscus sinensis 37.76 1.00e-25 109.00
IUUC-Pma-094423 Petromyzon marinus 44.00 6.00e-21 92.40
IUUC-Pno-095091 Phaeosphaeria nodorum 42.67 2.00e-27 115.00
IUUC-Ppa-096013 Physcomitrella patens 39.51 5.00e-81 294.00
IUUC-Pfo-097146 Poecilia formosa 38.43 6.00e-31 126.00
IUUC-Pab-098744 Pongo abelii 39.66 3.00e-26 111.00
IUUC-Pop-099917 Populus trichocarpa 64.49 5.00e-156 543.00
IUUC-Pca-100111 Procavia capensis 40.96 4.00e-31 127.00
IUUC-Ppe-101984 Prunus persica 67.10 8.00e-176 609.00
IUUC-Pva-103078 Pteropus vampyrus 40.84 2.00e-29 121.00
IUUC-Pgr-103438 Puccinia graminis 40.11 2.00e-27 115.00
IUUC-Ptt-103875 Puccinia triticina 38.68 6.00e-28 117.00
IUUC-Pte-104180 Pyrenophora teres 44.00 9.00e-28 116.00
IUUC-Pyt-104552 Pyrenophora triticirepentis 44.00 8.00e-28 116.00
IUUC-Rno-105506 Rattus norvegicus 41.36 6.00e-31 126.00
IUUC-Sce-106375 Saccharomyces cerevisiae 41.21 9.00e-29 119.00
IUUC-Sha-107585 Sarcophilus harrisii 46.22 2.00e-23 100.00
IUUC-Sja-107871 Schizosaccharomyces japonicus 37.98 3.00e-30 124.00
IUUC-Spo-108282 Schizosaccharomyces pombe 36.81 3.00e-28 117.00
IUUC-Smo-109561 Selaginella moellendorffii 42.82 3.00e-79 288.00
IUUC-Sit-110577 Setaria italica 53.90 3.00e-115 408.00
IUUC-Sly-111719 Solanum lycopersicum 62.58 9.00e-154 535.00
IUUC-Stu-112752 Solanum tuberosum 61.66 3.00e-148 517.00
IUUC-Sar-113701 Sorex araneus 42.11 3.00e-31 127.00
IUUC-Sbi-114308 Sorghum bicolor 53.23 2.00e-120 424.00
IUUC-Sre-115125 Sporisorium reilianum 39.87 7.00e-26 110.00
IUUC-Tgu-117039 Taeniopygia guttata 44.35 4.00e-23 99.40
IUUC-Tru-117939 Takifugu rubripes 39.27 3.00e-29 121.00
IUUC-Tsy-118852 Tarsius syrichta 38.71 1.00e-16 78.20
IUUC-Tni-120356 Tetraodon nigroviridis 40.84 1.00e-30 125.00
IUUC-Tca-121422 Theobroma cacao 65.23 5.00e-169 586.00
IUUC-Tre-122035 Trichoderma reesei 36.02 3.00e-28 117.00
IUUC-Tvi-122649 Trichoderma virens 43.79 3.00e-28 118.00
IUUC-Tae-124146 Triticum aestivum 48.22 1.00e-75 276.00
IUUC-Tme-127015 Tuber melanosporum 40.72 1.00e-28 119.00
IUUC-Tbe-128024 Tupaia belangeri 38.71 1.00e-16 77.80
IUUC-Ttr-128474 Tursiops truncatus 40.96 7.00e-31 126.00
IUUC-Uma-129655 Ustilago maydis 39.87 1.00e-25 110.00
IUUC-Vda-129970 Verticillium dahliae 39.52 9.00e-28 116.00
IUUC-Vpa-130564 Vicugna pacos 45.90 2.00e-23 100.00
IUUC-Vvi-131597 Vitis vinifera 62.70 9.00e-157 545.00
IUUC-Xtr-132201 Xenopus tropicalis 40.31 3.00e-30 124.00
IUUC-Xma-133679 Xiphophorus maculatus 36.47 1.00e-31 129.00
IUUC-Yli-134489 Yarrowia lipolytica 45.75 2.00e-29 121.00
IUUC-Zma-135058 Zea mays 50.56 1.00e-116 412.00
Created Date 25-Jun-2017

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