iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fox-037698

Ensembl Protein ID

FOXG_01565P0

UniProt Accession

A0A0D2XCE2; A0A0D2XCE2_FUSO4

Genbank Protein ID

KNA96315.1

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

DS231697

Gene Name

URM1; FOXG_01565

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FOXG_01565	FOXG_01565T0	FOXG_01565P0

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	44.12	2.00e-20	91.70	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Fusarium oxysporum

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAESTSAPKL NIDVEFSGGL EMLFSNKRQH ALTIPAADQD GKPVDIAYLI DHLCQNVMDD 60
SRKDLFVLDN HLRPGILVLI NDADWELEGE EAYEIQSGDN ILFVSTLHGG

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Nucleotide Sequence
(Fasta)

ATGGCTGAAT CGACATCGGC CCCCAAGCTC AACATCGACG TCGAGTTCTC GTAAGTCGCT 60
TCACCAAGAT TTTCATCTTG CATGTATTAT ATGATCTATC AGCTCCCGCT TGCACGGTCT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	46.15	2.00e-23	98.20
IUUC-Atr-003089	Amborella trichopoda	38.61	3.00e-18	80.90
IUUC-Apl-003382	Anas platyrhynchos	48.42	1.00e-21	92.00
IUUC-Aca-004981	Anolis carolinensis	44.23	3.00e-22	94.70
IUUC-Aly-005517	Arabidopsis lyrata	39.18	2.00e-13	65.50
IUUC-Ath-006718	Arabidopsis thaliana	48.98	3.00e-11	58.20
IUUC-Ago-007917	Ashbya gossypii	44.12	2.00e-22	95.10
IUUC-Acl-008054	Aspergillus clavatus	77.36	5.00e-22	93.20
IUUC-Afl-008704	Aspergillus flavus	64.04	2.00e-32	128.00
IUUC-Aor-009890	Aspergillus oryzae	64.36	1.00e-37	146.00
IUUC-Bta-012448	Bos taurus	46.15	1.00e-23	99.40
IUUC-Bci-013865	Botrytis cinerea	68.32	7.00e-41	156.00
IUUC-Bdi-014980	Brachypodium distachyon	36.78	2.00e-11	58.50
IUUC-Bol-016055	Brassica oleracea	51.02	6.00e-12	60.50
IUUC-Bra-016845	Brassica rapa	51.02	6.00e-12	60.50
IUUC-Cel-018485	Caenorhabditis elegans	37.62	7.00e-09	50.10
IUUC-Cja-019587	Callithrix jacchus	47.12	1.00e-23	99.00
IUUC-Cfa-020653	Canis familiaris	47.12	8.00e-24	99.80
IUUC-Cpo-021622	Cavia porcellus	47.12	1.00e-23	99.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	46.53	2.00e-22	95.50
IUUC-Csa-023756	Chlorocebus sabaeus	44.44	1.00e-15	73.60
IUUC-Cgl-026518	Colletotrichum gloeosporioides	71.56	5.00e-46	174.00
IUUC-Cne-026953	Cryptococcus neoformans	42.31	2.00e-21	92.40
IUUC-Cme-027314	Cyanidioschyzon merolae	39.00	8.00e-15	69.70
IUUC-Dre-027884	Danio rerio	47.12	2.00e-21	91.70
IUUC-Dno-029262	Dasypus novemcinctus	43.37	2.00e-14	69.70
IUUC-Dor-030601	Dipodomys ordii	43.94	3.00e-08	48.10
IUUC-Dme-031893	Drosophila melanogaster	48.11	2.00e-21	92.00
IUUC-Ete-032773	Echinops telfairi	48.45	2.00e-21	92.00
IUUC-Eca-034187	Equus caballus	48.08	8.00e-24	99.80
IUUC-Eeu-034808	Erinaceus europaeus	47.12	4.00e-23	97.40
IUUC-Fca-036107	Felis catus	48.08	4.00e-24	100.00
IUUC-Fal-036607	Ficedula albicollis	48.42	1.00e-21	92.40
IUUC-Gmo-039492	Gadus morhua	44.23	9.00e-22	92.80
IUUC-Ggr-039965	Gaeumannomyces graminis	68.81	8.00e-41	157.00
IUUC-Gga-041268	Gallus gallus	48.08	7.00e-24	100.00
IUUC-Gac-042111	Gasterosteus aculeatus	45.19	6.00e-22	93.60
IUUC-Gma-043240	Glycine max	46.94	4.00e-11	57.80
IUUC-Ggo-045176	Gorilla gorilla	44.44	4.00e-13	65.50
IUUC-Hsa-046077	Homo sapiens	47.12	4.00e-21	90.90
IUUC-Itr-048111	Ictidomys tridecemlineatus	47.31	8.00e-18	79.30
IUUC-Kpa-049157	Komagataella pastoris	48.04	6.00e-22	93.60
IUUC-Lch-049889	Latimeria chalumnae	44.23	1.00e-22	96.30
IUUC-Lpe-050783	Leersia perrieri	50.00	2.00e-10	55.50
IUUC-Loc-052400	Lepisosteus oculatus	43.27	4.00e-21	90.50
IUUC-Lma-053259	Leptosphaeria maculans	65.66	1.00e-37	145.00
IUUC-Laf-053596	Loxodonta africana	46.23	7.00e-23	96.70
IUUC-Mcc-054845	Macaca mulatta	45.54	2.00e-20	88.60
IUUC-Meu-055968	Macropus eugenii	48.08	2.00e-24	102.00
IUUC-Mor-057126	Magnaporthe oryzae	75.70	7.00e-46	173.00
IUUC-Mpo-057311	Magnaporthe poae	68.52	4.00e-41	158.00
IUUC-Mtr-058266	Medicago truncatula	46.94	1.00e-11	59.30
IUUC-Mla-058847	Melampsora laricipopulina	39.81	9.00e-15	70.10
IUUC-Mga-059468	Meleagris gallopavo	49.47	3.00e-22	94.40
IUUC-Mvi-060235	Microbotryum violaceum	36.31	6.00e-20	87.80
IUUC-Mdo-061948	Monodelphis domestica	47.12	3.00e-24	100.00
IUUC-Mmu-063946	Mus musculus	47.12	1.00e-22	95.90
IUUC-Mac-064812	Musa acuminata	53.06	2.00e-12	62.40
IUUC-Mpu-066763	Mustela putorius furo	47.12	1.00e-22	96.30
IUUC-Mlu-066970	Myotis lucifugus	44.44	1.00e-15	72.40
IUUC-Ncr-068824	Neurospora crassa	64.36	2.00e-37	145.00
IUUC-Nle-069849	Nomascus leucogenys	44.44	2.00e-15	73.20
IUUC-Opr-070227	Ochotona princeps	47.12	1.00e-23	99.00
IUUC-Ont-072530	Oreochromis niloticus	46.15	5.00e-23	97.10
IUUC-Oan-073191	Ornithorhynchus anatinus	46.81	1.00e-20	89.00
IUUC-Ocu-074460	Oryctolagus cuniculus	48.51	8.00e-24	99.80
IUUC-Oba-075499	Oryza barthii	38.37	1.00e-11	60.80
IUUC-Obr-076896	Oryza brachyantha	36.47	8.00e-11	58.50
IUUC-Ogl-077834	Oryza glaberrima	38.37	3.00e-12	61.20
IUUC-Ogu-078622	Oryza glumaepatula	38.37	3.00e-12	61.20
IUUC-Oin-079358	Oryza indica	38.82	9.00e-12	61.20
IUUC-Olo-081035	Oryza longistaminata	38.78	8.00e-14	68.20
IUUC-Oni-082425	Oryza nivara	38.37	3.00e-12	61.20
IUUC-Opu-083461	Oryza punctata	37.65	2.00e-11	59.70
IUUC-Oru-084875	Oryza rufipogon	52.17	8.00e-10	52.80
IUUC-Oga-089128	Otolemur garnettii	48.08	9.00e-24	99.80
IUUC-Oar-089896	Ovis aries	46.15	1.00e-23	99.40
IUUC-Ptr-091618	Pan troglodytes	44.44	4.00e-13	65.10
IUUC-Pan-092238	Papio anubis	44.44	1.00e-15	73.60
IUUC-Psi-093879	Pelodiscus sinensis	47.12	2.00e-23	98.60
IUUC-Pma-094484	Petromyzon marinus	47.22	3.00e-15	71.20
IUUC-Ppa-095801	Physcomitrella patens	37.65	5.00e-14	67.00
IUUC-Pfo-097192	Poecilia formosa	45.19	2.00e-21	92.00
IUUC-Pab-098203	Pongo abelii	48.08	2.00e-21	92.00
IUUC-Pop-099614	Populus trichocarpa	48.98	5.00e-12	60.80
IUUC-Pca-100507	Procavia capensis	43.21	1.00e-15	71.60
IUUC-Ppe-101174	Prunus persica	32.67	3.00e-14	68.20
IUUC-Pva-102735	Pteropus vampyrus	47.12	1.00e-20	89.00
IUUC-Pgr-103510	Puccinia graminis	40.19	4.00e-15	71.20
IUUC-Ptt-103918	Puccinia triticina	41.12	1.00e-13	66.60
IUUC-Pte-104173	Pyrenophora teres	54.55	8.00e-36	139.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	54.55	1.00e-35	139.00
IUUC-Rno-105820	Rattus norvegicus	48.08	3.00e-23	97.80
IUUC-Sce-106366	Saccharomyces cerevisiae	44.12	2.00e-21	91.70
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.42	1.00e-19	86.30
IUUC-Spo-108074	Schizosaccharomyces pombe	44.55	5.00e-16	73.90
IUUC-Smo-108944	Selaginella moellendorffii	37.63	1.00e-14	68.90
IUUC-Sit-110277	Setaria italica	39.53	1.00e-13	66.20
IUUC-Sly-111505	Solanum lycopersicum	42.47	4.00e-13	64.30
IUUC-Stu-112076	Solanum tuberosum	41.10	1.00e-12	62.40
IUUC-Sbi-114274	Sorghum bicolor	38.46	2.00e-13	65.90
IUUC-Sre-114953	Sporisorium reilianum	44.44	3.00e-26	107.00
IUUC-Ssc-115418	Sus scrofa	48.08	5.00e-24	100.00
IUUC-Tgu-117311	Taeniopygia guttata	48.42	1.00e-21	92.00
IUUC-Tru-118598	Takifugu rubripes	48.94	2.00e-22	94.40
IUUC-Tsy-119481	Tarsius syrichta	56.52	2.90e+00	25.40
IUUC-Tni-120109	Tetraodon nigroviridis	46.67	2.00e-20	88.60
IUUC-Tca-120942	Theobroma cacao	38.46	4.00e-11	57.40
IUUC-Tre-122099	Trichoderma reesei	79.79	1.00e-36	142.00
IUUC-Tvi-122285	Trichoderma virens	75.24	2.00e-39	152.00
IUUC-Tae-125193	Triticum aestivum	53.06	4.00e-12	60.80
IUUC-Tur-126677	Triticum urartu	60.53	1.00e-09	53.10
IUUC-Tme-127120	Tuber melanosporum	66.34	1.00e-38	149.00
IUUC-Tbe-128050	Tupaia belangeri	39.42	2.00e-16	75.50
IUUC-Ttr-129019	Tursiops truncatus	46.15	4.00e-22	94.00
IUUC-Uma-129483	Ustilago maydis	47.66	2.00e-25	105.00
IUUC-Vda-129690	Verticillium dahliae	59.82	2.00e-35	138.00
IUUC-Vvi-131174	Vitis vinifera	48.98	2.00e-11	58.50
IUUC-Xma-133862	Xiphophorus maculatus	45.19	2.00e-21	92.00
IUUC-Yli-134398	Yarrowia lipolytica	44.76	1.00e-22	95.90
IUUC-Zma-134964	Zea mays	38.37	2.00e-12	62.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence