iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007318

UUCD1 version

UUC-ArT-01470

Ensembl Protein ID

AT5G64920.1

UniProt Accession

Q9SPL2; CIP8_ARATH

Genbank Protein ID

AAD56636.1; BAA97304.1; AED97970.1; AAL91168.1; AAP42743.1

Protein Name

E3 ubiquitin-protein ligase CIP8; COP1-interacting protein 8; RING-type E3 ubiquitin transferase CIP8

Genbank Nucleotide ID

AF162150; AB019236; CP002688; AY081279; BT008730

Gene Name

CIP8; At5g64920; MXK3.15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G64920	AT5G64920.1	AT5G64920.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12028569

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.00e-07	31.4	257	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C++ +   ++  + lpCgH++h dC+  w        ++ +CP+Cr
   Q: 257  CAVCKDGMvmgET-GKKLPCGHCYHGDCIVPW------LGTRNSCPVCR 298
           ******9988544.678***************......**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Probably forms a minimal ubiquitin ligase complex in cooperation with the E2 enzyme UBC8. Its interaction with COP1 suggests that it may participate in proteasome-mediated degradation of HY5 in vivo.

Protein Sequence
(Fasta)

MSDAPSSSPD ATASHWCYHC NKRVVVETLD DFVVCCECNK GFVESIQPTP AAYSSPAPPQ 60
PLSPDLNVED SSIGSHFLQM LRLLAHAPSQ RSPPRHLDVL SYEDDFFRLE LNSRNEIDDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGAGAGAC CTTTTTCTTT TATTTTCTCC ATCCTCTTAA TCGGCTTATC GGATCCGAAT 60
CCGGACCCGA AAGCCTGAAA ACCCGACGAT TAATTGCACG ATGTCCGATG CTCCGTCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G64920

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006264	Arabidopsis lyrata	88.57	2.00e-133	468.00
IUUC-Bdi-014039	Brachypodium distachyon	41.78	8.00e-24	103.00
IUUC-Bol-015980	Brassica oleracea	65.68	1.00e-75	275.00
IUUC-Bra-017830	Brassica rapa	69.61	3.00e-97	347.00
IUUC-Gma-042770	Glycine max	67.74	2.00e-50	191.00
IUUC-Mtr-058545	Medicago truncatula	64.29	4.00e-49	187.00
IUUC-Oba-075271	Oryza barthii	53.49	5.00e-20	90.50
IUUC-Ogl-077383	Oryza glaberrima	53.49	5.00e-20	90.50
IUUC-Ppe-101680	Prunus persica	60.76	5.00e-44	171.00
IUUC-Sly-110882	Solanum lycopersicum	66.22	2.00e-46	178.00
IUUC-Stu-112141	Solanum tuberosum	66.22	1.00e-46	179.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence