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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046096
Ensembl Protein ID ENSP00000414851.2
UniProt Accession Q6IA86; A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81; ELP2_HUMAN
Genbank Protein ID AAK97355.1; AAQ03093.1; BAA91874.1; BAB14193.1; BAF85740.1; BAG61972.1; BAG63452.1; CAG33550.1; BAD96511.1; AAH09211.2; AAH32553.1
Protein Name Elongator complex protein 2; SHINC-2; STAT3-interacting protein 1
Genbank Nucleotide ID AF332505; AF403223; AK001741; AK022709; AK293051; AK300201; AK302062; CR457269; AK222791; AC023043; BC032553
Gene Name ELP2; STATIP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134759.13 ENST00000358232.10 ENSP00000350967.6
ENSG00000134759.13 ENST00000544267.5 ENSP00000440516.1
ENSG00000134759.13 ENST00000351393.10 ENSP00000257191.7
ENSG00000134759.13 ENST00000442325.6 ENSP00000414851.2
ENSG00000134759.13 ENST00000423854.6 ENSP00000391202.2
ENSG00000134759.13 ENST00000539560.5 ENSP00000443555.1
ENSG00000134759.13 ENST00000542430.5 ENSP00000440774.1
ENSG00000134759.13 ENST00000350494.10 ENSP00000316051.6
ENSG00000134759.13 ENST00000542824.5 ENSP00000443800.1
ENSG00000134759.13 ENST00000540799.1 ENSP00000468091.1
ENSG00000134759.13 ENST00000540766.5 ENSP00000440651.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-40 136.9 733 762
UBD/Beta-Prp 5.40e-43 148.9 635 886
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H+  ++++++ +d +++ +Gs+D+++ vW 
   Q: 733  HSRIIWSCDWsPDsKYFFTGSRDKKVVVWG 762
           8999*******999***************5 PP
   

   UBD/Beta-Prp
   S: 13   itcvkfspdksllatgs.....rdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw...dls...........tgk 85
           i cv++  +k+lla+++     + + i++w++t++k ++ l  h+ +vt++ fsp++k+l+ +s+Drt  +w   d             +++
   Q: 635  IFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTIspefepvfslfAFT 726
           55788888888888888222223567**********************************************77733357666777766333 PP
   S: 86   cvhtlkghedsvlslsfspsgdklvsGshdrtirvwd..letgqclee..........tlsghdgvvncvvvhpdgnllvs.GslDrtvrlW 164
             +t   h++ ++s+++sp+++++ +Gs+d+ + vw    +t+ c+e+          +    ++v  c v+hp+++++v+ G   +++ l+
   Q: 727  NKITS-VHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGecDSTDDCIEHnigpcssvldVGGAVTAVSVCPVLHPSQRYVVAvGLECGKICLY 817
           33333.488999************************755689999999*******9888888999999********66655166669***** PP
   S: 165  dl..........ktgkllrtl..tgghtdsvyslsfdsng.............kelvsgsldgtvklwdl 209
                           +++t   +  ht ++++l ++  +              +++s+++d tvk+  +
   Q: 818  TWkktdqvpeinDWTHCVETSqsQ-SHTLAIRKLCWKNCSgkteqkeaegaewLHFASCGEDHTVKIHRV 886
           997666666666555555555744.5999999999777777888889999****************9876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
 Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
Protein Sequence
(Fasta)
MVAPVLETSH VFCCPNRVRG VLNWSSGPRG LLAFGTSCSV VLYDPLKRVV VTNLNGHTAR 60
VNCIQWICKQ DGSPSTELVS GGSDNQVIHW EIEDNQLLKA VHLQGHEGPV YAVHAVYQRR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046096|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTTTTCCGT GTGTTCGCCG ACGCCGCGGG GGCGTGGCGC GGCCCTAGCG CATTGTAAGC 60
AGTTGGGGGT CATTTCCTCG AGGCCCTACT CGCTAGCCAG CGCCCCCGGG GCCAGCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046096|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0033588--C:Elongator holoenzyme complex
GO:0000123--C:histone acetyltransferase complex
GO:0008023--C:transcription elongation factor complex
GO:0046425--P:regulation of JAK-STAT cascade
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
KEGG hsa:55250
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000056 Aegilops tauschii 31.78 1.00e-107 384.00
IUUC-Aml-002049 Ailuropoda melanoleuca 86.84 0.00e+00 1325.00
IUUC-Atr-002456 Amborella trichopoda 31.70 2.00e-109 390.00
IUUC-Apl-004053 Anas platyrhynchos 56.82 0.00e+00 963.00
IUUC-Aca-004535 Anolis carolinensis 58.80 0.00e+00 1035.00
IUUC-Aly-005746 Arabidopsis lyrata 31.70 6.00e-108 385.00
IUUC-Ath-006664 Arabidopsis thaliana 31.49 3.00e-104 373.00
IUUC-Ago-007971 Ashbya gossypii 35.38 2.00e-87 317.00
IUUC-Acl-008173 Aspergillus clavatus 29.71 2.00e-96 347.00
IUUC-Afl-008665 Aspergillus flavus 23.68 7.00e-25 108.00
IUUC-Afu-008976 Aspergillus fumigatus 32.40 4.00e-91 329.00
IUUC-Ani-009284 Aspergillus nidulans 33.09 5.00e-93 335.00
IUUC-Ang-009809 Aspergillus niger 33.66 5.00e-85 309.00
IUUC-Aor-009959 Aspergillus oryzae 28.52 8.00e-86 311.00
IUUC-Ate-010442 Aspergillus terreus 29.42 8.00e-91 328.00
IUUC-Ame-011409 Astyanax mexicanus 47.92 0.00e+00 794.00
IUUC-Bgr-012137 Blumeria graminis 29.61 7.00e-88 318.00
IUUC-Bta-012892 Bos taurus 82.06 0.00e+00 1513.00
IUUC-Bci-013944 Botrytis cinerea 29.34 8.00e-82 298.00
IUUC-Bdi-014512 Brachypodium distachyon 32.20 4.00e-112 399.00
IUUC-Bol-015741 Brassica oleracea 32.06 2.00e-110 394.00
IUUC-Bra-017367 Brassica rapa 31.73 9.00e-111 394.00
IUUC-Cel-018712 Caenorhabditis elegans 34.77 8.00e-91 328.00
IUUC-Cja-018865 Callithrix jacchus 94.73 0.00e+00 1760.00
IUUC-Cfa-021006 Canis familiaris 75.20 0.00e+00 1329.00
IUUC-Cpo-021370 Cavia porcellus 68.16 0.00e+00 1187.00
IUUC-Csa-023845 Chlorocebus sabaeus 90.57 0.00e+00 1639.00
IUUC-Cho-024640 Choloepus hoffmanni 68.88 0.00e+00 744.00
IUUC-Cin-025772 Ciona intestinalis 38.43 4.00e-145 508.00
IUUC-Csv-025891 Ciona savignyi 44.19 1.00e-147 517.00
IUUC-Cgl-026443 Colletotrichum gloeosporioides 28.57 2.00e-90 327.00
IUUC-Cne-027081 Cryptococcus neoformans 31.42 1.00e-87 317.00
IUUC-Cme-027225 Cyanidioschyzon merolae 27.59 2.00e-45 177.00
IUUC-Dre-028250 Danio rerio 57.43 0.00e+00 793.00
IUUC-Dno-028847 Dasypus novemcinctus 79.69 0.00e+00 1436.00
IUUC-Dor-030351 Dipodomys ordii 69.63 0.00e+00 1195.00
IUUC-Dse-031317 Dothistroma septosporum 31.68 2.00e-89 324.00
IUUC-Dme-032019 Drosophila melanogaster 38.76 4.00e-172 598.00
IUUC-Ete-033194 Echinops telfairi 87.03 2.00e-169 589.00
IUUC-Eca-033779 Equus caballus 83.28 0.00e+00 1524.00
IUUC-Eeu-034790 Erinaceus europaeus 76.83 0.00e+00 959.00
IUUC-Fca-036090 Felis catus 82.34 0.00e+00 1395.00
IUUC-Fal-037663 Ficedula albicollis 62.53 0.00e+00 1068.00
IUUC-Fox-037828 Fusarium oxysporum 31.94 3.00e-88 320.00
IUUC-Fso-038462 Fusarium solani 34.78 4.00e-88 319.00
IUUC-Gmo-039450 Gadus morhua 48.59 0.00e+00 828.00
IUUC-Ggr-040023 Gaeumannomyces graminis 30.52 1.00e-71 264.00
IUUC-Gga-040480 Gallus gallus 56.60 0.00e+00 991.00
IUUC-Gac-041544 Gasterosteus aculeatus 48.92 0.00e+00 846.00
IUUC-Gma-044048 Glycine max 33.51 3.00e-115 409.00
IUUC-Ggo-045381 Gorilla gorilla 84.52 0.00e+00 1520.00
IUUC-Hvu-047494 Hordeum vulgare 32.10 8.00e-115 408.00
IUUC-Itr-048823 Ictidomys tridecemlineatus 80.42 0.00e+00 1361.00
IUUC-Kpa-049241 Komagataella pastoris 33.33 7.00e-91 328.00
IUUC-Lch-050512 Latimeria chalumnae 59.69 0.00e+00 1051.00
IUUC-Lpe-051448 Leersia perrieri 31.56 1.00e-112 400.00
IUUC-Loc-051882 Lepisosteus oculatus 51.78 0.00e+00 896.00
IUUC-Lma-053023 Leptosphaeria maculans 31.81 1.00e-93 337.00
IUUC-Laf-054519 Loxodonta africana 80.58 0.00e+00 1473.00
IUUC-Mcc-055580 Macaca mulatta 96.97 0.00e+00 1781.00
IUUC-Meu-056606 Macropus eugenii 68.06 1.00e-107 384.00
IUUC-Mor-057109 Magnaporthe oryzae 30.00 4.00e-91 329.00
IUUC-Mpo-057297 Magnaporthe poae 29.44 4.00e-75 276.00
IUUC-Mtr-058348 Medicago truncatula 33.12 2.00e-114 407.00
IUUC-Mla-059159 Melampsora laricipopulina 34.10 4.00e-81 296.00
IUUC-Mga-059778 Meleagris gallopavo 56.70 0.00e+00 707.00
IUUC-Mvi-060447 Microbotryum violaceum 30.93 3.00e-98 353.00
IUUC-Mmr-061139 Microcebus murinus 91.14 0.00e+00 1689.00
IUUC-Mdo-061866 Monodelphis domestica 60.98 0.00e+00 1095.00
IUUC-Mmu-063390 Mus musculus 65.97 0.00e+00 1148.00
IUUC-Mac-064693 Musa acuminata 31.92 5.00e-119 422.00
IUUC-Mpu-066547 Mustela putorius furo 83.05 0.00e+00 1491.00
IUUC-Mlu-067156 Myotis lucifugus 81.71 0.00e+00 1508.00
IUUC-Nfi-068616 Neosartorya fischeri 31.01 6.00e-92 332.00
IUUC-Ncr-068915 Neurospora crassa 26.17 2.00e-74 273.00
IUUC-Nle-069958 Nomascus leucogenys 88.40 0.00e+00 1582.00
IUUC-Opr-071093 Ochotona princeps 73.76 0.00e+00 636.00
IUUC-Ont-072178 Oreochromis niloticus 51.43 0.00e+00 889.00
IUUC-Oan-073667 Ornithorhynchus anatinus 60.85 0.00e+00 1066.00
IUUC-Ocu-074662 Oryctolagus cuniculus 82.38 0.00e+00 1493.00
IUUC-Oba-075577 Oryza barthii 32.86 3.00e-120 426.00
IUUC-Obr-076566 Oryza brachyantha 32.18 6.00e-119 422.00
IUUC-Ogl-077054 Oryza glaberrima 32.86 3.00e-120 426.00
IUUC-Ogu-078846 Oryza glumaepatula 33.00 5.00e-120 425.00
IUUC-Oin-079084 Oryza indica 33.00 4.00e-120 426.00
IUUC-Olo-080933 Oryza longistaminata 30.63 4.00e-96 346.00
IUUC-Ome-081500 Oryza meridionalis 30.74 1.00e-102 367.00
IUUC-Oni-082352 Oryza nivara 33.04 1.00e-118 421.00
IUUC-Opu-084116 Oryza punctata 36.75 5.00e-111 395.00
IUUC-Oru-085249 Oryza rufipogon 33.00 4.00e-120 426.00
IUUC-Osa-086270 Oryza sativa 33.00 4.00e-120 426.00
IUUC-Ola-086625 Oryzias latipes 44.90 0.00e+00 727.00
IUUC-Olu-087638 Ostreococcus lucimarinus 32.65 2.00e-82 300.00
IUUC-Oga-088634 Otolemur garnettii 85.04 0.00e+00 1554.00
IUUC-Oar-089475 Ovis aries 82.25 0.00e+00 1493.00
IUUC-Ptr-091131 Pan troglodytes 91.81 0.00e+00 1662.00
IUUC-Pan-092869 Papio anubis 90.06 0.00e+00 1630.00
IUUC-Psi-093146 Pelodiscus sinensis 70.57 0.00e+00 1011.00
IUUC-Pma-094479 Petromyzon marinus 50.17 0.00e+00 835.00
IUUC-Pno-095061 Phaeosphaeria nodorum 31.00 3.00e-66 246.00
IUUC-Ppa-095618 Physcomitrella patens 37.32 3.00e-118 420.00
IUUC-Pfo-096816 Poecilia formosa 49.19 0.00e+00 829.00
IUUC-Pab-097548 Pongo abelii 90.91 0.00e+00 1645.00
IUUC-Pop-099643 Populus trichocarpa 32.94 7.00e-120 425.00
IUUC-Pca-100983 Procavia capensis 62.51 0.00e+00 1067.00
IUUC-Ppe-101301 Prunus persica 36.42 4.00e-110 392.00
IUUC-Pva-102460 Pteropus vampyrus 84.06 0.00e+00 1528.00
IUUC-Pgr-103507 Puccinia graminis 30.15 3.00e-70 260.00
IUUC-Ptt-103892 Puccinia triticina 30.00 1.00e-59 224.00
IUUC-Pte-104283 Pyrenophora teres 32.83 4.00e-94 339.00
IUUC-Pyt-104465 Pyrenophora triticirepentis 31.22 4.00e-90 326.00
IUUC-Rno-105842 Rattus norvegicus 67.26 0.00e+00 1160.00
IUUC-Sce-106459 Saccharomyces cerevisiae 28.91 4.00e-88 319.00
IUUC-Sha-106586 Sarcophilus harrisii 57.84 0.00e+00 1003.00
IUUC-Sja-107868 Schizosaccharomyces japonicus 33.89 4.00e-81 296.00
IUUC-Spo-108302 Schizosaccharomyces pombe 34.72 8.00e-83 301.00
IUUC-Smo-108861 Selaginella moellendorffii 39.82 5.00e-120 425.00
IUUC-Sit-109915 Setaria italica 32.43 2.00e-117 417.00
IUUC-Sly-111714 Solanum lycopersicum 32.49 8.00e-119 421.00
IUUC-Stu-112631 Solanum tuberosum 32.53 1.00e-118 421.00
IUUC-Sar-113200 Sorex araneus 66.67 0.00e+00 1149.00
IUUC-Sbi-114582 Sorghum bicolor 32.87 2.00e-119 423.00
IUUC-Sre-115001 Sporisorium reilianum 30.20 1.00e-42 169.00
IUUC-Ssc-115519 Sus scrofa 83.16 0.00e+00 1518.00
IUUC-Tgu-116987 Taeniopygia guttata 55.84 0.00e+00 959.00
IUUC-Tru-118476 Takifugu rubripes 49.26 0.00e+00 818.00
IUUC-Tsy-119230 Tarsius syrichta 67.63 1.00e-170 593.00
IUUC-Tni-120448 Tetraodon nigroviridis 33.05 3.00e-114 406.00
IUUC-Tca-121650 Theobroma cacao 32.34 2.00e-114 406.00
IUUC-Tre-122086 Trichoderma reesei 30.21 2.00e-93 337.00
IUUC-Tvi-122397 Trichoderma virens 33.39 2.00e-76 280.00
IUUC-Tae-125778 Triticum aestivum 32.21 7.00e-115 408.00
IUUC-Tur-126578 Triticum urartu 32.46 2.00e-114 406.00
IUUC-Tme-126927 Tuber melanosporum 32.28 4.00e-87 316.00
IUUC-Tbe-127922 Tupaia belangeri 74.45 9.00e-133 468.00
IUUC-Ttr-128918 Tursiops truncatus 84.18 0.00e+00 1539.00
IUUC-Uma-129474 Ustilago maydis 28.48 2.00e-40 162.00
IUUC-Vda-129944 Verticillium dahliae 28.63 2.00e-79 290.00
IUUC-Vpa-130693 Vicugna pacos 80.13 0.00e+00 1448.00
IUUC-Vvi-130949 Vitis vinifera 31.79 8.00e-112 398.00
IUUC-Xtr-132639 Xenopus tropicalis 58.20 0.00e+00 1033.00
IUUC-Xma-134223 Xiphophorus maculatus 60.04 0.00e+00 634.00
IUUC-Yli-134601 Yarrowia lipolytica 36.35 1.00e-102 367.00
IUUC-Zma-135952 Zea mays 38.10 1.00e-112 401.00
Created Date 25-Jun-2017

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