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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063721
UUCD1 version UUC-MuM-01129
Ensembl Protein ID ENSMUSP00000140543.1
UniProt Accession P31254; Q60639; Q8CDH7; Q9QYS4; Q9QZX2; UBA1Y_MOUSE
Genbank Protein ID AAD56603.1; AAD56603.1; AAD56603.1; AAD56603.1; AAD56603.1; AAD56603.1; AAD56603.1; AAD56603.1; AAF00149.1; BAC26749.1; CAA44466.1; AAC52170.1
Protein Name Ubiquitin-like modifier-activating enzyme 1 Y; Ubiquitin-activating enzyme E1; Ubiquitin-activating enzyme E1 Y
Genbank Nucleotide ID AF127490; AF127483; AF127484; AF127485; AF127486; AF127487; AF127488; AF127489; AF150963; AK030031; X62581; U09052
Gene Name Uba1y; Sby; Ube1ay; Ube1y; Ube1y1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000069053.11 ENSMUST00000190013.6 ENSMUSP00000140543.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E1 2.40e-223 742.8 450 931
Active Site
Position(s) Description Evidence
631 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+itv+Dmdt+e+snlnrqFLfr++d+ k K+e+aa+a++++
   Q: 450  YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgedGEITVTDMDTIEKSNLNRQFLFRPWDITKLKSETAAAAVRDI 538
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np++++ +h++++ +++e+++   Ff+k+d+V++aldn++ar++v+r+c+++r+pl+esgtlG++G+v+v+++ lte+ys+s+dpp+k+
   Q: 539  NPHIRIFSHQNRVGPETEHVYdddFFQKLDGVANALDNVDARLYVDRRCVYYRKPLLESGTLGTKGNVQVVVPFLTESYSSSQDPPEKS 627
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l +++++ e++ +l+ ++++e+++++  +l+ ++++++++++++a +++++
   Q: 628  IPICTLKNFPNAIEHTVQWArdefeglfkqsaENVNQYL-TDPKFMERTLQLAGTQPLEVLEAIHCSLVLQRPQTWADCVTWAYQHWHT 715
           ***************************************.777777788889************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv....................................................sfcsnaealq 284
           +++++i+qll++f+++++t+s++ fw+                                                              
   Q: 716  QYSHNIQQLLHNFPPAQLTSSGALFWSgpkrcphpltfdinnplhldyvmaaanlfaqtyglggsqdcavvakllqslpV--------- 795
           *****************************************************************666655554444430......... PP
   S: 285  vp........ekvekdeevvkasap......lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddl 357
            p          +++++e ++ sa+      l+ l++al + +k  g k++ ++fekddds  ++d++ aa+nlrae++gi+p +d+++
   Q: 796  -PkfapksgiRIHVSEQELQSTSATtiddshLEELKTALPTPDKLLGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYGISP-ADRHK 882
           .2333333433333333333333334444579***************************************************.***** PP
   S: 358  ikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
            k iag+iipaiatt++++ Gl+++E++Kvv+g  + e +kn f+++a+
   Q: 883  SKLIAGKIIPAIATTTSAIVGLVCLELYKVVQGhqQLESYKNSFINLAL 931
           *********************************999*********9875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia.
 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia.
Protein Sequence
(Fasta)
MSSSVLSKKR KVSGPDSSLD SSWSPTYSVM FGVPPGPTNE MSKNKEMDID ESLYSRQLYV 60
LGHEAMKHLQ ASSVLISGLQ GLGVEIAKNI ILGGVKAVTL HDQGIAQWAD LSSQFCLREE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063721|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCATTTTGT GGAAGGAGTT TCCCGAGAGA AACTGGCTGC TGGCCAGGGA CTTGAAGGTG 60
GAGGCTGCTC CGTTCTGGGA CCGGATCCTC GAGGAAGAGG AGGTGCGAAG AGAGGGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063721|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0007283--P:spermatogenesis
KEGG mmu:22202
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000367 Aegilops tauschii 45.96 0.00e+00 848.00
IUUC-Aly-005515 Arabidopsis lyrata 46.15 0.00e+00 919.00
IUUC-Ath-006891 Arabidopsis thaliana 46.05 0.00e+00 915.00
IUUC-Bol-015665 Brassica oleracea 44.44 0.00e+00 899.00
IUUC-Bra-017522 Brassica rapa 45.49 0.00e+00 882.00
IUUC-Gma-043198 Glycine max 44.29 0.00e+00 869.00
IUUC-Mtr-058572 Medicago truncatula 44.42 0.00e+00 850.00
IUUC-Oba-075120 Oryza barthii 45.45 0.00e+00 871.00
IUUC-Obr-076557 Oryza brachyantha 46.04 0.00e+00 866.00
IUUC-Ogl-077887 Oryza glaberrima 45.10 0.00e+00 873.00
IUUC-Ome-081942 Oryza meridionalis 45.10 0.00e+00 874.00
IUUC-Oni-082365 Oryza nivara 45.20 0.00e+00 877.00
IUUC-Opu-083977 Oryza punctata 45.84 0.00e+00 879.00
IUUC-Osa-085949 Oryza sativa 45.55 0.00e+00 879.00
IUUC-Pop-098934 Populus trichocarpa 44.96 0.00e+00 909.00
IUUC-Rno-105541 Rattus norvegicus 92.05 0.00e+00 2023.00
IUUC-Sit-110281 Setaria italica 45.59 0.00e+00 889.00
IUUC-Sly-110914 Solanum lycopersicum 45.28 0.00e+00 900.00
IUUC-Stu-112109 Solanum tuberosum 45.28 0.00e+00 910.00
IUUC-Sbi-114089 Sorghum bicolor 45.79 0.00e+00 890.00
IUUC-Tca-121672 Theobroma cacao 44.93 0.00e+00 902.00
IUUC-Tae-125113 Triticum aestivum 46.10 0.00e+00 848.00
IUUC-Tur-126189 Triticum urartu 45.86 0.00e+00 849.00
Created Date 25-Jun-2017

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