iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-027083

Ensembl Protein ID

AAW45433

UniProt Accession

P0CM38; Q55NS2; Q5KC57; ATG7_CRYNJ

Genbank Protein ID

AAW45433.1

Protein Name

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7

Genbank Nucleotide ID

AE017349

Gene Name

ATG7; CNI00160

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNI00160	AAW45433	AAW45433

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	39.90	1.00e-113	405.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
538	Glycyl thioester intermediate	{ECO:0000250}

Organism

Cryptococcus neoformans

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MAPLQFQPLA SQPTPAFWAA LAAHKLNHLK LDDSHLPITA QIEPAKRVLI NKERVDDTAD 60
VGIDGSLVVG GDAFEAERGR LPPNAVSVTG TLKIFNTIEE FKDTSAKKRL FDDLVSQMLE 120

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Nucleotide Sequence
(Fasta)

ATGGCGCCAC TCCAGTTCCA GCCACTCGCC TCCCAGCCAA CCCCCGCCTT CTGGGCAGCC 60
CTCGCAGCCC ACAAACTCAA CCACCTCAAG CTCGACGACT CCCACCTCCC CATCACAGCC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0000407--C:pre-autophagosomal structure
GO:0008641--F:small protein activating enzyme activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

cne:CNI00160

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	32.61	2.00e-86	312.00
IUUC-Aml-002316	Ailuropoda melanoleuca	44.04	4.00e-131	459.00
IUUC-Atr-002579	Amborella trichopoda	41.92	7.00e-146	509.00
IUUC-Apl-003805	Anas platyrhynchos	40.90	5.00e-141	493.00
IUUC-Aca-004618	Anolis carolinensis	44.60	4.00e-128	449.00
IUUC-Aly-005670	Arabidopsis lyrata	41.92	3.00e-122	430.00
IUUC-Ath-007499	Arabidopsis thaliana	41.63	1.00e-121	428.00
IUUC-Ago-007838	Ashbya gossypii	39.85	2.00e-117	414.00
IUUC-Acl-008093	Aspergillus clavatus	39.57	3.00e-130	456.00
IUUC-Afl-008663	Aspergillus flavus	42.37	9.00e-131	458.00
IUUC-Afu-008926	Aspergillus fumigatus	39.56	2.00e-131	461.00
IUUC-Ani-009156	Aspergillus nidulans	39.97	5.00e-132	462.00
IUUC-Ang-009853	Aspergillus niger	46.67	6.00e-55	204.00
IUUC-Aor-010055	Aspergillus oryzae	48.68	5.00e-123	432.00
IUUC-Ate-010281	Aspergillus terreus	41.72	5.00e-101	360.00
IUUC-Ame-010939	Astyanax mexicanus	42.60	6.00e-146	509.00
IUUC-Bgr-012006	Blumeria graminis	39.01	2.00e-134	471.00
IUUC-Bta-012336	Bos taurus	41.88	7.00e-130	455.00
IUUC-Bci-013598	Botrytis cinerea	40.88	3.00e-143	499.00
IUUC-Bdi-014170	Brachypodium distachyon	49.85	2.00e-83	301.00
IUUC-Bol-015357	Brassica oleracea	42.20	5.00e-131	459.00
IUUC-Bra-016835	Brassica rapa	42.35	6.00e-132	462.00
IUUC-Cel-018172	Caenorhabditis elegans	40.53	2.00e-110	391.00
IUUC-Cja-019544	Callithrix jacchus	41.83	2.00e-135	474.00
IUUC-Cfa-021043	Canis familiaris	41.88	1.00e-134	471.00
IUUC-Cpo-022366	Cavia porcellus	41.46	5.00e-136	476.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	38.84	1.00e-80	292.00
IUUC-Csa-023373	Chlorocebus sabaeus	41.83	2.00e-136	477.00
IUUC-Cho-024965	Choloepus hoffmanni	64.62	6.00e-49	187.00
IUUC-Cin-025710	Ciona intestinalis	44.04	9.00e-141	492.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	43.06	1.00e-149	521.00
IUUC-Dre-028740	Danio rerio	40.45	9.00e-129	452.00
IUUC-Dno-029637	Dasypus novemcinctus	44.51	2.00e-133	467.00
IUUC-Dor-030492	Dipodomys ordii	42.74	7.00e-138	482.00
IUUC-Dse-031267	Dothistroma septosporum	49.65	3.00e-117	414.00
IUUC-Dme-032084	Drosophila melanogaster	40.03	2.00e-119	421.00
IUUC-Ete-032616	Echinops telfairi	39.91	2.00e-116	411.00
IUUC-Eca-033991	Equus caballus	42.25	3.00e-135	473.00
IUUC-Eeu-035126	Erinaceus europaeus	57.21	8.00e-67	246.00
IUUC-Fca-035472	Felis catus	41.83	2.00e-135	474.00
IUUC-Fal-037178	Ficedula albicollis	42.53	4.00e-142	496.00
IUUC-Fox-037901	Fusarium oxysporum	41.20	2.00e-142	497.00
IUUC-Fso-038279	Fusarium solani	40.68	3.00e-138	483.00
IUUC-Gmo-039329	Gadus morhua	42.65	7.00e-137	479.00
IUUC-Ggr-040061	Gaeumannomyces graminis	41.03	1.00e-132	464.00
IUUC-Gga-040244	Gallus gallus	42.55	4.00e-143	499.00
IUUC-Gac-041880	Gasterosteus aculeatus	39.70	2.00e-132	464.00
IUUC-Gma-043235	Glycine max	41.34	3.00e-133	467.00
IUUC-Ggo-045428	Gorilla gorilla	42.45	4.00e-137	479.00
IUUC-Hsa-046183	Homo sapiens	41.97	1.00e-136	478.00
IUUC-Hvu-047509	Hordeum vulgare	48.19	5.00e-81	294.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	42.03	8.00e-126	442.00
IUUC-Kpa-049142	Komagataella pastoris	40.64	7.00e-134	469.00
IUUC-Lch-049601	Latimeria chalumnae	36.36	8.00e-89	319.00
IUUC-Lpe-051496	Leersia perrieri	48.06	3.00e-83	301.00
IUUC-Loc-051751	Lepisosteus oculatus	42.69	2.00e-146	510.00
IUUC-Lma-053203	Leptosphaeria maculans	40.14	2.00e-99	354.00
IUUC-Laf-053424	Loxodonta africana	42.22	6.00e-138	482.00
IUUC-Mcc-054633	Macaca mulatta	41.69	7.00e-136	475.00
IUUC-Meu-056523	Macropus eugenii	39.06	3.00e-120	424.00
IUUC-Mor-056983	Magnaporthe oryzae	40.68	1.00e-142	498.00
IUUC-Mpo-057615	Magnaporthe poae	41.08	1.00e-139	488.00
IUUC-Mtr-058366	Medicago truncatula	41.68	2.00e-130	457.00
IUUC-Mla-058826	Melampsora laricipopulina	46.15	9.00e-167	578.00
IUUC-Mga-059447	Meleagris gallopavo	42.84	3.00e-143	500.00
IUUC-Mvi-060537	Microbotryum violaceum	48.21	9.00e-169	585.00
IUUC-Mmr-060676	Microcebus murinus	42.47	3.00e-136	476.00
IUUC-Mdo-062967	Monodelphis domestica	41.51	1.00e-133	468.00
IUUC-Mmu-063217	Mus musculus	41.18	3.00e-134	470.00
IUUC-Mac-065527	Musa acuminata	43.82	1.00e-122	432.00
IUUC-Mpu-066417	Mustela putorius furo	41.88	4.00e-135	473.00
IUUC-Mlu-067195	Myotis lucifugus	42.55	1.00e-139	488.00
IUUC-Nfi-068576	Neosartorya fischeri	39.89	2.00e-137	481.00
IUUC-Ncr-068867	Neurospora crassa	41.85	3.00e-136	476.00
IUUC-Nle-069447	Nomascus leucogenys	51.94	4.00e-98	349.00
IUUC-Opr-070737	Ochotona princeps	40.69	2.00e-124	437.00
IUUC-Ont-071260	Oreochromis niloticus	40.95	1.00e-140	491.00
IUUC-Oan-073622	Ornithorhynchus anatinus	40.72	3.00e-88	317.00
IUUC-Ocu-074584	Oryctolagus cuniculus	42.14	2.00e-141	494.00
IUUC-Oba-075483	Oryza barthii	46.59	5.00e-84	304.00
IUUC-Obr-076786	Oryza brachyantha	49.11	7.00e-84	303.00
IUUC-Ogl-077388	Oryza glaberrima	46.59	5.00e-84	304.00
IUUC-Ogu-078618	Oryza glumaepatula	45.78	3.00e-84	304.00
IUUC-Oin-080007	Oryza indica	45.50	1.00e-83	302.00
IUUC-Olo-080994	Oryza longistaminata	48.80	3.00e-84	305.00
IUUC-Ome-081735	Oryza meridionalis	46.05	5.00e-84	303.00
IUUC-Oni-082153	Oryza nivara	45.50	1.00e-83	302.00
IUUC-Opu-083146	Oryza punctata	48.06	2.00e-83	302.00
IUUC-Oru-084919	Oryza rufipogon	45.50	1.00e-83	302.00
IUUC-Osa-086182	Oryza sativa	45.23	3.00e-83	301.00
IUUC-Ola-086441	Oryzias latipes	41.81	2.00e-143	501.00
IUUC-Olu-087664	Ostreococcus lucimarinus	40.36	2.00e-125	441.00
IUUC-Oga-089074	Otolemur garnettii	42.45	7.00e-128	449.00
IUUC-Oar-090159	Ovis aries	41.60	1.00e-129	455.00
IUUC-Ptr-091105	Pan troglodytes	45.79	1.00e-127	448.00
IUUC-Pan-092446	Papio anubis	41.83	5.00e-136	476.00
IUUC-Psi-093372	Pelodiscus sinensis	41.60	6.00e-132	462.00
IUUC-Pma-094661	Petromyzon marinus	41.85	1.00e-117	415.00
IUUC-Pno-094813	Phaeosphaeria nodorum	37.50	1.00e-107	381.00
IUUC-Ppa-095224	Physcomitrella patens	41.93	4.00e-131	459.00
IUUC-Pfo-096565	Poecilia formosa	41.32	3.00e-137	480.00
IUUC-Pop-099702	Populus trichocarpa	41.11	5.00e-137	479.00
IUUC-Pca-100324	Procavia capensis	36.19	7.00e-69	253.00
IUUC-Ppe-101416	Prunus persica	40.81	2.00e-127	447.00
IUUC-Pva-102589	Pteropus vampyrus	40.26	8.00e-122	429.00
IUUC-Pgr-103497	Puccinia graminis	44.83	6.00e-160	555.00
IUUC-Ptt-103718	Puccinia triticina	45.62	2.00e-161	560.00
IUUC-Pte-104206	Pyrenophora teres	39.15	2.00e-99	354.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	39.58	4.00e-120	423.00
IUUC-Rno-105911	Rattus norvegicus	41.18	5.00e-134	469.00
IUUC-Sce-106413	Saccharomyces cerevisiae	39.22	8.00e-119	419.00
IUUC-Sha-106679	Sarcophilus harrisii	42.08	1.00e-135	475.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	37.52	6.00e-121	426.00
IUUC-Spo-108107	Schizosaccharomyces pombe	38.94	8.00e-116	409.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	41.46	2.00e-147	514.00
IUUC-Smo-109677	Selaginella moellendorffii	38.76	8.00e-113	399.00
IUUC-Sit-110319	Setaria italica	47.71	1.00e-87	315.00
IUUC-Sly-111215	Solanum lycopersicum	41.57	7.00e-135	472.00
IUUC-Stu-112442	Solanum tuberosum	41.52	1.00e-132	465.00
IUUC-Sar-113370	Sorex araneus	52.03	1.00e-107	381.00
IUUC-Sbi-114261	Sorghum bicolor	49.11	2.00e-84	305.00
IUUC-Sre-114997	Sporisorium reilianum	44.75	8.00e-162	562.00
IUUC-Ssc-115304	Sus scrofa	42.54	3.00e-133	466.00
IUUC-Tgu-117235	Taeniopygia guttata	41.68	6.00e-140	489.00
IUUC-Tru-118374	Takifugu rubripes	42.61	1.00e-140	491.00
IUUC-Tsy-118966	Tarsius syrichta	35.71	3.00e-98	350.00
IUUC-Tni-120269	Tetraodon nigroviridis	40.51	2.00e-120	424.00
IUUC-Tca-121245	Theobroma cacao	41.73	6.00e-140	489.00
IUUC-Tre-121966	Trichoderma reesei	41.64	8.00e-137	479.00
IUUC-Tvi-122360	Trichoderma virens	40.51	1.00e-131	461.00
IUUC-Tae-125251	Triticum aestivum	31.82	1.00e-85	309.00
IUUC-Tur-126294	Triticum urartu	48.49	5.00e-82	297.00
IUUC-Tme-127117	Tuber melanosporum	41.26	6.00e-131	459.00
IUUC-Tbe-127662	Tupaia belangeri	45.50	5.00e-42	164.00
IUUC-Ttr-129054	Tursiops truncatus	41.69	3.00e-137	480.00
IUUC-Uma-129526	Ustilago maydis	42.04	1.00e-157	548.00
IUUC-Vda-129878	Verticillium dahliae	41.90	2.00e-143	501.00
IUUC-Vpa-130264	Vicugna pacos	36.16	7.00e-65	239.00
IUUC-Vvi-131163	Vitis vinifera	40.69	1.00e-134	471.00
IUUC-Xtr-132328	Xenopus tropicalis	34.94	1.00e-92	332.00
IUUC-Xma-133015	Xiphophorus maculatus	39.86	2.00e-126	444.00
IUUC-Yli-134468	Yarrowia lipolytica	38.37	4.00e-121	426.00
IUUC-Zma-134871	Zea mays	33.67	5.00e-84	304.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence