iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108107

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-like modifier-activating enzyme atg7; ATG12-activating enzyme E1 atg7; Autophagy-related protein 7

Genbank Nucleotide ID

CU329671

Gene Name

atg7; SPBC6B1.05c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC6B1.05c	SPBC6B1.05c.1	SPBC6B1.05c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	38.99	3.00e-112	400.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
521	Glycyl thioester intermediate	{ECO:0000250}

Organism

Schizosaccharomyces pombe

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity). Plays a role in meiosis and sporulation.

Protein Sequence
(Fasta)

MFVGKALQFQ SFHSSIDATF WHQLSNYKVE KQKLDASPLT IHGKFNTYSR GNISIVFGEA 60
PSNSNIKDCL AEGTLLNANT PQEFTNADVK KIREEIGEVL LNSIKNGVVS ERPNELLRFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGCTTCAA CATGTAATGA CATCTATAAT TTACTACACT ACTTACTGTG TATACCCAGC 60
AGTATATAGT AACTGTGTAG CAAACTAACG TTGTAGCAAC GTTCAGAAAT GTTTGTTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0034045--C:pre-autophagosomal structure membrane
GO:0061660--F:Atg12 ligase activity
GO:0019776--F:Atg8 ligase activity
GO:0008641--F:small protein activating enzyme activity
GO:0006914--P:autophagy
GO:0016236--P:macroautophagy
GO:0015031--P:protein transport

KEGG

spo:SPBC6B1.05c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	32.04	6.00e-86	310.00
IUUC-Aml-002316	Ailuropoda melanoleuca	40.75	3.00e-122	430.00
IUUC-Atr-002579	Amborella trichopoda	39.61	1.00e-135	474.00
IUUC-Apl-003805	Anas platyrhynchos	41.18	2.00e-135	474.00
IUUC-Aca-004618	Anolis carolinensis	40.30	1.00e-114	404.00
IUUC-Aly-005670	Arabidopsis lyrata	40.27	3.00e-114	404.00
IUUC-Ath-007499	Arabidopsis thaliana	40.33	1.00e-115	408.00
IUUC-Ago-007838	Ashbya gossypii	39.97	1.00e-116	411.00
IUUC-Acl-008093	Aspergillus clavatus	39.77	2.00e-129	454.00
IUUC-Afl-008663	Aspergillus flavus	43.73	7.00e-129	452.00
IUUC-Afu-008926	Aspergillus fumigatus	39.80	1.00e-130	458.00
IUUC-Ani-009156	Aspergillus nidulans	41.25	2.00e-135	474.00
IUUC-Ang-009853	Aspergillus niger	52.28	7.00e-64	234.00
IUUC-Aor-010055	Aspergillus oryzae	40.43	8.00e-133	465.00
IUUC-Ate-010281	Aspergillus terreus	35.00	1.00e-110	392.00
IUUC-Ame-010939	Astyanax mexicanus	39.75	3.00e-137	480.00
IUUC-Bgr-012006	Blumeria graminis	39.21	4.00e-128	449.00
IUUC-Bta-012336	Bos taurus	39.29	1.00e-124	438.00
IUUC-Bci-013598	Botrytis cinerea	39.79	2.00e-128	450.00
IUUC-Bdi-014170	Brachypodium distachyon	32.59	9.00e-91	326.00
IUUC-Bol-015357	Brassica oleracea	40.60	1.00e-123	434.00
IUUC-Bra-016835	Brassica rapa	41.05	2.00e-124	437.00
IUUC-Cel-018172	Caenorhabditis elegans	36.29	2.00e-105	374.00
IUUC-Cja-019544	Callithrix jacchus	40.43	2.00e-129	454.00
IUUC-Cfa-021043	Canis familiaris	39.23	3.00e-129	453.00
IUUC-Cpo-022366	Cavia porcellus	39.68	2.00e-130	457.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	34.93	3.00e-81	293.00
IUUC-Csa-023373	Chlorocebus sabaeus	40.08	2.00e-131	460.00
IUUC-Cho-024965	Choloepus hoffmanni	53.01	1.00e-44	172.00
IUUC-Cin-025710	Ciona intestinalis	40.66	1.00e-132	465.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	40.94	1.00e-140	491.00
IUUC-Cne-027083	Cryptococcus neoformans	38.76	1.00e-116	411.00
IUUC-Dre-028740	Danio rerio	37.14	2.00e-119	421.00
IUUC-Dno-029637	Dasypus novemcinctus	41.23	7.00e-124	435.00
IUUC-Dor-030492	Dipodomys ordii	40.14	1.00e-131	461.00
IUUC-Dse-031267	Dothistroma septosporum	32.41	7.00e-109	386.00
IUUC-Dme-032084	Drosophila melanogaster	38.25	5.00e-122	429.00
IUUC-Ete-032616	Echinops telfairi	36.70	2.00e-111	394.00
IUUC-Eca-033991	Equus caballus	39.38	4.00e-129	453.00
IUUC-Eeu-035126	Erinaceus europaeus	50.42	8.00e-62	229.00
IUUC-Fca-035472	Felis catus	39.37	8.00e-131	458.00
IUUC-Fal-037178	Ficedula albicollis	40.62	4.00e-133	466.00
IUUC-Fox-037901	Fusarium oxysporum	41.31	1.00e-133	468.00
IUUC-Fso-038279	Fusarium solani	40.90	6.00e-135	472.00
IUUC-Gmo-039329	Gadus morhua	39.10	7.00e-128	449.00
IUUC-Ggr-040061	Gaeumannomyces graminis	39.85	6.00e-126	442.00
IUUC-Gga-040244	Gallus gallus	40.72	9.00e-136	475.00
IUUC-Gac-041880	Gasterosteus aculeatus	38.58	7.00e-127	445.00
IUUC-Gma-043235	Glycine max	38.07	2.00e-119	420.00
IUUC-Ggo-045428	Gorilla gorilla	39.80	3.00e-130	457.00
IUUC-Hsa-046183	Homo sapiens	39.97	2.00e-130	457.00
IUUC-Hvu-047509	Hordeum vulgare	31.67	3.00e-85	308.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	41.74	1.00e-125	441.00
IUUC-Kpa-049142	Komagataella pastoris	41.01	2.00e-124	437.00
IUUC-Lch-049601	Latimeria chalumnae	36.07	8.00e-95	338.00
IUUC-Lpe-051496	Leersia perrieri	31.79	5.00e-85	307.00
IUUC-Loc-051751	Lepisosteus oculatus	38.83	4.00e-137	479.00
IUUC-Lma-053203	Leptosphaeria maculans	37.46	4.00e-95	339.00
IUUC-Laf-053424	Loxodonta africana	39.63	8.00e-131	459.00
IUUC-Mcc-054633	Macaca mulatta	39.77	9.00e-131	458.00
IUUC-Meu-056523	Macropus eugenii	37.16	6.00e-114	402.00
IUUC-Mor-056983	Magnaporthe oryzae	40.18	2.00e-133	468.00
IUUC-Mpo-057615	Magnaporthe poae	41.62	2.00e-136	478.00
IUUC-Mtr-058366	Medicago truncatula	38.78	3.00e-121	427.00
IUUC-Mla-058826	Melampsora laricipopulina	37.36	1.00e-127	448.00
IUUC-Mga-059447	Meleagris gallopavo	40.58	1.00e-135	474.00
IUUC-Mvi-060537	Microbotryum violaceum	38.26	1.00e-129	454.00
IUUC-Mmr-060676	Microcebus murinus	39.80	7.00e-131	459.00
IUUC-Mdo-062967	Monodelphis domestica	40.14	2.00e-129	454.00
IUUC-Mmu-063217	Mus musculus	40.40	6.00e-132	462.00
IUUC-Mac-065527	Musa acuminata	36.90	3.00e-114	404.00
IUUC-Mpu-066417	Mustela putorius furo	40.09	7.00e-131	459.00
IUUC-Mlu-067195	Myotis lucifugus	40.44	1.00e-132	464.00
IUUC-Nfi-068576	Neosartorya fischeri	38.59	1.00e-133	468.00
IUUC-Ncr-068867	Neurospora crassa	44.26	1.00e-141	494.00
IUUC-Nle-069447	Nomascus leucogenys	48.23	2.00e-90	323.00
IUUC-Opr-070737	Ochotona princeps	46.89	1.00e-106	378.00
IUUC-Ont-071260	Oreochromis niloticus	38.39	5.00e-131	459.00
IUUC-Oan-073622	Ornithorhynchus anatinus	39.06	4.00e-88	316.00
IUUC-Ocu-074584	Oryctolagus cuniculus	40.23	2.00e-134	470.00
IUUC-Oba-075483	Oryza barthii	31.35	5.00e-81	293.00
IUUC-Obr-076786	Oryza brachyantha	31.60	2.00e-85	308.00
IUUC-Ogl-077388	Oryza glaberrima	31.32	3.00e-79	288.00
IUUC-Ogu-078618	Oryza glumaepatula	31.35	1.00e-84	306.00
IUUC-Oin-080007	Oryza indica	31.21	3.00e-81	294.00
IUUC-Olo-080994	Oryza longistaminata	44.81	6.00e-80	290.00
IUUC-Ome-081735	Oryza meridionalis	31.06	2.00e-80	292.00
IUUC-Oni-082153	Oryza nivara	31.10	2.00e-81	295.00
IUUC-Opu-083146	Oryza punctata	31.21	3.00e-79	288.00
IUUC-Oru-084919	Oryza rufipogon	31.21	1.00e-81	295.00
IUUC-Osa-086182	Oryza sativa	31.16	4.00e-81	294.00
IUUC-Ola-086441	Oryzias latipes	39.45	3.00e-134	470.00
IUUC-Olu-087664	Ostreococcus lucimarinus	35.36	1.00e-112	398.00
IUUC-Oga-089074	Otolemur garnettii	40.78	1.00e-125	441.00
IUUC-Oar-090159	Ovis aries	39.85	4.00e-125	439.00
IUUC-Ptr-091105	Pan troglodytes	40.86	1.00e-115	408.00
IUUC-Pan-092446	Papio anubis	40.08	2.00e-131	461.00
IUUC-Psi-093372	Pelodiscus sinensis	39.97	2.00e-125	440.00
IUUC-Pma-094661	Petromyzon marinus	39.33	2.00e-110	390.00
IUUC-Pno-094813	Phaeosphaeria nodorum	37.29	3.00e-103	367.00
IUUC-Ppa-095224	Physcomitrella patens	37.90	2.00e-121	427.00
IUUC-Pfo-096565	Poecilia formosa	40.03	2.00e-131	461.00
IUUC-Pop-099702	Populus trichocarpa	37.85	2.00e-123	434.00
IUUC-Pca-100324	Procavia capensis	33.19	2.00e-63	234.00
IUUC-Ppe-101416	Prunus persica	38.57	3.00e-115	407.00
IUUC-Pva-102589	Pteropus vampyrus	38.09	2.00e-117	414.00
IUUC-Pgr-103497	Puccinia graminis	38.34	5.00e-135	473.00
IUUC-Ptt-103718	Puccinia triticina	38.35	6.00e-127	446.00
IUUC-Pte-104206	Pyrenophora teres	36.79	1.00e-89	321.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	37.35	2.00e-107	380.00
IUUC-Rno-105911	Rattus norvegicus	40.09	2.00e-130	457.00
IUUC-Sce-106413	Saccharomyces cerevisiae	38.99	8.00e-121	425.00
IUUC-Sha-106679	Sarcophilus harrisii	39.42	9.00e-131	458.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	48.38	0.00e+00	645.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	40.18	3.00e-131	460.00
IUUC-Smo-109677	Selaginella moellendorffii	38.07	9.00e-115	405.00
IUUC-Sit-110319	Setaria italica	43.36	4.00e-77	280.00
IUUC-Sly-111215	Solanum lycopersicum	38.47	3.00e-123	433.00
IUUC-Stu-112442	Solanum tuberosum	38.77	8.00e-121	426.00
IUUC-Sar-113370	Sorex araneus	47.56	2.00e-95	341.00
IUUC-Sbi-114261	Sorghum bicolor	30.85	1.00e-84	305.00
IUUC-Sre-114997	Sporisorium reilianum	36.14	4.00e-120	423.00
IUUC-Ssc-115304	Sus scrofa	40.89	7.00e-128	449.00
IUUC-Tgu-117235	Taeniopygia guttata	40.17	3.00e-131	460.00
IUUC-Tru-118374	Takifugu rubripes	39.59	1.00e-132	465.00
IUUC-Tsy-118966	Tarsius syrichta	33.48	5.00e-94	336.00
IUUC-Tni-120269	Tetraodon nigroviridis	39.35	3.00e-120	423.00
IUUC-Tca-121245	Theobroma cacao	38.42	2.00e-125	441.00
IUUC-Tre-121966	Trichoderma reesei	41.57	2.00e-136	477.00
IUUC-Tvi-122360	Trichoderma virens	42.06	2.00e-129	454.00
IUUC-Tae-125251	Triticum aestivum	32.49	1.00e-88	319.00
IUUC-Tur-126294	Triticum urartu	32.34	3.00e-84	304.00
IUUC-Tme-127117	Tuber melanosporum	40.83	6.00e-127	446.00
IUUC-Tbe-127662	Tupaia belangeri	39.91	6.00e-36	143.00
IUUC-Ttr-129054	Tursiops truncatus	39.06	6.00e-128	449.00
IUUC-Uma-129526	Ustilago maydis	35.36	9.00e-124	435.00
IUUC-Vda-129878	Verticillium dahliae	40.03	2.00e-131	460.00
IUUC-Vpa-130264	Vicugna pacos	35.66	9.00e-65	239.00
IUUC-Vvi-131163	Vitis vinifera	38.21	4.00e-125	440.00
IUUC-Xtr-132328	Xenopus tropicalis	31.32	3.00e-80	290.00
IUUC-Xma-133015	Xiphophorus maculatus	37.65	1.00e-118	418.00
IUUC-Yli-134468	Yarrowia lipolytica	39.02	2.00e-117	414.00
IUUC-Zma-134871	Zea mays	32.38	3.00e-92	331.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence