iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088886

Ensembl Protein ID

ENSOGAP00000002877.2

UniProt Accession

H0WMC2; H0WMC2_OTOGA

Genbank Protein ID

ENSOGAP00000002877

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Genbank Nucleotide ID

AAQR03001690

Gene Name

EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000003220.2	ENSOGAT00000003224.2	ENSOGAP00000002877.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	99.25	2.00e-159	559.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

ANSLPSGLGS FFHKMAAPAV TASDPPANPG PAPAAAPALA PASTPAPAPT PAPAPAAAPA 60
SSSDPAAAAA TATAPGQTPA SAQAPSQTPA PALTGPALPG PFPGGRVVKL HPVILASIVD 120

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Nucleotide Sequence
(Fasta)

GCTAATTCAC TCCCATCTGG TCTTGGCTCC TTCTTTCACA AGATGGCCGC CCCGGCAGTA 60
ACAGCGAGTG ATCCTCCCGC CAATCCCGGC CCAGCCCCGG CGGCGGCTCC AGCGTTAGCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	36.54	7.00e-47	181.00
IUUC-Aml-001527	Ailuropoda melanoleuca	99.25	5.00e-161	560.00
IUUC-Atr-002686	Amborella trichopoda	41.44	1.00e-50	193.00
IUUC-Apl-003977	Anas platyrhynchos	91.07	7.00e-123	432.00
IUUC-Aca-004335	Anolis carolinensis	90.37	7.00e-149	519.00
IUUC-Aly-005945	Arabidopsis lyrata	38.40	7.00e-50	190.00
IUUC-Ath-007045	Arabidopsis thaliana	38.78	6.00e-50	190.00
IUUC-Acl-008365	Aspergillus clavatus	34.80	2.00e-41	163.00
IUUC-Afl-008742	Aspergillus flavus	35.53	1.00e-40	160.00
IUUC-Afu-009030	Aspergillus fumigatus	34.43	4.00e-41	161.00
IUUC-Ani-009212	Aspergillus nidulans	35.42	5.00e-42	164.00
IUUC-Ang-009712	Aspergillus niger	34.43	4.00e-40	158.00
IUUC-Aor-009885	Aspergillus oryzae	35.53	3.00e-42	165.00
IUUC-Ate-010315	Aspergillus terreus	35.53	6.00e-40	157.00
IUUC-Ame-010801	Astyanax mexicanus	54.44	1.00e-67	249.00
IUUC-Bgr-011982	Blumeria graminis	35.49	9.00e-41	160.00
IUUC-Bta-012804	Bos taurus	98.22	2.00e-167	581.00
IUUC-Bci-013891	Botrytis cinerea	34.91	2.00e-35	142.00
IUUC-Bdi-014328	Brachypodium distachyon	39.25	2.00e-48	185.00
IUUC-Bol-015446	Brassica oleracea	38.78	6.00e-51	194.00
IUUC-Bra-016862	Brassica rapa	39.16	2.00e-51	195.00
IUUC-Cel-018171	Caenorhabditis elegans	35.19	5.00e-47	181.00
IUUC-Cja-019335	Callithrix jacchus	99.26	8.00e-164	569.00
IUUC-Cfa-020138	Canis familiaris	98.88	1.00e-160	558.00
IUUC-Cpo-022109	Cavia porcellus	87.27	2.00e-136	478.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	39.18	8.00e-59	220.00
IUUC-Csa-023994	Chlorocebus sabaeus	99.26	7.00e-164	569.00
IUUC-Cho-024351	Choloepus hoffmanni	76.47	3.00e-115	408.00
IUUC-Cin-025801	Ciona intestinalis	56.88	4.00e-89	320.00
IUUC-Csv-025805	Ciona savignyi	53.85	6.00e-87	313.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.87	1.00e-35	143.00
IUUC-Cne-026868	Cryptococcus neoformans	29.15	7.00e-29	120.00
IUUC-Cme-027328	Cyanidioschyzon merolae	27.22	5.00e-23	101.00
IUUC-Dre-028085	Danio rerio	80.67	2.00e-130	458.00
IUUC-Dno-030099	Dasypus novemcinctus	98.88	2.00e-160	558.00
IUUC-Dor-030324	Dipodomys ordii	90.30	3.00e-140	491.00
IUUC-Dse-031314	Dothistroma septosporum	35.74	4.00e-45	175.00
IUUC-Dme-031926	Drosophila melanogaster	48.89	9.00e-77	280.00
IUUC-Ete-032569	Echinops telfairi	92.45	2.00e-152	531.00
IUUC-Eca-033502	Equus caballus	93.59	8.00e-154	536.00
IUUC-Eeu-034883	Erinaceus europaeus	81.62	1.00e-82	298.00
IUUC-Fca-035873	Felis catus	99.25	4.00e-161	560.00
IUUC-Fal-036921	Ficedula albicollis	91.85	6.00e-150	522.00
IUUC-Fox-037765	Fusarium oxysporum	32.73	3.00e-30	125.00
IUUC-Fso-038240	Fusarium solani	33.09	1.00e-32	133.00
IUUC-Gmo-038864	Gadus morhua	78.81	2.00e-130	457.00
IUUC-Ggr-039862	Gaeumannomyces graminis	31.52	2.00e-30	126.00
IUUC-Gga-040952	Gallus gallus	91.91	4.00e-151	527.00
IUUC-Gac-041677	Gasterosteus aculeatus	79.93	9.00e-131	459.00
IUUC-Gma-043061	Glycine max	41.44	2.00e-50	192.00
IUUC-Ggo-045591	Gorilla gorilla	99.26	3.00e-164	570.00
IUUC-Hsa-046860	Homo sapiens	99.26	7.00e-164	569.00
IUUC-Hvu-047410	Hordeum vulgare	31.08	1.00e-20	91.70
IUUC-Itr-048211	Ictidomys tridecemlineatus	98.88	1.00e-160	558.00
IUUC-Lch-049410	Latimeria chalumnae	70.72	6.00e-88	316.00
IUUC-Lpe-051102	Leersia perrieri	40.00	1.00e-47	183.00
IUUC-Loc-052016	Lepisosteus oculatus	69.55	2.00e-115	408.00
IUUC-Lma-053157	Leptosphaeria maculans	34.71	2.00e-43	169.00
IUUC-Laf-054568	Loxodonta africana	98.90	3.00e-163	567.00
IUUC-Mcc-054613	Macaca mulatta	99.26	6.00e-164	570.00
IUUC-Meu-056832	Macropus eugenii	73.33	2.00e-83	301.00
IUUC-Mor-057104	Magnaporthe oryzae	31.32	2.00e-30	126.00
IUUC-Mtr-058445	Medicago truncatula	41.06	9.00e-59	220.00
IUUC-Mla-059038	Melampsora laricipopulina	30.62	9.00e-33	134.00
IUUC-Mga-059548	Meleagris gallopavo	91.95	2.00e-130	457.00
IUUC-Mvi-060520	Microbotryum violaceum	28.28	3.00e-22	99.40
IUUC-Mdo-062376	Monodelphis domestica	94.40	2.00e-151	528.00
IUUC-Mmu-063254	Mus musculus	98.51	1.00e-159	555.00
IUUC-Mac-065635	Musa acuminata	40.73	3.00e-52	198.00
IUUC-Mpu-066314	Mustela putorius furo	99.25	4.00e-161	560.00
IUUC-Mlu-067512	Myotis lucifugus	97.39	2.00e-156	545.00
IUUC-Nfi-068262	Neosartorya fischeri	34.43	4.00e-41	161.00
IUUC-Ncr-068872	Neurospora crassa	32.36	3.00e-33	135.00
IUUC-Nle-070118	Nomascus leucogenys	99.25	4.00e-161	560.00
IUUC-Opr-071228	Ochotona princeps	99.15	1.00e-140	491.00
IUUC-Ont-072600	Oreochromis niloticus	81.04	2.00e-133	468.00
IUUC-Oan-073584	Ornithorhynchus anatinus	93.64	2.00e-133	468.00
IUUC-Ocu-074542	Oryctolagus cuniculus	98.88	3.00e-160	557.00
IUUC-Oba-075923	Oryza barthii	38.57	1.00e-50	192.00
IUUC-Obr-076313	Oryza brachyantha	40.00	5.00e-49	187.00
IUUC-Ogl-076932	Oryza glaberrima	38.57	1.00e-50	192.00
IUUC-Ogu-078152	Oryza glumaepatula	38.57	1.00e-50	192.00
IUUC-Oin-079528	Oryza indica	38.57	1.00e-50	192.00
IUUC-Olo-080401	Oryza longistaminata	38.57	1.00e-50	192.00
IUUC-Ome-081553	Oryza meridionalis	38.21	3.00e-50	191.00
IUUC-Oni-082090	Oryza nivara	38.57	1.00e-50	192.00
IUUC-Opu-083583	Oryza punctata	40.00	2.00e-48	186.00
IUUC-Oru-084492	Oryza rufipogon	38.57	1.00e-50	192.00
IUUC-Osa-085383	Oryza sativa	38.57	1.00e-50	192.00
IUUC-Ola-086835	Oryzias latipes	79.93	7.00e-130	456.00
IUUC-Olu-087716	Ostreococcus lucimarinus	29.70	3.00e-28	118.00
IUUC-Oar-090079	Ovis aries	97.87	8.00e-166	575.00
IUUC-Ptr-091457	Pan troglodytes	99.26	7.00e-164	569.00
IUUC-Pan-092317	Papio anubis	99.46	2.00e-108	384.00
IUUC-Psi-093129	Pelodiscus sinensis	85.71	6.00e-131	459.00
IUUC-Pma-094488	Petromyzon marinus	72.11	8.00e-125	439.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.84	2.00e-43	169.00
IUUC-Ppa-095341	Physcomitrella patens	41.95	5.00e-65	240.00
IUUC-Pfo-096286	Poecilia formosa	79.55	8.00e-131	459.00
IUUC-Pab-097765	Pongo abelii	99.26	7.00e-164	569.00
IUUC-Pop-099131	Populus trichocarpa	41.06	4.00e-55	207.00
IUUC-Pca-100524	Procavia capensis	82.91	4.00e-108	383.00
IUUC-Ppe-101934	Prunus persica	42.21	6.00e-60	224.00
IUUC-Pva-102577	Pteropus vampyrus	98.51	3.00e-160	557.00
IUUC-Pgr-103521	Puccinia graminis	30.06	2.00e-31	129.00
IUUC-Pte-104304	Pyrenophora teres	35.54	6.00e-44	171.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	35.54	5.00e-44	171.00
IUUC-Rno-105717	Rattus norvegicus	98.88	2.00e-160	558.00
IUUC-Sha-107190	Sarcophilus harrisii	95.02	1.00e-147	516.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	36.30	5.00e-46	177.00
IUUC-Spo-108355	Schizosaccharomyces pombe	35.59	4.00e-46	177.00
IUUC-Smo-109374	Selaginella moellendorffii	44.65	2.00e-69	255.00
IUUC-Sit-110119	Setaria italica	39.16	4.00e-49	187.00
IUUC-Sly-111570	Solanum lycopersicum	37.76	9.00e-47	180.00
IUUC-Stu-112308	Solanum tuberosum	40.08	6.00e-53	200.00
IUUC-Sar-113515	Sorex araneus	97.87	2.00e-52	197.00
IUUC-Sbi-114605	Sorghum bicolor	38.78	4.00e-49	188.00
IUUC-Sre-114906	Sporisorium reilianum	39.78	6.00e-52	197.00
IUUC-Tgu-117087	Taeniopygia guttata	90.25	1.00e-127	448.00
IUUC-Tru-117700	Takifugu rubripes	79.55	1.00e-130	458.00
IUUC-Tni-120470	Tetraodon nigroviridis	80.30	3.00e-131	460.00
IUUC-Tca-121109	Theobroma cacao	40.30	7.00e-49	187.00
IUUC-Tre-122095	Trichoderma reesei	33.94	1.00e-32	133.00
IUUC-Tvi-122580	Trichoderma virens	33.57	8.00e-32	130.00
IUUC-Tae-125129	Triticum aestivum	38.79	2.00e-51	195.00
IUUC-Tur-126658	Triticum urartu	36.43	4.00e-43	167.00
IUUC-Tme-127043	Tuber melanosporum	38.87	3.00e-48	185.00
IUUC-Tbe-127927	Tupaia belangeri	99.25	4.00e-161	560.00
IUUC-Ttr-129231	Tursiops truncatus	98.88	1.00e-160	559.00
IUUC-Uma-129578	Ustilago maydis	39.42	7.00e-51	193.00
IUUC-Vda-129730	Verticillium dahliae	32.36	3.00e-37	149.00
IUUC-Vpa-130677	Vicugna pacos	64.75	3.00e-42	165.00
IUUC-Vvi-130968	Vitis vinifera	41.83	2.00e-54	205.00
IUUC-Xtr-132203	Xenopus tropicalis	85.13	2.00e-137	481.00
IUUC-Xma-133972	Xiphophorus maculatus	79.18	2.00e-130	457.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	4.00e-40	158.00
IUUC-Zma-134941	Zea mays	38.40	1.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence