iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064324

UUCD1 version

UUC-MuM-00802

Ensembl Protein ID

ENSMUSP00000039604.4

UniProt Accession

Q8VCM5; A2AM82; A2AM84; B5M498; Q3TDK4; Q8BHF2; Q9DCV9; MUL1_MOUSE

Genbank Protein ID

ACH72646.1; BAB22084.1; BAC31768.1; BAC36332.1; BAC38848.1; BAE32279.1; BAE41597.1; CAM18879.1; CAM18880.1; CAM18881.1; AAH19516.1

Protein Name

Mitochondrial ubiquitin ligase activator of NFKB 1; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; RING-type E3 ubiquitin transferase NFKB 1

Genbank Nucleotide ID

EU935009; AK002416; AK044088; AK076419; AK083295; AK153956; AK170149; AL807249; AL807249; AL807249; BC019516

Gene Name

Mul1; Gide

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000041241.12	ENSMUST00000044058.10	ENSMUSP00000039604.4
ENSMUSG00000041241.12	ENSMUST00000105813.7	ENSMUSP00000101439.1
ENSMUSG00000041241.12	ENSMUST00000105815.1	ENSMUSP00000101441.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	89.77	2.00e-177	619.00	IUUC-Hsa-046597

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination (By similarity).

Protein Sequence
(Fasta)

MESGSRPSLG QVILLGTSSM VTAVLYSIYR QKAQVAQELK GAKKIHLGED LKGILSEAPG 60
KCVPYAVIEG AVRSVKETLN SQFVENCKGV IQRLSLQEHK MVWNRTTHLW NDYSKIIHQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGACGGGC GACGGGTTCC GGGAAGGGCT GCGCGGCTGC GTAGGGGTCG CAGGTGATTT 60
CGAGGCGGCT GGTGCGGCTT GGGGTCGCCA TGGAGAGCGG TTCGCGACCG TCGCTCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0576--Peroxisome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR022170--GIDE
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

Pfam

PF12483--GIDE

Gene Ontology

GO:0030424--C:axon
GO:0031307--C:integral component of mitochondrial outer membrane
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005777--C:peroxisome
GO:0042802--F:identical protein binding
GO:0004871--F:signal transducer activity
GO:0019789--F:SUMO transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257--P:activation of JUN kinase activity
GO:0006915--P:apoptotic process
GO:0071360--P:cellular response to exogenous dsRNA
GO:0000266--P:mitochondrial fission
GO:0051646--P:mitochondrion localization
GO:0030308--P:negative regulation of cell growth
GO:0071650--P:negative regulation of chemokine (C-C motif) ligand 5 production
GO:0050689--P:negative regulation of defense response to virus by host
GO:0045824--P:negative regulation of innate immune response
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0060339--P:negative regulation of type I interferon-mediated signaling pathway
GO:1903861--P:positive regulation of dendrite extension
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090141--P:positive regulation of mitochondrial fission
GO:1904925--P:positive regulation of mitophagy in response to mitochondrial depolarization
GO:0033235--P:positive regulation of protein sumoylation
GO:0031648--P:protein destabilization
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0051881--P:regulation of mitochondrial membrane potential
GO:1901028--P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0010821--P:regulation of mitochondrion organization
GO:0031647--P:regulation of protein stability

KEGG

mmu:68350

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000342	Aegilops tauschii	24.92	5.00e-11	63.20
IUUC-Aml-002287	Ailuropoda melanoleuca	89.49	0.00e+00	632.00
IUUC-Atr-002698	Amborella trichopoda	24.10	2.00e-08	53.50
IUUC-Aca-005039	Anolis carolinensis	38.55	7.00e-64	237.00
IUUC-Aly-006181	Arabidopsis lyrata	27.51	2.00e-20	92.80
IUUC-Ath-007438	Arabidopsis thaliana	27.79	3.00e-21	95.90
IUUC-Ame-010671	Astyanax mexicanus	61.08	1.00e-125	442.00
IUUC-Bta-012407	Bos taurus	78.19	1.00e-161	562.00
IUUC-Bdi-014735	Brachypodium distachyon	24.85	5.00e-16	78.60
IUUC-Bol-015493	Brassica oleracea	26.93	5.00e-21	95.10
IUUC-Bra-016933	Brassica rapa	26.07	5.00e-18	85.10
IUUC-Cja-019709	Callithrix jacchus	90.03	1.00e-169	588.00
IUUC-Cfa-020818	Canis familiaris	90.06	0.00e+00	646.00
IUUC-Cpo-022490	Cavia porcellus	91.48	0.00e+00	630.00
IUUC-Csa-023259	Chlorocebus sabaeus	89.77	0.00e+00	640.00
IUUC-Cho-024730	Choloepus hoffmanni	89.20	0.00e+00	637.00
IUUC-Cin-025301	Ciona intestinalis	30.93	6.00e-45	174.00
IUUC-Dre-028644	Danio rerio	61.36	3.00e-127	448.00
IUUC-Dno-028925	Dasypus novemcinctus	88.92	0.00e+00	639.00
IUUC-Dor-030692	Dipodomys ordii	92.33	0.00e+00	644.00
IUUC-Dme-031761	Drosophila melanogaster	31.25	3.00e-31	129.00
IUUC-Ete-032329	Echinops telfairi	80.11	6.00e-153	533.00
IUUC-Eca-034008	Equus caballus	86.65	3.00e-180	624.00
IUUC-Eeu-034895	Erinaceus europaeus	75.00	3.00e-121	427.00
IUUC-Fca-036104	Felis catus	89.20	0.00e+00	637.00
IUUC-Fal-036900	Ficedula albicollis	71.14	2.00e-138	484.00
IUUC-Gmo-039049	Gadus morhua	57.39	3.00e-105	375.00
IUUC-Gga-040254	Gallus gallus	68.75	2.00e-137	482.00
IUUC-Gac-042277	Gasterosteus aculeatus	60.23	2.00e-131	461.00
IUUC-Gma-043979	Glycine max	25.98	2.00e-18	87.00
IUUC-Ggo-045509	Gorilla gorilla	89.77	0.00e+00	640.00
IUUC-Hsa-046597	Homo sapiens	89.77	0.00e+00	640.00
IUUC-Hvu-047335	Hordeum vulgare	25.09	7.00e-17	80.90
IUUC-Itr-048691	Ictidomys tridecemlineatus	93.18	0.00e+00	646.00
IUUC-Lch-050344	Latimeria chalumnae	67.90	1.00e-141	496.00
IUUC-Lpe-051343	Leersia perrieri	26.21	8.00e-12	64.30
IUUC-Loc-052376	Lepisosteus oculatus	66.19	4.00e-144	504.00
IUUC-Laf-054414	Loxodonta africana	89.77	0.00e+00	642.00
IUUC-Mcc-054604	Macaca mulatta	89.49	0.00e+00	639.00
IUUC-Meu-056087	Macropus eugenii	82.95	7.00e-165	573.00
IUUC-Mtr-057779	Medicago truncatula	25.44	1.00e-18	87.40
IUUC-Mga-060188	Meleagris gallopavo	71.15	8.00e-137	479.00
IUUC-Mmr-060704	Microcebus murinus	91.48	0.00e+00	649.00
IUUC-Mdo-062842	Monodelphis domestica	82.39	1.00e-161	562.00
IUUC-Mpu-065940	Mustela putorius furo	87.78	2.00e-177	614.00
IUUC-Mlu-067028	Myotis lucifugus	90.06	0.00e+00	653.00
IUUC-Nle-069254	Nomascus leucogenys	83.33	4.00e-169	587.00
IUUC-Opr-070827	Ochotona princeps	86.08	2.00e-178	618.00
IUUC-Ont-072008	Oreochromis niloticus	61.93	3.00e-135	474.00
IUUC-Oan-072935	Ornithorhynchus anatinus	78.98	1.00e-163	569.00
IUUC-Ocu-074526	Oryctolagus cuniculus	90.62	0.00e+00	627.00
IUUC-Oba-075954	Oryza barthii	26.21	9.00e-12	64.30
IUUC-Obr-076592	Oryza brachyantha	26.26	2.00e-19	89.70
IUUC-Ogl-077732	Oryza glaberrima	26.26	2.00e-19	89.70
IUUC-Ogu-078565	Oryza glumaepatula	26.42	9.00e-12	64.30
IUUC-Oin-080188	Oryza indica	26.26	2.00e-19	89.70
IUUC-Olo-080705	Oryza longistaminata	25.53	2.00e-09	57.40
IUUC-Ome-081154	Oryza meridionalis	26.21	7.00e-12	65.10
IUUC-Oni-082201	Oryza nivara	26.21	9.00e-12	64.30
IUUC-Opu-083497	Oryza punctata	26.42	8.00e-12	64.70
IUUC-Oru-084332	Oryza rufipogon	26.21	9.00e-12	64.30
IUUC-Osa-086059	Oryza sativa	26.21	3.00e-12	65.50
IUUC-Ola-087288	Oryzias latipes	57.67	6.00e-124	437.00
IUUC-Oga-088402	Otolemur garnettii	90.34	0.00e+00	645.00
IUUC-Oar-089851	Ovis aries	90.12	6.00e-86	309.00
IUUC-Ptr-091226	Pan troglodytes	89.49	0.00e+00	639.00
IUUC-Pan-092575	Papio anubis	89.20	0.00e+00	638.00
IUUC-Psi-094062	Pelodiscus sinensis	76.42	2.00e-158	551.00
IUUC-Pma-094501	Petromyzon marinus	37.29	5.00e-46	177.00
IUUC-Ppa-095285	Physcomitrella patens	25.55	6.00e-14	71.60
IUUC-Pfo-096146	Poecilia formosa	57.95	2.00e-121	428.00
IUUC-Pab-098524	Pongo abelii	89.49	0.00e+00	639.00
IUUC-Pop-099864	Populus trichocarpa	26.85	7.00e-16	78.20
IUUC-Pca-100314	Procavia capensis	89.20	0.00e+00	639.00
IUUC-Ppe-101663	Prunus persica	25.59	4.00e-17	82.00
IUUC-Pva-102947	Pteropus vampyrus	89.20	0.00e+00	644.00
IUUC-Rno-105024	Rattus norvegicus	96.88	0.00e+00	666.00
IUUC-Sha-107500	Sarcophilus harrisii	67.30	2.00e-114	405.00
IUUC-Smo-109194	Selaginella moellendorffii	25.79	7.00e-18	84.70
IUUC-Sit-109922	Setaria italica	26.82	2.00e-18	86.30
IUUC-Sly-111826	Solanum lycopersicum	26.28	5.00e-19	88.60
IUUC-Stu-112907	Solanum tuberosum	25.90	5.00e-18	85.10
IUUC-Sar-113522	Sorex araneus	86.86	1.00e-155	541.00
IUUC-Sbi-114536	Sorghum bicolor	27.11	2.00e-20	92.80
IUUC-Ssc-115445	Sus scrofa	91.19	0.00e+00	627.00
IUUC-Tgu-116551	Taeniopygia guttata	71.31	6.00e-137	480.00
IUUC-Tru-118407	Takifugu rubripes	57.39	6.00e-116	410.00
IUUC-Tsy-118794	Tarsius syrichta	88.35	8.00e-180	622.00
IUUC-Tni-120128	Tetraodon nigroviridis	64.83	4.00e-94	337.00
IUUC-Tca-121508	Theobroma cacao	27.54	9.00e-20	90.90
IUUC-Tae-125185	Triticum aestivum	25.88	4.00e-20	92.40
IUUC-Tur-126470	Triticum urartu	25.59	4.00e-20	92.00
IUUC-Tbe-127432	Tupaia belangeri	89.49	5.00e-178	616.00
IUUC-Ttr-128573	Tursiops truncatus	87.50	0.00e+00	630.00
IUUC-Vpa-130583	Vicugna pacos	89.10	9.00e-163	565.00
IUUC-Vvi-131710	Vitis vinifera	25.45	7.00e-15	74.70
IUUC-Xtr-132009	Xenopus tropicalis	64.12	1.00e-132	466.00
IUUC-Xma-134121	Xiphophorus maculatus	56.82	8.00e-124	436.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence