iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011067

Ensembl Protein ID

ENSAMXP00000013493.1

UniProt Accession

W5L0Y1; W5L0Y1_ASTMX

Genbank Protein ID

ENSAMXP00000013493

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01080956

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000013105.1	ENSAMXT00000013493.1	ENSAMXP00000013493.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-120	403.2	4244	4578
UBD/Alpha-Helix/UBA	7.10e-06	26.2	1395	1432

Active Site

Position(s)	Description	Evidence
4546	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++d+k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4244 PEDMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRVVAKAVYDNRLL 4329
           689********************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d  +++ l +++en   d+++lg +ltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4330 ECYFTRSFYKHILGKSVRYTDMESEDYPFFQGLVYLLEN---DVSTLGYELTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4413
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv++++++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4414 LVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKANTEYHK-YQSSSIQIQWFWRALRSFDQADRA 4499
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4500 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4578
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++ +l ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1395 NQAQLTQLMDMGFSREHAMEALLN-TTTMEQATEYLLTH 1432
           67899*******************.7***********98 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MKVDRSKLKK TPTEAPADCR TLIEKLKGCS DEQLLLELQH IKTWNIGKCE LYHWVDLLDR 60
FDGILCDAGQ TVENMSWMLV CDRPDNGQLK ALLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGTTG ACAGAAGCAA GTTAAAGAAA ACCCCCACTG AAGCGGTCAG TATTCCCAGA 60
TTTTTTTTCA CTGTATTCCA TTATATATGA AAATATGTAC GTATTCATGC ATGTATATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	46.73	2.00e-105	379.00
IUUC-Aml-001684	Ailuropoda melanoleuca	81.83	0.00e+00	3745.00
IUUC-Atr-002582	Amborella trichopoda	51.75	4.00e-125	444.00
IUUC-Apl-003729	Anas platyrhynchos	91.57	0.00e+00	684.00
IUUC-Aca-005263	Anolis carolinensis	81.80	0.00e+00	3771.00
IUUC-Aly-006083	Arabidopsis lyrata	51.54	4.00e-125	444.00
IUUC-Ath-007472	Arabidopsis thaliana	51.54	3.00e-125	445.00
IUUC-Ago-008005	Ashbya gossypii	54.27	1.00e-131	465.00
IUUC-Acl-008254	Aspergillus clavatus	53.41	5.00e-133	471.00
IUUC-Afl-008712	Aspergillus flavus	46.59	4.00e-134	473.00
IUUC-Afu-009022	Aspergillus fumigatus	52.94	2.00e-132	469.00
IUUC-Ani-009412	Aspergillus nidulans	46.97	1.00e-134	476.00
IUUC-Ang-009771	Aspergillus niger	46.40	2.00e-133	472.00
IUUC-Aor-010186	Aspergillus oryzae	45.88	5.00e-124	439.00
IUUC-Ate-010253	Aspergillus terreus	46.68	2.00e-133	472.00
IUUC-Bgr-012043	Blumeria graminis	47.06	3.00e-139	491.00
IUUC-Bta-012813	Bos taurus	81.85	0.00e+00	3775.00
IUUC-Bci-013995	Botrytis cinerea	52.63	9.00e-138	486.00
IUUC-Bdi-014884	Brachypodium distachyon	51.75	5.00e-126	447.00
IUUC-Bol-016533	Brassica oleracea	57.97	4.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	50.55	2.00e-122	435.00
IUUC-Cel-018179	Caenorhabditis elegans	61.12	0.00e+00	640.00
IUUC-Cja-018741	Callithrix jacchus	81.73	0.00e+00	3759.00
IUUC-Cfa-020083	Canis familiaris	82.19	0.00e+00	3785.00
IUUC-Cpo-021923	Cavia porcellus	81.76	0.00e+00	3732.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.71	3.00e-117	414.00
IUUC-Csa-023853	Chlorocebus sabaeus	81.73	0.00e+00	3759.00
IUUC-Cho-024718	Choloepus hoffmanni	97.60	0.00e+00	800.00
IUUC-Cin-025627	Ciona intestinalis	40.65	0.00e+00	1866.00
IUUC-Csv-025824	Ciona savignyi	46.09	0.00e+00	1392.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	53.08	4.00e-136	481.00
IUUC-Cne-027095	Cryptococcus neoformans	41.48	1.00e-102	369.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.00	8.00e-115	409.00
IUUC-Dre-028525	Danio rerio	92.62	0.00e+00	5098.00
IUUC-Dno-029680	Dasypus novemcinctus	80.86	0.00e+00	3685.00
IUUC-Dor-030902	Dipodomys ordii	85.28	0.00e+00	1078.00
IUUC-Dse-031197	Dothistroma septosporum	47.27	8.00e-136	480.00
IUUC-Dme-032122	Drosophila melanogaster	68.67	0.00e+00	780.00
IUUC-Ete-032690	Echinops telfairi	82.31	0.00e+00	824.00
IUUC-Eca-033915	Equus caballus	81.11	0.00e+00	3712.00
IUUC-Eeu-034963	Erinaceus europaeus	79.79	0.00e+00	2596.00
IUUC-Fca-035824	Felis catus	81.81	0.00e+00	3755.00
IUUC-Fox-037756	Fusarium oxysporum	52.53	2.00e-136	482.00
IUUC-Fso-038464	Fusarium solani	52.64	1.00e-137	486.00
IUUC-Gmo-039073	Gadus morhua	89.62	0.00e+00	3992.00
IUUC-Ggr-039946	Gaeumannomyces graminis	52.62	4.00e-134	474.00
IUUC-Gga-040309	Gallus gallus	97.08	0.00e+00	645.00
IUUC-Gac-042430	Gasterosteus aculeatus	89.54	0.00e+00	4116.00
IUUC-Gma-044247	Glycine max	51.98	9.00e-125	443.00
IUUC-Ggo-044785	Gorilla gorilla	81.69	0.00e+00	3729.00
IUUC-Hsa-046879	Homo sapiens	81.73	0.00e+00	3732.00
IUUC-Hvu-047697	Hordeum vulgare	51.75	2.00e-126	449.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	93.71	0.00e+00	1051.00
IUUC-Kpa-049228	Komagataella pastoris	48.29	5.00e-138	487.00
IUUC-Lch-050252	Latimeria chalumnae	85.60	0.00e+00	1685.00
IUUC-Lpe-051550	Leersia perrieri	50.91	3.00e-126	448.00
IUUC-Loc-052472	Lepisosteus oculatus	87.02	0.00e+00	3918.00
IUUC-Lma-053159	Leptosphaeria maculans	45.83	2.00e-134	475.00
IUUC-Laf-054154	Loxodonta africana	81.50	0.00e+00	3707.00
IUUC-Mcc-055085	Macaca mulatta	82.13	0.00e+00	3761.00
IUUC-Meu-056727	Macropus eugenii	85.66	0.00e+00	1780.00
IUUC-Mor-057201	Magnaporthe oryzae	47.35	6.00e-136	480.00
IUUC-Mpo-057597	Magnaporthe poae	46.21	3.00e-133	471.00
IUUC-Mtr-058273	Medicago truncatula	52.68	2.00e-126	449.00
IUUC-Mla-058888	Melampsora laricipopulina	49.62	1.00e-116	412.00
IUUC-Mvi-060320	Microbotryum violaceum	49.30	6.00e-121	431.00
IUUC-Mmr-060820	Microcebus murinus	81.45	0.00e+00	3759.00
IUUC-Mdo-062930	Monodelphis domestica	82.38	0.00e+00	3788.00
IUUC-Mmu-063601	Mus musculus	87.01	0.00e+00	2212.00
IUUC-Mac-065557	Musa acuminata	51.85	7.00e-118	420.00
IUUC-Mpu-066653	Mustela putorius furo	80.27	0.00e+00	3623.00
IUUC-Mlu-067418	Myotis lucifugus	81.49	0.00e+00	3811.00
IUUC-Nfi-068278	Neosartorya fischeri	53.18	5.00e-133	471.00
IUUC-Ncr-068813	Neurospora crassa	53.65	5.00e-137	484.00
IUUC-Nle-069418	Nomascus leucogenys	81.63	0.00e+00	3716.00
IUUC-Opr-070187	Ochotona princeps	77.82	0.00e+00	836.00
IUUC-Ont-071300	Oreochromis niloticus	86.56	0.00e+00	5246.00
IUUC-Oan-073046	Ornithorhynchus anatinus	78.36	0.00e+00	1964.00
IUUC-Ocu-074178	Oryctolagus cuniculus	81.73	0.00e+00	3798.00
IUUC-Oba-075757	Oryza barthii	50.91	2.00e-126	449.00
IUUC-Obr-076553	Oryza brachyantha	51.37	2.00e-126	448.00
IUUC-Ogl-077520	Oryza glaberrima	50.91	2.00e-126	449.00
IUUC-Ogu-078278	Oryza glumaepatula	50.91	2.00e-126	449.00
IUUC-Oin-079767	Oryza indica	50.91	2.00e-126	448.00
IUUC-Olo-080380	Oryza longistaminata	50.45	1.00e-124	442.00
IUUC-Ome-081925	Oryza meridionalis	50.45	1.00e-124	443.00
IUUC-Oni-082619	Oryza nivara	50.91	2.00e-126	448.00
IUUC-Opu-083684	Oryza punctata	50.45	7.00e-125	443.00
IUUC-Oru-084501	Oryza rufipogon	50.91	2.00e-126	448.00
IUUC-Osa-086251	Oryza sativa	50.91	4.00e-125	442.00
IUUC-Ola-087437	Oryzias latipes	88.19	0.00e+00	2256.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.25	1.00e-113	403.00
IUUC-Oga-088903	Otolemur garnettii	81.57	0.00e+00	3736.00
IUUC-Oar-090210	Ovis aries	82.05	0.00e+00	3773.00
IUUC-Ptr-090502	Pan troglodytes	81.18	0.00e+00	2826.00
IUUC-Pan-092368	Papio anubis	81.37	0.00e+00	3780.00
IUUC-Pma-094246	Petromyzon marinus	71.36	0.00e+00	1254.00
IUUC-Pno-094871	Phaeosphaeria nodorum	51.12	5.00e-134	474.00
IUUC-Ppa-095657	Physcomitrella patens	47.47	2.00e-124	442.00
IUUC-Pfo-096232	Poecilia formosa	87.24	0.00e+00	6818.00
IUUC-Pab-098583	Pongo abelii	81.73	0.00e+00	3732.00
IUUC-Pop-099613	Populus trichocarpa	53.15	1.00e-127	452.00
IUUC-Pca-100310	Procavia capensis	72.59	0.00e+00	1457.00
IUUC-Ppe-102109	Prunus persica	52.45	4.00e-126	447.00
IUUC-Pva-102116	Pteropus vampyrus	81.43	0.00e+00	3791.00
IUUC-Pgr-103465	Puccinia graminis	44.00	7.00e-126	447.00
IUUC-Ptt-103813	Puccinia triticina	41.90	1.00e-113	406.00
IUUC-Pte-104018	Pyrenophora teres	51.24	9.00e-133	470.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	51.25	3.00e-132	468.00
IUUC-Rno-105889	Rattus norvegicus	87.01	0.00e+00	2211.00
IUUC-Sce-106449	Saccharomyces cerevisiae	45.14	8.00e-127	450.00
IUUC-Sha-106961	Sarcophilus harrisii	87.57	0.00e+00	2304.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.63	4.00e-126	447.00
IUUC-Spo-108024	Schizosaccharomyces pombe	52.18	9.00e-129	456.00
IUUC-Smo-109428	Selaginella moellendorffii	50.66	7.00e-129	456.00
IUUC-Sit-110598	Setaria italica	52.21	9.00e-127	449.00
IUUC-Sly-111285	Solanum lycopersicum	51.66	4.00e-127	451.00
IUUC-Stu-112582	Solanum tuberosum	32.68	4.00e-56	213.00
IUUC-Sar-113291	Sorex araneus	75.60	0.00e+00	2280.00
IUUC-Sbi-114042	Sorghum bicolor	51.75	5.00e-126	447.00
IUUC-Sre-114958	Sporisorium reilianum	56.40	3.00e-138	485.00
IUUC-Ssc-115754	Sus scrofa	81.69	0.00e+00	3742.00
IUUC-Tru-118570	Takifugu rubripes	85.13	0.00e+00	6723.00
IUUC-Tsy-119159	Tarsius syrichta	86.85	0.00e+00	1739.00
IUUC-Tni-120836	Tetraodon nigroviridis	85.43	0.00e+00	2252.00
IUUC-Tca-121479	Theobroma cacao	51.52	3.00e-124	441.00
IUUC-Tre-121909	Trichoderma reesei	52.97	6.00e-134	474.00
IUUC-Tvi-122370	Trichoderma virens	52.73	4.00e-134	474.00
IUUC-Tae-125214	Triticum aestivum	51.41	5.00e-126	446.00
IUUC-Tme-127172	Tuber melanosporum	46.68	7.00e-136	480.00
IUUC-Tbe-127506	Tupaia belangeri	71.24	0.00e+00	1154.00
IUUC-Ttr-129253	Tursiops truncatus	71.12	0.00e+00	1742.00
IUUC-Uma-129355	Ustilago maydis	56.40	3.00e-138	485.00
IUUC-Vda-129886	Verticillium dahliae	47.92	7.00e-138	487.00
IUUC-Vpa-130708	Vicugna pacos	79.77	0.00e+00	3271.00
IUUC-Vvi-131170	Vitis vinifera	51.00	4.00e-126	446.00
IUUC-Xtr-132123	Xenopus tropicalis	84.91	0.00e+00	2128.00
IUUC-Xma-133869	Xiphophorus maculatus	87.36	0.00e+00	6868.00
IUUC-Yli-134657	Yarrowia lipolytica	51.42	1.00e-128	456.00
IUUC-Zma-135570	Zea mays	44.40	7.00e-127	450.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence