iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034306

UUCD1 version

UUC-EqC-00575

Ensembl Protein ID

ENSECAP00000016546.1

UniProt Accession

F6Z8W0; F6Z8W0_HORSE

Protein Name

Uncharacterized protein

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000018435.1	ENSECAT00000020175.1	ENSECAP00000016546.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.00e-36	121.6	227	257
UBD/Beta-Prp	7.70e-56	189.6	49	327

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 227  HDGGIYAISWsPDsTHLLSASGDKTSKIWDV 257
           99*********999****************7 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlk 91
           ++h +++ + k++p++ ++a+g  +g++++wd+t+   l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++
   Q: 49   TEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQREHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEIT 137
           4566667778*************************988777632334567***********99999999887777777789******** PP
   S: 92   ghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tg 177
           gh++ + s+++ +s+ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l   +
   Q: 138  GHNKIINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALggGK 225
           *************999*****************9999998.99******************************************9955 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvks.vrfspnderlvsgssDgsiriWdlrs.gdllktlqlhn 264
           +h++ +y +s+++++++l+s+s d+t k+wd+  +++v+t++  ++   + +  + ++++l+s s  g i+  d+ + +++l+++++h 
   Q: 226  AHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVNTFTMGSNVLDQqLGCLWQKDHLLSISLSGYINYLDKNNpSKPLRVIKGHS 314
           6****************************************98776655414444789999999999*****87654356777777777 PP
   S: 265  ssvisvavlsfgd 277
           +s+ + +v++ g+
   Q: 315  KSIQCLTVHKNGG 327
           7777777766554 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

KVFASLPQVE RGVSKIIGGD PKGNNFLYTN GKCVILRNID NPAIADIYTE HAHQVVVAKY 60
APSGFYIASG DVSGKLRIWD TTQREHLLKY EYQPFAGKIK DIAWTEDSKR IAVVGEGREK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGTGTTCG CCAGCCTCCC CCAGGTGGAG AGAGGCGTCT CCAAAATCAT CGGCGGCGAC 60
CCCAAGGGCA ACAATTTTCT TTACACCAAT GGAAAGTGCG TCATCTTAAG GAACATCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0042643--C:actomyosin, actin portion
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0051015--F:actin filament binding
GO:0030042--P:actin filament depolymerization
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0040011--P:locomotion
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.39	3.00e-79	289.00
IUUC-Aml-002368	Ailuropoda melanoleuca	95.34	0.00e+00	1156.00
IUUC-Atr-003160	Amborella trichopoda	36.66	1.00e-109	390.00
IUUC-Apl-004012	Anas platyrhynchos	86.36	0.00e+00	1048.00
IUUC-Aca-004707	Anolis carolinensis	82.03	0.00e+00	1016.00
IUUC-Aly-006465	Arabidopsis lyrata	36.11	2.00e-104	372.00
IUUC-Ath-006740	Arabidopsis thaliana	35.95	6.00e-104	371.00
IUUC-Ago-007920	Ashbya gossypii	28.27	6.00e-70	258.00
IUUC-Acl-008262	Aspergillus clavatus	36.10	2.00e-105	375.00
IUUC-Afl-008471	Aspergillus flavus	30.55	1.00e-68	254.00
IUUC-Afu-008989	Aspergillus fumigatus	38.42	2.00e-96	346.00
IUUC-Ani-009167	Aspergillus nidulans	37.54	5.00e-115	408.00
IUUC-Ang-009595	Aspergillus niger	37.63	6.00e-103	368.00
IUUC-Aor-009908	Aspergillus oryzae	36.64	5.00e-102	364.00
IUUC-Ate-010580	Aspergillus terreus	37.62	2.00e-106	381.00
IUUC-Ame-011269	Astyanax mexicanus	58.59	4.00e-124	438.00
IUUC-Bgr-011996	Blumeria graminis	34.64	2.00e-103	369.00
IUUC-Bta-013278	Bos taurus	94.68	0.00e+00	1174.00
IUUC-Bci-013925	Botrytis cinerea	35.74	9.00e-105	374.00
IUUC-Bdi-014659	Brachypodium distachyon	35.90	3.00e-100	359.00
IUUC-Bol-016043	Brassica oleracea	35.41	1.00e-104	373.00
IUUC-Bra-017139	Brassica rapa	35.95	7.00e-103	367.00
IUUC-Cel-018417	Caenorhabditis elegans	40.66	2.00e-120	426.00
IUUC-Cja-019952	Callithrix jacchus	94.18	0.00e+00	1121.00
IUUC-Cfa-020225	Canis familiaris	95.67	0.00e+00	1161.00
IUUC-Cpo-021900	Cavia porcellus	92.18	0.00e+00	1134.00
IUUC-Csa-023028	Chlorocebus sabaeus	95.17	0.00e+00	1129.00
IUUC-Cho-025030	Choloepus hoffmanni	68.39	0.00e+00	757.00
IUUC-Cin-025152	Ciona intestinalis	56.18	7.00e-81	293.00
IUUC-Csv-025986	Ciona savignyi	36.48	8.00e-88	317.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	37.93	2.00e-107	382.00
IUUC-Cne-026814	Cryptococcus neoformans	34.30	2.00e-94	339.00
IUUC-Dre-027498	Danio rerio	81.48	2.00e-93	334.00
IUUC-Dno-029383	Dasypus novemcinctus	92.85	0.00e+00	1103.00
IUUC-Dor-030633	Dipodomys ordii	94.65	0.00e+00	1104.00
IUUC-Dse-031526	Dothistroma septosporum	38.11	6.00e-114	404.00
IUUC-Dme-031597	Drosophila melanogaster	46.76	4.00e-160	557.00
IUUC-Ete-032780	Echinops telfairi	86.63	0.00e+00	1050.00
IUUC-Eeu-034531	Erinaceus europaeus	73.60	5.00e-135	474.00
IUUC-Fca-036301	Felis catus	95.34	0.00e+00	1181.00
IUUC-Fal-037361	Ficedula albicollis	86.86	0.00e+00	1105.00
IUUC-Fox-037924	Fusarium oxysporum	35.40	1.00e-98	353.00
IUUC-Fso-038199	Fusarium solani	34.85	2.00e-96	346.00
IUUC-Gmo-039238	Gadus morhua	70.98	0.00e+00	861.00
IUUC-Ggr-039830	Gaeumannomyces graminis	36.35	5.00e-93	335.00
IUUC-Gga-040235	Gallus gallus	87.35	0.00e+00	1071.00
IUUC-Gac-042363	Gasterosteus aculeatus	70.81	0.00e+00	887.00
IUUC-Gma-044189	Glycine max	36.89	3.00e-109	389.00
IUUC-Ggo-044632	Gorilla gorilla	95.01	0.00e+00	1136.00
IUUC-Hsa-045792	Homo sapiens	94.51	0.00e+00	1145.00
IUUC-Hvu-047517	Hordeum vulgare	35.46	1.00e-104	374.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	94.51	0.00e+00	1144.00
IUUC-Kpa-049183	Komagataella pastoris	32.51	4.00e-82	298.00
IUUC-Lch-050428	Latimeria chalumnae	75.87	0.00e+00	972.00
IUUC-Lpe-051306	Leersia perrieri	35.57	6.00e-105	374.00
IUUC-Loc-052096	Lepisosteus oculatus	70.70	0.00e+00	858.00
IUUC-Lma-053313	Leptosphaeria maculans	38.89	8.00e-114	406.00
IUUC-Laf-054060	Loxodonta africana	91.76	0.00e+00	1122.00
IUUC-Mcc-055619	Macaca mulatta	95.53	0.00e+00	1139.00
IUUC-Meu-056689	Macropus eugenii	79.13	0.00e+00	631.00
IUUC-Mor-056940	Magnaporthe oryzae	34.64	6.00e-94	338.00
IUUC-Mpo-057557	Magnaporthe poae	28.37	1.00e-54	207.00
IUUC-Mtr-057922	Medicago truncatula	35.53	5.00e-106	378.00
IUUC-Mla-059103	Melampsora laricipopulina	33.04	4.00e-75	275.00
IUUC-Mga-060150	Meleagris gallopavo	87.69	0.00e+00	1071.00
IUUC-Mvi-060448	Microbotryum violaceum	31.74	1.00e-74	274.00
IUUC-Mmr-061226	Microcebus murinus	93.51	0.00e+00	1139.00
IUUC-Mdo-062674	Monodelphis domestica	90.85	0.00e+00	1111.00
IUUC-Mmu-064170	Mus musculus	93.51	0.00e+00	1142.00
IUUC-Mac-065124	Musa acuminata	37.11	1.00e-108	387.00
IUUC-Mpu-066001	Mustela putorius furo	91.67	0.00e+00	1133.00
IUUC-Mlu-067253	Myotis lucifugus	93.69	0.00e+00	1163.00
IUUC-Nfi-068550	Neosartorya fischeri	38.40	2.00e-109	389.00
IUUC-Ncr-068948	Neurospora crassa	36.14	1.00e-110	394.00
IUUC-Nle-070115	Nomascus leucogenys	93.22	0.00e+00	1084.00
IUUC-Opr-070254	Ochotona princeps	94.51	0.00e+00	1122.00
IUUC-Ont-071666	Oreochromis niloticus	73.96	0.00e+00	916.00
IUUC-Oan-073594	Ornithorhynchus anatinus	90.12	6.00e-160	556.00
IUUC-Ocu-074824	Oryctolagus cuniculus	93.01	0.00e+00	1097.00
IUUC-Oba-075010	Oryza barthii	36.33	1.00e-105	377.00
IUUC-Obr-076364	Oryza brachyantha	36.50	4.00e-107	382.00
IUUC-Ogl-077019	Oryza glaberrima	36.33	1.00e-105	377.00
IUUC-Ogu-078496	Oryza glumaepatula	36.33	1.00e-105	377.00
IUUC-Oin-080116	Oryza indica	36.50	4.00e-106	378.00
IUUC-Olo-080290	Oryza longistaminata	36.33	3.00e-105	375.00
IUUC-Ome-081969	Oryza meridionalis	36.33	1.00e-105	376.00
IUUC-Oni-082075	Oryza nivara	36.33	1.00e-105	377.00
IUUC-Opu-083959	Oryza punctata	36.17	4.00e-106	378.00
IUUC-Oru-084711	Oryza rufipogon	36.33	1.00e-105	377.00
IUUC-Osa-085958	Oryza sativa	36.50	4.00e-106	378.00
IUUC-Ola-086968	Oryzias latipes	75.33	0.00e+00	930.00
IUUC-Oga-089108	Otolemur garnettii	93.39	0.00e+00	1170.00
IUUC-Oar-089986	Ovis aries	89.02	0.00e+00	1093.00
IUUC-Ptr-091281	Pan troglodytes	94.84	0.00e+00	1150.00
IUUC-Pan-092585	Papio anubis	95.34	0.00e+00	1132.00
IUUC-Psi-093811	Pelodiscus sinensis	85.00	0.00e+00	1081.00
IUUC-Pma-094542	Petromyzon marinus	69.04	0.00e+00	867.00
IUUC-Pno-095086	Phaeosphaeria nodorum	36.92	3.00e-106	379.00
IUUC-Ppa-095876	Physcomitrella patens	35.91	1.00e-106	380.00
IUUC-Pfo-096973	Poecilia formosa	74.00	0.00e+00	950.00
IUUC-Pab-098391	Pongo abelii	94.68	0.00e+00	1127.00
IUUC-Pop-098850	Populus trichocarpa	36.89	7.00e-108	384.00
IUUC-Pca-100257	Procavia capensis	62.63	4.00e-97	348.00
IUUC-Ppe-101578	Prunus persica	37.60	9.00e-110	390.00
IUUC-Pva-102872	Pteropus vampyrus	91.85	0.00e+00	1145.00
IUUC-Pgr-103593	Puccinia graminis	32.45	2.00e-75	276.00
IUUC-Pte-104365	Pyrenophora teres	39.05	3.00e-110	392.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.73	1.00e-112	400.00
IUUC-Rno-105737	Rattus norvegicus	94.01	0.00e+00	1172.00
IUUC-Sce-106383	Saccharomyces cerevisiae	28.71	6.00e-65	241.00
IUUC-Sha-107084	Sarcophilus harrisii	87.52	0.00e+00	982.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.05	4.00e-107	381.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.06	4.00e-91	328.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.08	2.00e-103	369.00
IUUC-Smo-109255	Selaginella moellendorffii	33.88	5.00e-95	341.00
IUUC-Sit-109962	Setaria italica	36.72	5.00e-108	385.00
IUUC-Sly-110897	Solanum lycopersicum	37.83	4.00e-110	391.00
IUUC-Stu-111971	Solanum tuberosum	37.66	4.00e-109	388.00
IUUC-Sar-113415	Sorex araneus	71.59	8.00e-109	387.00
IUUC-Sbi-114857	Sorghum bicolor	36.39	4.00e-106	378.00
IUUC-Sre-114900	Sporisorium reilianum	33.11	2.00e-86	313.00
IUUC-Tgu-117256	Taeniopygia guttata	86.69	0.00e+00	1097.00
IUUC-Tru-117871	Takifugu rubripes	69.00	0.00e+00	853.00
IUUC-Tsy-119172	Tarsius syrichta	95.83	5.00e-138	484.00
IUUC-Tni-120339	Tetraodon nigroviridis	69.00	0.00e+00	888.00
IUUC-Tca-121609	Theobroma cacao	35.93	3.00e-107	382.00
IUUC-Tre-122076	Trichoderma reesei	35.34	2.00e-93	336.00
IUUC-Tvi-122528	Trichoderma virens	34.25	4.00e-93	335.00
IUUC-Tae-124549	Triticum aestivum	35.78	1.00e-105	377.00
IUUC-Tur-126845	Triticum urartu	33.82	2.00e-78	286.00
IUUC-Tme-127217	Tuber melanosporum	34.68	6.00e-100	358.00
IUUC-Tbe-127526	Tupaia belangeri	94.34	0.00e+00	1170.00
IUUC-Ttr-128898	Tursiops truncatus	89.18	0.00e+00	1111.00
IUUC-Uma-129631	Ustilago maydis	31.89	5.00e-90	325.00
IUUC-Vda-129732	Verticillium dahliae	36.05	7.00e-90	324.00
IUUC-Vvi-131217	Vitis vinifera	37.77	9.00e-109	387.00
IUUC-Xtr-132860	Xenopus tropicalis	72.36	0.00e+00	910.00
IUUC-Xma-133830	Xiphophorus maculatus	74.00	0.00e+00	950.00
IUUC-Yli-134335	Yarrowia lipolytica	31.80	1.00e-73	270.00
IUUC-Zma-135907	Zea mays	36.39	5.00e-107	381.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence