iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121865

Ensembl Protein ID

EOY10426

UniProt Accession

A0A061F038; A0A061F038_THECC

Genbank Protein ID

EOY10426.1

Protein Name

Presenilin

Genbank Nucleotide ID

CM001883

Gene Name

TCM_025793

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_025793	EOY10426	EOY10426

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	32.07	2.00e-39	160.00	IUUC-Cel-018553

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Theobroma cacao

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MESSILESIG QEIIGVMSPV SLCMLLVVLL VYSLSPSNPF SSSSPAPIRT AANLVYLENP 60
SDTAAQKLEG ALLNALVFVI LIAIVTFVLV LLYYYNFTNF LKNYMRFSAF FVLGTMGGSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGTGATT GATTGGTTGC GTAATATGTA AAGGAGAAAT TAATTAATTA ATTAATTAAT 60
TTAGATAGTG TACTTAACCT TTGAATAAAT GATAAAACGT TTTCTATAAT ATAACTTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	52.03	2.00e-81	296.00
IUUC-Aml-001648	Ailuropoda melanoleuca	36.20	2.00e-35	142.00
IUUC-Atr-003039	Amborella trichopoda	62.63	4.00e-137	480.00
IUUC-Apl-003727	Anas platyrhynchos	36.08	1.00e-35	143.00
IUUC-Aca-004582	Anolis carolinensis	33.08	8.00e-35	140.00
IUUC-Aly-005455	Arabidopsis lyrata	67.97	3.00e-141	493.00
IUUC-Ath-006730	Arabidopsis thaliana	68.74	9.00e-145	505.00
IUUC-Ame-010686	Astyanax mexicanus	31.67	6.00e-35	140.00
IUUC-Bta-013026	Bos taurus	33.58	2.00e-35	142.00
IUUC-Bdi-014196	Brachypodium distachyon	52.89	1.00e-95	342.00
IUUC-Bol-015841	Brassica oleracea	67.62	4.00e-128	450.00
IUUC-Bra-017580	Brassica rapa	68.55	2.00e-118	418.00
IUUC-Cel-018553	Caenorhabditis elegans	32.06	6.00e-43	167.00
IUUC-Cja-019994	Callithrix jacchus	33.59	5.00e-37	147.00
IUUC-Cfa-020074	Canis familiaris	32.83	3.00e-35	142.00
IUUC-Cpo-022237	Cavia porcellus	33.75	1.00e-36	146.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	45.45	3.00e-43	169.00
IUUC-Csa-023537	Chlorocebus sabaeus	33.92	1.00e-36	146.00
IUUC-Cho-024735	Choloepus hoffmanni	34.27	5.00e-33	134.00
IUUC-Cin-025780	Ciona intestinalis	32.81	4.00e-42	164.00
IUUC-Csv-025967	Ciona savignyi	34.64	3.00e-24	105.00
IUUC-Dre-028526	Danio rerio	33.08	3.00e-39	155.00
IUUC-Dno-029758	Dasypus novemcinctus	33.00	1.00e-34	140.00
IUUC-Dor-031127	Dipodomys ordii	36.67	2.00e-23	102.00
IUUC-Dme-031929	Drosophila melanogaster	30.63	5.00e-38	151.00
IUUC-Ete-032487	Echinops telfairi	36.99	2.00e-18	86.30
IUUC-Eca-034387	Equus caballus	36.11	2.00e-26	112.00
IUUC-Eeu-035134	Erinaceus europaeus	35.94	1.00e-35	142.00
IUUC-Fca-036243	Felis catus	33.00	2.00e-35	142.00
IUUC-Fal-036600	Ficedula albicollis	31.99	4.00e-33	135.00
IUUC-Gmo-038550	Gadus morhua	33.70	1.00e-22	100.00
IUUC-Gga-040993	Gallus gallus	32.49	9.00e-36	143.00
IUUC-Gac-042511	Gasterosteus aculeatus	32.59	2.00e-35	142.00
IUUC-Gma-043822	Glycine max	73.51	5.00e-57	214.00
IUUC-Ggo-044859	Gorilla gorilla	30.86	6.00e-24	103.00
IUUC-Hsa-046822	Homo sapiens	33.92	1.00e-36	146.00
IUUC-Hvu-047141	Hordeum vulgare	52.73	1.00e-88	319.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	35.00	1.00e-37	149.00
IUUC-Lch-049638	Latimeria chalumnae	28.97	3.00e-28	119.00
IUUC-Lpe-051132	Leersia perrieri	55.02	2.00e-95	341.00
IUUC-Loc-052427	Lepisosteus oculatus	32.66	7.00e-39	154.00
IUUC-Laf-053758	Loxodonta africana	33.00	2.00e-37	149.00
IUUC-Mcc-055682	Macaca mulatta	33.92	1.00e-36	146.00
IUUC-Meu-056004	Macropus eugenii	34.07	3.00e-22	98.60
IUUC-Mtr-058392	Medicago truncatula	65.94	3.00e-125	441.00
IUUC-Mga-059466	Meleagris gallopavo	33.00	7.00e-35	140.00
IUUC-Mmr-060890	Microcebus murinus	34.44	2.00e-24	105.00
IUUC-Mdo-062122	Monodelphis domestica	32.75	6.00e-36	144.00
IUUC-Mmu-063176	Mus musculus	33.25	3.00e-34	138.00
IUUC-Mac-064858	Musa acuminata	68.99	2.00e-42	165.00
IUUC-Mpu-065927	Mustela putorius furo	33.33	2.00e-35	142.00
IUUC-Mlu-067079	Myotis lucifugus	33.58	1.00e-40	159.00
IUUC-Nle-070180	Nomascus leucogenys	33.92	1.00e-36	146.00
IUUC-Opr-070847	Ochotona princeps	32.83	6.00e-33	134.00
IUUC-Ont-071867	Oreochromis niloticus	31.17	1.00e-31	130.00
IUUC-Oan-072783	Ornithorhynchus anatinus	35.91	4.00e-34	137.00
IUUC-Ocu-074527	Oryctolagus cuniculus	32.91	2.00e-34	139.00
IUUC-Oba-075256	Oryza barthii	53.57	9.00e-87	312.00
IUUC-Obr-076302	Oryza brachyantha	52.80	2.00e-90	325.00
IUUC-Ogl-077097	Oryza glaberrima	55.47	3.00e-94	338.00
IUUC-Ogu-078570	Oryza glumaepatula	55.47	5.00e-94	337.00
IUUC-Oin-079244	Oryza indica	55.72	5.00e-95	340.00
IUUC-Olo-080484	Oryza longistaminata	52.48	3.00e-64	237.00
IUUC-Ome-081814	Oryza meridionalis	53.12	5.00e-94	337.00
IUUC-Oni-082057	Oryza nivara	55.96	7.00e-95	340.00
IUUC-Opu-084176	Oryza punctata	54.57	4.00e-95	340.00
IUUC-Oru-084618	Oryza rufipogon	55.47	3.00e-94	338.00
IUUC-Osa-085602	Oryza sativa	55.80	2.00e-95	342.00
IUUC-Ola-086707	Oryzias latipes	32.97	6.00e-24	103.00
IUUC-Olu-087811	Ostreococcus lucimarinus	48.57	2.00e-45	175.00
IUUC-Oga-088560	Otolemur garnettii	34.44	2.00e-24	106.00
IUUC-Oar-090348	Ovis aries	33.33	3.00e-36	145.00
IUUC-Ptr-091060	Pan troglodytes	33.92	1.00e-36	146.00
IUUC-Pan-091855	Papio anubis	34.78	7.00e-22	97.80
IUUC-Psi-093505	Pelodiscus sinensis	32.75	8.00e-36	144.00
IUUC-Pma-094612	Petromyzon marinus	34.18	1.00e-21	96.70
IUUC-Ppa-095431	Physcomitrella patens	46.53	5.00e-88	317.00
IUUC-Pfo-097396	Poecilia formosa	31.66	2.00e-36	145.00
IUUC-Pab-098591	Pongo abelii	33.92	2.00e-36	146.00
IUUC-Pop-099661	Populus trichocarpa	50.11	1.00e-84	305.00
IUUC-Pca-101029	Procavia capensis	37.07	4.00e-35	141.00
IUUC-Ppe-101495	Prunus persica	75.43	4.00e-163	566.00
IUUC-Pva-102934	Pteropus vampyrus	33.89	7.00e-25	107.00
IUUC-Rno-105861	Rattus norvegicus	34.89	2.00e-33	136.00
IUUC-Sha-107045	Sarcophilus harrisii	32.92	2.00e-34	139.00
IUUC-Smo-109325	Selaginella moellendorffii	51.32	3.00e-40	158.00
IUUC-Sit-110624	Setaria italica	53.62	2.00e-89	322.00
IUUC-Sly-110865	Solanum lycopersicum	91.43	1.00e-33	133.00
IUUC-Stu-112433	Solanum tuberosum	64.02	4.00e-120	423.00
IUUC-Sar-113169	Sorex araneus	35.20	1.00e-34	140.00
IUUC-Sbi-114305	Sorghum bicolor	54.09	4.00e-89	320.00
IUUC-Ssc-115766	Sus scrofa	33.42	2.00e-35	142.00
IUUC-Tgu-117280	Taeniopygia guttata	32.50	3.00e-33	135.00
IUUC-Tru-117732	Takifugu rubripes	31.71	5.00e-32	131.00
IUUC-Tsy-119624	Tarsius syrichta	43.93	1.00e-21	97.10
IUUC-Tni-119852	Tetraodon nigroviridis	31.91	4.00e-31	128.00
IUUC-Tae-123984	Triticum aestivum	52.45	9.00e-87	313.00
IUUC-Tur-126237	Triticum urartu	51.45	8.00e-83	300.00
IUUC-Tbe-128148	Tupaia belangeri	35.80	2.00e-22	99.40
IUUC-Ttr-128793	Tursiops truncatus	35.71	2.00e-33	135.00
IUUC-Vpa-130625	Vicugna pacos	31.35	2.00e-25	109.00
IUUC-Vvi-131312	Vitis vinifera	72.23	7.00e-147	512.00
IUUC-Xtr-132756	Xenopus tropicalis	32.92	2.00e-37	149.00
IUUC-Xma-133377	Xiphophorus maculatus	32.51	8.00e-35	140.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence