iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009156

Ensembl Protein ID

CADANIAP00000518

UniProt Accession

Q5AWA2; C8VBA1; ATG7_EMENI

Genbank Protein ID

EAA62008.1; CBF79362.1

Protein Name

Ubiquitin-like modifier-activating enzyme atg7; ATG12-activating enzyme E1 atg7; Autophagy-related protein 7

Genbank Nucleotide ID

AACD01000129; BN001304

Gene Name

ANIA_07428; atg7; AN7428

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00000518	CADANIAT00000518	CADANIAP00000518

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	40.99	2.00e-117	417.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
543	Glycyl thioester intermediate	{ECO:0000250}

Organism

Aspergillus nidulans

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MQYTPFASDI ELPFYIALAS LKINHDKLDD SARKVLGLYE LRPSDAPNAS CRIQIHGNAL 60
TSDEVPSTYY RAEGMIKNVN TIEEYAKADK MGMLQQSGET IWNAINNGTI YSCPSLLSAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGTACA CTCCATTTGC CTCAGATATA GAGCTGCCGT TCTATATTGC CCTGGCTTCT 60
CTCAAGATAA ATCATGACAA GCTCGATGAT TCCGCGCGCA AAGTTCTGGG CCTGTACGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0000407--C:pre-autophagosomal structure
GO:0008641--F:small protein activating enzyme activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

ani:AN7428.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	31.84	4.00e-84	305.00
IUUC-Aml-002316	Ailuropoda melanoleuca	44.97	8.00e-141	492.00
IUUC-Atr-002579	Amborella trichopoda	41.37	3.00e-138	484.00
IUUC-Apl-003805	Anas platyrhynchos	42.78	3.00e-147	513.00
IUUC-Aca-004618	Anolis carolinensis	45.83	4.00e-131	459.00
IUUC-Aly-005670	Arabidopsis lyrata	40.63	1.00e-122	431.00
IUUC-Ath-007499	Arabidopsis thaliana	41.11	3.00e-126	444.00
IUUC-Ago-007838	Ashbya gossypii	40.47	3.00e-123	433.00
IUUC-Acl-008093	Aspergillus clavatus	71.12	0.00e+00	981.00
IUUC-Afl-008663	Aspergillus flavus	72.16	0.00e+00	852.00
IUUC-Afu-008926	Aspergillus fumigatus	67.20	0.00e+00	891.00
IUUC-Ang-009853	Aspergillus niger	73.55	3.00e-97	345.00
IUUC-Aor-010055	Aspergillus oryzae	71.27	0.00e+00	1003.00
IUUC-Ate-010281	Aspergillus terreus	64.53	0.00e+00	883.00
IUUC-Ame-010939	Astyanax mexicanus	41.72	1.00e-145	508.00
IUUC-Bgr-012006	Blumeria graminis	53.46	0.00e+00	723.00
IUUC-Bta-012336	Bos taurus	43.10	1.00e-140	492.00
IUUC-Bci-013598	Botrytis cinerea	59.74	0.00e+00	786.00
IUUC-Bdi-014170	Brachypodium distachyon	31.19	1.00e-80	293.00
IUUC-Bol-015357	Brassica oleracea	40.06	1.00e-129	454.00
IUUC-Bra-016835	Brassica rapa	40.34	4.00e-131	460.00
IUUC-Cel-018172	Caenorhabditis elegans	37.69	4.00e-101	360.00
IUUC-Cja-019544	Callithrix jacchus	43.08	1.00e-144	504.00
IUUC-Cfa-021043	Canis familiaris	42.94	4.00e-146	509.00
IUUC-Cpo-022366	Cavia porcellus	42.82	7.00e-144	502.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	43.32	3.00e-68	251.00
IUUC-Csa-023373	Chlorocebus sabaeus	42.90	2.00e-145	507.00
IUUC-Cho-024965	Choloepus hoffmanni	53.49	2.00e-47	181.00
IUUC-Cin-025710	Ciona intestinalis	42.71	9.00e-144	502.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	59.12	0.00e+00	774.00
IUUC-Cne-027083	Cryptococcus neoformans	39.69	6.00e-126	442.00
IUUC-Dre-028740	Danio rerio	38.90	1.00e-124	438.00
IUUC-Dno-029637	Dasypus novemcinctus	44.41	9.00e-139	485.00
IUUC-Dor-030492	Dipodomys ordii	42.57	2.00e-144	504.00
IUUC-Dse-031267	Dothistroma septosporum	50.00	0.00e+00	722.00
IUUC-Dme-032084	Drosophila melanogaster	40.20	5.00e-128	449.00
IUUC-Ete-032616	Echinops telfairi	40.59	2.00e-128	451.00
IUUC-Eca-033991	Equus caballus	43.22	5.00e-148	516.00
IUUC-Eeu-035126	Erinaceus europaeus	51.27	7.00e-61	226.00
IUUC-Fca-035472	Felis catus	43.22	2.00e-147	514.00
IUUC-Fal-037178	Ficedula albicollis	43.42	2.00e-147	514.00
IUUC-Fox-037901	Fusarium oxysporum	59.35	0.00e+00	793.00
IUUC-Fso-038279	Fusarium solani	60.12	0.00e+00	806.00
IUUC-Gmo-039329	Gadus morhua	42.82	4.00e-141	493.00
IUUC-Ggr-040061	Gaeumannomyces graminis	59.21	0.00e+00	754.00
IUUC-Gga-040244	Gallus gallus	43.24	2.00e-149	521.00
IUUC-Gac-041880	Gasterosteus aculeatus	50.86	1.00e-118	418.00
IUUC-Gma-043235	Glycine max	40.11	7.00e-132	462.00
IUUC-Ggo-045428	Gorilla gorilla	42.48	4.00e-144	503.00
IUUC-Hsa-046183	Homo sapiens	42.62	1.00e-144	504.00
IUUC-Hvu-047509	Hordeum vulgare	32.54	1.00e-81	296.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	43.38	2.00e-137	481.00
IUUC-Kpa-049142	Komagataella pastoris	42.12	3.00e-136	477.00
IUUC-Lch-049601	Latimeria chalumnae	36.74	1.00e-93	335.00
IUUC-Lpe-051496	Leersia perrieri	31.30	2.00e-76	279.00
IUUC-Loc-051751	Lepisosteus oculatus	41.76	4.00e-146	510.00
IUUC-Lma-053203	Leptosphaeria maculans	57.76	0.00e+00	637.00
IUUC-Laf-053424	Loxodonta africana	42.94	3.00e-144	503.00
IUUC-Mcc-054633	Macaca mulatta	42.90	2.00e-145	507.00
IUUC-Meu-056523	Macropus eugenii	38.90	1.00e-117	415.00
IUUC-Mor-056983	Magnaporthe oryzae	58.27	0.00e+00	763.00
IUUC-Mpo-057615	Magnaporthe poae	59.44	0.00e+00	776.00
IUUC-Mtr-058366	Medicago truncatula	41.12	1.00e-126	445.00
IUUC-Mla-058826	Melampsora laricipopulina	41.22	5.00e-150	523.00
IUUC-Mga-059447	Meleagris gallopavo	42.88	8.00e-149	518.00
IUUC-Mvi-060537	Microbotryum violaceum	43.13	2.00e-145	507.00
IUUC-Mmr-060676	Microcebus murinus	43.08	2.00e-146	511.00
IUUC-Mdo-062967	Monodelphis domestica	41.33	7.00e-137	479.00
IUUC-Mmu-063217	Mus musculus	43.40	4.00e-145	506.00
IUUC-Mac-065527	Musa acuminata	39.08	1.00e-116	412.00
IUUC-Mpu-066417	Mustela putorius furo	43.27	3.00e-146	510.00
IUUC-Mlu-067195	Myotis lucifugus	42.61	2.00e-147	514.00
IUUC-Nfi-068576	Neosartorya fischeri	67.09	0.00e+00	938.00
IUUC-Ncr-068867	Neurospora crassa	59.57	0.00e+00	768.00
IUUC-Nle-069447	Nomascus leucogenys	50.41	1.00e-91	328.00
IUUC-Opr-070737	Ochotona princeps	50.35	1.00e-111	395.00
IUUC-Ont-071260	Oreochromis niloticus	41.29	7.00e-140	489.00
IUUC-Oan-073622	Ornithorhynchus anatinus	40.00	3.00e-93	334.00
IUUC-Ocu-074584	Oryctolagus cuniculus	42.07	6.00e-147	512.00
IUUC-Oba-075483	Oryza barthii	30.72	2.00e-73	269.00
IUUC-Obr-076786	Oryza brachyantha	31.78	5.00e-83	300.00
IUUC-Ogl-077388	Oryza glaberrima	42.70	2.00e-73	269.00
IUUC-Ogu-078618	Oryza glumaepatula	30.66	8.00e-79	286.00
IUUC-Oin-080007	Oryza indica	31.02	4.00e-75	275.00
IUUC-Olo-080994	Oryza longistaminata	44.54	2.00e-73	269.00
IUUC-Ome-081735	Oryza meridionalis	42.70	2.00e-74	273.00
IUUC-Oni-082153	Oryza nivara	30.87	3.00e-74	271.00
IUUC-Opu-083146	Oryza punctata	30.92	1.00e-74	273.00
IUUC-Oru-084919	Oryza rufipogon	31.02	3.00e-75	275.00
IUUC-Osa-086182	Oryza sativa	30.97	2.00e-74	272.00
IUUC-Ola-086441	Oryzias latipes	42.02	4.00e-144	503.00
IUUC-Olu-087664	Ostreococcus lucimarinus	38.84	1.00e-115	408.00
IUUC-Oga-089074	Otolemur garnettii	42.92	4.00e-135	473.00
IUUC-Oar-090159	Ovis aries	43.27	8.00e-141	492.00
IUUC-Ptr-091105	Pan troglodytes	45.08	3.00e-131	460.00
IUUC-Pan-092446	Papio anubis	42.90	2.00e-145	507.00
IUUC-Psi-093372	Pelodiscus sinensis	42.79	2.00e-141	494.00
IUUC-Pma-094661	Petromyzon marinus	40.57	4.00e-120	423.00
IUUC-Pno-094813	Phaeosphaeria nodorum	53.11	9.00e-180	621.00
IUUC-Ppa-095224	Physcomitrella patens	40.58	3.00e-131	460.00
IUUC-Pfo-096565	Poecilia formosa	42.65	2.00e-138	484.00
IUUC-Pop-099702	Populus trichocarpa	40.26	9.00e-139	485.00
IUUC-Pca-100324	Procavia capensis	35.84	6.00e-73	266.00
IUUC-Ppe-101416	Prunus persica	40.48	6.00e-131	459.00
IUUC-Pva-102589	Pteropus vampyrus	40.37	9.00e-129	452.00
IUUC-Pgr-103497	Puccinia graminis	41.81	3.00e-146	510.00
IUUC-Ptt-103718	Puccinia triticina	41.54	2.00e-145	508.00
IUUC-Pte-104206	Pyrenophora teres	56.94	0.00e+00	628.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	54.91	0.00e+00	699.00
IUUC-Rno-105911	Rattus norvegicus	43.55	3.00e-146	510.00
IUUC-Sce-106413	Saccharomyces cerevisiae	40.99	7.00e-121	426.00
IUUC-Sha-106679	Sarcophilus harrisii	42.03	2.00e-141	494.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	40.00	4.00e-129	453.00
IUUC-Spo-108107	Schizosaccharomyces pombe	41.25	6.00e-131	459.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	58.96	0.00e+00	790.00
IUUC-Smo-109677	Selaginella moellendorffii	37.66	6.00e-114	402.00
IUUC-Sit-110319	Setaria italica	41.42	1.00e-73	269.00
IUUC-Sly-111215	Solanum lycopersicum	40.69	6.00e-135	473.00
IUUC-Stu-112442	Solanum tuberosum	41.26	5.00e-134	469.00
IUUC-Sar-113370	Sorex araneus	50.77	7.00e-102	362.00
IUUC-Sbi-114261	Sorghum bicolor	43.37	5.00e-71	261.00
IUUC-Sre-114997	Sporisorium reilianum	39.21	4.00e-139	486.00
IUUC-Ssc-115304	Sus scrofa	43.38	1.00e-140	491.00
IUUC-Tgu-117235	Taeniopygia guttata	42.71	4.00e-146	509.00
IUUC-Tru-118374	Takifugu rubripes	42.45	1.00e-140	491.00
IUUC-Tsy-118966	Tarsius syrichta	35.73	2.00e-109	387.00
IUUC-Tni-120269	Tetraodon nigroviridis	41.42	1.00e-123	434.00
IUUC-Tca-121245	Theobroma cacao	40.88	9.00e-136	475.00
IUUC-Tre-121966	Trichoderma reesei	57.37	0.00e+00	755.00
IUUC-Tvi-122360	Trichoderma virens	57.83	0.00e+00	752.00
IUUC-Tae-125251	Triticum aestivum	31.84	6.00e-85	306.00
IUUC-Tur-126294	Triticum urartu	31.84	2.00e-80	292.00
IUUC-Tme-127117	Tuber melanosporum	55.31	0.00e+00	665.00
IUUC-Tbe-127662	Tupaia belangeri	45.67	6.00e-41	160.00
IUUC-Ttr-129054	Tursiops truncatus	42.37	2.00e-143	501.00
IUUC-Uma-129526	Ustilago maydis	39.06	2.00e-140	491.00
IUUC-Vda-129878	Verticillium dahliae	57.33	0.00e+00	755.00
IUUC-Vpa-130264	Vicugna pacos	36.83	3.00e-72	264.00
IUUC-Vvi-131163	Vitis vinifera	41.30	4.00e-138	483.00
IUUC-Xtr-132328	Xenopus tropicalis	33.53	2.00e-91	328.00
IUUC-Xma-133015	Xiphophorus maculatus	40.74	5.00e-126	443.00
IUUC-Yli-134468	Yarrowia lipolytica	41.72	4.00e-131	459.00
IUUC-Zma-134871	Zea mays	31.52	2.00e-78	285.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence