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Tag Content
iUUCD ID IUUC-Afu-008952
Ensembl Protein ID CADAFUAP00006596
UniProt Accession Q4WVU5; PPIL2_ASPFU
Genbank Protein ID EAL91281.2
Protein Name Peptidyl-prolyl cis-trans isomerase-like 2; Cyclophilin-60; Cyclophilin-like protein Cyp-60; RING-type E3 ubiquitin transferase isomerase-like 2; Rotamase
Genbank Nucleotide ID AAHF01000003
Gene Name AFUA_5G13350; cyp8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADAFUAG00006596 CADAFUAT00006596 CADAFUAP00006596
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 3.90e-13 48.3 48 108
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 7    lCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqaw 68
            C++sl+++++Pv++psG  +d +sI  w+++ g+ +Pv+++pl+++dl+  +  ++   ++
   Q: 48   FCSLSLQPFSHPVCTPSGTIFDLTSILPWIKKHGT-NPVDGSPLKSSDLIKLNIAKNESGEY 108
           6******************************9998.**************999988876666 PP
   
Organism Aspergillus fumigatus
Functional Description
(View)

Functional Description


     May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
 May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Protein Sequence
(Fasta)
MGKGTDKLYI THSEWASEDA YSASAGAGVG KARRGGENAG FRRLPFNFCS LSLQPFSHPV 60
CTPSGTIFDL TSILPWIKKH GTNPVDGSPL KSSDLIKLNI AKNESGEYVD PVTYKVLTDN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Afu-008952|E3,U-box|Aspergillus fumigatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCAAGG GTGAGTTTCT TTACCAAACT ATATTTCCAA CGCTTACAAC TGACTCCTGA 60
CTTGTTAGGA ACGGATAAGC TTTACGTATG ATGTTCCACA CTTTCTCTGC CTTCATGACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Afu-008952|E3,U-box|Aspergillus fumigatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX
Pfam

PF00160--Pro_isomerase
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00504--Ubox
Gene Ontology

GO:0005634--C:nucleus
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006457--P:protein folding
KEGG afm:AFUA_5G13350
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000982 Aegilops tauschii 40.12 1.00e-80 292.00
IUUC-Aml-002351 Ailuropoda melanoleuca 43.56 5.00e-109 386.00
IUUC-Atr-002724 Amborella trichopoda 38.81 5.00e-96 343.00
IUUC-Apl-003515 Anas platyrhynchos 43.33 4.00e-100 356.00
IUUC-Aca-004802 Anolis carolinensis 42.86 1.00e-108 384.00
IUUC-Aly-005928 Arabidopsis lyrata 39.50 2.00e-91 328.00
IUUC-Ath-007574 Arabidopsis thaliana 38.93 7.00e-85 306.00
IUUC-Acl-008183 Aspergillus clavatus 90.04 0.00e+00 907.00
IUUC-Afl-008382 Aspergillus flavus 81.38 0.00e+00 819.00
IUUC-Ani-009146 Aspergillus nidulans 82.36 0.00e+00 882.00
IUUC-Ang-009743 Aspergillus niger 85.01 0.00e+00 850.00
IUUC-Aor-010027 Aspergillus oryzae 80.62 0.00e+00 812.00
IUUC-Ate-010569 Aspergillus terreus 84.00 0.00e+00 877.00
IUUC-Ame-010783 Astyanax mexicanus 41.98 2.00e-108 384.00
IUUC-Bgr-012172 Blumeria graminis 48.43 4.00e-114 403.00
IUUC-Bta-012459 Bos taurus 42.58 8.00e-103 365.00
IUUC-Bci-013693 Botrytis cinerea 57.91 2.00e-157 547.00
IUUC-Bdi-014623 Brachypodium distachyon 40.31 1.00e-99 355.00
IUUC-Bol-015781 Brassica oleracea 40.08 2.00e-94 338.00
IUUC-Bra-016624 Brassica rapa 40.08 6.00e-94 336.00
IUUC-Cel-018328 Caenorhabditis elegans 39.24 1.00e-91 328.00
IUUC-Cja-019427 Callithrix jacchus 45.53 6.00e-107 379.00
IUUC-Cfa-020829 Canis familiaris 43.01 3.00e-109 386.00
IUUC-Cpo-022189 Cavia porcellus 42.45 3.00e-108 383.00
IUUC-Cre-022723 Chlamydomonas reinhardtii 45.51 7.00e-46 176.00
IUUC-Csa-024212 Chlorocebus sabaeus 44.38 2.00e-107 380.00
IUUC-Cin-025720 Ciona intestinalis 41.74 4.00e-108 383.00
IUUC-Csv-026137 Ciona savignyi 42.28 1.00e-99 355.00
IUUC-Cgl-026532 Colletotrichum gloeosporioides 56.94 2.00e-155 540.00
IUUC-Cne-026830 Cryptococcus neoformans 41.98 9.00e-113 398.00
IUUC-Dre-028561 Danio rerio 44.91 3.00e-105 373.00
IUUC-Dno-029029 Dasypus novemcinctus 41.39 4.00e-95 340.00
IUUC-Dor-030683 Dipodomys ordii 49.67 1.00e-37 149.00
IUUC-Dse-031506 Dothistroma septosporum 63.14 4.00e-178 615.00
IUUC-Dme-032058 Drosophila melanogaster 41.56 3.00e-97 347.00
IUUC-Ete-033157 Echinops telfairi 35.35 9.00e-73 265.00
IUUC-Eeu-034470 Erinaceus europaeus 43.25 1.00e-67 248.00
IUUC-Fca-036571 Felis catus 44.99 5.00e-108 382.00
IUUC-Fal-037613 Ficedula albicollis 42.03 2.00e-107 380.00
IUUC-Fox-037795 Fusarium oxysporum 56.53 8.00e-165 571.00
IUUC-Fso-038213 Fusarium solani 51.56 1.00e-148 518.00
IUUC-Gmo-039609 Gadus morhua 44.77 2.00e-97 347.00
IUUC-Ggr-039825 Gaeumannomyces graminis 53.98 1.00e-150 524.00
IUUC-Gga-041191 Gallus gallus 42.51 6.00e-110 389.00
IUUC-Gac-041524 Gasterosteus aculeatus 45.00 1.00e-105 374.00
IUUC-Gma-042936 Glycine max 40.80 7.00e-96 342.00
IUUC-Ggo-045352 Gorilla gorilla 42.55 7.00e-108 382.00
IUUC-Hsa-045709 Homo sapiens 42.55 9.00e-108 382.00
IUUC-Hvu-047058 Hordeum vulgare 40.19 4.00e-94 337.00
IUUC-Itr-048483 Ictidomys tridecemlineatus 46.04 9.00e-107 378.00
IUUC-Lch-049681 Latimeria chalumnae 44.58 7.00e-100 355.00
IUUC-Lpe-050799 Leersia perrieri 39.16 1.00e-82 298.00
IUUC-Loc-052566 Lepisosteus oculatus 42.75 7.00e-95 339.00
IUUC-Lma-053028 Leptosphaeria maculans 61.26 2.00e-169 587.00
IUUC-Laf-054547 Loxodonta africana 43.68 9.00e-110 388.00
IUUC-Mcc-054753 Macaca mulatta 42.88 1.00e-107 382.00
IUUC-Meu-056855 Macropus eugenii 34.16 2.00e-35 140.00
IUUC-Mor-056941 Magnaporthe oryzae 54.10 7.00e-139 485.00
IUUC-Mpo-057306 Magnaporthe poae 53.81 9.00e-153 531.00
IUUC-Mtr-058349 Medicago truncatula 41.37 8.00e-94 335.00
IUUC-Mla-058842 Melampsora laricipopulina 43.92 2.00e-108 384.00
IUUC-Mga-060099 Meleagris gallopavo 42.52 9.00e-99 352.00
IUUC-Mvi-060413 Microbotryum violaceum 41.39 5.00e-101 359.00
IUUC-Mmr-061530 Microcebus murinus 43.01 7.00e-109 385.00
IUUC-Mdo-062668 Monodelphis domestica 45.27 2.00e-106 378.00
IUUC-Mmu-063871 Mus musculus 42.78 7.00e-109 385.00
IUUC-Mac-064559 Musa acuminata 51.12 2.00e-48 185.00
IUUC-Mpu-065919 Mustela putorius furo 43.73 5.00e-109 386.00
IUUC-Mlu-067846 Myotis lucifugus 44.10 4.00e-97 347.00
IUUC-Nfi-068507 Neosartorya fischeri 97.79 0.00e+00 906.00
IUUC-Ncr-068805 Neurospora crassa 54.29 1.00e-128 451.00
IUUC-Nle-070125 Nomascus leucogenys 39.20 2.00e-94 337.00
IUUC-Opr-070486 Ochotona princeps 42.24 7.00e-79 285.00
IUUC-Ont-071597 Oreochromis niloticus 46.67 4.00e-110 389.00
IUUC-Ocu-074411 Oryctolagus cuniculus 46.36 5.00e-108 382.00
IUUC-Oba-075040 Oryza barthii 43.18 1.00e-51 195.00
IUUC-Obr-076727 Oryza brachyantha 42.73 2.00e-50 192.00
IUUC-Ogl-077605 Oryza glaberrima 43.18 1.00e-51 195.00
IUUC-Ogu-078177 Oryza glumaepatula 43.18 1.00e-51 195.00
IUUC-Oin-079549 Oryza indica 43.18 3.00e-51 194.00
IUUC-Olo-081090 Oryza longistaminata 43.18 1.00e-51 195.00
IUUC-Ome-081979 Oryza meridionalis 43.18 2.00e-51 195.00
IUUC-Oni-082819 Oryza nivara 43.18 2.00e-51 194.00
IUUC-Opu-083212 Oryza punctata 43.18 1.00e-51 195.00
IUUC-Oru-084412 Oryza rufipogon 43.18 1.00e-51 195.00
IUUC-Osa-085431 Oryza sativa 46.04 5.00e-32 128.00
IUUC-Ola-086602 Oryzias latipes 47.96 3.00e-104 370.00
IUUC-Olu-087682 Ostreococcus lucimarinus 40.30 8.00e-85 305.00
IUUC-Oga-088999 Otolemur garnettii 41.68 1.00e-101 362.00
IUUC-Oar-089338 Ovis aries 38.64 2.00e-80 291.00
IUUC-Ptr-091185 Pan troglodytes 42.55 7.00e-108 382.00
IUUC-Pan-092321 Papio anubis 42.73 8.00e-109 385.00
IUUC-Psi-094018 Pelodiscus sinensis 45.34 4.00e-55 206.00
IUUC-Pma-094111 Petromyzon marinus 40.65 3.00e-79 286.00
IUUC-Pno-094782 Phaeosphaeria nodorum 59.79 5.00e-173 598.00
IUUC-Ppa-095335 Physcomitrella patens 36.67 5.00e-95 340.00
IUUC-Pfo-097393 Poecilia formosa 45.62 2.00e-108 384.00
IUUC-Pab-098263 Pongo abelii 38.91 8.00e-92 328.00
IUUC-Pop-099316 Populus trichocarpa 41.63 3.00e-86 310.00
IUUC-Pca-100387 Procavia capensis 57.94 2.00e-41 161.00
IUUC-Ppe-101275 Prunus persica 40.08 3.00e-94 337.00
IUUC-Pva-102150 Pteropus vampyrus 46.43 4.00e-94 336.00
IUUC-Pgr-103378 Puccinia graminis 48.34 3.00e-118 417.00
IUUC-Ptt-103908 Puccinia triticina 43.76 3.00e-103 367.00
IUUC-Pte-104248 Pyrenophora teres 59.22 3.00e-173 599.00
IUUC-Pyt-104645 Pyrenophora triticirepentis 59.22 1.00e-174 604.00
IUUC-Rno-105162 Rattus norvegicus 43.09 3.00e-110 390.00
IUUC-Sha-107123 Sarcophilus harrisii 54.44 2.00e-43 168.00
IUUC-Sja-107828 Schizosaccharomyces japonicus 46.68 7.00e-124 435.00
IUUC-Spo-108368 Schizosaccharomyces pombe 46.59 7.00e-130 455.00
IUUC-Smo-109102 Selaginella moellendorffii 40.00 4.00e-99 353.00
IUUC-Sit-110821 Setaria italica 41.30 5.00e-96 343.00
IUUC-Sly-111803 Solanum lycopersicum 38.89 1.00e-99 355.00
IUUC-Stu-112730 Solanum tuberosum 39.39 1.00e-98 352.00
IUUC-Sar-113618 Sorex araneus 44.38 3.00e-106 377.00
IUUC-Sbi-114487 Sorghum bicolor 41.87 8.00e-97 345.00
IUUC-Sre-115009 Sporisorium reilianum 41.43 6.00e-99 352.00
IUUC-Ssc-115984 Sus scrofa 43.07 6.00e-108 382.00
IUUC-Tgu-117410 Taeniopygia guttata 41.75 2.00e-108 384.00
IUUC-Tru-118537 Takifugu rubripes 41.94 4.00e-106 376.00
IUUC-Tsy-119318 Tarsius syrichta 33.33 1.00e-40 159.00
IUUC-Tni-120514 Tetraodon nigroviridis 44.09 1.00e-73 268.00
IUUC-Tca-121620 Theobroma cacao 40.45 2.00e-93 335.00
IUUC-Tre-121904 Trichoderma reesei 51.77 5.00e-128 449.00
IUUC-Tvi-122585 Trichoderma virens 56.79 3.00e-132 463.00
IUUC-Tae-125342 Triticum aestivum 40.00 8.00e-94 336.00
IUUC-Tme-126960 Tuber melanosporum 62.13 8.00e-168 581.00
IUUC-Tbe-127839 Tupaia belangeri 36.07 2.00e-34 137.00
IUUC-Ttr-129173 Tursiops truncatus 33.33 9.00e-72 262.00
IUUC-Uma-129595 Ustilago maydis 41.19 3.00e-92 330.00
IUUC-Vda-130012 Verticillium dahliae 56.26 2.00e-157 547.00
IUUC-Vvi-131156 Vitis vinifera 39.59 8.00e-101 359.00
IUUC-Xtr-132807 Xenopus tropicalis 43.75 5.00e-102 363.00
IUUC-Yli-134361 Yarrowia lipolytica 45.04 9.00e-37 145.00
IUUC-Zma-135759 Zea mays 50.97 5.00e-45 174.00
Created Date 25-Jun-2017

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