iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025763

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

EAAA01001478

Gene Name

LOC100185177

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000008647.3	ENSCINT00000017661.3	ENSCINP00000017661.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.20e-93	312.3	12	521

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++q+ l++a+++l++++++ +E+lKnL+l Gvgs+ ++D+ +++ ++ +++F+++++ +g+ KA+va e l elnpdv+
   Q: 12   YDRQLRLWGDHGQQVLERARICLINVTATSTEILKNLILPGVGSFLILDGGRISGEDAGNNFFLDPSAIGQLKAKVATELLLELNPDVK 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++  ee++++l ++++ Ff+ f+v+++    + + +k++ l++++++pl+++ ++G++G++r+i++++ + +s++d   +++++  Pf+
   Q: 101  GDYTEEDLNQLLDRNPqFFQCFTVIIASSLDVVTHKKLAALLWKHNIPLVTCYSYGFIGYMRIIVREHCVVESHPDnahEDLRLLDPFP 189
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l e++          ++++++++ v++ k+l+ ++ e+ ++++++ +ek+ +k+kv ++++       edeenfeea + +++a+ ++
   Q: 190  ELVEYIDsidlekmdkKQHSHVPYLVILYKFLQAWKNEHGGQAPKNWKEKKLFKEKVLQGVRInehgmqEDEENFEEASKQVNTALVES 278
           *****88888888888******************************************99998889999******************** PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i++  +q++++ +c ++++++++fw+                                                              
   Q: 279  KIPEnLQQIFNDAKCCNISENSTNFWIlanglkqfvqnndksslplrgslpdmfsdsesyvklqniyktkakqdidlltsyirdfgavn 367
           ***************************************************************************************** PP
   S: 275  .........sfcsnaealqvpekvekdeevvkasap..............lylllralerfekkkgrkpgelsfekdddsavdlvtaaa 340
                    +fc na+ lqv  +   +ee+  as++              +y++lr +e+f ++ +r+pg+   + d d + +l++ + 
   Q: 368  grlsdqeikRFCRNASFLQVVRSRSLSEEYENASQSildglisegdsdaiWYVMLRCVEQFYTNFSRYPGVKADDIDID-VTRLKNCVQ 455
           *******************886666666665555556778888888889********************7777666667.666666555 PP
   S: 341  nlraeslgiep...kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            l   s g+++    ++dd+++ei++ ++++i++++++ gG+aaqEviK+++++++p+  +++++++
   Q: 456  ELT-RSWGVPGlveAMSDDYVQEICRVGAAEIHSVASYMGGVAAQEVIKLITAQYVPIVGVYIYNGL 521
           444.555555432269*******************************************99999875 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

SIAKMGEKEK KYDRQLRLWG DHGQQVLERA RICLINVTAT STEILKNLIL PGVGSFLILD 60
GGRISGEDAG NNFFLDPSAI GQLKAKVATE LLLELNPDVK GDYTEEDLNQ LLDRNPQFFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACACATTAA AAATTAAATA ACTGTCCAAT GTTCTATGAT TTTGGGCAAC ATTAAAATAT 60
CAGCTGTTAG CAAAGCTATA GAAACTGTAT TTTTTTCTAT GGACTTTGCA AAAAAGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	40.75	4.00e-113	400.00
IUUC-Aml-002333	Ailuropoda melanoleuca	49.72	6.00e-160	555.00
IUUC-Atr-002644	Amborella trichopoda	40.04	1.00e-107	382.00
IUUC-Apl-003446	Anas platyrhynchos	50.37	8.00e-155	538.00
IUUC-Aca-004450	Anolis carolinensis	50.94	1.00e-164	571.00
IUUC-Aly-006187	Arabidopsis lyrata	39.29	8.00e-114	402.00
IUUC-Ath-007600	Arabidopsis thaliana	39.10	4.00e-112	397.00
IUUC-Ago-007900	Ashbya gossypii	26.31	2.00e-41	161.00
IUUC-Acl-008333	Aspergillus clavatus	35.45	2.00e-83	301.00
IUUC-Afl-008529	Aspergillus flavus	35.88	2.00e-87	315.00
IUUC-Afu-009071	Aspergillus fumigatus	35.08	1.00e-82	299.00
IUUC-Ani-009443	Aspergillus nidulans	34.81	4.00e-77	280.00
IUUC-Ang-009669	Aspergillus niger	34.60	6.00e-83	300.00
IUUC-Aor-009914	Aspergillus oryzae	35.27	5.00e-85	306.00
IUUC-Ate-010450	Aspergillus terreus	35.48	1.00e-87	315.00
IUUC-Ame-011183	Astyanax mexicanus	49.15	4.00e-161	560.00
IUUC-Bgr-012111	Blumeria graminis	34.16	1.00e-72	265.00
IUUC-Bta-012583	Bos taurus	49.72	6.00e-161	559.00
IUUC-Bci-013892	Botrytis cinerea	34.81	5.00e-71	260.00
IUUC-Bdi-014592	Brachypodium distachyon	40.94	1.00e-112	399.00
IUUC-Bol-016399	Brassica oleracea	40.42	3.00e-117	413.00
IUUC-Bra-018084	Brassica rapa	39.20	3.00e-110	390.00
IUUC-Cel-018456	Caenorhabditis elegans	33.08	2.00e-88	318.00
IUUC-Cja-020007	Callithrix jacchus	50.19	5.00e-160	556.00
IUUC-Cfa-020324	Canis familiaris	49.72	8.00e-161	558.00
IUUC-Cpo-022248	Cavia porcellus	48.12	2.00e-92	331.00
IUUC-Csa-023149	Chlorocebus sabaeus	45.92	8.00e-124	436.00
IUUC-Cho-024537	Choloepus hoffmanni	38.79	2.00e-101	361.00
IUUC-Csv-026113	Ciona savignyi	75.23	0.00e+00	847.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.49	6.00e-71	260.00
IUUC-Cne-026884	Cryptococcus neoformans	34.33	3.00e-80	291.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.30	3.00e-24	105.00
IUUC-Dre-028140	Danio rerio	49.34	9.00e-161	558.00
IUUC-Dno-030033	Dasypus novemcinctus	49.36	2.00e-140	491.00
IUUC-Dor-030513	Dipodomys ordii	30.38	1.00e-37	149.00
IUUC-Dse-031536	Dothistroma septosporum	33.10	1.00e-80	292.00
IUUC-Dme-031683	Drosophila melanogaster	41.12	3.00e-117	414.00
IUUC-Ete-032420	Echinops telfairi	42.77	4.00e-128	450.00
IUUC-Eca-033992	Equus caballus	46.09	8.00e-123	432.00
IUUC-Eeu-034713	Erinaceus europaeus	35.80	1.00e-46	179.00
IUUC-Fca-036548	Felis catus	49.81	1.00e-157	548.00
IUUC-Fal-037600	Ficedula albicollis	50.57	2.00e-153	534.00
IUUC-Fox-038037	Fusarium oxysporum	32.34	1.00e-76	279.00
IUUC-Fso-038387	Fusarium solani	32.89	2.00e-78	285.00
IUUC-Gmo-038562	Gadus morhua	48.69	6.00e-162	562.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.69	6.00e-75	273.00
IUUC-Gga-041129	Gallus gallus	52.26	2.00e-159	554.00
IUUC-Gac-042558	Gasterosteus aculeatus	48.32	8.00e-158	548.00
IUUC-Gma-043610	Glycine max	40.80	5.00e-113	400.00
IUUC-Ggo-045611	Gorilla gorilla	49.26	4.00e-160	556.00
IUUC-Hsa-046563	Homo sapiens	49.53	4.00e-161	559.00
IUUC-Hvu-047790	Hordeum vulgare	38.87	1.00e-73	268.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	49.53	2.00e-159	554.00
IUUC-Kpa-049309	Komagataella pastoris	37.00	7.00e-83	300.00
IUUC-Lch-050038	Latimeria chalumnae	47.36	3.00e-153	533.00
IUUC-Lpe-051535	Leersia perrieri	39.10	2.00e-93	335.00
IUUC-Loc-051917	Lepisosteus oculatus	46.40	9.00e-146	508.00
IUUC-Lma-053112	Leptosphaeria maculans	32.69	9.00e-81	292.00
IUUC-Laf-053690	Loxodonta africana	50.28	7.00e-162	562.00
IUUC-Mcc-055117	Macaca mulatta	48.41	4.00e-155	540.00
IUUC-Meu-056761	Macropus eugenii	40.04	7.00e-115	406.00
IUUC-Mor-057230	Magnaporthe oryzae	34.44	3.00e-84	304.00
IUUC-Mpo-057514	Magnaporthe poae	32.17	2.00e-74	271.00
IUUC-Mtr-058551	Medicago truncatula	38.67	1.00e-105	375.00
IUUC-Mla-059183	Melampsora laricipopulina	37.64	7.00e-107	379.00
IUUC-Mga-060144	Meleagris gallopavo	51.33	5.00e-156	543.00
IUUC-Mvi-060221	Microbotryum violaceum	37.13	6.00e-91	327.00
IUUC-Mmr-061325	Microcebus murinus	48.50	6.00e-155	539.00
IUUC-Mdo-062532	Monodelphis domestica	50.66	2.00e-162	564.00
IUUC-Mmu-063956	Mus musculus	49.91	2.00e-161	560.00
IUUC-Mac-064521	Musa acuminata	39.69	7.00e-112	396.00
IUUC-Mpu-066716	Mustela putorius furo	49.09	2.00e-149	521.00
IUUC-Mlu-067459	Myotis lucifugus	49.81	1.00e-159	555.00
IUUC-Nfi-068245	Neosartorya fischeri	34.67	3.00e-84	304.00
IUUC-Ncr-068910	Neurospora crassa	33.89	1.00e-81	296.00
IUUC-Nle-070034	Nomascus leucogenys	48.28	6.00e-152	529.00
IUUC-Opr-070552	Ochotona princeps	45.56	8.00e-127	445.00
IUUC-Ont-071426	Oreochromis niloticus	48.21	3.00e-160	556.00
IUUC-Oan-073389	Ornithorhynchus anatinus	45.86	1.00e-115	408.00
IUUC-Ocu-074911	Oryctolagus cuniculus	49.53	3.00e-160	556.00
IUUC-Oba-075437	Oryza barthii	41.33	9.00e-105	372.00
IUUC-Obr-076684	Oryza brachyantha	42.45	2.00e-100	358.00
IUUC-Ogl-077170	Oryza glaberrima	41.33	9.00e-105	372.00
IUUC-Ogu-078844	Oryza glumaepatula	41.19	1.00e-96	345.00
IUUC-Oin-079105	Oryza indica	41.33	5.00e-104	370.00
IUUC-Olo-080943	Oryza longistaminata	39.17	4.00e-90	323.00
IUUC-Oni-082891	Oryza nivara	39.05	3.00e-97	347.00
IUUC-Opu-083457	Oryza punctata	41.71	2.00e-105	374.00
IUUC-Oru-084960	Oryza rufipogon	39.05	6.00e-91	326.00
IUUC-Osa-085358	Oryza sativa	41.14	4.00e-103	367.00
IUUC-Ola-086420	Oryzias latipes	44.68	6.00e-102	362.00
IUUC-Olu-087625	Ostreococcus lucimarinus	28.77	6.00e-58	217.00
IUUC-Oga-088810	Otolemur garnettii	49.15	8.00e-161	558.00
IUUC-Oar-089196	Ovis aries	49.44	2.00e-159	554.00
IUUC-Ptr-090617	Pan troglodytes	49.53	2.00e-161	560.00
IUUC-Pan-092761	Papio anubis	49.91	2.00e-160	557.00
IUUC-Psi-093191	Pelodiscus sinensis	49.62	1.00e-156	544.00
IUUC-Pma-094380	Petromyzon marinus	50.50	2.00e-151	527.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.73	3.00e-69	256.00
IUUC-Ppa-095798	Physcomitrella patens	40.37	6.00e-119	419.00
IUUC-Pfo-096467	Poecilia formosa	47.75	2.00e-155	540.00
IUUC-Pab-098255	Pongo abelii	51.61	7.00e-137	479.00
IUUC-Pop-099722	Populus trichocarpa	41.18	5.00e-117	413.00
IUUC-Pca-100807	Procavia capensis	50.57	8.00e-69	252.00
IUUC-Ppe-101280	Prunus persica	38.72	3.00e-112	397.00
IUUC-Pva-102333	Pteropus vampyrus	47.56	1.00e-147	514.00
IUUC-Pgr-103401	Puccinia graminis	29.23	2.00e-73	268.00
IUUC-Ptt-103889	Puccinia triticina	27.55	1.00e-62	233.00
IUUC-Pte-104355	Pyrenophora teres	33.33	4.00e-85	307.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.21	2.00e-81	295.00
IUUC-Rno-105810	Rattus norvegicus	48.98	2.00e-158	551.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.62	2.00e-42	165.00
IUUC-Sha-106770	Sarcophilus harrisii	59.34	3.00e-96	343.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.13	4.00e-68	250.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.59	8.00e-82	296.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	34.55	4.00e-74	270.00
IUUC-Smo-109296	Selaginella moellendorffii	37.00	7.00e-103	366.00
IUUC-Sit-110157	Setaria italica	41.68	1.00e-118	418.00
IUUC-Sly-111105	Solanum lycopersicum	38.82	2.00e-112	397.00
IUUC-Stu-112469	Solanum tuberosum	39.37	1.00e-115	408.00
IUUC-Sar-113083	Sorex araneus	36.22	3.00e-103	367.00
IUUC-Sbi-113813	Sorghum bicolor	41.49	1.00e-116	412.00
IUUC-Sre-115058	Sporisorium reilianum	36.16	1.00e-77	283.00
IUUC-Tgu-116772	Taeniopygia guttata	51.22	2.00e-155	540.00
IUUC-Tru-118686	Takifugu rubripes	47.38	3.00e-159	553.00
IUUC-Tsy-119111	Tarsius syrichta	54.24	3.00e-82	298.00
IUUC-Tni-120231	Tetraodon nigroviridis	44.34	9.00e-140	488.00
IUUC-Tca-121491	Theobroma cacao	40.04	3.00e-110	390.00
IUUC-Tre-122103	Trichoderma reesei	36.92	7.00e-87	313.00
IUUC-Tvi-122672	Trichoderma virens	37.50	3.00e-84	304.00
IUUC-Tae-125679	Triticum aestivum	40.94	6.00e-114	403.00
IUUC-Tur-126487	Triticum urartu	39.54	9.00e-108	382.00
IUUC-Tme-127097	Tuber melanosporum	35.17	1.00e-92	332.00
IUUC-Ttr-128465	Tursiops truncatus	46.99	7.00e-146	509.00
IUUC-Uma-129645	Ustilago maydis	34.86	6.00e-79	286.00
IUUC-Vda-129989	Verticillium dahliae	29.74	1.00e-59	222.00
IUUC-Vpa-130529	Vicugna pacos	47.18	2.00e-148	517.00
IUUC-Vvi-131059	Vitis vinifera	40.41	4.00e-112	396.00
IUUC-Xtr-132002	Xenopus tropicalis	50.47	5.00e-164	569.00
IUUC-Xma-133930	Xiphophorus maculatus	47.65	1.00e-155	541.00
IUUC-Yli-134505	Yarrowia lipolytica	34.23	1.00e-79	289.00
IUUC-Zma-135895	Zea mays	41.27	1.00e-115	409.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence